4ISOB

Crystal structure of matriptase in complex with its inhibitor hai-1
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
60
structure length
60
Chain Sequence
QTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Suppressor of tumorigenicity 14 protein
total genus 14
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 2013-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4isoB00
2JOTA 1DTXA 3AUDA 4U30W 1P2II 3LDIA 2CA7A 1TAWB 3FP8I 1FANA 1BZ5A 1YKTB 3LDJA 3P95E 4Y10I 4BD9B 4BNRI 4Y0ZI 2ZVXA 3UIRC 4ISOB 4Y0YI 3BYBA 2UUYB 4NTXB 1BPTA 2IJOI 1P2QB 2KNTA 4TPII 4DG4C 1JV8A 1KTHA 1AALA 2LFLA 3TPII 3BTDI 4WWYC 1BTHP 2TPII 4Y11I 1KNTA 1F5RI 1UUBA 2KAII 1IRHA 1JC6A 4NTYB 1TAPA 2RA3C 1BF0A 1FAKI 2FTLI 3BTTI 1CA0D 1OA55 1BHCA 1LD6A 1OA65 1CO7I 2KCRA 2M01A 4NTWB 1P2MB 1NAGA 5PTIA 1T7CB 1T8NB 1BUNB 1K6UA 1P2KI 3FP6I 1JV9A 5JB7A 1AAPA 1D0DA 2FI3I 3TGJI 1YLDB 1BPIA 1BIKA 5JB6A 3OFWA 4ISNB 1QLQA 2UUXA 4ISLB 3P92E 2FI4I 3L3TE 3BTGI 5C67C 1SHPA 3AUIA 3WNYA 1MTND 8PTIA 3BTMI 1TOCR 1Y62A 2R9PE 3D65I 1YLCB 3T62D 1T8OB 4U32X 3AUEA 1PITA 2TGPI 1BZXI 1G6XA 4WXVC 1D0DB 2DDIA 3BTKI 1DEMA 1T8LB 1EAWB 1TCPA 3OTJI 2FTMB 2ODYE 2W8XA 1KIGI 2ZJXA 1P2NB 5JB5A 3BTWI 3UOUB 3U1JE 1TFXC 3CI7A 3BTQI 3BTHI 3AUGA 3AUHA 1ADZA 1FY8I 2M99A 6PTIA 1T8MB 1BRCI 1F7ZI 1ZJDB 1KUNA 3TGKI 1EJMB 1P2OB 1YC0I 3BTFI 3M7QB 2PTCI 3FP7J 2HEXA 2FI5I 3TGII 1LD5A 2J6DA 1P2JI 1CBWD 1UUAA 3AUCA 5JB4A 1ZR0B 4DTGK 1BRBI 3LDMA 4BQDA 2LFKA 3L33E 3GYMI 7PTIA 3AUBA 9PTIA 4PTIA 1DENA 1TPAI 1B0CA 3BTEI 2DDJA 1BTIA 1DTKA
chains in the Genus database with same CATH superfamily
2JOTA 1DTXA 3AUDA 4U30W 1P2II 3LDIA 2CA7A 1TAWB 3FP8I 1FANA 1BZ5A 1YKTB 3LDJA 3P95E 4Y10I 4BD9B 4BNRI 4Y0ZI 2ZVXA 3UIRC 4ISOB 4Y0YI 3BYBA 2UUYB 4NTXB 1BPTA 2IJOI 1P2QB 2KNTA 4TPII 4DG4C 1JV8A 1KTHA 1AALA 2LFLA 3TPII 3BTDI 4WWYC 1BTHP 2TPII 4Y11I 1KNTA 1F5RI 1UUBA 2KAII 1IRHA 1JC6A 4NTYB 1TAPA 2RA3C 1BF0A 1FAKI 2FTLI 3BTTI 1CA0D 1OA55 1BHCA 1LD6A 1OA65 1CO7I 2KCRA 2M01A 4NTWB 1P2MB 1NAGA 5PTIA 1T7CB 1T8NB 1BUNB 1K6UA 1P2KI 3FP6I 1JV9A 5JB7A 1AAPA 1D0DA 2FI3I 3TGJI 1YLDB 1BPIA 1BIKA 5JB6A 3OFWA 4ISNB 1QLQA 2UUXA 4ISLB 3P92E 2FI4I 3L3TE 3BTGI 5C67C 1SHPA 3AUIA 3WNYA 1MTND 8PTIA 3BTMI 1TOCR 1Y62A 2R9PE 3D65I 1YLCB 3T62D 1T8OB 4U32X 3AUEA 1PITA 2TGPI 1BZXI 1G6XA 4WXVC 1D0DB 2DDIA 3BTKI 1DEMA 1T8LB 1EAWB 1TCPA 3OTJI 2FTMB 2ODYE 2W8XA 1KIGI 2ZJXA 1P2NB 5JB5A 3BTWI 3UOUB 3U1JE 1TFXC 3CI7A 3BTQI 3BTHI 3AUGA 3AUHA 1ADZA 1FY8I 2M99A 6PTIA 1T8MB 1BRCI 1F7ZI 1ZJDB 1KUNA 3TGKI 1EJMB 1P2OB 1YC0I 3BTFI 3M7QB 2PTCI 3FP7J 2HEXA 2FI5I 3TGII 1LD5A 2J6DA 1P2JI 1CBWD 1UUAA 3AUCA 5JB4A 1ZR0B 4DTGK 1BRBI 3LDMA 4BQDA 2LFKA 3L33E 3GYMI 7PTIA 3AUBA 9PTIA 4PTIA 1DENA 1TPAI 1B0CA 3BTEI 2DDJA 1BTIA 1DTKA
chains in the Genus database with same CATH topology
2JOTA 1DTXA 3AUDA 4U30W 1P2II 3LDIA 2CA7A 1TAWB 3FP8I 1FANA 1BZ5A 1YKTB 3LDJA 3P95E 4Y10I 4BD9B 4BNRI 4Y0ZI 2ZVXA 3UIRC 4ISOB 4Y0YI 3BYBA 2UUYB 4NTXB 1BPTA 2IJOI 1P2QB 2KNTA 4TPII 4DG4C 1JV8A 1KTHA 1AALA 2LFLA 3TPII 3BTDI 4WWYC 1BTHP 2TPII 4Y11I 1KNTA 1F5RI 1UUBA 2KAII 1IRHA 1JC6A 4NTYB 1TAPA 2RA3C 1BF0A 1FAKI 2FTLI 3BTTI 1CA0D 1OA55 1BHCA 1LD6A 1OA65 1CO7I 2KCRA 2M01A 4NTWB 1P2MB 1NAGA 5PTIA 1T7CB 1T8NB 1BUNB 1K6UA 1P2KI 3FP6I 1JV9A 5JB7A 1AAPA 1D0DA 2FI3I 3TGJI 1YLDB 1BPIA 1BIKA 5JB6A 3OFWA 4ISNB 1QLQA 2UUXA 4ISLB 3P92E 2FI4I 3L3TE 3BTGI 5C67C 1SHPA 3AUIA 3WNYA 1MTND 8PTIA 3BTMI 1TOCR 1Y62A 2R9PE 3D65I 1YLCB 3T62D 1T8OB 4U32X 3AUEA 1PITA 2TGPI 1BZXI 1G6XA 4WXVC 1D0DB 2DDIA 3BTKI 1DEMA 1T8LB 1EAWB 1TCPA 3OTJI 2FTMB 2ODYE 2W8XA 1KIGI 2ZJXA 1P2NB 5JB5A 3BTWI 3UOUB 3U1JE 1TFXC 3CI7A 3BTQI 3BTHI 3AUGA 3AUHA 1ADZA 1FY8I 2M99A 6PTIA 1T8MB 1BRCI 1F7ZI 1ZJDB 1KUNA 3TGKI 1EJMB 1P2OB 1YC0I 3BTFI 3M7QB 2PTCI 3FP7J 2HEXA 2FI5I 3TGII 1LD5A 2J6DA 1P2JI 1CBWD 1UUAA 3AUCA 5JB4A 1ZR0B 4DTGK 1BRBI 3LDMA 4BQDA 2LFKA 3L33E 3GYMI 7PTIA 3AUBA 9PTIA 4PTIA 1DENA 1TPAI 1B0CA 3BTEI 2DDJA 1BTIA 1DTKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JOT A;  1DTX A;  3AUD A;  4U30 W;  1P2I I;  3LDI A;  2CA7 A;  1TAW B;  3FP8 I;  1FAN A;  1BZ5 A;  1YKT B;  3LDJ A;  3P95 E;  4Y10 I;  4BD9 B;  4BNR I;  4Y0Z I;  2ZVX A;  3UIR C;  4ISO B;  4Y0Y I;  3BYB A;  2UUY B;  4NTX B;  1BPT A;  2IJO I;  1P2Q B;  2KNT A;  4TPI I;  4DG4 C;  1JV8 A;  1KTH A;  1AAL A;  2LFL A;  3TPI I;  3BTD I;  4WWY C;  1BTH P;  2TPI I;  4Y11 I;  1KNT A;  1F5R I;  1UUB A;  2KAI I;  1IRH A;  1JC6 A;  4NTY B;  1TAP A;  2RA3 C;  1BF0 A;  1FAK I;  2FTL I;  3BTT I;  1CA0 D;  1OA5 5;  1BHC A;  1LD6 A;  1OA6 5;  1CO7 I;  2KCR A;  2M01 A;  4NTW B;  1P2M B;  1NAG A;  5PTI A;  1T7C B;  1T8N B;  1BUN B;  1K6U A;  1P2K I;  3FP6 I;  1JV9 A;  5JB7 A;  1AAP A;  1D0D A;  2FI3 I;  3TGJ I;  1YLD B;  1BPI A;  1BIK A;  5JB6 A;  3OFW A;  4ISN B;  1QLQ A;  2UUX A;  4ISL B;  3P92 E;  2FI4 I;  3L3T E;  3BTG I;  5C67 C;  1SHP A;  3AUI A;  3WNY A;  1MTN D;  8PTI A;  3BTM I;  1TOC R;  1Y62 A;  2R9P E;  3D65 I;  1YLC B;  3T62 D;  1T8O B;  4U32 X;  3AUE A;  1PIT A;  2TGP I;  1BZX I;  1G6X A;  4WXV C;  1D0D B;  2DDI A;  3BTK I;  1DEM A;  1T8L B;  1EAW B;  1TCP A;  3OTJ I;  2FTM B;  2ODY E;  2W8X A;  1KIG I;  2ZJX A;  1P2N B;  5JB5 A;  3BTW I;  3UOU B;  3U1J E;  1TFX C;  3CI7 A;  3BTQ I;  3BTH I;  3AUG A;  3AUH A;  1ADZ A;  1FY8 I;  2M99 A;  6PTI A;  1T8M B;  1BRC I;  1F7Z I;  1ZJD B;  1KUN A;  3TGK I;  1EJM B;  1P2O B;  1YC0 I;  3BTF I;  3M7Q B;  2PTC I;  3FP7 J;  2HEX A;  2FI5 I;  3TGI I;  1LD5 A;  2J6D A;  1P2J I;  1CBW D;  1UUA A;  3AUC A;  5JB4 A;  1ZR0 B;  4DTG K;  1BRB I;  3LDM A;  4BQD A;  2LFK A;  3L33 E;  3GYM I;  7PTI A;  3AUB A;  9PTI A;  4PTI A;  1DEN A;  1TPA I;  1B0C A;  3BTE I;  2DDJ A;  1BTI A;  1DTK A; 
#chains in the Genus database with same CATH topology
 2JOT A;  1DTX A;  3AUD A;  4U30 W;  1P2I I;  3LDI A;  2CA7 A;  1TAW B;  3FP8 I;  1FAN A;  1BZ5 A;  1YKT B;  3LDJ A;  3P95 E;  4Y10 I;  4BD9 B;  4BNR I;  4Y0Z I;  2ZVX A;  3UIR C;  4ISO B;  4Y0Y I;  3BYB A;  2UUY B;  4NTX B;  1BPT A;  2IJO I;  1P2Q B;  2KNT A;  4TPI I;  4DG4 C;  1JV8 A;  1KTH A;  1AAL A;  2LFL A;  3TPI I;  3BTD I;  4WWY C;  1BTH P;  2TPI I;  4Y11 I;  1KNT A;  1F5R I;  1UUB A;  2KAI I;  1IRH A;  1JC6 A;  4NTY B;  1TAP A;  2RA3 C;  1BF0 A;  1FAK I;  2FTL I;  3BTT I;  1CA0 D;  1OA5 5;  1BHC A;  1LD6 A;  1OA6 5;  1CO7 I;  2KCR A;  2M01 A;  4NTW B;  1P2M B;  1NAG A;  5PTI A;  1T7C B;  1T8N B;  1BUN B;  1K6U A;  1P2K I;  3FP6 I;  1JV9 A;  5JB7 A;  1AAP A;  1D0D A;  2FI3 I;  3TGJ I;  1YLD B;  1BPI A;  1BIK A;  5JB6 A;  3OFW A;  4ISN B;  1QLQ A;  2UUX A;  4ISL B;  3P92 E;  2FI4 I;  3L3T E;  3BTG I;  5C67 C;  1SHP A;  3AUI A;  3WNY A;  1MTN D;  8PTI A;  3BTM I;  1TOC R;  1Y62 A;  2R9P E;  3D65 I;  1YLC B;  3T62 D;  1T8O B;  4U32 X;  3AUE A;  1PIT A;  2TGP I;  1BZX I;  1G6X A;  4WXV C;  1D0D B;  2DDI A;  3BTK I;  1DEM A;  1T8L B;  1EAW B;  1TCP A;  3OTJ I;  2FTM B;  2ODY E;  2W8X A;  1KIG I;  2ZJX A;  1P2N B;  5JB5 A;  3BTW I;  3UOU B;  3U1J E;  1TFX C;  3CI7 A;  3BTQ I;  3BTH I;  3AUG A;  3AUH A;  1ADZ A;  1FY8 I;  2M99 A;  6PTI A;  1T8M B;  1BRC I;  1F7Z I;  1ZJD B;  1KUN A;  3TGK I;  1EJM B;  1P2O B;  1YC0 I;  3BTF I;  3M7Q B;  2PTC I;  3FP7 J;  2HEX A;  2FI5 I;  3TGI I;  1LD5 A;  2J6D A;  1P2J I;  1CBW D;  1UUA A;  3AUC A;  5JB4 A;  1ZR0 B;  4DTG K;  1BRB I;  3LDM A;  4BQD A;  2LFK A;  3L33 E;  3GYM I;  7PTI A;  3AUB A;  9PTI A;  4PTI A;  1DEN A;  1TPA I;  1B0C A;  3BTE I;  2DDJ A;  1BTI A;  1DTK A; 
#chains in the Genus database with same CATH homology
 2JOT A;  1DTX A;  3AUD A;  4U30 W;  1P2I I;  3LDI A;  2CA7 A;  1TAW B;  3FP8 I;  1FAN A;  1BZ5 A;  1YKT B;  3LDJ A;  3P95 E;  4Y10 I;  4BD9 B;  4BNR I;  4Y0Z I;  2ZVX A;  3UIR C;  4ISO B;  4Y0Y I;  3BYB A;  2UUY B;  4NTX B;  1BPT A;  2IJO I;  1P2Q B;  2KNT A;  4TPI I;  4DG4 C;  1JV8 A;  1KTH A;  1AAL A;  2LFL A;  3TPI I;  3BTD I;  4WWY C;  1BTH P;  2TPI I;  4Y11 I;  1KNT A;  1F5R I;  1UUB A;  2KAI I;  1IRH A;  1JC6 A;  4NTY B;  1TAP A;  2RA3 C;  1BF0 A;  1FAK I;  2FTL I;  3BTT I;  1CA0 D;  1OA5 5;  1BHC A;  1LD6 A;  1OA6 5;  1CO7 I;  2KCR A;  2M01 A;  4NTW B;  1P2M B;  1NAG A;  5PTI A;  1T7C B;  1T8N B;  1BUN B;  1K6U A;  1P2K I;  3FP6 I;  1JV9 A;  5JB7 A;  1AAP A;  1D0D A;  2FI3 I;  3TGJ I;  1YLD B;  1BPI A;  1BIK A;  5JB6 A;  3OFW A;  4ISN B;  1QLQ A;  2UUX A;  4ISL B;  3P92 E;  2FI4 I;  3L3T E;  3BTG I;  5C67 C;  1SHP A;  3AUI A;  3WNY A;  1MTN D;  8PTI A;  3BTM I;  1TOC R;  1Y62 A;  2R9P E;  3D65 I;  1YLC B;  3T62 D;  1T8O B;  4U32 X;  3AUE A;  1PIT A;  2TGP I;  1BZX I;  1G6X A;  4WXV C;  1D0D B;  2DDI A;  3BTK I;  1DEM A;  1T8L B;  1EAW B;  1TCP A;  3OTJ I;  2FTM B;  2ODY E;  2W8X A;  1KIG I;  2ZJX A;  1P2N B;  5JB5 A;  3BTW I;  3UOU B;  3U1J E;  1TFX C;  3CI7 A;  3BTQ I;  3BTH I;  3AUG A;  3AUH A;  1ADZ A;  1FY8 I;  2M99 A;  6PTI A;  1T8M B;  1BRC I;  1F7Z I;  1ZJD B;  1KUN A;  3TGK I;  1EJM B;  1P2O B;  1YC0 I;  3BTF I;  3M7Q B;  2PTC I;  3FP7 J;  2HEX A;  2FI5 I;  3TGI I;  1LD5 A;  2J6D A;  1P2J I;  1CBW D;  1UUA A;  3AUC A;  5JB4 A;  1ZR0 B;  4DTG K;  1BRB I;  3LDM A;  4BQD A;  2LFK A;  3L33 E;  3GYM I;  7PTI A;  3AUB A;  9PTI A;  4PTI A;  1DEN A;  1TPA I;  1B0C A;  3BTE I;  2DDJ A;  1BTI A;  1DTK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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