4ISNB

Crystal structure of matriptase in complex with its inhibitor hai-1
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
62
structure length
62
Chain Sequence
QTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Kunitz-type protease inhibitor 1
total genus 11
structure length 62
sequence length 62
ec nomenclature
pdb deposition date 2013-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4isnB00
3BTWI 1SHPA 5PTIA 1BPTA 1BRBI 3P92E 3AUCA 2KAII 3LDIA 4TPII 1AALA 2FI4I 2RA3C 5C67C 2HEXA 1BZXI 2FI3I 1CA0D 2TGPI 1ZR0B 1DEMA 1JC6A 2LFLA 1YC0I 1P2II 1JV9A 4BD9B 1B0CA 4ISLB 1BHCA 4NTYB 4BNRI 3UIRC 1BTIA 2LFKA 3BTFI 1P2OB 3BTKI 4ISNB 1F5RI 1P2NB 4WWYC 4Y10I 1MTND 3TGKI 1CBWD 1YLCB 4DG4C 3AUGA 3TPII 1BRCI 1G6XA 4BQDA 1LD5A 6PTIA 1F7ZI 2UUYB 1IRHA 4WXVC 1BZ5A 1KNTA 3BYBA 1JV8A 1K6UA 1DTXA 1DTKA 2DDJA 1QLQA 1TCPA 2CA7A 3FP6I 3AUDA 3M7QB 4U32X 4NTWB 3AUBA 3OTJI 1BF0A 1UUBA 2IJOI 1PITA 3BTDI 3BTTI 1TAWB 5JB5A 3BTEI 1FAKI 1OA65 1T7CB 4NTXB 1D0DA 3FP7J 2W8XA 1AAPA 4U30W 1NAGA 2FTLI 1P2JI 4PTIA 1CO7I 1LD6A 2PTCI 1YLDB 3LDJA 1BTHP 5JB6A 1BUNB 1ADZA 3D65I 1FY8I 2ZJXA 2JOTA 3BTQI 1UUAA 3L33E 1KTHA 2R9PE 1BPIA 1T8LB 2ODYE 3LDMA 3AUHA 1FANA 1EJMB 3AUEA 3P95E 1KIGI 2FI5I 7PTIA 2M99A 2UUXA 1P2MB 5JB7A 2J6DA 1OA55 3CI7A 1TFXC 3BTMI 2TPII 3TGII 3TGJI 1TOCR 3L3TE 8PTIA 2FTMB 1D0DB 3U1JE 3GYMI 3T62D 1BIKA 4Y0YI 1EAWB 1Y62A 1DENA 1TPAI 2M01A 3FP8I 1ZJDB 2DDIA 4DTGK 2KNTA 3BTHI 1T8OB 3BTGI 3AUIA 4ISOB 1T8MB 3UOUB 3OFWA 4Y0ZI 9PTIA 2ZVXA 1KUNA 3WNYA 1P2KI 1TAPA 2KCRA 1YKTB 5JB4A 1P2QB 1T8NB 4Y11I
chains in the Genus database with same CATH superfamily
3BTWI 1SHPA 5PTIA 1BPTA 1BRBI 3P92E 3AUCA 2KAII 3LDIA 4TPII 1AALA 2FI4I 2RA3C 5C67C 2HEXA 1BZXI 2FI3I 1CA0D 2TGPI 1ZR0B 1DEMA 1JC6A 2LFLA 1YC0I 1P2II 1JV9A 4BD9B 1B0CA 4ISLB 1BHCA 4NTYB 4BNRI 3UIRC 1BTIA 2LFKA 3BTFI 1P2OB 3BTKI 4ISNB 1F5RI 1P2NB 4WWYC 4Y10I 1MTND 3TGKI 1CBWD 1YLCB 4DG4C 3AUGA 3TPII 1BRCI 1G6XA 4BQDA 1LD5A 6PTIA 1F7ZI 2UUYB 1IRHA 4WXVC 1BZ5A 1KNTA 3BYBA 1JV8A 1K6UA 1DTXA 1DTKA 2DDJA 1QLQA 1TCPA 2CA7A 3FP6I 3AUDA 3M7QB 4U32X 4NTWB 3AUBA 3OTJI 1BF0A 1UUBA 2IJOI 1PITA 3BTDI 3BTTI 1TAWB 5JB5A 3BTEI 1FAKI 1OA65 1T7CB 4NTXB 1D0DA 3FP7J 2W8XA 1AAPA 4U30W 1NAGA 2FTLI 1P2JI 4PTIA 1CO7I 1LD6A 2PTCI 1YLDB 3LDJA 1BTHP 5JB6A 1BUNB 1ADZA 3D65I 1FY8I 2ZJXA 2JOTA 3BTQI 1UUAA 3L33E 1KTHA 2R9PE 1BPIA 1T8LB 2ODYE 3LDMA 3AUHA 1FANA 1EJMB 3AUEA 3P95E 1KIGI 2FI5I 7PTIA 2M99A 2UUXA 1P2MB 5JB7A 2J6DA 1OA55 3CI7A 1TFXC 3BTMI 2TPII 3TGII 3TGJI 1TOCR 3L3TE 8PTIA 2FTMB 1D0DB 3U1JE 3GYMI 3T62D 1BIKA 4Y0YI 1EAWB 1Y62A 1DENA 1TPAI 2M01A 3FP8I 1ZJDB 2DDIA 4DTGK 2KNTA 3BTHI 1T8OB 3BTGI 3AUIA 4ISOB 1T8MB 3UOUB 3OFWA 4Y0ZI 9PTIA 2ZVXA 1KUNA 3WNYA 1P2KI 1TAPA 2KCRA 1YKTB 5JB4A 1P2QB 1T8NB 4Y11I
chains in the Genus database with same CATH topology
3BTWI 1SHPA 5PTIA 1BPTA 1BRBI 3P92E 3AUCA 2KAII 3LDIA 4TPII 1AALA 2FI4I 2RA3C 5C67C 2HEXA 1BZXI 2FI3I 1CA0D 2TGPI 1ZR0B 1DEMA 1JC6A 2LFLA 1YC0I 1P2II 1JV9A 4BD9B 1B0CA 4ISLB 1BHCA 4NTYB 4BNRI 3UIRC 1BTIA 2LFKA 3BTFI 1P2OB 3BTKI 4ISNB 1F5RI 1P2NB 4WWYC 4Y10I 1MTND 3TGKI 1CBWD 1YLCB 4DG4C 3AUGA 3TPII 1BRCI 1G6XA 4BQDA 1LD5A 6PTIA 1F7ZI 2UUYB 1IRHA 4WXVC 1BZ5A 1KNTA 3BYBA 1JV8A 1K6UA 1DTXA 1DTKA 2DDJA 1QLQA 1TCPA 2CA7A 3FP6I 3AUDA 3M7QB 4U32X 4NTWB 3AUBA 3OTJI 1BF0A 1UUBA 2IJOI 1PITA 3BTDI 3BTTI 1TAWB 5JB5A 3BTEI 1FAKI 1OA65 1T7CB 4NTXB 1D0DA 3FP7J 2W8XA 1AAPA 4U30W 1NAGA 2FTLI 1P2JI 4PTIA 1CO7I 1LD6A 2PTCI 1YLDB 3LDJA 1BTHP 5JB6A 1BUNB 1ADZA 3D65I 1FY8I 2ZJXA 2JOTA 3BTQI 1UUAA 3L33E 1KTHA 2R9PE 1BPIA 1T8LB 2ODYE 3LDMA 3AUHA 1FANA 1EJMB 3AUEA 3P95E 1KIGI 2FI5I 7PTIA 2M99A 2UUXA 1P2MB 5JB7A 2J6DA 1OA55 3CI7A 1TFXC 3BTMI 2TPII 3TGII 3TGJI 1TOCR 3L3TE 8PTIA 2FTMB 1D0DB 3U1JE 3GYMI 3T62D 1BIKA 4Y0YI 1EAWB 1Y62A 1DENA 1TPAI 2M01A 3FP8I 1ZJDB 2DDIA 4DTGK 2KNTA 3BTHI 1T8OB 3BTGI 3AUIA 4ISOB 1T8MB 3UOUB 3OFWA 4Y0ZI 9PTIA 2ZVXA 1KUNA 3WNYA 1P2KI 1TAPA 2KCRA 1YKTB 5JB4A 1P2QB 1T8NB 4Y11I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BTW I;  1SHP A;  5PTI A;  1BPT A;  1BRB I;  3P92 E;  3AUC A;  2KAI I;  3LDI A;  4TPI I;  1AAL A;  2FI4 I;  2RA3 C;  5C67 C;  2HEX A;  1BZX I;  2FI3 I;  1CA0 D;  2TGP I;  1ZR0 B;  1DEM A;  1JC6 A;  2LFL A;  1YC0 I;  1P2I I;  1JV9 A;  4BD9 B;  1B0C A;  4ISL B;  1BHC A;  4NTY B;  4BNR I;  3UIR C;  1BTI A;  2LFK A;  3BTF I;  1P2O B;  3BTK I;  4ISN B;  1F5R I;  1P2N B;  4WWY C;  4Y10 I;  1MTN D;  3TGK I;  1CBW D;  1YLC B;  4DG4 C;  3AUG A;  3TPI I;  1BRC I;  1G6X A;  4BQD A;  1LD5 A;  6PTI A;  1F7Z I;  2UUY B;  1IRH A;  4WXV C;  1BZ5 A;  1KNT A;  3BYB A;  1JV8 A;  1K6U A;  1DTX A;  1DTK A;  2DDJ A;  1QLQ A;  1TCP A;  2CA7 A;  3FP6 I;  3AUD A;  3M7Q B;  4U32 X;  4NTW B;  3AUB A;  3OTJ I;  1BF0 A;  1UUB A;  2IJO I;  1PIT A;  3BTD I;  3BTT I;  1TAW B;  5JB5 A;  3BTE I;  1FAK I;  1OA6 5;  1T7C B;  4NTX B;  1D0D A;  3FP7 J;  2W8X A;  1AAP A;  4U30 W;  1NAG A;  2FTL I;  1P2J I;  4PTI A;  1CO7 I;  1LD6 A;  2PTC I;  1YLD B;  3LDJ A;  1BTH P;  5JB6 A;  1BUN B;  1ADZ A;  3D65 I;  1FY8 I;  2ZJX A;  2JOT A;  3BTQ I;  1UUA A;  3L33 E;  1KTH A;  2R9P E;  1BPI A;  1T8L B;  2ODY E;  3LDM A;  3AUH A;  1FAN A;  1EJM B;  3AUE A;  3P95 E;  1KIG I;  2FI5 I;  7PTI A;  2M99 A;  2UUX A;  1P2M B;  5JB7 A;  2J6D A;  1OA5 5;  3CI7 A;  1TFX C;  3BTM I;  2TPI I;  3TGI I;  3TGJ I;  1TOC R;  3L3T E;  8PTI A;  2FTM B;  1D0D B;  3U1J E;  3GYM I;  3T62 D;  1BIK A;  4Y0Y I;  1EAW B;  1Y62 A;  1DEN A;  1TPA I;  2M01 A;  3FP8 I;  1ZJD B;  2DDI A;  4DTG K;  2KNT A;  3BTH I;  1T8O B;  3BTG I;  3AUI A;  4ISO B;  1T8M B;  3UOU B;  3OFW A;  4Y0Z I;  9PTI A;  2ZVX A;  1KUN A;  3WNY A;  1P2K I;  1TAP A;  2KCR A;  1YKT B;  5JB4 A;  1P2Q B;  1T8N B;  4Y11 I; 
#chains in the Genus database with same CATH topology
 3BTW I;  1SHP A;  5PTI A;  1BPT A;  1BRB I;  3P92 E;  3AUC A;  2KAI I;  3LDI A;  4TPI I;  1AAL A;  2FI4 I;  2RA3 C;  5C67 C;  2HEX A;  1BZX I;  2FI3 I;  1CA0 D;  2TGP I;  1ZR0 B;  1DEM A;  1JC6 A;  2LFL A;  1YC0 I;  1P2I I;  1JV9 A;  4BD9 B;  1B0C A;  4ISL B;  1BHC A;  4NTY B;  4BNR I;  3UIR C;  1BTI A;  2LFK A;  3BTF I;  1P2O B;  3BTK I;  4ISN B;  1F5R I;  1P2N B;  4WWY C;  4Y10 I;  1MTN D;  3TGK I;  1CBW D;  1YLC B;  4DG4 C;  3AUG A;  3TPI I;  1BRC I;  1G6X A;  4BQD A;  1LD5 A;  6PTI A;  1F7Z I;  2UUY B;  1IRH A;  4WXV C;  1BZ5 A;  1KNT A;  3BYB A;  1JV8 A;  1K6U A;  1DTX A;  1DTK A;  2DDJ A;  1QLQ A;  1TCP A;  2CA7 A;  3FP6 I;  3AUD A;  3M7Q B;  4U32 X;  4NTW B;  3AUB A;  3OTJ I;  1BF0 A;  1UUB A;  2IJO I;  1PIT A;  3BTD I;  3BTT I;  1TAW B;  5JB5 A;  3BTE I;  1FAK I;  1OA6 5;  1T7C B;  4NTX B;  1D0D A;  3FP7 J;  2W8X A;  1AAP A;  4U30 W;  1NAG A;  2FTL I;  1P2J I;  4PTI A;  1CO7 I;  1LD6 A;  2PTC I;  1YLD B;  3LDJ A;  1BTH P;  5JB6 A;  1BUN B;  1ADZ A;  3D65 I;  1FY8 I;  2ZJX A;  2JOT A;  3BTQ I;  1UUA A;  3L33 E;  1KTH A;  2R9P E;  1BPI A;  1T8L B;  2ODY E;  3LDM A;  3AUH A;  1FAN A;  1EJM B;  3AUE A;  3P95 E;  1KIG I;  2FI5 I;  7PTI A;  2M99 A;  2UUX A;  1P2M B;  5JB7 A;  2J6D A;  1OA5 5;  3CI7 A;  1TFX C;  3BTM I;  2TPI I;  3TGI I;  3TGJ I;  1TOC R;  3L3T E;  8PTI A;  2FTM B;  1D0D B;  3U1J E;  3GYM I;  3T62 D;  1BIK A;  4Y0Y I;  1EAW B;  1Y62 A;  1DEN A;  1TPA I;  2M01 A;  3FP8 I;  1ZJD B;  2DDI A;  4DTG K;  2KNT A;  3BTH I;  1T8O B;  3BTG I;  3AUI A;  4ISO B;  1T8M B;  3UOU B;  3OFW A;  4Y0Z I;  9PTI A;  2ZVX A;  1KUN A;  3WNY A;  1P2K I;  1TAP A;  2KCR A;  1YKT B;  5JB4 A;  1P2Q B;  1T8N B;  4Y11 I; 
#chains in the Genus database with same CATH homology
 3BTW I;  1SHP A;  5PTI A;  1BPT A;  1BRB I;  3P92 E;  3AUC A;  2KAI I;  3LDI A;  4TPI I;  1AAL A;  2FI4 I;  2RA3 C;  5C67 C;  2HEX A;  1BZX I;  2FI3 I;  1CA0 D;  2TGP I;  1ZR0 B;  1DEM A;  1JC6 A;  2LFL A;  1YC0 I;  1P2I I;  1JV9 A;  4BD9 B;  1B0C A;  4ISL B;  1BHC A;  4NTY B;  4BNR I;  3UIR C;  1BTI A;  2LFK A;  3BTF I;  1P2O B;  3BTK I;  4ISN B;  1F5R I;  1P2N B;  4WWY C;  4Y10 I;  1MTN D;  3TGK I;  1CBW D;  1YLC B;  4DG4 C;  3AUG A;  3TPI I;  1BRC I;  1G6X A;  4BQD A;  1LD5 A;  6PTI A;  1F7Z I;  2UUY B;  1IRH A;  4WXV C;  1BZ5 A;  1KNT A;  3BYB A;  1JV8 A;  1K6U A;  1DTX A;  1DTK A;  2DDJ A;  1QLQ A;  1TCP A;  2CA7 A;  3FP6 I;  3AUD A;  3M7Q B;  4U32 X;  4NTW B;  3AUB A;  3OTJ I;  1BF0 A;  1UUB A;  2IJO I;  1PIT A;  3BTD I;  3BTT I;  1TAW B;  5JB5 A;  3BTE I;  1FAK I;  1OA6 5;  1T7C B;  4NTX B;  1D0D A;  3FP7 J;  2W8X A;  1AAP A;  4U30 W;  1NAG A;  2FTL I;  1P2J I;  4PTI A;  1CO7 I;  1LD6 A;  2PTC I;  1YLD B;  3LDJ A;  1BTH P;  5JB6 A;  1BUN B;  1ADZ A;  3D65 I;  1FY8 I;  2ZJX A;  2JOT A;  3BTQ I;  1UUA A;  3L33 E;  1KTH A;  2R9P E;  1BPI A;  1T8L B;  2ODY E;  3LDM A;  3AUH A;  1FAN A;  1EJM B;  3AUE A;  3P95 E;  1KIG I;  2FI5 I;  7PTI A;  2M99 A;  2UUX A;  1P2M B;  5JB7 A;  2J6D A;  1OA5 5;  3CI7 A;  1TFX C;  3BTM I;  2TPI I;  3TGI I;  3TGJ I;  1TOC R;  3L3T E;  8PTI A;  2FTM B;  1D0D B;  3U1J E;  3GYM I;  3T62 D;  1BIK A;  4Y0Y I;  1EAW B;  1Y62 A;  1DEN A;  1TPA I;  2M01 A;  3FP8 I;  1ZJD B;  2DDI A;  4DTG K;  2KNT A;  3BTH I;  1T8O B;  3BTG I;  3AUI A;  4ISO B;  1T8M B;  3UOU B;  3OFW A;  4Y0Z I;  9PTI A;  2ZVX A;  1KUN A;  3WNY A;  1P2K I;  1TAP A;  2KCR A;  1YKT B;  5JB4 A;  1P2Q B;  1T8N B;  4Y11 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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