4HLMC

Crystal structure of tankyrase 2 in complex with 3',4'-dihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlmC00
4UI3C 4L2KC 5ADSB 4UI8C 5C5PC 4UI5C 4L0BC 4KZLC 4UI7C 4L0TC 4L0IC 4HLMC 4HMHC 4HLHC 4HLKC 4L0VC 4KZQC 5ADRB 4KZUC 4L2FC 5C5QC 4L0SC 4UI6C 4HLGC 4HLFC 5ADTB 4L32C 5ADQB 4HKKB 4UI4C 5FPFC 4L10C 4HKNC 4L09C 4L33C 4HL5C 4UVPB 4L31C 5C5RC 4L34C 4HKIC 4L2GC
chains in the Genus database with same CATH superfamily
4UI3C 2ODKA 4L2KC 5ADSB 2A6QA 4UI8C 5C5PC 4ZM2A 4UI5C 4L0BC 4KZLC 4UI7C 4L0TC 4HLMC 4L0IC 4HMHC 3K33B 3CTOA 4HLHC 4HLKC 4L0VC 4KZQC 5ADRB 4KZUC 4L2FC 5C5QC 3HJ6A 3OEIA 4L0SC 4UI6C 4HLGC 4HLFC 3KH2E 3OEIE 5ADTB 3HS2A 2ZIXB 4L32C 5ADQB 4ZM0A 4HKKB 4UI4C 3G5OA 5FPFC 4L10C 4HKNC 4L09C 4L33C 4HL5C 4UVPB 3D55A 3K6QA 4L31C 4L34C 4L2GC 4HKIC 5C5RC 4ZLXA 3HRYA
chains in the Genus database with same CATH topology
4UI3C 4L2KC 5ADSB 4UI8C 5C5PC 4UI5C 4L0BC 4KZLC 4UI7C 4L0TC 4L0IC 4HLMC 4HMHC 4HLHC 4HLKC 4L0VC 4KZQC 5ADRB 4KZUC 4L2FC 5C5QC 3HJ6A 4L0SC 4UI6C 4HLGC 4HLFC 5ADTB 2ZIXB 4L32C 5ADQB 4HKKB 4UI4C 5FPFC 4L10C 4HKNC 4L09C 4L33C 4HL5C 4UVPB 4L31C 5C5RC 4L34C 4HKIC 4L2GC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UI3 C;  4L2K C;  5ADS B;  4UI8 C;  5C5P C;  4UI5 C;  4L0B C;  4KZL C;  4UI7 C;  4L0T C;  4L0I C;  4HLM C;  4HMH C;  4HLH C;  4HLK C;  4L0V C;  4KZQ C;  5ADR B;  4KZU C;  4L2F C;  5C5Q C;  4L0S C;  4UI6 C;  4HLG C;  4HLF C;  5ADT B;  4L32 C;  5ADQ B;  4HKK B;  4UI4 C;  5FPF C;  4L10 C;  4HKN C;  4L09 C;  4L33 C;  4HL5 C;  4UVP B;  4L31 C;  5C5R C;  4L34 C;  4HKI C;  4L2G C; 
#chains in the Genus database with same CATH topology
 4UI3 C;  2ODK A;  4L2K C;  5ADS B;  2A6Q A;  4UI8 C;  5C5P C;  4ZM2 A;  4UI5 C;  4L0B C;  4KZL C;  4UI7 C;  4L0T C;  4HLM C;  4L0I C;  4HMH C;  3K33 B;  3CTO A;  4HLH C;  4HLK C;  4L0V C;  4KZQ C;  5ADR B;  4KZU C;  4L2F C;  5C5Q C;  3HJ6 A;  3OEI A;  4L0S C;  4UI6 C;  4HLG C;  4HLF C;  3KH2 E;  3OEI E;  5ADT B;  3HS2 A;  2ZIX B;  4L32 C;  5ADQ B;  4ZM0 A;  4HKK B;  4UI4 C;  3G5O A;  5FPF C;  4L10 C;  4HKN C;  4L09 C;  4L33 C;  4HL5 C;  4UVP B;  3D55 A;  3K6Q A;  4L31 C;  4L34 C;  4L2G C;  4HKI C;  5C5R C;  4ZLX A;  3HRY A; 
#chains in the Genus database with same CATH homology
 4UI3 C;  4L2K C;  5ADS B;  4UI8 C;  5C5P C;  4UI5 C;  4L0B C;  4KZL C;  4UI7 C;  4L0T C;  4L0I C;  4HLM C;  4HMH C;  4HLH C;  4HLK C;  4L0V C;  4KZQ C;  5ADR B;  4KZU C;  4L2F C;  5C5Q C;  3HJ6 A;  4L0S C;  4UI6 C;  4HLG C;  4HLF C;  5ADT B;  2ZIX B;  4L32 C;  5ADQ B;  4HKK B;  4UI4 C;  5FPF C;  4L10 C;  4HKN C;  4L09 C;  4L33 C;  4HL5 C;  4UVP B;  4L31 C;  5C5R C;  4L34 C;  4HKI C;  4L2G C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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