4A3ME

Rna polymerase ii initial transcribing complex with a 4nt dna-rna hybrid and soaked with ampcpp
Total Genus 62
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural basis of initial RNA polymerase II transcription.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 62
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2011-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 4a3mE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 4a3mE02
1R9TE 1I6HE 1TWCE 4BXXE 2E2JE 4A3IE 1I3QE 4BY1E 1TWGE 5IYDE 3RZDE 4A3BE 5C3EE 5M5XE 2R7ZE 3S15E 2WB1H 3GTJE 4C2ME 3HKZH 5M3ME 2Y0SH 4A3KE 5IP9E 3HOYE 3HOZE 1Y1VE 1TWHE 4BBRE 3GTKE 3H3VF 2NVXE 3HOWE 3RZOE 3HOXE 3H0GE 5M5WE 3I4NE 3S14E 4Y52E 2JA7E 4A3LE 5M5YE 3S1RE 3S1QE 3GTOE 1Y1WE 2NVQE 5IYBE 2NVTE 2B63E 5C4JE 3S2HE 5C44E 3GTLE 4A3EE 4A93E 4BY7E 4C3HE 2JA6E 5C4XE 3GTME 3CQZE 2WAQH 3S17E 3FKIE 4A3DE 2VUME 2R93E 1SFOE 3HOVE 4C3IE 3S1ME 3M4OE 3PO3E 1TWFE 3S1NE 1I50E 4A3FE 1DZFA 2R92E 3I4ME 3PO2E 5M3FE 4Y7NE 2JA5E 2NVYE 4X6AE 5IP7E 3K7AE 1WCME 2JA8E 1EIKA 2PMZH 3M3YE 5FJ8E 1K83E 4A3JE 4A3ME 4C3JE 4AYBH 2YU9E 3GTGE 2E2IE 5IYCE 4QIWH 2E2HE 3S16E 3GTPE 3S2DE 4A3CE 4BBSE 3GTQE 1TWAE 4A3GE 5FLME 3HOUE
chains in the Genus database with same CATH superfamily
1R9TE 1I6HE 1TWCE 4A3DF 4BXXE 4KN7E 2VUMF 1SFOF 2E2JE 4LLGE 4A3IE 1I3QE 4C3IF 1IW7E 5TMCE 4XLNE 3M4OF 4OIPE 3S1MF 3HOXF 4BY1E 4KN4E 2BE5E 3H0GF 1TWGE 5IYDE 3RZDE 4A3BE 3PO3F 1TWFF 3S1NF 5C3EE 1I50F 5M5XE 3DXJE 2R7ZE 5E17E 4A3FF 3S15E 2WB1H 4A3LF 2R92F 5D4DE 3S1RF 3GTJE 3I4MF 1YNNK 3PO2F 3GTOF 4C2ME 3HKZH 5M3FF 4Y7NF 5M3ME 2JA5F 4OINE 2NVQF 2Y0SH 2NVYF 2NVTF 1SMYE 4A3KE 5C4JF 5IP9E 3HOYE 3HOZE 5IP7F 4A3EF 1Y1VE 1TWHE 4BBRE 1I6VE 4MQ9E 3GTKE 2JA6F 4A93F 5C4XF 3H3VF 2NVXE 4QIWK 3M3YF 3S17F 3HOWE 3RZOE 3FKIF 2R93F 3H3VG 1K83F 4A3JF 3HOXE 4ZH4E 5D4EE 3HOVF 3H0GE 5M5WE 3I4NE 1ZYRE 3S14E 4A3MF 4Y52E 4C3JF 3GTGF 2JA7E 4GZYE 4A3LE 5M5YE 3S1RE 4LJZE 3S1QE 3S16F 2PMZK 4LK1E 3GTOE 1Y1WE 4A3CF 4OIRE 4BBSF 2NVQE 5IYBE 3GTQF 2NVTE 2B63E 5C4JE 3S2HE 4JK1E 2WB1I 5C44E 3GTLE 4LK0E 4X6AF 4A3EE 4A93E 4BY7E 4AYBK 5FLMF 4C3HE 2JA6E 3HOUF 5C4XE 3GTME 3K7AF 4XSXE 3CQZE 1WCMF 2WAQH 4YFNE 2JA8F 4G7OE 2A69E 4Q4ZE 3S17E 2Y0SI 3FKIE 4A3DE 2E2JF 4A3IF 2O5JE 2VUME 2R93E 1SFOE 3HOVE 4C3IE 3S1ME 3M4OE 1QKLA 5FJ8F 4A3BF 4OIOE 3EQLE 3PO3E 5C3EF 1TWFE 3S1NE 5M5XF 2R7ZF 1I50E 5TMFE 5D4CE 2YU9F 3S15F 2E2IF 4A3FE 3GTKF 5IYCF 1DZFA 2R92E 4MEYE 3GTJF 4OIQE 2E2HF 3I4ME 3GTPF 4C2MF 3PO2E 3S2DF 4Q5SE 4G7HE 5M3FE 4Y7NE 2JA5E 4A3KF 2NVYE 5IP9F 4X6AE 3HOYF 1TWAF 4A3GF 1Y1VF 1TWHF 4BBRF 5IPLE 5IP7E 3K7AE 1HQME 2CW0E 2O5IE 1WCME 2NVXF 2JA8E 1EIKA 2PMZH 4G7ZE 4YFXE 1R9TF 3M3YE 1TWCF 1I6HF 3HOWF 3RZOF 4BXXF 1YNJK 3WODE 5FJ8E 5E18E 1I3QF 3HKZK 5M5WF 4MEXE 1K83E 4A3JE 3I4NF 3S14F 4BY1F 4A3ME 4Y52F 1TWGF 5IYDF 3RZDF 2PPBE 4YG2E 4C3JE 4AYBH 2A6EE 2KRXA 2A6HE 2JA7F 2YU9E 3GTGE 2E2IE 5M5YF 4XSZE 2WAQK 3S1QF 5IYCE 4XLPE 2A68E 4QIWH 2E2HE 3S16E 1Y1WF 3GTPE 3S2DE 4A3CE 4YFKE 5IYBF 4BBSE 5M3MF 2B63F 4KMUE 5BYHE 3S2HF 3GTQE 5C44F 3GTLF 1TWAE 4A3GE 4BY7F 3HOZF 4C3HF 3GTMF 5FLME 3CQZF 3HOUE
chains in the Genus database with same CATH topology
1R9TE 1I6HE 1TWCE 4BXXE 2E2JE 4A3IE 1I3QE 4BY1E 1TWGE 5IYDE 3RZDE 4A3BE 5C3EE 5M5XE 2R7ZE 3S15E 2WB1H 3GTJE 4C2ME 3HKZH 5M3ME 2Y0SH 4A3KE 5IP9E 3HOYE 3HOZE 1Y1VE 1TWHE 4BBRE 3GTKE 3H3VF 2NVXE 3HOWE 3RZOE 3HOXE 3H0GE 5M5WE 3I4NE 3S14E 4Y52E 2JA7E 4A3LE 5M5YE 3S1RE 3S1QE 3GTOE 1Y1WE 2NVQE 5IYBE 2NVTE 2B63E 5C4JE 3S2HE 5C44E 3GTLE 4A3EE 4A93E 4BY7E 4C3HE 2JA6E 5C4XE 3GTME 3CQZE 2WAQH 3S17E 3FKIE 4A3DE 2VUME 2R93E 1SFOE 3HOVE 4C3IE 3S1ME 3M4OE 3PO3E 1TWFE 3S1NE 1I50E 4A3FE 1DZFA 2R92E 3I4ME 3PO2E 5M3FE 4Y7NE 2JA5E 2NVYE 4X6AE 5IP7E 3K7AE 1WCME 2JA8E 1EIKA 2PMZH 3M3YE 5FJ8E 1K83E 4A3JE 4A3ME 4C3JE 4AYBH 2YU9E 3GTGE 2E2IE 5IYCE 4QIWH 2E2HE 3S16E 3GTPE 3S2DE 4A3CE 4BBSE 3GTQE 1TWAE 4A3GE 5FLME 3HOUE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R9T E;  1I6H E;  1TWC E;  4BXX E;  2E2J E;  4A3I E;  1I3Q E;  4BY1 E;  1TWG E;  5IYD E;  3RZD E;  4A3B E;  5C3E E;  5M5X E;  2R7Z E;  3S15 E;  2WB1 H;  3GTJ E;  4C2M E;  3HKZ H;  5M3M E;  2Y0S H;  4A3K E;  5IP9 E;  3HOY E;  3HOZ E;  1Y1V E;  1TWH E;  4BBR E;  3GTK E;  3H3V F;  2NVX E;  3HOW E;  3RZO E;  3HOX E;  3H0G E;  5M5W E;  3I4N E;  3S14 E;  4Y52 E;  2JA7 E;  4A3L E;  5M5Y E;  3S1R E;  3S1Q E;  3GTO E;  1Y1W E;  2NVQ E;  5IYB E;  2NVT E;  2B63 E;  5C4J E;  3S2H E;  5C44 E;  3GTL E;  4A3E E;  4A93 E;  4BY7 E;  4C3H E;  2JA6 E;  5C4X E;  3GTM E;  3CQZ E;  2WAQ H;  3S17 E;  3FKI E;  4A3D E;  2VUM E;  2R93 E;  1SFO E;  3HOV E;  4C3I E;  3S1M E;  3M4O E;  3PO3 E;  1TWF E;  3S1N E;  1I50 E;  4A3F E;  1DZF A;  2R92 E;  3I4M E;  3PO2 E;  5M3F E;  4Y7N E;  2JA5 E;  2NVY E;  4X6A E;  5IP7 E;  3K7A E;  1WCM E;  2JA8 E;  1EIK A;  2PMZ H;  3M3Y E;  5FJ8 E;  1K83 E;  4A3J E;  4A3M E;  4C3J E;  4AYB H;  2YU9 E;  3GTG E;  2E2I E;  5IYC E;  4QIW H;  2E2H E;  3S16 E;  3GTP E;  3S2D E;  4A3C E;  4BBS E;  3GTQ E;  1TWA E;  4A3G E;  5FLM E;  3HOU E; 
#chains in the Genus database with same CATH topology
 1R9T E;  1I6H E;  1TWC E;  4A3D F;  4BXX E;  4KN7 E;  2VUM F;  1SFO F;  2E2J E;  4LLG E;  4A3I E;  1I3Q E;  4C3I F;  1IW7 E;  5TMC E;  4XLN E;  3M4O F;  4OIP E;  3S1M F;  3HOX F;  4BY1 E;  4KN4 E;  2BE5 E;  3H0G F;  1TWG E;  5IYD E;  3RZD E;  4A3B E;  3PO3 F;  1TWF F;  3S1N F;  5C3E E;  1I50 F;  5M5X E;  3DXJ E;  2R7Z E;  5E17 E;  4A3F F;  3S15 E;  2WB1 H;  4A3L F;  2R92 F;  5D4D E;  3S1R F;  3GTJ E;  3I4M F;  1YNN K;  3PO2 F;  3GTO F;  4C2M E;  3HKZ H;  5M3F F;  4Y7N F;  5M3M E;  2JA5 F;  4OIN E;  2NVQ F;  2Y0S H;  2NVY F;  2NVT F;  1SMY E;  4A3K E;  5C4J F;  5IP9 E;  3HOY E;  3HOZ E;  5IP7 F;  4A3E F;  1Y1V E;  1TWH E;  4BBR E;  1I6V E;  4MQ9 E;  3GTK E;  2JA6 F;  4A93 F;  5C4X F;  3H3V F;  2NVX E;  4QIW K;  3M3Y F;  3S17 F;  3HOW E;  3RZO E;  3FKI F;  2R93 F;  3H3V G;  1K83 F;  4A3J F;  3HOX E;  4ZH4 E;  5D4E E;  3HOV F;  3H0G E;  5M5W E;  3I4N E;  1ZYR E;  3S14 E;  4A3M F;  4Y52 E;  4C3J F;  3GTG F;  2JA7 E;  4GZY E;  4A3L E;  5M5Y E;  3S1R E;  4LJZ E;  3S1Q E;  3S16 F;  2PMZ K;  4LK1 E;  3GTO E;  1Y1W E;  4A3C F;  4OIR E;  4BBS F;  2NVQ E;  5IYB E;  3GTQ F;  2NVT E;  2B63 E;  5C4J E;  3S2H E;  4JK1 E;  2WB1 I;  5C44 E;  3GTL E;  4LK0 E;  4X6A F;  4A3E E;  4A93 E;  4BY7 E;  4AYB K;  5FLM F;  4C3H E;  2JA6 E;  3HOU F;  5C4X E;  3GTM E;  3K7A F;  4XSX E;  3CQZ E;  1WCM F;  2WAQ H;  4YFN E;  2JA8 F;  4G7O E;  2A69 E;  4Q4Z E;  3S17 E;  2Y0S I;  3FKI E;  4A3D E;  2E2J F;  4A3I F;  2O5J E;  2VUM E;  2R93 E;  1SFO E;  3HOV E;  4C3I E;  3S1M E;  3M4O E;  1QKL A;  5FJ8 F;  4A3B F;  4OIO E;  3EQL E;  3PO3 E;  5C3E F;  1TWF E;  3S1N E;  5M5X F;  2R7Z F;  1I50 E;  5TMF E;  5D4C E;  2YU9 F;  3S15 F;  2E2I F;  4A3F E;  3GTK F;  5IYC F;  1DZF A;  2R92 E;  4MEY E;  3GTJ F;  4OIQ E;  2E2H F;  3I4M E;  3GTP F;  4C2M F;  3PO2 E;  3S2D F;  4Q5S E;  4G7H E;  5M3F E;  4Y7N E;  2JA5 E;  4A3K F;  2NVY E;  5IP9 F;  4X6A E;  3HOY F;  1TWA F;  4A3G F;  1Y1V F;  1TWH F;  4BBR F;  5IPL E;  5IP7 E;  3K7A E;  1HQM E;  2CW0 E;  2O5I E;  1WCM E;  2NVX F;  2JA8 E;  1EIK A;  2PMZ H;  4G7Z E;  4YFX E;  1R9T F;  3M3Y E;  1TWC F;  1I6H F;  3HOW F;  3RZO F;  4BXX F;  1YNJ K;  3WOD E;  5FJ8 E;  5E18 E;  1I3Q F;  3HKZ K;  5M5W F;  4MEX E;  1K83 E;  4A3J E;  3I4N F;  3S14 F;  4BY1 F;  4A3M E;  4Y52 F;  1TWG F;  5IYD F;  3RZD F;  2PPB E;  4YG2 E;  4C3J E;  4AYB H;  2A6E E;  2KRX A;  2A6H E;  2JA7 F;  2YU9 E;  3GTG E;  2E2I E;  5M5Y F;  4XSZ E;  2WAQ K;  3S1Q F;  5IYC E;  4XLP E;  2A68 E;  4QIW H;  2E2H E;  3S16 E;  1Y1W F;  3GTP E;  3S2D E;  4A3C E;  4YFK E;  5IYB F;  4BBS E;  5M3M F;  2B63 F;  4KMU E;  5BYH E;  3S2H F;  3GTQ E;  5C44 F;  3GTL F;  1TWA E;  4A3G E;  4BY7 F;  3HOZ F;  4C3H F;  3GTM F;  5FLM E;  3CQZ F;  3HOU E; 
#chains in the Genus database with same CATH homology
 1R9T E;  1I6H E;  1TWC E;  4BXX E;  2E2J E;  4A3I E;  1I3Q E;  4BY1 E;  1TWG E;  5IYD E;  3RZD E;  4A3B E;  5C3E E;  5M5X E;  2R7Z E;  3S15 E;  2WB1 H;  3GTJ E;  4C2M E;  3HKZ H;  5M3M E;  2Y0S H;  4A3K E;  5IP9 E;  3HOY E;  3HOZ E;  1Y1V E;  1TWH E;  4BBR E;  3GTK E;  3H3V F;  2NVX E;  3HOW E;  3RZO E;  3HOX E;  3H0G E;  5M5W E;  3I4N E;  3S14 E;  4Y52 E;  2JA7 E;  4A3L E;  5M5Y E;  3S1R E;  3S1Q E;  3GTO E;  1Y1W E;  2NVQ E;  5IYB E;  2NVT E;  2B63 E;  5C4J E;  3S2H E;  5C44 E;  3GTL E;  4A3E E;  4A93 E;  4BY7 E;  4C3H E;  2JA6 E;  5C4X E;  3GTM E;  3CQZ E;  2WAQ H;  3S17 E;  3FKI E;  4A3D E;  2VUM E;  2R93 E;  1SFO E;  3HOV E;  4C3I E;  3S1M E;  3M4O E;  3PO3 E;  1TWF E;  3S1N E;  1I50 E;  4A3F E;  1DZF A;  2R92 E;  3I4M E;  3PO2 E;  5M3F E;  4Y7N E;  2JA5 E;  2NVY E;  4X6A E;  5IP7 E;  3K7A E;  1WCM E;  2JA8 E;  1EIK A;  2PMZ H;  3M3Y E;  5FJ8 E;  1K83 E;  4A3J E;  4A3M E;  4C3J E;  4AYB H;  2YU9 E;  3GTG E;  2E2I E;  5IYC E;  4QIW H;  2E2H E;  3S16 E;  3GTP E;  3S2D E;  4A3C E;  4BBS E;  3GTQ E;  1TWA E;  4A3G E;  5FLM E;  3HOU E; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...