4A3KE

Rna polymerase ii initial transcribing complex with a 7nt dna-rna hybrid
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of Initial RNA Polymerase II Transcription.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 64
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2011-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 4a3kE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 4a3kE02
5C4JE 4Y52E 4A3BE 4Y7NE 1SFOE 2R93E 2NVXE 3GTOE 5IYCE 5M5XE 5M5YE 3GTME 2JA8E 3S1NE 2PMZH 5C4XE 3HOVE 4A3ME 2JA6E 4QIWH 2YU9E 4A3KE 3S1ME 3I4ME 2E2JE 3HOWE 5IYBE 1TWCE 4A3GE 4A3FE 5IP9E 3I4NE 4X6AE 3RZDE 3HOUE 1I50E 2E2HE 3RZOE 5M5WE 1R9TE 4BBSE 3HOZE 5IYDE 5C44E 1Y1VE 3S2HE 3CQZE 3HOXE 4BY1E 4AYBH 3M4OE 3GTPE 4C3IE 3K7AE 3HOYE 3S15E 2R92E 3M3YE 1I3QE 3GTGE 1I6HE 1WCME 4A3IE 4A3LE 4C2ME 1EIKA 3PO2E 1K83E 2NVQE 3GTQE 3S1RE 3GTLE 3S17E 4A3DE 4C3HE 2E2IE 5M3ME 3PO3E 3H0GE 1TWFE 4BXXE 3FKIE 2R7ZE 2VUME 4C3JE 5M3FE 4BBRE 2NVYE 1Y1WE 2WAQH 2WB1H 3HKZH 1TWAE 3S14E 2NVTE 3S1QE 5IP7E 5FJ8E 3GTKE 5C3EE 3S16E 4A3JE 2JA5E 5FLME 1DZFA 2Y0SH 3S2DE 1TWHE 4A3EE 2JA7E 4A93E 3H3VF 4BY7E 4A3CE 3GTJE 1TWGE 2B63E
chains in the Genus database with same CATH superfamily
4A3MF 4AYBK 5C4JE 4Y52E 2A6EE 2PMZK 2JA6F 3K7AF 4MQ9E 4A3KF 3DXJE 4A3BE 5D4EE 4Y7NE 1SFOE 2R93E 3S1MF 2A69E 3S15F 2NVXE 5D4DE 4LK0E 2E2JF 1I3QF 3GTOE 3GTGF 1YNJK 3HOWF 5IYBF 5IYCE 1TWCF 4A3GF 5M5XE 4A3FF 4A3LF 5M5YE 4C2MF 4OIOE 4YFKE 3I4NF 3RZDF 4X6AF 2E2HF 3GTME 2JA8E 3S1NE 4LJZE 2PMZH 4LK1E 5C4XE 3RZOF 3HOVE 1R9TF 4A3ME 5IPLE 2JA6E 1ZYRE 2YU9E 4KN4E 4QIWH 4Q4ZE 5IYDF 5C44F 2O5JE 4A3KE 3S1ME 3I4ME 2Y0SI 4Q5SE 3S2HF 3CQZF 1I6VE 4BY1F 4OIQE 3GTPF 2E2JE 4JK1E 4OINE 3HOWE 5IYBE 1TWCE 4C3IF 4A3GE 4A3FE 3H0GF 4BXXF 5IP9E 3I4NE 3HOYF 4X6AE 3RZDE 4GZYE 3HOUE 1I50E 2E2HE 2R92F 3RZOE 2CW0E 5M5WE 3M3YF 1R9TE 5M3FF 1QKLA 4BBSE 3HOZE 4XLNE 1WCMF 2NVYF 1I6HF 4A3IF 5IYDE 5C44E 1Y1VE 3S2HE 3CQZE 3HOXE 3S14F 4BY1E 4AYBH 3M4OE 3GTPE 3EQLE 5C3EF 4MEYE 3PO2F 4G7ZE 1K83F 4OIRE 2NVQF 4C3IE 3K7AE 5FLMF 3GTQF 3S1RF 3GTLF 3HOYE 3S17F 2BE5E 4A3DF 1TWHF 3S15E 2R92E 5BYHE 4A3EF 4A93F 3M3YE 4C3HF 2E2IF 3H3VG 1I3QE 3GTGE 1I6HE 4A3CF 5M3MF 1WCME 3PO3F 2B63F 4A3IE 4A3LE 1TWFF 3FKIF 4C2ME 2R7ZF 4Y52F 5C4JF 1HQME 5D4CE 4A3BF 4G7OE 4Y7NF 2VUMF 4C3JF 1EIKA 4YFXE 3PO2E 4BBRF 1K83E 1Y1WF 2NVQE 3GTQE 3S1RE 3GTLE 3S17E 1TWAF 2KRXA 4A3DE 2NVTF 2WAQK 4XSXE 5TMCE 4OIPE 3S1QF 3HKZK 5IP7F 5FJ8F 4MEXE 4C3HE 4KN7E 2E2IE 3GTKF 2JA8F 4YFNE 3S16F 4A3JF 5M3ME 3PO3E 4ZH4E 4G7HE 2JA5F 3H0GE 1TWFE 4BXXE 3FKIE 2R7ZE 2YU9F 4LLGE 3S2DF 2A68E 3I4MF 5TMFE 2JA7F 4XSZE 2VUME 4C3JE 4QIWK 4BY7F 5M3FE 4BBRE 2PPBE 2NVYE 1Y1WE 1TWGF 2WAQH 2WB1H 3GTJF 5E17E 4YG2E 3HKZH 1TWAE 3S14E 2NVTE 2WB1I 3S1QE 2A6HE 5IP9F 1SFOF 5IP7E 2R93F 5FJ8E 3GTKE 3HOUF 5C3EE 1I50F 1YNNK 1SMYE 5E18E 2NVXF 3WODE 3S16E 4A3JE 5M5WF 2JA5E 2O5IE 5FLME 3GTOF 1DZFA 2Y0SH 1IW7E 4XLPE 5IYCF 3HOZF 4BBSF 5M5XF 3S2DE 1TWHE 5M5YF 4A3EE 2JA7E 4A93E 1Y1VF 3HOXF 3H3VF 3GTMF 4BY7E 3S1NF 3M4OF 4A3CE 4KMUE 3HOVF 3GTJE 5C4XF 1TWGE 2B63E
chains in the Genus database with same CATH topology
5C4JE 4Y52E 4A3BE 4Y7NE 1SFOE 2R93E 2NVXE 3GTOE 5IYCE 5M5XE 5M5YE 3GTME 2JA8E 3S1NE 2PMZH 5C4XE 3HOVE 4A3ME 2JA6E 4QIWH 2YU9E 4A3KE 3S1ME 3I4ME 2E2JE 3HOWE 5IYBE 1TWCE 4A3GE 4A3FE 5IP9E 3I4NE 4X6AE 3RZDE 3HOUE 1I50E 2E2HE 3RZOE 5M5WE 1R9TE 4BBSE 3HOZE 5IYDE 5C44E 1Y1VE 3S2HE 3CQZE 3HOXE 4BY1E 4AYBH 3M4OE 3GTPE 4C3IE 3K7AE 3HOYE 3S15E 2R92E 3M3YE 1I3QE 3GTGE 1I6HE 1WCME 4A3IE 4A3LE 4C2ME 1EIKA 3PO2E 1K83E 2NVQE 3GTQE 3S1RE 3GTLE 3S17E 4A3DE 4C3HE 2E2IE 5M3ME 3PO3E 3H0GE 1TWFE 4BXXE 3FKIE 2R7ZE 2VUME 4C3JE 5M3FE 4BBRE 2NVYE 1Y1WE 2WAQH 2WB1H 3HKZH 1TWAE 3S14E 2NVTE 3S1QE 5IP7E 5FJ8E 3GTKE 5C3EE 3S16E 4A3JE 2JA5E 5FLME 1DZFA 2Y0SH 3S2DE 1TWHE 4A3EE 2JA7E 4A93E 3H3VF 4BY7E 4A3CE 3GTJE 1TWGE 2B63E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C4J E;  4Y52 E;  4A3B E;  4Y7N E;  1SFO E;  2R93 E;  2NVX E;  3GTO E;  5IYC E;  5M5X E;  5M5Y E;  3GTM E;  2JA8 E;  3S1N E;  2PMZ H;  5C4X E;  3HOV E;  4A3M E;  2JA6 E;  4QIW H;  2YU9 E;  4A3K E;  3S1M E;  3I4M E;  2E2J E;  3HOW E;  5IYB E;  1TWC E;  4A3G E;  4A3F E;  5IP9 E;  3I4N E;  4X6A E;  3RZD E;  3HOU E;  1I50 E;  2E2H E;  3RZO E;  5M5W E;  1R9T E;  4BBS E;  3HOZ E;  5IYD E;  5C44 E;  1Y1V E;  3S2H E;  3CQZ E;  3HOX E;  4BY1 E;  4AYB H;  3M4O E;  3GTP E;  4C3I E;  3K7A E;  3HOY E;  3S15 E;  2R92 E;  3M3Y E;  1I3Q E;  3GTG E;  1I6H E;  1WCM E;  4A3I E;  4A3L E;  4C2M E;  1EIK A;  3PO2 E;  1K83 E;  2NVQ E;  3GTQ E;  3S1R E;  3GTL E;  3S17 E;  4A3D E;  4C3H E;  2E2I E;  5M3M E;  3PO3 E;  3H0G E;  1TWF E;  4BXX E;  3FKI E;  2R7Z E;  2VUM E;  4C3J E;  5M3F E;  4BBR E;  2NVY E;  1Y1W E;  2WAQ H;  2WB1 H;  3HKZ H;  1TWA E;  3S14 E;  2NVT E;  3S1Q E;  5IP7 E;  5FJ8 E;  3GTK E;  5C3E E;  3S16 E;  4A3J E;  2JA5 E;  5FLM E;  1DZF A;  2Y0S H;  3S2D E;  1TWH E;  4A3E E;  2JA7 E;  4A93 E;  3H3V F;  4BY7 E;  4A3C E;  3GTJ E;  1TWG E;  2B63 E; 
#chains in the Genus database with same CATH topology
 4A3M F;  4AYB K;  5C4J E;  4Y52 E;  2A6E E;  2PMZ K;  2JA6 F;  3K7A F;  4MQ9 E;  4A3K F;  3DXJ E;  4A3B E;  5D4E E;  4Y7N E;  1SFO E;  2R93 E;  3S1M F;  2A69 E;  3S15 F;  2NVX E;  5D4D E;  4LK0 E;  2E2J F;  1I3Q F;  3GTO E;  3GTG F;  1YNJ K;  3HOW F;  5IYB F;  5IYC E;  1TWC F;  4A3G F;  5M5X E;  4A3F F;  4A3L F;  5M5Y E;  4C2M F;  4OIO E;  4YFK E;  3I4N F;  3RZD F;  4X6A F;  2E2H F;  3GTM E;  2JA8 E;  3S1N E;  4LJZ E;  2PMZ H;  4LK1 E;  5C4X E;  3RZO F;  3HOV E;  1R9T F;  4A3M E;  5IPL E;  2JA6 E;  1ZYR E;  2YU9 E;  4KN4 E;  4QIW H;  4Q4Z E;  5IYD F;  5C44 F;  2O5J E;  4A3K E;  3S1M E;  3I4M E;  2Y0S I;  4Q5S E;  3S2H F;  3CQZ F;  1I6V E;  4BY1 F;  4OIQ E;  3GTP F;  2E2J E;  4JK1 E;  4OIN E;  3HOW E;  5IYB E;  1TWC E;  4C3I F;  4A3G E;  4A3F E;  3H0G F;  4BXX F;  5IP9 E;  3I4N E;  3HOY F;  4X6A E;  3RZD E;  4GZY E;  3HOU E;  1I50 E;  2E2H E;  2R92 F;  3RZO E;  2CW0 E;  5M5W E;  3M3Y F;  1R9T E;  5M3F F;  1QKL A;  4BBS E;  3HOZ E;  4XLN E;  1WCM F;  2NVY F;  1I6H F;  4A3I F;  5IYD E;  5C44 E;  1Y1V E;  3S2H E;  3CQZ E;  3HOX E;  3S14 F;  4BY1 E;  4AYB H;  3M4O E;  3GTP E;  3EQL E;  5C3E F;  4MEY E;  3PO2 F;  4G7Z E;  1K83 F;  4OIR E;  2NVQ F;  4C3I E;  3K7A E;  5FLM F;  3GTQ F;  3S1R F;  3GTL F;  3HOY E;  3S17 F;  2BE5 E;  4A3D F;  1TWH F;  3S15 E;  2R92 E;  5BYH E;  4A3E F;  4A93 F;  3M3Y E;  4C3H F;  2E2I F;  3H3V G;  1I3Q E;  3GTG E;  1I6H E;  4A3C F;  5M3M F;  1WCM E;  3PO3 F;  2B63 F;  4A3I E;  4A3L E;  1TWF F;  3FKI F;  4C2M E;  2R7Z F;  4Y52 F;  5C4J F;  1HQM E;  5D4C E;  4A3B F;  4G7O E;  4Y7N F;  2VUM F;  4C3J F;  1EIK A;  4YFX E;  3PO2 E;  4BBR F;  1K83 E;  1Y1W F;  2NVQ E;  3GTQ E;  3S1R E;  3GTL E;  3S17 E;  1TWA F;  2KRX A;  4A3D E;  2NVT F;  2WAQ K;  4XSX E;  5TMC E;  4OIP E;  3S1Q F;  3HKZ K;  5IP7 F;  5FJ8 F;  4MEX E;  4C3H E;  4KN7 E;  2E2I E;  3GTK F;  2JA8 F;  4YFN E;  3S16 F;  4A3J F;  5M3M E;  3PO3 E;  4ZH4 E;  4G7H E;  2JA5 F;  3H0G E;  1TWF E;  4BXX E;  3FKI E;  2R7Z E;  2YU9 F;  4LLG E;  3S2D F;  2A68 E;  3I4M F;  5TMF E;  2JA7 F;  4XSZ E;  2VUM E;  4C3J E;  4QIW K;  4BY7 F;  5M3F E;  4BBR E;  2PPB E;  2NVY E;  1Y1W E;  1TWG F;  2WAQ H;  2WB1 H;  3GTJ F;  5E17 E;  4YG2 E;  3HKZ H;  1TWA E;  3S14 E;  2NVT E;  2WB1 I;  3S1Q E;  2A6H E;  5IP9 F;  1SFO F;  5IP7 E;  2R93 F;  5FJ8 E;  3GTK E;  3HOU F;  5C3E E;  1I50 F;  1YNN K;  1SMY E;  5E18 E;  2NVX F;  3WOD E;  3S16 E;  4A3J E;  5M5W F;  2JA5 E;  2O5I E;  5FLM E;  3GTO F;  1DZF A;  2Y0S H;  1IW7 E;  4XLP E;  5IYC F;  3HOZ F;  4BBS F;  5M5X F;  3S2D E;  1TWH E;  5M5Y F;  4A3E E;  2JA7 E;  4A93 E;  1Y1V F;  3HOX F;  3H3V F;  3GTM F;  4BY7 E;  3S1N F;  3M4O F;  4A3C E;  4KMU E;  3HOV F;  3GTJ E;  5C4X F;  1TWG E;  2B63 E; 
#chains in the Genus database with same CATH homology
 5C4J E;  4Y52 E;  4A3B E;  4Y7N E;  1SFO E;  2R93 E;  2NVX E;  3GTO E;  5IYC E;  5M5X E;  5M5Y E;  3GTM E;  2JA8 E;  3S1N E;  2PMZ H;  5C4X E;  3HOV E;  4A3M E;  2JA6 E;  4QIW H;  2YU9 E;  4A3K E;  3S1M E;  3I4M E;  2E2J E;  3HOW E;  5IYB E;  1TWC E;  4A3G E;  4A3F E;  5IP9 E;  3I4N E;  4X6A E;  3RZD E;  3HOU E;  1I50 E;  2E2H E;  3RZO E;  5M5W E;  1R9T E;  4BBS E;  3HOZ E;  5IYD E;  5C44 E;  1Y1V E;  3S2H E;  3CQZ E;  3HOX E;  4BY1 E;  4AYB H;  3M4O E;  3GTP E;  4C3I E;  3K7A E;  3HOY E;  3S15 E;  2R92 E;  3M3Y E;  1I3Q E;  3GTG E;  1I6H E;  1WCM E;  4A3I E;  4A3L E;  4C2M E;  1EIK A;  3PO2 E;  1K83 E;  2NVQ E;  3GTQ E;  3S1R E;  3GTL E;  3S17 E;  4A3D E;  4C3H E;  2E2I E;  5M3M E;  3PO3 E;  3H0G E;  1TWF E;  4BXX E;  3FKI E;  2R7Z E;  2VUM E;  4C3J E;  5M3F E;  4BBR E;  2NVY E;  1Y1W E;  2WAQ H;  2WB1 H;  3HKZ H;  1TWA E;  3S14 E;  2NVT E;  3S1Q E;  5IP7 E;  5FJ8 E;  3GTK E;  5C3E E;  3S16 E;  4A3J E;  2JA5 E;  5FLM E;  1DZF A;  2Y0S H;  3S2D E;  1TWH E;  4A3E E;  2JA7 E;  4A93 E;  3H3V F;  4BY7 E;  4A3C E;  3GTJ E;  1TWG E;  2B63 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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