4HLFC

Crystal structure of tankyrase 2 in complex with 7,3',4'-trihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlfC00
4KZLC 4L0TC 4HLKC 5ADTB 4UI5C 4UI6C 4L31C 4L0BC 5ADRB 4L2GC 4UVPB 4HKKB 4UI8C 4L34C 4HLHC 4HLGC 4KZQC 4L2KC 4L09C 5C5RC 4HKIC 4L0IC 4L32C 4UI7C 4UI3C 5C5QC 4L0VC 4L10C 4HLMC 4KZUC 4L2FC 4HMHC 4HL5C 5ADQB 4HLFC 5ADSB 4L33C 4HKNC 4UI4C 5C5PC 4L0SC 5FPFC
chains in the Genus database with same CATH superfamily
4KZLC 4L0TC 4HLKC 2ZIXB 5ADTB 4UI5C 4UI6C 4L31C 4L0BC 5ADRB 4L2GC 4UVPB 3CTOA 4HKKB 4UI8C 3OEIA 4L34C 4HLHC 4HLGC 3D55A 4KZQC 4L2KC 4L09C 5C5RC 4HKIC 4L0IC 4L32C 4ZLXA 3K6QA 3HRYA 4UI7C 4UI3C 5C5QC 4L10C 4HLMC 4L0VC 4KZUC 4L2FC 3KH2E 4HL5C 4HMHC 2A6QA 4ZM0A 4HLFC 5ADQB 3OEIE 5ADSB 3HJ6A 4ZM2A 4L33C 4HKNC 3HS2A 4UI4C 2ODKA 3K33B 5C5PC 4L0SC 5FPFC 3G5OA
chains in the Genus database with same CATH topology
4KZLC 4L0TC 4HLKC 2ZIXB 5ADTB 4UI5C 4UI6C 4L31C 4L0BC 5ADRB 4L2GC 4UVPB 4HKKB 4UI8C 4L34C 4HLHC 4HLGC 4KZQC 4L2KC 4L09C 5C5RC 4HKIC 4L0IC 4L32C 4UI7C 4UI3C 5C5QC 4L0VC 4L10C 4HLMC 4KZUC 4L2FC 4HMHC 4HL5C 5ADQB 4HLFC 5ADSB 3HJ6A 4L33C 4HKNC 4UI4C 5C5PC 4L0SC 5FPFC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KZL C;  4L0T C;  4HLK C;  5ADT B;  4UI5 C;  4UI6 C;  4L31 C;  4L0B C;  5ADR B;  4L2G C;  4UVP B;  4HKK B;  4UI8 C;  4L34 C;  4HLH C;  4HLG C;  4KZQ C;  4L2K C;  4L09 C;  5C5R C;  4HKI C;  4L0I C;  4L32 C;  4UI7 C;  4UI3 C;  5C5Q C;  4L0V C;  4L10 C;  4HLM C;  4KZU C;  4L2F C;  4HMH C;  4HL5 C;  5ADQ B;  4HLF C;  5ADS B;  4L33 C;  4HKN C;  4UI4 C;  5C5P C;  4L0S C;  5FPF C; 
#chains in the Genus database with same CATH topology
 4KZL C;  4L0T C;  4HLK C;  2ZIX B;  5ADT B;  4UI5 C;  4UI6 C;  4L31 C;  4L0B C;  5ADR B;  4L2G C;  4UVP B;  3CTO A;  4HKK B;  4UI8 C;  3OEI A;  4L34 C;  4HLH C;  4HLG C;  3D55 A;  4KZQ C;  4L2K C;  4L09 C;  5C5R C;  4HKI C;  4L0I C;  4L32 C;  4ZLX A;  3K6Q A;  3HRY A;  4UI7 C;  4UI3 C;  5C5Q C;  4L10 C;  4HLM C;  4L0V C;  4KZU C;  4L2F C;  3KH2 E;  4HL5 C;  4HMH C;  2A6Q A;  4ZM0 A;  4HLF C;  5ADQ B;  3OEI E;  5ADS B;  3HJ6 A;  4ZM2 A;  4L33 C;  4HKN C;  3HS2 A;  4UI4 C;  2ODK A;  3K33 B;  5C5P C;  4L0S C;  5FPF C;  3G5O A; 
#chains in the Genus database with same CATH homology
 4KZL C;  4L0T C;  4HLK C;  2ZIX B;  5ADT B;  4UI5 C;  4UI6 C;  4L31 C;  4L0B C;  5ADR B;  4L2G C;  4UVP B;  4HKK B;  4UI8 C;  4L34 C;  4HLH C;  4HLG C;  4KZQ C;  4L2K C;  4L09 C;  5C5R C;  4HKI C;  4L0I C;  4L32 C;  4UI7 C;  4UI3 C;  5C5Q C;  4L0V C;  4L10 C;  4HLM C;  4KZU C;  4L2F C;  4HMH C;  4HL5 C;  5ADQ B;  4HLF C;  5ADS B;  3HJ6 A;  4L33 C;  4HKN C;  4UI4 C;  5C5P C;  4L0S C;  5FPF C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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