4LK1E

Crystal structure analysis of the e.coli holoenzyme
Total Genus 25
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
89
structure length
89
Chain Sequence
ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
pubmed doi rcsb
molecule tags Transferase
source organism Escherichia coli
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 25
structure length 89
sequence length 89
chains with identical sequence K
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2013-07-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4lk1E00
2JA7F 1YNJK 2E2JF 3HOWF 5M3MF 2O5IE 3FKIF 4A3DF 1I6VE 4MEYE 3S1NF 1K83F 4XSXE 1SFOF 1ZYRE 5FJ8F 4JK1E 2A69E 2E2IF 2JA6F 2JA8F 5IYCF 2BE5E 4A3FF 4A3KF 2NVTF 5M5XF 2A68E 4YFNE 5FLMF 2WAQK 2R92F 4C3HF 1YNNK 4YFKE 3GTMF 3S14F 5C4JF 3S2DF 4YFXE 3S2HF 2R93F 1TWFF 5BYHE 4Q5SE 4BBRF 2NVYF 4BY1F 5IP7F 2WB1I 4OIOE 4OIQE 4A3EF 2A6EE 5C4XF 2O5JE 5IP9F 5IYBF 2NVQF 2CW0E 2PMZK 3I4NF 5IPLE 3H0GF 3GTQF 4A3IF 3GTLF 1I3QF 4YG2E 1HQME 2PPBE 5C3EF 4OIPE 4G7ZE 3GTJF 4AYBK 5C44F 3S1QF 1I50F 2Y0SI 1SMYE 3S1RF 3HOUF 5D4CE 3HOVF 3HOYF 4A3LF 5E18E 4KN7E 2A6HE 4KN4E 4A3JF 4LLGE 3EQLE 5E17E 5TMFE 4Y52F 3DXJE 4MEXE 4OIRE 3K7AF 4A3CF 4MQ9E 4GZYE 4A3BF 3S16F 3GTOF 4BY7F 1IW7E 4XSZE 3M4OF 5M5WF 5IYDF 3GTKF 4Y7NF 1QKLA 4C3JF 2JA5F 2NVXF 3PO3F 3RZOF 4G7OE 4LJZE 3S17F 3HOXF 4KMUE 5M5YF 2R7ZF 4BXXF 1TWGF 4A93F 4Q4ZE 3HOZF 4XLPE 5TMCE 2E2HF 1I6HF 3CQZF 3WODE 3GTGF 1R9TF 1TWAF 4ZH4E 2B63F 4A3GF 1Y1VF 3I4MF 2YU9F 4BBSF 3GTPF 1TWCF 3S1MF 3PO2F 4X6AF 4C3IF 4XLNE 4LK1E 1Y1WF 4OINE 4A3MF 5D4DE 3RZDF 4LK0E 1WCMF 2VUMF 3M3YF 1TWHF 3S15F 5M3FF 4C2MF 3H3VG 5D4EE 4G7HE 3HKZK
chains in the Genus database with same CATH superfamily
1I3QE 4AYBH 3PO3E 2JA7F 1YNJK 2E2JF 3HOWF 3GTJE 5M3MF 2O5IE 3FKIF 3S17E 4A3DF 5C44E 3S1QE 1I50E 3S1RE 3HOUE 1I6VE 4MEYE 3H3VF 3HOVE 3HOYE 4A3LE 3S1NF 4A3JE 1K83F 4XSXE 2E2HE 1SFOF 1ZYRE 5FJ8F 1R9TE 4Y52E 4JK1E 2A69E 2E2IF 2JA6F 2JA8F 5IYCF 3K7AE 2BE5E 1Y1VE 4A3FF 4A3KF 4A3CE 2WB1H 2NVTF 5M5XF 2A68E 4YFNE 5FLMF 4A3BE 2WAQK 2R92F 3GTPE 3GTQE 3S16E 4C3HF 3GTOE 4BY7E 1YNNK 4YFKE 3GTMF 3S14F 5C4JF 3S2DF 4YFXE 5M5WE 1Y1WE 3M4OE 3S2HF 5IYDE 3GTKE 4QIWK 1TWFF 5BYHE 4Q5SE 4BBRF 4C3JE 2NVYF 2JA5E 2NVXE 1EIKA 4BY1F 5IP7F 2WB1I 4OIOE 4OIQE 3M3YE 4A3EF 3RZOE 2A6EE 3HOXE 5C4XF 2O5JE 5IP9F 5M5YE 5IYBF 2NVQF 2R7ZE 4BXXE 2CW0E 2PMZK 1TWGE 4A93E 3I4NF 5IPLE 3HOZE 3H0GF 3GTQF 2KRXA 4A3IF 3GTLF 1I3QF 4YG2E 1HQME 2PPBE 2JA7E 1I6HE 5C3EF 4OIPE 3CQZE 3GTGE 4G7ZE 3FKIE 3GTJF 4AYBK 1TWAE 5C44F 3S1QF 1I50F 2Y0SI 2B63E 1SMYE 3S1RF 3HOUF 4A3GE 3I4ME 5D4CE 3HOVF 2YU9E 3HOYF 5E18E 4KN7E 4A3LF 4BBSE 2A6HE 4KN4E 1TWCE 4A3JF 3S1ME 1SFOE 4LLGE 3PO2E 4X6AE 4C3IE 3EQLE 5E17E 5TMFE 4Y52F 3DXJE 4MEXE 4A3ME 3RZDE 4OIRE 3K7AF 4G7HE 4A3CF 1WCME 4MQ9E 5M5XE 1TWHE 2VUME 3S15E 4A3BF 4GZYE 5M3FE 3S16F 3HKZH 2Y0SH 3GTOF 4BY7F 1IW7E 4C2ME 4XSZE 3M4OF 5M5WF 5IYDF 3GTKF 4Y7NF 1QKLA 4C3JF 2JA5F 2NVXF 2E2JE 3HOWE 3PO3F 3RZOF 5M3ME 4A3DE 4G7OE 4LJZE 3S17F 3HOXF 4KMUE 5M5YF 2R7ZF 4BXXF 3GTLE 3S1NE 1TWGF 4A93F 1K83E 4Q4ZE 3HOZF 4XLPE 5TMCE 2E2HF 5C3EE 2R93F 1I6HF 5FJ8E 3CQZF 3WODE 3GTGF 1R9TF 2E2IE 2JA6E 2WAQH 1TWAF 4ZH4E 5IYCE 4A3KE 4A3FE 2B63F 2JA8E 4A3GF 1Y1VF 2NVTE 5FLME 3I4MF 2YU9F 2R92E 4BBSF 4C3HE 3GTPF 4QIWH 1TWCF 3S1MF 3GTME 3S14E 5C4JE 3S2DE 4C3IF 4XLNE 4LK1E 3PO2F 3S2HE 2R93E 4X6AF 1TWFE 1Y1WF 4OINE 4BBRE 2NVYE 4A3MF 5D4DE 3RZDF 4BY1E 5IP7E 1DZFA 4A3EE 4LK0E 1WCMF 2PMZH 2VUMF 1TWHF 3M3YF 3S15F 5C4XE 5IP9E 5IYBE 2NVQE 5M3FF 4C2MF 3H3VG 3I4NE 5D4EE 4Y7NE 3HKZK 3H0GE 4A3IE
chains in the Genus database with same CATH topology
2JA7F 1YNJK 2E2JF 3HOWF 5M3MF 2O5IE 3FKIF 4A3DF 1I6VE 4MEYE 3S1NF 1K83F 4XSXE 1SFOF 1ZYRE 5FJ8F 4JK1E 2A69E 2E2IF 2JA6F 2JA8F 5IYCF 2BE5E 4A3FF 4A3KF 2NVTF 5M5XF 2A68E 4YFNE 5FLMF 2WAQK 2R92F 4C3HF 1YNNK 4YFKE 3GTMF 3S14F 5C4JF 3S2DF 4YFXE 3S2HF 2R93F 4QIWK 1TWFF 5BYHE 4Q5SE 4BBRF 2NVYF 4BY1F 5IP7F 2WB1I 4OIOE 4OIQE 4A3EF 2A6EE 5C4XF 2O5JE 5IP9F 5IYBF 2NVQF 2CW0E 2PMZK 3I4NF 5IPLE 3H0GF 3GTQF 2KRXA 4A3IF 3GTLF 1I3QF 4YG2E 1HQME 2PPBE 5C3EF 4OIPE 4G7ZE 3GTJF 4AYBK 5C44F 3S1QF 1I50F 2Y0SI 1SMYE 3S1RF 3HOUF 5D4CE 3HOVF 3HOYF 4A3LF 5E18E 4KN7E 2A6HE 4KN4E 4A3JF 4LLGE 3EQLE 5E17E 5TMFE 4Y52F 3DXJE 4MEXE 4OIRE 3K7AF 4A3CF 4MQ9E 4GZYE 4A3BF 3S16F 3GTOF 4BY7F 1IW7E 4XSZE 3M4OF 5M5WF 5IYDF 3GTKF 4Y7NF 1QKLA 4C3JF 2JA5F 2NVXF 3PO3F 3RZOF 4G7OE 4LJZE 3S17F 3HOXF 4KMUE 5M5YF 2R7ZF 4BXXF 1TWGF 4A93F 4Q4ZE 3HOZF 4XLPE 5TMCE 2E2HF 1I6HF 3CQZF 3WODE 3GTGF 1R9TF 1TWAF 4ZH4E 2B63F 4A3GF 1Y1VF 3I4MF 2YU9F 4BBSF 3GTPF 1TWCF 3S1MF 3PO2F 4X6AF 4C3IF 4XLNE 4LK1E 1Y1WF 4OINE 4A3MF 5D4DE 3RZDF 4LK0E 1WCMF 2VUMF 3M3YF 1TWHF 3S15F 5M3FF 4C2MF 3H3VG 5D4EE 4G7HE 3HKZK
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JA7 F;  1YNJ K;  2E2J F;  3HOW F;  5M3M F;  2O5I E;  3FKI F;  4A3D F;  1I6V E;  4MEY E;  3S1N F;  1K83 F;  4XSX E;  1SFO F;  1ZYR E;  5FJ8 F;  4JK1 E;  2A69 E;  2E2I F;  2JA6 F;  2JA8 F;  5IYC F;  2BE5 E;  4A3F F;  4A3K F;  2NVT F;  5M5X F;  2A68 E;  4YFN E;  5FLM F;  2WAQ K;  2R92 F;  4C3H F;  1YNN K;  4YFK E;  3GTM F;  3S14 F;  5C4J F;  3S2D F;  4YFX E;  3S2H F;  2R93 F;  1TWF F;  5BYH E;  4Q5S E;  4BBR F;  2NVY F;  4BY1 F;  5IP7 F;  2WB1 I;  4OIO E;  4OIQ E;  4A3E F;  2A6E E;  5C4X F;  2O5J E;  5IP9 F;  5IYB F;  2NVQ F;  2CW0 E;  2PMZ K;  3I4N F;  5IPL E;  3H0G F;  3GTQ F;  4A3I F;  3GTL F;  1I3Q F;  4YG2 E;  1HQM E;  2PPB E;  5C3E F;  4OIP E;  4G7Z E;  3GTJ F;  4AYB K;  5C44 F;  3S1Q F;  1I50 F;  2Y0S I;  1SMY E;  3S1R F;  3HOU F;  5D4C E;  3HOV F;  3HOY F;  4A3L F;  5E18 E;  4KN7 E;  2A6H E;  4KN4 E;  4A3J F;  4LLG E;  3EQL E;  5E17 E;  5TMF E;  4Y52 F;  3DXJ E;  4MEX E;  4OIR E;  3K7A F;  4A3C F;  4MQ9 E;  4GZY E;  4A3B F;  3S16 F;  3GTO F;  4BY7 F;  1IW7 E;  4XSZ E;  3M4O F;  5M5W F;  5IYD F;  3GTK F;  4Y7N F;  1QKL A;  4C3J F;  2JA5 F;  2NVX F;  3PO3 F;  3RZO F;  4G7O E;  4LJZ E;  3S17 F;  3HOX F;  4KMU E;  5M5Y F;  2R7Z F;  4BXX F;  1TWG F;  4A93 F;  4Q4Z E;  3HOZ F;  4XLP E;  5TMC E;  2E2H F;  1I6H F;  3CQZ F;  3WOD E;  3GTG F;  1R9T F;  1TWA F;  4ZH4 E;  2B63 F;  4A3G F;  1Y1V F;  3I4M F;  2YU9 F;  4BBS F;  3GTP F;  1TWC F;  3S1M F;  3PO2 F;  4X6A F;  4C3I F;  4XLN E;  4LK1 E;  1Y1W F;  4OIN E;  4A3M F;  5D4D E;  3RZD F;  4LK0 E;  1WCM F;  2VUM F;  3M3Y F;  1TWH F;  3S15 F;  5M3F F;  4C2M F;  3H3V G;  5D4E E;  4G7H E;  3HKZ K; 
#chains in the Genus database with same CATH topology
 1I3Q E;  4AYB H;  3PO3 E;  2JA7 F;  1YNJ K;  2E2J F;  3HOW F;  3GTJ E;  5M3M F;  2O5I E;  3FKI F;  3S17 E;  4A3D F;  5C44 E;  3S1Q E;  1I50 E;  3S1R E;  3HOU E;  1I6V E;  4MEY E;  3H3V F;  3HOV E;  3HOY E;  4A3L E;  3S1N F;  4A3J E;  1K83 F;  4XSX E;  2E2H E;  1SFO F;  1ZYR E;  5FJ8 F;  1R9T E;  4Y52 E;  4JK1 E;  2A69 E;  2E2I F;  2JA6 F;  2JA8 F;  5IYC F;  3K7A E;  2BE5 E;  1Y1V E;  4A3F F;  4A3K F;  4A3C E;  2WB1 H;  2NVT F;  5M5X F;  2A68 E;  4YFN E;  5FLM F;  4A3B E;  2WAQ K;  2R92 F;  3GTP E;  3GTQ E;  3S16 E;  4C3H F;  3GTO E;  4BY7 E;  1YNN K;  4YFK E;  3GTM F;  3S14 F;  5C4J F;  3S2D F;  4YFX E;  5M5W E;  1Y1W E;  3M4O E;  3S2H F;  5IYD E;  3GTK E;  4QIW K;  1TWF F;  5BYH E;  4Q5S E;  4BBR F;  4C3J E;  2NVY F;  2JA5 E;  2NVX E;  1EIK A;  4BY1 F;  5IP7 F;  2WB1 I;  4OIO E;  4OIQ E;  3M3Y E;  4A3E F;  3RZO E;  2A6E E;  3HOX E;  5C4X F;  2O5J E;  5IP9 F;  5M5Y E;  5IYB F;  2NVQ F;  2R7Z E;  4BXX E;  2CW0 E;  2PMZ K;  1TWG E;  4A93 E;  3I4N F;  5IPL E;  3HOZ E;  3H0G F;  3GTQ F;  2KRX A;  4A3I F;  3GTL F;  1I3Q F;  4YG2 E;  1HQM E;  2PPB E;  2JA7 E;  1I6H E;  5C3E F;  4OIP E;  3CQZ E;  3GTG E;  4G7Z E;  3FKI E;  3GTJ F;  4AYB K;  1TWA E;  5C44 F;  3S1Q F;  1I50 F;  2Y0S I;  2B63 E;  1SMY E;  3S1R F;  3HOU F;  4A3G E;  3I4M E;  5D4C E;  3HOV F;  2YU9 E;  3HOY F;  5E18 E;  4KN7 E;  4A3L F;  4BBS E;  2A6H E;  4KN4 E;  1TWC E;  4A3J F;  3S1M E;  1SFO E;  4LLG E;  3PO2 E;  4X6A E;  4C3I E;  3EQL E;  5E17 E;  5TMF E;  4Y52 F;  3DXJ E;  4MEX E;  4A3M E;  3RZD E;  4OIR E;  3K7A F;  4G7H E;  4A3C F;  1WCM E;  4MQ9 E;  5M5X E;  1TWH E;  2VUM E;  3S15 E;  4A3B F;  4GZY E;  5M3F E;  3S16 F;  3HKZ H;  2Y0S H;  3GTO F;  4BY7 F;  1IW7 E;  4C2M E;  4XSZ E;  3M4O F;  5M5W F;  5IYD F;  3GTK F;  4Y7N F;  1QKL A;  4C3J F;  2JA5 F;  2NVX F;  2E2J E;  3HOW E;  3PO3 F;  3RZO F;  5M3M E;  4A3D E;  4G7O E;  4LJZ E;  3S17 F;  3HOX F;  4KMU E;  5M5Y F;  2R7Z F;  4BXX F;  3GTL E;  3S1N E;  1TWG F;  4A93 F;  1K83 E;  4Q4Z E;  3HOZ F;  4XLP E;  5TMC E;  2E2H F;  5C3E E;  2R93 F;  1I6H F;  5FJ8 E;  3CQZ F;  3WOD E;  3GTG F;  1R9T F;  2E2I E;  2JA6 E;  2WAQ H;  1TWA F;  4ZH4 E;  5IYC E;  4A3K E;  4A3F E;  2B63 F;  2JA8 E;  4A3G F;  1Y1V F;  2NVT E;  5FLM E;  3I4M F;  2YU9 F;  2R92 E;  4BBS F;  4C3H E;  3GTP F;  4QIW H;  1TWC F;  3S1M F;  3GTM E;  3S14 E;  5C4J E;  3S2D E;  4C3I F;  4XLN E;  4LK1 E;  3PO2 F;  3S2H E;  2R93 E;  4X6A F;  1TWF E;  1Y1W F;  4OIN E;  4BBR E;  2NVY E;  4A3M F;  5D4D E;  3RZD F;  4BY1 E;  5IP7 E;  1DZF A;  4A3E E;  4LK0 E;  1WCM F;  2PMZ H;  2VUM F;  1TWH F;  3M3Y F;  3S15 F;  5C4X E;  5IP9 E;  5IYB E;  2NVQ E;  5M3F F;  4C2M F;  3H3V G;  3I4N E;  5D4E E;  4Y7N E;  3HKZ K;  3H0G E;  4A3I E; 
#chains in the Genus database with same CATH homology
 2JA7 F;  1YNJ K;  2E2J F;  3HOW F;  5M3M F;  2O5I E;  3FKI F;  4A3D F;  1I6V E;  4MEY E;  3S1N F;  1K83 F;  4XSX E;  1SFO F;  1ZYR E;  5FJ8 F;  4JK1 E;  2A69 E;  2E2I F;  2JA6 F;  2JA8 F;  5IYC F;  2BE5 E;  4A3F F;  4A3K F;  2NVT F;  5M5X F;  2A68 E;  4YFN E;  5FLM F;  2WAQ K;  2R92 F;  4C3H F;  1YNN K;  4YFK E;  3GTM F;  3S14 F;  5C4J F;  3S2D F;  4YFX E;  3S2H F;  2R93 F;  4QIW K;  1TWF F;  5BYH E;  4Q5S E;  4BBR F;  2NVY F;  4BY1 F;  5IP7 F;  2WB1 I;  4OIO E;  4OIQ E;  4A3E F;  2A6E E;  5C4X F;  2O5J E;  5IP9 F;  5IYB F;  2NVQ F;  2CW0 E;  2PMZ K;  3I4N F;  5IPL E;  3H0G F;  3GTQ F;  2KRX A;  4A3I F;  3GTL F;  1I3Q F;  4YG2 E;  1HQM E;  2PPB E;  5C3E F;  4OIP E;  4G7Z E;  3GTJ F;  4AYB K;  5C44 F;  3S1Q F;  1I50 F;  2Y0S I;  1SMY E;  3S1R F;  3HOU F;  5D4C E;  3HOV F;  3HOY F;  4A3L F;  5E18 E;  4KN7 E;  2A6H E;  4KN4 E;  4A3J F;  4LLG E;  3EQL E;  5E17 E;  5TMF E;  4Y52 F;  3DXJ E;  4MEX E;  4OIR E;  3K7A F;  4A3C F;  4MQ9 E;  4GZY E;  4A3B F;  3S16 F;  3GTO F;  4BY7 F;  1IW7 E;  4XSZ E;  3M4O F;  5M5W F;  5IYD F;  3GTK F;  4Y7N F;  1QKL A;  4C3J F;  2JA5 F;  2NVX F;  3PO3 F;  3RZO F;  4G7O E;  4LJZ E;  3S17 F;  3HOX F;  4KMU E;  5M5Y F;  2R7Z F;  4BXX F;  1TWG F;  4A93 F;  4Q4Z E;  3HOZ F;  4XLP E;  5TMC E;  2E2H F;  1I6H F;  3CQZ F;  3WOD E;  3GTG F;  1R9T F;  1TWA F;  4ZH4 E;  2B63 F;  4A3G F;  1Y1V F;  3I4M F;  2YU9 F;  4BBS F;  3GTP F;  1TWC F;  3S1M F;  3PO2 F;  4X6A F;  4C3I F;  4XLN E;  4LK1 E;  1Y1W F;  4OIN E;  4A3M F;  5D4D E;  3RZD F;  4LK0 E;  1WCM F;  2VUM F;  3M3Y F;  1TWH F;  3S15 F;  5M3F F;  4C2M F;  3H3V G;  5D4E E;  4G7H E;  3HKZ K; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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