4JK1E

X-ray crystal structure of escherichia coli sigma70 holoenzyme in complex with guanosine tetraphosphate (ppgpp)
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
90
structure length
90
Chain Sequence
ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Differential regulation by ppGpp versus pppGpp in Escherichia coli.
pubmed doi rcsb
molecule tags Transcription, transferase
source organism Escherichia coli
molecule keywords Escherichia coli RNA polymerase alpha subunit
total genus 22
structure length 90
sequence length 90
chains with identical sequence J
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2013-03-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4jk1E00
5M3MF 4OIQE 3M3YF 2WAQK 4G7OE 4A3IF 4YG2E 3S17F 4LK1E 2NVTF 4A3CF 5M5WF 1HQME 1I3QF 4C3IF 5FJ8F 2VUMF 4A3EF 4XSZE 4Q4ZE 2O5IE 1WCMF 5D4DE 3HOUF 3S15F 3S1QF 4A3GF 5E18E 4GZYE 2CW0E 1TWGF 4LJZE 3HKZK 4G7HE 1IW7E 3CQZF 3EQLE 5BYHE 2A69E 3K7AF 2B63F 2R92F 4C3JF 1I50F 3GTQF 1QKLA 4A93F 4OIRE 5C44F 4JK1E 5IP9F 3HOXF 2E2JF 4Q5SE 4AYBK 1I6VE 4OIOE 3PO3F 4X6AF 3DXJE 4MEYE 3GTGF 5TMCE 4LK0E 4KN7E 1Y1WF 2YU9F 2A6HE 5IYCF 3HOYF 4ZH4E 2WB1I 4A3LF 2A6EE 4A3DF 3H3VG 3GTLF 3GTOF 3GTJF 4BY7F 4BXXF 5IPLE 5M5XF 3S1NF 4A3KF 2A68E 3WODE 3H0GF 3S2HF 5C4JF 4MEXE 2JA5F 3S1RF 2JA7F 5C4XF 3HOWF 5IYBF 4BBRF 2Y0SI 4MQ9E 2JA6F 4G7ZE 5IYDF 2BE5E 3HOZF 3S14F 3RZOF 4YFKE 3S16F 1Y1VF 2JA8F 4A3FF 2O5JE 4A3BF 5E17E 4XSXE 3I4MF 2E2HF 4XLNE 5TMFE 3FKIF 4A3JF 4Y7NF 1SFOF 3M4OF 2NVYF 5M5YF 2PPBE 4LLGE 5D4EE 2PMZK 1TWFF 3S1MF 4KN4E 4KMUE 5C3EF 3GTMF 1SMYE 4OIPE 3PO2F 4Y52F 2NVXF 1K83F 2R93F 1YNNK 1R9TF 1TWAF 3HOVF 5M3FF 4YFNE 3S2DF 1YNJK 4OINE 4C2MF 5FLMF 4BBSF 4C3HF 1TWCF 1TWHF 2E2IF 4XLPE 5D4CE 3GTKF 4A3MF 3RZDF 3GTPF 5IP7F 1I6HF 2NVQF 3I4NF 2R7ZF 4BY1F 4YFXE 1ZYRE
chains in the Genus database with same CATH superfamily
5M3MF 1DZFA 4OIQE 3M3YF 2WAQK 5M3ME 5C44E 3M3YE 4G7OE 4A3IF 4YG2E 3S17F 4LK1E 2NVTF 4A3CF 3S17E 3PO3E 5M5WF 4X6AE 1HQME 2NVTE 4A3CE 1I3QF 5M5WE 4C3IF 3GTGE 5FJ8F 4C3IE 1Y1WE 2YU9E 2VUMF 4A3EF 2WAQH 4XSZE 4Q4ZE 1WCMF 5D4DE 2O5IE 2VUME 3HOUF 3HOUE 3S15F 1WCME 3S15E 3S1QF 5E18E 2R7ZE 2CW0E 4GZYE 1TWGF 4LJZE 1TWGE 3HKZK 4A3DE 3GTLE 4G7HE 1IW7E 3CQZF 3GTOE 3EQLE 5BYHE 2A69E 3K7AF 4BXXE 3CQZE 4BY7E 2B63F 3S1NE 4A3KE 2R92F 4C3JF 1I50F 3GTQF 3H0GE 3GTQE 3S2HE 4A3GF 3HKZH 1QKLA 2JA5E 4OIRE 3S1RE 2KRXA 5C44F 2JA7E 4A93F 4JK1E 5IP9F 3HOXF 2E2JF 3HOWE 4BBRE 4A93E 4Q5SE 5IP9E 3HOXE 2E2JE 2JA6E 4AYBK 5IYDE 3H3VF 1I6VE 4OIOE 3PO3F 4X6AF 3DXJE 4MEYE 3S14E 3GTGF 1Y1VE 4LK0E 4KN7E 5TMCE 1Y1WF 2YU9F 2JA8E 2A6HE 5IYCF 4A3FE 4A3BE 5IYCE 3I4ME 3HOYF 4ZH4E 4AYBH 2WB1I 4A3JE 3HOYE 3FKIE 4A3LF 2A6EE 4Y7NE 1SFOE 4A3LE 4A3DF 3H3VG 3GTLF 2NVYE 4QIWK 3GTOF 3GTJF 4BY7F 4BXXF 5IPLE 5M5XF 3GTJE 3S1NF 4A3KF 3S1ME 3GTME 5M5XE 2A68E 3WODE 3PO2E 3H0GF 2NVXE 3S2HF 5C4JF 4MEXE 2JA5F 1I50E 3S1RF 2JA7F 2R93E 4QIWH 5C4JE 3HOWF 5IYBF 5C4XF 5C4XE 1TWAE 2Y0SI 4BBRF 1EIKA 5IYBE 4MQ9E 2JA6F 4G7ZE 5IYDF 5M3FE 3HOVE 3S2DE 2BE5E 4C2ME 3HOZF 2WB1H 3S14F 3RZOF 4YFKE 3S16F 1Y1VF 3HOZE 3RZOE 1TWCE 1TWHE 4A3FF 2JA8F 3S16E 4A3BF 2O5JE 5E17E 4XSXE 2E2IE 3I4MF 2E2HF 4XLNE 5TMFE 3FKIF 4A3JF 2E2HE 4A3ME 3RZDE 3GTPE 4Y7NF 1SFOF 3M4OF 2NVYF 3M4OE 5IP7E 2NVQE 5M5YF 2PPBE 4LLGE 5D4EE 2PMZK 5M5YE 1TWFF 2Y0SH 3S1MF 4KN4E 1TWFE 4KMUE 5C3EF 1SMYE 3GTMF 4OIPE 5C3EE 3PO2F 4Y52F 2NVXF 1K83F 2R93F 4Y52E 1K83E 1YNNK 1R9TF 4A3IE 1TWAF 2PMZH 1R9TE 3HOVF 5M3FF 4YFNE 3S2DF 1YNJK 4OINE 1I3QE 4C2MF 5FLMF 4BBSF 5FLME 5FJ8E 4C3HF 1TWCF 1TWHF 4A3EE 4BBSE 4A3GE 4C3HE 3S1QE 2E2IF 4XLPE 5D4CE 3GTKF 4A3MF 3RZDF 3GTPF 3GTKE 5IP7F 1I6HF 2NVQF 3I4NF 3K7AE 3I4NE 1I6HE 2B63E 2R7ZF 2R92E 4BY1F 4C3JE 4YFXE 1ZYRE 4BY1E
chains in the Genus database with same CATH topology
5M3MF 4OIQE 3M3YF 2WAQK 4G7OE 4A3IF 4YG2E 3S17F 4LK1E 2NVTF 4A3CF 5M5WF 1HQME 1I3QF 4C3IF 5FJ8F 2VUMF 4A3EF 4XSZE 4Q4ZE 2O5IE 1WCMF 5D4DE 3HOUF 3S15F 3S1QF 4A3GF 5E18E 4GZYE 2CW0E 1TWGF 4LJZE 3HKZK 4G7HE 1IW7E 3CQZF 3EQLE 5BYHE 2A69E 3K7AF 2B63F 2R92F 4C3JF 1I50F 3GTQF 1QKLA 4A93F 4OIRE 2KRXA 5C44F 4JK1E 5IP9F 3HOXF 2E2JF 4Q5SE 4AYBK 1I6VE 4OIOE 3PO3F 4X6AF 3DXJE 4MEYE 3GTGF 5TMCE 4LK0E 4KN7E 1Y1WF 2YU9F 2A6HE 5IYCF 3HOYF 4ZH4E 2WB1I 4A3LF 2A6EE 4A3DF 3H3VG 3GTLF 4QIWK 3GTOF 3GTJF 4BY7F 4BXXF 5IPLE 5M5XF 3S1NF 4A3KF 2A68E 3WODE 3H0GF 3S2HF 5C4JF 4MEXE 2JA5F 3S1RF 2JA7F 5C4XF 3HOWF 5IYBF 4BBRF 2Y0SI 4MQ9E 2JA6F 4G7ZE 5IYDF 2BE5E 3HOZF 3S14F 3RZOF 4YFKE 3S16F 1Y1VF 2JA8F 4A3FF 2O5JE 4A3BF 5E17E 4XSXE 3I4MF 2E2HF 4XLNE 5TMFE 3FKIF 4A3JF 4Y7NF 1SFOF 3M4OF 2NVYF 5M5YF 2PPBE 4LLGE 5D4EE 2PMZK 1TWFF 3S1MF 4KN4E 4KMUE 5C3EF 3GTMF 1SMYE 4OIPE 3PO2F 4Y52F 2NVXF 1K83F 2R93F 1YNNK 1R9TF 1TWAF 3HOVF 5M3FF 4YFNE 3S2DF 1YNJK 4OINE 4C2MF 5FLMF 4BBSF 4C3HF 1TWCF 1TWHF 2E2IF 4XLPE 5D4CE 3GTKF 4A3MF 3RZDF 3GTPF 5IP7F 1I6HF 2NVQF 3I4NF 2R7ZF 4BY1F 4YFXE 1ZYRE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5M3M F;  4OIQ E;  3M3Y F;  2WAQ K;  4G7O E;  4A3I F;  4YG2 E;  3S17 F;  4LK1 E;  2NVT F;  4A3C F;  5M5W F;  1HQM E;  1I3Q F;  4C3I F;  5FJ8 F;  2VUM F;  4A3E F;  4XSZ E;  4Q4Z E;  2O5I E;  1WCM F;  5D4D E;  3HOU F;  3S15 F;  3S1Q F;  4A3G F;  5E18 E;  4GZY E;  2CW0 E;  1TWG F;  4LJZ E;  3HKZ K;  4G7H E;  1IW7 E;  3CQZ F;  3EQL E;  5BYH E;  2A69 E;  3K7A F;  2B63 F;  2R92 F;  4C3J F;  1I50 F;  3GTQ F;  1QKL A;  4A93 F;  4OIR E;  5C44 F;  4JK1 E;  5IP9 F;  3HOX F;  2E2J F;  4Q5S E;  4AYB K;  1I6V E;  4OIO E;  3PO3 F;  4X6A F;  3DXJ E;  4MEY E;  3GTG F;  5TMC E;  4LK0 E;  4KN7 E;  1Y1W F;  2YU9 F;  2A6H E;  5IYC F;  3HOY F;  4ZH4 E;  2WB1 I;  4A3L F;  2A6E E;  4A3D F;  3H3V G;  3GTL F;  3GTO F;  3GTJ F;  4BY7 F;  4BXX F;  5IPL E;  5M5X F;  3S1N F;  4A3K F;  2A68 E;  3WOD E;  3H0G F;  3S2H F;  5C4J F;  4MEX E;  2JA5 F;  3S1R F;  2JA7 F;  5C4X F;  3HOW F;  5IYB F;  4BBR F;  2Y0S I;  4MQ9 E;  2JA6 F;  4G7Z E;  5IYD F;  2BE5 E;  3HOZ F;  3S14 F;  3RZO F;  4YFK E;  3S16 F;  1Y1V F;  2JA8 F;  4A3F F;  2O5J E;  4A3B F;  5E17 E;  4XSX E;  3I4M F;  2E2H F;  4XLN E;  5TMF E;  3FKI F;  4A3J F;  4Y7N F;  1SFO F;  3M4O F;  2NVY F;  5M5Y F;  2PPB E;  4LLG E;  5D4E E;  2PMZ K;  1TWF F;  3S1M F;  4KN4 E;  4KMU E;  5C3E F;  3GTM F;  1SMY E;  4OIP E;  3PO2 F;  4Y52 F;  2NVX F;  1K83 F;  2R93 F;  1YNN K;  1R9T F;  1TWA F;  3HOV F;  5M3F F;  4YFN E;  3S2D F;  1YNJ K;  4OIN E;  4C2M F;  5FLM F;  4BBS F;  4C3H F;  1TWC F;  1TWH F;  2E2I F;  4XLP E;  5D4C E;  3GTK F;  4A3M F;  3RZD F;  3GTP F;  5IP7 F;  1I6H F;  2NVQ F;  3I4N F;  2R7Z F;  4BY1 F;  4YFX E;  1ZYR E; 
#chains in the Genus database with same CATH topology
 5M3M F;  1DZF A;  4OIQ E;  3M3Y F;  2WAQ K;  5M3M E;  5C44 E;  3M3Y E;  4G7O E;  4A3I F;  4YG2 E;  3S17 F;  4LK1 E;  2NVT F;  4A3C F;  3S17 E;  3PO3 E;  5M5W F;  4X6A E;  1HQM E;  2NVT E;  4A3C E;  1I3Q F;  5M5W E;  4C3I F;  3GTG E;  5FJ8 F;  4C3I E;  1Y1W E;  2YU9 E;  2VUM F;  4A3E F;  2WAQ H;  4XSZ E;  4Q4Z E;  1WCM F;  5D4D E;  2O5I E;  2VUM E;  3HOU F;  3HOU E;  3S15 F;  1WCM E;  3S15 E;  3S1Q F;  5E18 E;  2R7Z E;  2CW0 E;  4GZY E;  1TWG F;  4LJZ E;  1TWG E;  3HKZ K;  4A3D E;  3GTL E;  4G7H E;  1IW7 E;  3CQZ F;  3GTO E;  3EQL E;  5BYH E;  2A69 E;  3K7A F;  4BXX E;  3CQZ E;  4BY7 E;  2B63 F;  3S1N E;  4A3K E;  2R92 F;  4C3J F;  1I50 F;  3GTQ F;  3H0G E;  3GTQ E;  3S2H E;  4A3G F;  3HKZ H;  1QKL A;  2JA5 E;  4OIR E;  3S1R E;  2KRX A;  5C44 F;  2JA7 E;  4A93 F;  4JK1 E;  5IP9 F;  3HOX F;  2E2J F;  3HOW E;  4BBR E;  4A93 E;  4Q5S E;  5IP9 E;  3HOX E;  2E2J E;  2JA6 E;  4AYB K;  5IYD E;  3H3V F;  1I6V E;  4OIO E;  3PO3 F;  4X6A F;  3DXJ E;  4MEY E;  3S14 E;  3GTG F;  1Y1V E;  4LK0 E;  4KN7 E;  5TMC E;  1Y1W F;  2YU9 F;  2JA8 E;  2A6H E;  5IYC F;  4A3F E;  4A3B E;  5IYC E;  3I4M E;  3HOY F;  4ZH4 E;  4AYB H;  2WB1 I;  4A3J E;  3HOY E;  3FKI E;  4A3L F;  2A6E E;  4Y7N E;  1SFO E;  4A3L E;  4A3D F;  3H3V G;  3GTL F;  2NVY E;  4QIW K;  3GTO F;  3GTJ F;  4BY7 F;  4BXX F;  5IPL E;  5M5X F;  3GTJ E;  3S1N F;  4A3K F;  3S1M E;  3GTM E;  5M5X E;  2A68 E;  3WOD E;  3PO2 E;  3H0G F;  2NVX E;  3S2H F;  5C4J F;  4MEX E;  2JA5 F;  1I50 E;  3S1R F;  2JA7 F;  2R93 E;  4QIW H;  5C4J E;  3HOW F;  5IYB F;  5C4X F;  5C4X E;  1TWA E;  2Y0S I;  4BBR F;  1EIK A;  5IYB E;  4MQ9 E;  2JA6 F;  4G7Z E;  5IYD F;  5M3F E;  3HOV E;  3S2D E;  2BE5 E;  4C2M E;  3HOZ F;  2WB1 H;  3S14 F;  3RZO F;  4YFK E;  3S16 F;  1Y1V F;  3HOZ E;  3RZO E;  1TWC E;  1TWH E;  4A3F F;  2JA8 F;  3S16 E;  4A3B F;  2O5J E;  5E17 E;  4XSX E;  2E2I E;  3I4M F;  2E2H F;  4XLN E;  5TMF E;  3FKI F;  4A3J F;  2E2H E;  4A3M E;  3RZD E;  3GTP E;  4Y7N F;  1SFO F;  3M4O F;  2NVY F;  3M4O E;  5IP7 E;  2NVQ E;  5M5Y F;  2PPB E;  4LLG E;  5D4E E;  2PMZ K;  5M5Y E;  1TWF F;  2Y0S H;  3S1M F;  4KN4 E;  1TWF E;  4KMU E;  5C3E F;  1SMY E;  3GTM F;  4OIP E;  5C3E E;  3PO2 F;  4Y52 F;  2NVX F;  1K83 F;  2R93 F;  4Y52 E;  1K83 E;  1YNN K;  1R9T F;  4A3I E;  1TWA F;  2PMZ H;  1R9T E;  3HOV F;  5M3F F;  4YFN E;  3S2D F;  1YNJ K;  4OIN E;  1I3Q E;  4C2M F;  5FLM F;  4BBS F;  5FLM E;  5FJ8 E;  4C3H F;  1TWC F;  1TWH F;  4A3E E;  4BBS E;  4A3G E;  4C3H E;  3S1Q E;  2E2I F;  4XLP E;  5D4C E;  3GTK F;  4A3M F;  3RZD F;  3GTP F;  3GTK E;  5IP7 F;  1I6H F;  2NVQ F;  3I4N F;  3K7A E;  3I4N E;  1I6H E;  2B63 E;  2R7Z F;  2R92 E;  4BY1 F;  4C3J E;  4YFX E;  1ZYR E;  4BY1 E; 
#chains in the Genus database with same CATH homology
 5M3M F;  4OIQ E;  3M3Y F;  2WAQ K;  4G7O E;  4A3I F;  4YG2 E;  3S17 F;  4LK1 E;  2NVT F;  4A3C F;  5M5W F;  1HQM E;  1I3Q F;  4C3I F;  5FJ8 F;  2VUM F;  4A3E F;  4XSZ E;  4Q4Z E;  2O5I E;  1WCM F;  5D4D E;  3HOU F;  3S15 F;  3S1Q F;  4A3G F;  5E18 E;  4GZY E;  2CW0 E;  1TWG F;  4LJZ E;  3HKZ K;  4G7H E;  1IW7 E;  3CQZ F;  3EQL E;  5BYH E;  2A69 E;  3K7A F;  2B63 F;  2R92 F;  4C3J F;  1I50 F;  3GTQ F;  1QKL A;  4A93 F;  4OIR E;  2KRX A;  5C44 F;  4JK1 E;  5IP9 F;  3HOX F;  2E2J F;  4Q5S E;  4AYB K;  1I6V E;  4OIO E;  3PO3 F;  4X6A F;  3DXJ E;  4MEY E;  3GTG F;  5TMC E;  4LK0 E;  4KN7 E;  1Y1W F;  2YU9 F;  2A6H E;  5IYC F;  3HOY F;  4ZH4 E;  2WB1 I;  4A3L F;  2A6E E;  4A3D F;  3H3V G;  3GTL F;  4QIW K;  3GTO F;  3GTJ F;  4BY7 F;  4BXX F;  5IPL E;  5M5X F;  3S1N F;  4A3K F;  2A68 E;  3WOD E;  3H0G F;  3S2H F;  5C4J F;  4MEX E;  2JA5 F;  3S1R F;  2JA7 F;  5C4X F;  3HOW F;  5IYB F;  4BBR F;  2Y0S I;  4MQ9 E;  2JA6 F;  4G7Z E;  5IYD F;  2BE5 E;  3HOZ F;  3S14 F;  3RZO F;  4YFK E;  3S16 F;  1Y1V F;  2JA8 F;  4A3F F;  2O5J E;  4A3B F;  5E17 E;  4XSX E;  3I4M F;  2E2H F;  4XLN E;  5TMF E;  3FKI F;  4A3J F;  4Y7N F;  1SFO F;  3M4O F;  2NVY F;  5M5Y F;  2PPB E;  4LLG E;  5D4E E;  2PMZ K;  1TWF F;  3S1M F;  4KN4 E;  4KMU E;  5C3E F;  3GTM F;  1SMY E;  4OIP E;  3PO2 F;  4Y52 F;  2NVX F;  1K83 F;  2R93 F;  1YNN K;  1R9T F;  1TWA F;  3HOV F;  5M3F F;  4YFN E;  3S2D F;  1YNJ K;  4OIN E;  4C2M F;  5FLM F;  4BBS F;  4C3H F;  1TWC F;  1TWH F;  2E2I F;  4XLP E;  5D4C E;  3GTK F;  4A3M F;  3RZD F;  3GTP F;  5IP7 F;  1I6H F;  2NVQ F;  3I4N F;  2R7Z F;  4BY1 F;  4YFX E;  1ZYR E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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