4ISLB

Crystal structure of the inactive matriptase in complex with its inhibitor hai-1
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
60
structure length
60
Chain Sequence
QTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Kunitz-type protease inhibitor 1
total genus 10
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 2013-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4islB00
1NAGA 3P92E 1Y62A 2DDIA 1SHPA 1DENA 3AUIA 2DDJA 2KAII 4WWYC 1CA0D 1TOCR 2ODYE 2TPII 3TGKI 3UIRC 7PTIA 5JB6A 4BD9B 3AUBA 1P2KI 1QLQA 3LDIA 1P2OB 1BUNB 4U30W 4BQDA 3AUDA 3U1JE 2JOTA 3P95E 1ZR0B 1KIGI 3D65I 5JB4A 1BZ5A 1OA65 1P2QB 3BTWI 9PTIA 1TPAI 3BTQI 1BRBI 1FY8I 4PTIA 1BPTA 1BTIA 1UUAA 1AAPA 3LDMA 3WNYA 4NTYB 4ISOB 3TGII 1KTHA 4DG4C 1BF0A 1JC6A 3FP7J 1BZXI 1T8OB 2TGPI 1FAKI 4Y0YI 2KCRA 3L33E 3FP6I 1TCPA 1P2II 2KNTA 1CO7I 4DTGK 3AUEA 4U32X 1D0DB 2FI5I 4WXVC 3BTFI 4NTXB 1KUNA 3OFWA 3BTTI 1F7ZI 2FTMB 2ZVXA 3BTHI 1JV9A 1BPIA 2HEXA 3FP8I 1JV8A 1P2MB 2LFKA 1YC0I 1ADZA 2CA7A 1G6XA 1YLCB 4Y0ZI 1TAPA 1T8MB 2UUXA 3OTJI 1K6UA 1MTND 1D0DA 3L3TE 3BYBA 3LDJA 2FTLI 1F5RI 3TGJI 1IRHA 1DTXA 1EJMB 1CBWD 3BTMI 3TPII 2J6DA 1BHCA 3CI7A 2ZJXA 3M7QB 2M01A 5JB5A 1ZJDB 1AALA 1KNTA 1FANA 3AUGA 3BTKI 4ISNB 3GYMI 1P2NB 5JB7A 4Y10I 1YLDB 1DEMA 3T62D 1LD6A 4BNRI 1YKTB 2LFLA 2UUYB 2PTCI 4ISLB 1T8NB 3BTDI 4TPII 3UOUB 6PTIA 3BTGI 2RA3C 1T7CB 1EAWB 1P2JI 2M99A 1TFXC 1B0CA 3AUHA 1UUBA 2FI4I 8PTIA 5PTIA 1OA55 3AUCA 1TAWB 1DTKA 2FI3I 2IJOI 2R9PE 4NTWB 5C67C 1BRCI 1LD5A 4Y11I 1T8LB 1BTHP 1PITA 3BTEI 1BIKA 2W8XA
chains in the Genus database with same CATH superfamily
1NAGA 3P92E 1Y62A 2DDIA 1SHPA 1DENA 3AUIA 2DDJA 2KAII 4WWYC 1CA0D 1TOCR 2ODYE 2TPII 3TGKI 3UIRC 7PTIA 5JB6A 4BD9B 3AUBA 1P2KI 1QLQA 3LDIA 1P2OB 1BUNB 4U30W 4BQDA 3AUDA 3U1JE 2JOTA 3P95E 1ZR0B 1KIGI 3D65I 5JB4A 1BZ5A 1OA65 1P2QB 3BTWI 9PTIA 1TPAI 3BTQI 1BRBI 1FY8I 4PTIA 1BPTA 1BTIA 1UUAA 1AAPA 3LDMA 3WNYA 4NTYB 4ISOB 3TGII 1KTHA 4DG4C 1BF0A 1JC6A 3FP7J 1BZXI 1T8OB 2TGPI 1FAKI 4Y0YI 2KCRA 3L33E 3FP6I 1TCPA 1P2II 2KNTA 1CO7I 4DTGK 3AUEA 4U32X 1D0DB 2FI5I 4WXVC 3BTFI 4NTXB 1KUNA 3OFWA 3BTTI 1F7ZI 2FTMB 2ZVXA 3BTHI 1JV9A 1BPIA 2HEXA 3FP8I 1JV8A 1P2MB 2LFKA 1YC0I 1ADZA 2CA7A 1G6XA 1YLCB 4Y0ZI 1TAPA 1T8MB 2UUXA 3OTJI 1K6UA 1MTND 1D0DA 3L3TE 3BYBA 3LDJA 2FTLI 1F5RI 3TGJI 1IRHA 1DTXA 1EJMB 1CBWD 3BTMI 3TPII 2J6DA 1BHCA 3CI7A 2ZJXA 3M7QB 2M01A 5JB5A 1ZJDB 1AALA 1KNTA 1FANA 3AUGA 3BTKI 4ISNB 3GYMI 1P2NB 5JB7A 4Y10I 1YLDB 1DEMA 3T62D 1LD6A 4BNRI 1YKTB 2LFLA 2UUYB 2PTCI 4ISLB 1T8NB 3BTDI 4TPII 3UOUB 6PTIA 3BTGI 2RA3C 1T7CB 1EAWB 1P2JI 2M99A 1TFXC 1B0CA 3AUHA 1UUBA 2FI4I 8PTIA 5PTIA 1OA55 3AUCA 1TAWB 1DTKA 2FI3I 2IJOI 2R9PE 4NTWB 5C67C 1BRCI 1LD5A 4Y11I 1T8LB 1BTHP 1PITA 3BTEI 1BIKA 2W8XA
chains in the Genus database with same CATH topology
1NAGA 3P92E 1Y62A 2DDIA 1SHPA 1DENA 3AUIA 2DDJA 2KAII 4WWYC 1CA0D 1TOCR 2ODYE 2TPII 3TGKI 3UIRC 7PTIA 5JB6A 4BD9B 3AUBA 1P2KI 1QLQA 3LDIA 1P2OB 1BUNB 4U30W 4BQDA 3AUDA 3U1JE 2JOTA 3P95E 1ZR0B 1KIGI 3D65I 5JB4A 1BZ5A 1OA65 1P2QB 3BTWI 9PTIA 1TPAI 3BTQI 1BRBI 1FY8I 4PTIA 1BPTA 1BTIA 1UUAA 1AAPA 3LDMA 3WNYA 4NTYB 4ISOB 3TGII 1KTHA 4DG4C 1BF0A 1JC6A 3FP7J 1BZXI 1T8OB 2TGPI 1FAKI 4Y0YI 2KCRA 3L33E 3FP6I 1TCPA 1P2II 2KNTA 1CO7I 4DTGK 3AUEA 4U32X 1D0DB 2FI5I 4WXVC 3BTFI 4NTXB 1KUNA 3OFWA 3BTTI 1F7ZI 2FTMB 2ZVXA 3BTHI 1JV9A 1BPIA 2HEXA 3FP8I 1JV8A 1P2MB 2LFKA 1YC0I 1ADZA 2CA7A 1G6XA 1YLCB 4Y0ZI 1TAPA 1T8MB 2UUXA 3OTJI 1K6UA 1MTND 1D0DA 3L3TE 3BYBA 3LDJA 2FTLI 1F5RI 3TGJI 1IRHA 1DTXA 1EJMB 1CBWD 3BTMI 3TPII 2J6DA 1BHCA 3CI7A 2ZJXA 3M7QB 2M01A 5JB5A 1ZJDB 1AALA 1KNTA 1FANA 3AUGA 3BTKI 4ISNB 3GYMI 1P2NB 5JB7A 4Y10I 1YLDB 1DEMA 3T62D 1LD6A 4BNRI 1YKTB 2LFLA 2UUYB 2PTCI 4ISLB 1T8NB 3BTDI 4TPII 3UOUB 6PTIA 3BTGI 2RA3C 1T7CB 1EAWB 1P2JI 2M99A 1TFXC 1B0CA 3AUHA 1UUBA 2FI4I 8PTIA 5PTIA 1OA55 3AUCA 1TAWB 1DTKA 2FI3I 2IJOI 2R9PE 4NTWB 5C67C 1BRCI 1LD5A 4Y11I 1T8LB 1BTHP 1PITA 3BTEI 1BIKA 2W8XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NAG A;  3P92 E;  1Y62 A;  2DDI A;  1SHP A;  1DEN A;  3AUI A;  2DDJ A;  2KAI I;  4WWY C;  1CA0 D;  1TOC R;  2ODY E;  2TPI I;  3TGK I;  3UIR C;  7PTI A;  5JB6 A;  4BD9 B;  3AUB A;  1P2K I;  1QLQ A;  3LDI A;  1P2O B;  1BUN B;  4U30 W;  4BQD A;  3AUD A;  3U1J E;  2JOT A;  3P95 E;  1ZR0 B;  1KIG I;  3D65 I;  5JB4 A;  1BZ5 A;  1OA6 5;  1P2Q B;  3BTW I;  9PTI A;  1TPA I;  3BTQ I;  1BRB I;  1FY8 I;  4PTI A;  1BPT A;  1BTI A;  1UUA A;  1AAP A;  3LDM A;  3WNY A;  4NTY B;  4ISO B;  3TGI I;  1KTH A;  4DG4 C;  1BF0 A;  1JC6 A;  3FP7 J;  1BZX I;  1T8O B;  2TGP I;  1FAK I;  4Y0Y I;  2KCR A;  3L33 E;  3FP6 I;  1TCP A;  1P2I I;  2KNT A;  1CO7 I;  4DTG K;  3AUE A;  4U32 X;  1D0D B;  2FI5 I;  4WXV C;  3BTF I;  4NTX B;  1KUN A;  3OFW A;  3BTT I;  1F7Z I;  2FTM B;  2ZVX A;  3BTH I;  1JV9 A;  1BPI A;  2HEX A;  3FP8 I;  1JV8 A;  1P2M B;  2LFK A;  1YC0 I;  1ADZ A;  2CA7 A;  1G6X A;  1YLC B;  4Y0Z I;  1TAP A;  1T8M B;  2UUX A;  3OTJ I;  1K6U A;  1MTN D;  1D0D A;  3L3T E;  3BYB A;  3LDJ A;  2FTL I;  1F5R I;  3TGJ I;  1IRH A;  1DTX A;  1EJM B;  1CBW D;  3BTM I;  3TPI I;  2J6D A;  1BHC A;  3CI7 A;  2ZJX A;  3M7Q B;  2M01 A;  5JB5 A;  1ZJD B;  1AAL A;  1KNT A;  1FAN A;  3AUG A;  3BTK I;  4ISN B;  3GYM I;  1P2N B;  5JB7 A;  4Y10 I;  1YLD B;  1DEM A;  3T62 D;  1LD6 A;  4BNR I;  1YKT B;  2LFL A;  2UUY B;  2PTC I;  4ISL B;  1T8N B;  3BTD I;  4TPI I;  3UOU B;  6PTI A;  3BTG I;  2RA3 C;  1T7C B;  1EAW B;  1P2J I;  2M99 A;  1TFX C;  1B0C A;  3AUH A;  1UUB A;  2FI4 I;  8PTI A;  5PTI A;  1OA5 5;  3AUC A;  1TAW B;  1DTK A;  2FI3 I;  2IJO I;  2R9P E;  4NTW B;  5C67 C;  1BRC I;  1LD5 A;  4Y11 I;  1T8L B;  1BTH P;  1PIT A;  3BTE I;  1BIK A;  2W8X A; 
#chains in the Genus database with same CATH topology
 1NAG A;  3P92 E;  1Y62 A;  2DDI A;  1SHP A;  1DEN A;  3AUI A;  2DDJ A;  2KAI I;  4WWY C;  1CA0 D;  1TOC R;  2ODY E;  2TPI I;  3TGK I;  3UIR C;  7PTI A;  5JB6 A;  4BD9 B;  3AUB A;  1P2K I;  1QLQ A;  3LDI A;  1P2O B;  1BUN B;  4U30 W;  4BQD A;  3AUD A;  3U1J E;  2JOT A;  3P95 E;  1ZR0 B;  1KIG I;  3D65 I;  5JB4 A;  1BZ5 A;  1OA6 5;  1P2Q B;  3BTW I;  9PTI A;  1TPA I;  3BTQ I;  1BRB I;  1FY8 I;  4PTI A;  1BPT A;  1BTI A;  1UUA A;  1AAP A;  3LDM A;  3WNY A;  4NTY B;  4ISO B;  3TGI I;  1KTH A;  4DG4 C;  1BF0 A;  1JC6 A;  3FP7 J;  1BZX I;  1T8O B;  2TGP I;  1FAK I;  4Y0Y I;  2KCR A;  3L33 E;  3FP6 I;  1TCP A;  1P2I I;  2KNT A;  1CO7 I;  4DTG K;  3AUE A;  4U32 X;  1D0D B;  2FI5 I;  4WXV C;  3BTF I;  4NTX B;  1KUN A;  3OFW A;  3BTT I;  1F7Z I;  2FTM B;  2ZVX A;  3BTH I;  1JV9 A;  1BPI A;  2HEX A;  3FP8 I;  1JV8 A;  1P2M B;  2LFK A;  1YC0 I;  1ADZ A;  2CA7 A;  1G6X A;  1YLC B;  4Y0Z I;  1TAP A;  1T8M B;  2UUX A;  3OTJ I;  1K6U A;  1MTN D;  1D0D A;  3L3T E;  3BYB A;  3LDJ A;  2FTL I;  1F5R I;  3TGJ I;  1IRH A;  1DTX A;  1EJM B;  1CBW D;  3BTM I;  3TPI I;  2J6D A;  1BHC A;  3CI7 A;  2ZJX A;  3M7Q B;  2M01 A;  5JB5 A;  1ZJD B;  1AAL A;  1KNT A;  1FAN A;  3AUG A;  3BTK I;  4ISN B;  3GYM I;  1P2N B;  5JB7 A;  4Y10 I;  1YLD B;  1DEM A;  3T62 D;  1LD6 A;  4BNR I;  1YKT B;  2LFL A;  2UUY B;  2PTC I;  4ISL B;  1T8N B;  3BTD I;  4TPI I;  3UOU B;  6PTI A;  3BTG I;  2RA3 C;  1T7C B;  1EAW B;  1P2J I;  2M99 A;  1TFX C;  1B0C A;  3AUH A;  1UUB A;  2FI4 I;  8PTI A;  5PTI A;  1OA5 5;  3AUC A;  1TAW B;  1DTK A;  2FI3 I;  2IJO I;  2R9P E;  4NTW B;  5C67 C;  1BRC I;  1LD5 A;  4Y11 I;  1T8L B;  1BTH P;  1PIT A;  3BTE I;  1BIK A;  2W8X A; 
#chains in the Genus database with same CATH homology
 1NAG A;  3P92 E;  1Y62 A;  2DDI A;  1SHP A;  1DEN A;  3AUI A;  2DDJ A;  2KAI I;  4WWY C;  1CA0 D;  1TOC R;  2ODY E;  2TPI I;  3TGK I;  3UIR C;  7PTI A;  5JB6 A;  4BD9 B;  3AUB A;  1P2K I;  1QLQ A;  3LDI A;  1P2O B;  1BUN B;  4U30 W;  4BQD A;  3AUD A;  3U1J E;  2JOT A;  3P95 E;  1ZR0 B;  1KIG I;  3D65 I;  5JB4 A;  1BZ5 A;  1OA6 5;  1P2Q B;  3BTW I;  9PTI A;  1TPA I;  3BTQ I;  1BRB I;  1FY8 I;  4PTI A;  1BPT A;  1BTI A;  1UUA A;  1AAP A;  3LDM A;  3WNY A;  4NTY B;  4ISO B;  3TGI I;  1KTH A;  4DG4 C;  1BF0 A;  1JC6 A;  3FP7 J;  1BZX I;  1T8O B;  2TGP I;  1FAK I;  4Y0Y I;  2KCR A;  3L33 E;  3FP6 I;  1TCP A;  1P2I I;  2KNT A;  1CO7 I;  4DTG K;  3AUE A;  4U32 X;  1D0D B;  2FI5 I;  4WXV C;  3BTF I;  4NTX B;  1KUN A;  3OFW A;  3BTT I;  1F7Z I;  2FTM B;  2ZVX A;  3BTH I;  1JV9 A;  1BPI A;  2HEX A;  3FP8 I;  1JV8 A;  1P2M B;  2LFK A;  1YC0 I;  1ADZ A;  2CA7 A;  1G6X A;  1YLC B;  4Y0Z I;  1TAP A;  1T8M B;  2UUX A;  3OTJ I;  1K6U A;  1MTN D;  1D0D A;  3L3T E;  3BYB A;  3LDJ A;  2FTL I;  1F5R I;  3TGJ I;  1IRH A;  1DTX A;  1EJM B;  1CBW D;  3BTM I;  3TPI I;  2J6D A;  1BHC A;  3CI7 A;  2ZJX A;  3M7Q B;  2M01 A;  5JB5 A;  1ZJD B;  1AAL A;  1KNT A;  1FAN A;  3AUG A;  3BTK I;  4ISN B;  3GYM I;  1P2N B;  5JB7 A;  4Y10 I;  1YLD B;  1DEM A;  3T62 D;  1LD6 A;  4BNR I;  1YKT B;  2LFL A;  2UUY B;  2PTC I;  4ISL B;  1T8N B;  3BTD I;  4TPI I;  3UOU B;  6PTI A;  3BTG I;  2RA3 C;  1T7C B;  1EAW B;  1P2J I;  2M99 A;  1TFX C;  1B0C A;  3AUH A;  1UUB A;  2FI4 I;  8PTI A;  5PTI A;  1OA5 5;  3AUC A;  1TAW B;  1DTK A;  2FI3 I;  2IJO I;  2R9P E;  4NTW B;  5C67 C;  1BRC I;  1LD5 A;  4Y11 I;  1T8L B;  1BTH P;  1PIT A;  3BTE I;  1BIK A;  2W8X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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