4CU4A

Fhua from e. coli in complex with the lasso peptide microcin j25 (mccj25)
Total Genus 209
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
209
sequence length
706
structure length
693
Chain Sequence
SAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAVIDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNLRFAENKTSQNSVYGYGVCSDPANAYSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQLQSKFATGDIDHTLLTGVDFMRMRNDINAWFGYDDSVPLLNLYNNTDFDFNAKDPANSGPYRILNKQKQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTDKRDDKQFTWRGGVNYLFDNGVTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVPEDRPIVVTGAVYNLTKTNNLMADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTPAQVPKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTVVDALVRYDLARVGMAGSNVALHVNNLFDREYVASCFNTYGCFWGAERQVVATATFRF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Hijacking Siderophore Receptors by Antimicrobial Lasso Peptides.
pubmed doi rcsb
molecule tags Transport protein/antibiotic
source organism Escherichia coli str. k-12 substr. mg1655
molecule keywords FERRICHROME-IRON RECEPTOR
total genus 209
structure length 693
sequence length 706
ec nomenclature
pdb deposition date 2014-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00593 TonB_dep_Rec TonB dependent receptor
A PF07715 Plug TonB-dependent Receptor Plug Domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.170.20 Mainly Beta Beta Barrel Maltoporin; Chain A TonB-dependent receptor, beta-barrel domain 4cu4A02
2.170.130.10 Mainly Beta Beta Complex Ferric Hydroxamate Uptake Protein; Chain A, domain 1 TonB-dependent receptor, plug domain 4cu4A01
4AIQA 2W78A 2W6UA 1NQGA 2HDIA 1NQHA 2GRXA 3M8BA 3FHHA 3CSNA 4EPAA 1UJWA 1QKCA 1FI1A 4CU4A 1QFGA 2GUFA 1PO0A 1FEPA 1XKWA 3RGNA 2HDFA 2IAHA 1QFFA 4B7OA 3V89A 1KMOA 3M8DA 4RDTA 3EFMA 3CSLA 3QLBA 3RGMA 2W77A 1XKHA 1FCPA 3DDRA 2W75A 2YSUA 4RDRA 2W6TA 1PO3A 2W16A 5FOKA 2GSKA 3V8XA 4AIPA 1NQEA 2FCPA 1PNZA 1BY5A 1NQFA 1QJQA 1BY3A 2O5PA 2W76A 1KMPA
chains in the Genus database with same CATH superfamily
4AIQA 2W78A 2W6UA 1NQGA 2HDIA 1AF6A 1NQHA 3M8BA 2GRXA 3FHHA 3CSNA 4EPAA 1A0SP 1UJWA 1QKCA 1FI1A 1QJQA 4CU4A 1MPNA 1MPMA 1QFGA 2GUFA 1PO0A 1FEPA 1XKWA 3RGNA 1OH2Q 1MALA 2HDFA 2IAHA 1MPQA 1QFFA 4B7OA 3V89A 2MPRA 1KMOA 3M8DA 4RDTA 1OH2P 3EFMA 3CSLA 3QLBA 3RGMA 2W77A 1XKHA 1FCPA 3DDRA 2W75A 2YSUA 4RDRA 1JBIA 2W6TA 1A0TP 1PO3A 2W16A 5FOKA 2GSKA 3V8XA 4AIPA 1NQEA 2FCPA 1PNZA 1BY5A 1MPOA 1NQFA 1BY3A 2O5PA 2W76A 1KMPA 1MPRA
chains in the Genus database with same CATH topology
4AIQA 2W78A 2W6UA 1NQGA 2HDIA 1NQHA 2GRXA 3M8BA 3FHHA 3CSNA 4EPAA 1UJWA 1QKCA 1FI1A 4CU4A 1QFGA 2GUFA 1PO0A 1FEPA 1XKWA 3RGNA 2HDFA 2IAHA 1QFFA 4B7OA 3V89A 1KMOA 3M8DA 4RDTA 3EFMA 3CSLA 3QLBA 3RGMA 2W77A 1XKHA 1FCPA 3DDRA 2W75A 2YSUA 4RDRA 2W6TA 1PO3A 2W16A 5FOKA 2GSKA 3V8XA 4AIPA 1NQEA 2FCPA 1PNZA 1BY5A 1NQFA 1QJQA 1BY3A 2O5PA 2W76A 1KMPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AIQ A;  2W78 A;  2W6U A;  1NQG A;  2HDI A;  1NQH A;  2GRX A;  3M8B A;  3FHH A;  3CSN A;  4EPA A;  1UJW A;  1QKC A;  1FI1 A;  4CU4 A;  1QFG A;  2GUF A;  1PO0 A;  1FEP A;  1XKW A;  3RGN A;  2HDF A;  2IAH A;  1QFF A;  4B7O A;  3V89 A;  1KMO A;  3M8D A;  4RDT A;  3EFM A;  3CSL A;  3QLB A;  3RGM A;  2W77 A;  1XKH A;  1FCP A;  3DDR A;  2W75 A;  2YSU A;  4RDR A;  2W6T A;  1PO3 A;  2W16 A;  5FOK A;  2GSK A;  3V8X A;  4AIP A;  1NQE A;  2FCP A;  1PNZ A;  1BY5 A;  1NQF A;  1QJQ A;  1BY3 A;  2O5P A;  2W76 A;  1KMP A; 
#chains in the Genus database with same CATH topology
 4AIQ A;  2W78 A;  2W6U A;  1NQG A;  2HDI A;  1AF6 A;  1NQH A;  3M8B A;  2GRX A;  3FHH A;  3CSN A;  4EPA A;  1A0S P;  1UJW A;  1QKC A;  1FI1 A;  1QJQ A;  4CU4 A;  1MPN A;  1MPM A;  1QFG A;  2GUF A;  1PO0 A;  1FEP A;  1XKW A;  3RGN A;  1OH2 Q;  1MAL A;  2HDF A;  2IAH A;  1MPQ A;  1QFF A;  4B7O A;  3V89 A;  2MPR A;  1KMO A;  3M8D A;  4RDT A;  1OH2 P;  3EFM A;  3CSL A;  3QLB A;  3RGM A;  2W77 A;  1XKH A;  1FCP A;  3DDR A;  2W75 A;  2YSU A;  4RDR A;  1JBI A;  2W6T A;  1A0T P;  1PO3 A;  2W16 A;  5FOK A;  2GSK A;  3V8X A;  4AIP A;  1NQE A;  2FCP A;  1PNZ A;  1BY5 A;  1MPO A;  1NQF A;  1BY3 A;  2O5P A;  2W76 A;  1KMP A;  1MPR A; 
#chains in the Genus database with same CATH homology
 4AIQ A;  2W78 A;  2W6U A;  1NQG A;  2HDI A;  1NQH A;  2GRX A;  3M8B A;  3FHH A;  3CSN A;  4EPA A;  1UJW A;  1QKC A;  1FI1 A;  4CU4 A;  1QFG A;  2GUF A;  1PO0 A;  1FEP A;  1XKW A;  3RGN A;  2HDF A;  2IAH A;  1QFF A;  4B7O A;  3V89 A;  1KMO A;  3M8D A;  4RDT A;  3EFM A;  3CSL A;  3QLB A;  3RGM A;  2W77 A;  1XKH A;  1FCP A;  3DDR A;  2W75 A;  2YSU A;  4RDR A;  2W6T A;  1PO3 A;  2W16 A;  5FOK A;  2GSK A;  3V8X A;  4AIP A;  1NQE A;  2FCP A;  1PNZ A;  1BY5 A;  1NQF A;  1QJQ A;  1BY3 A;  2O5P A;  2W76 A;  1KMP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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