4HMHC

Crystal structure of tankyrase 2 in complex with 7,3-dihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hmhC00
4HLMC 5ADTB 4HKNC 4L33C 4HLHC 4L10C 5C5QC 4HLKC 4HKKB 5C5RC 5FPFC 4L0TC 4UI3C 4L0VC 5ADRB 4UVPB 4L2KC 4UI4C 4L09C 4L34C 4HLGC 4UI5C 4KZUC 4HMHC 5ADQB 4L2GC 4L0IC 4L31C 4UI8C 4L2FC 4L32C 5C5PC 4HLFC 4L0BC 4KZQC 4UI6C 4UI7C 4KZLC 4HL5C 4L0SC 5ADSB 4HKIC
chains in the Genus database with same CATH superfamily
3HS2A 3OEIA 3G5OA 4HLMC 5ADTB 4HKNC 5ADSB 4L33C 4HLHC 4L10C 5C5QC 4HLKC 4HKKB 5C5RC 5FPFC 3K33B 4L0TC 3HJ6A 4UI3C 2A6QA 3KH2E 4L0VC 5ADRB 4UVPB 4L2KC 4ZLXA 4UI4C 4L09C 4L34C 4HLGC 4UI5C 4KZUC 3CTOA 4HMHC 5ADQB 4L2GC 3K6QA 4L0IC 4L31C 4UI8C 4L2FC 4L32C 3OEIE 5C5PC 4ZM2A 3HRYA 4HLFC 4L0BC 4KZQC 4UI6C 4UI7C 4KZLC 2ZIXB 4ZM0A 2ODKA 4HL5C 4L0SC 3D55A 4HKIC
chains in the Genus database with same CATH topology
4HLMC 5ADTB 4HKNC 4L33C 4HLHC 4L10C 5C5QC 4HLKC 4HKKB 5C5RC 5FPFC 4L0TC 3HJ6A 4UI3C 4L0VC 5ADRB 4UVPB 4L2KC 4UI4C 4L09C 4L34C 4HLGC 4UI5C 4KZUC 4HMHC 5ADQB 4L2GC 4L0IC 4L31C 4UI8C 4L2FC 4L32C 5C5PC 4HLFC 4L0BC 4KZQC 4UI6C 4UI7C 4KZLC 2ZIXB 4HL5C 4L0SC 5ADSB 4HKIC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HLM C;  5ADT B;  4HKN C;  4L33 C;  4HLH C;  4L10 C;  5C5Q C;  4HLK C;  4HKK B;  5C5R C;  5FPF C;  4L0T C;  4UI3 C;  4L0V C;  5ADR B;  4UVP B;  4L2K C;  4UI4 C;  4L09 C;  4L34 C;  4HLG C;  4UI5 C;  4KZU C;  4HMH C;  5ADQ B;  4L2G C;  4L0I C;  4L31 C;  4UI8 C;  4L2F C;  4L32 C;  5C5P C;  4HLF C;  4L0B C;  4KZQ C;  4UI6 C;  4UI7 C;  4KZL C;  4HL5 C;  4L0S C;  5ADS B;  4HKI C; 
#chains in the Genus database with same CATH topology
 3HS2 A;  3OEI A;  3G5O A;  4HLM C;  5ADT B;  4HKN C;  5ADS B;  4L33 C;  4HLH C;  4L10 C;  5C5Q C;  4HLK C;  4HKK B;  5C5R C;  5FPF C;  3K33 B;  4L0T C;  3HJ6 A;  4UI3 C;  2A6Q A;  3KH2 E;  4L0V C;  5ADR B;  4UVP B;  4L2K C;  4ZLX A;  4UI4 C;  4L09 C;  4L34 C;  4HLG C;  4UI5 C;  4KZU C;  3CTO A;  4HMH C;  5ADQ B;  4L2G C;  3K6Q A;  4L0I C;  4L31 C;  4UI8 C;  4L2F C;  4L32 C;  3OEI E;  5C5P C;  4ZM2 A;  3HRY A;  4HLF C;  4L0B C;  4KZQ C;  4UI6 C;  4UI7 C;  4KZL C;  2ZIX B;  4ZM0 A;  2ODK A;  4HL5 C;  4L0S C;  3D55 A;  4HKI C; 
#chains in the Genus database with same CATH homology
 4HLM C;  5ADT B;  4HKN C;  4L33 C;  4HLH C;  4L10 C;  5C5Q C;  4HLK C;  4HKK B;  5C5R C;  5FPF C;  4L0T C;  3HJ6 A;  4UI3 C;  4L0V C;  5ADR B;  4UVP B;  4L2K C;  4UI4 C;  4L09 C;  4L34 C;  4HLG C;  4UI5 C;  4KZU C;  4HMH C;  5ADQ B;  4L2G C;  4L0I C;  4L31 C;  4UI8 C;  4L2F C;  4L32 C;  5C5P C;  4HLF C;  4L0B C;  4KZQ C;  4UI6 C;  4UI7 C;  4KZL C;  2ZIX B;  4HL5 C;  4L0S C;  5ADS B;  4HKI C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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