4L0IC

Tankyrase 2 catalytic domain in complex with ethyl 4-(4-oxo-4h-chromen-2-yl)benzoate
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2013-05-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4l0iC00
5FPFC 5C5QC 4UI5C 4L32C 4L0SC 4UI7C 4HMHC 4HLHC 4HKKB 4L34C 4UI8C 4HLMC 5ADRB 5ADQB 4HLKC 4HLGC 4L0BC 4L2FC 4UVPB 4KZLC 4UI3C 5C5RC 4L2KC 4L09C 4L2GC 4L0IC 4HKNC 4KZUC 4L0TC 4L10C 4L33C 4UI6C 4L0VC 4KZQC 4HLFC 4L31C 5C5PC 4UI4C 5ADSB 4HKIC 5ADTB 4HL5C
chains in the Genus database with same CATH superfamily
5FPFC 5C5QC 4UI5C 4L32C 4L0SC 3K6QA 3HJ6A 4UI7C 4HMHC 4HLHC 4HKKB 4L34C 4UI8C 4HLMC 4ZLXA 5ADRB 4HLKC 4HLGC 4L0BC 4L2FC 4UVPB 5ADQB 2A6QA 2ODKA 3D55A 3HRYA 4KZLC 4UI3C 5C5RC 4L2KC 4L09C 4L2GC 3OEIA 4HKNC 4L0IC 4KZUC 2ZIXB 3OEIE 4ZM2A 4L0TC 4L10C 4L33C 3KH2E 3G5OA 4UI6C 4L0VC 4KZQC 3CTOA 3K33B 3HS2A 4HLFC 4L31C 4HKIC 4UI4C 5C5PC 5ADSB 4ZM0A 5ADTB 4HL5C
chains in the Genus database with same CATH topology
5FPFC 5C5QC 4UI5C 4L32C 4L0SC 3HJ6A 4UI7C 4HMHC 4HLHC 4HKKB 4L34C 4UI8C 4HLMC 5ADRB 5ADQB 4HLKC 4HLGC 4L0BC 4L2FC 4UVPB 4KZLC 4UI3C 5C5RC 4L2KC 4L09C 4L2GC 4L0IC 4HKNC 4KZUC 2ZIXB 4L0TC 4L10C 4L33C 4UI6C 4L0VC 4KZQC 4HLFC 4L31C 5C5PC 4UI4C 5ADSB 4HKIC 5ADTB 4HL5C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FPF C;  5C5Q C;  4UI5 C;  4L32 C;  4L0S C;  4UI7 C;  4HMH C;  4HLH C;  4HKK B;  4L34 C;  4UI8 C;  4HLM C;  5ADR B;  5ADQ B;  4HLK C;  4HLG C;  4L0B C;  4L2F C;  4UVP B;  4KZL C;  4UI3 C;  5C5R C;  4L2K C;  4L09 C;  4L2G C;  4L0I C;  4HKN C;  4KZU C;  4L0T C;  4L10 C;  4L33 C;  4UI6 C;  4L0V C;  4KZQ C;  4HLF C;  4L31 C;  5C5P C;  4UI4 C;  5ADS B;  4HKI C;  5ADT B;  4HL5 C; 
#chains in the Genus database with same CATH topology
 5FPF C;  5C5Q C;  4UI5 C;  4L32 C;  4L0S C;  3K6Q A;  3HJ6 A;  4UI7 C;  4HMH C;  4HLH C;  4HKK B;  4L34 C;  4UI8 C;  4HLM C;  4ZLX A;  5ADR B;  4HLK C;  4HLG C;  4L0B C;  4L2F C;  4UVP B;  5ADQ B;  2A6Q A;  2ODK A;  3D55 A;  3HRY A;  4KZL C;  4UI3 C;  5C5R C;  4L2K C;  4L09 C;  4L2G C;  3OEI A;  4HKN C;  4L0I C;  4KZU C;  2ZIX B;  3OEI E;  4ZM2 A;  4L0T C;  4L10 C;  4L33 C;  3KH2 E;  3G5O A;  4UI6 C;  4L0V C;  4KZQ C;  3CTO A;  3K33 B;  3HS2 A;  4HLF C;  4L31 C;  4HKI C;  4UI4 C;  5C5P C;  5ADS B;  4ZM0 A;  5ADT B;  4HL5 C; 
#chains in the Genus database with same CATH homology
 5FPF C;  5C5Q C;  4UI5 C;  4L32 C;  4L0S C;  3HJ6 A;  4UI7 C;  4HMH C;  4HLH C;  4HKK B;  4L34 C;  4UI8 C;  4HLM C;  5ADR B;  5ADQ B;  4HLK C;  4HLG C;  4L0B C;  4L2F C;  4UVP B;  4KZL C;  4UI3 C;  5C5R C;  4L2K C;  4L09 C;  4L2G C;  4L0I C;  4HKN C;  4KZU C;  2ZIX B;  4L0T C;  4L10 C;  4L33 C;  4UI6 C;  4L0V C;  4KZQ C;  4HLF C;  4L31 C;  5C5P C;  4UI4 C;  5ADS B;  4HKI C;  5ADT B;  4HL5 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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