4MEYE

Crystal structure of escherichia coli rna polymerase holoenzyme
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
89
structure length
89
Chain Sequence
RVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Transcription inhibition by the depsipeptide antibiotic salinamide A.
pubmed doi rcsb
molecule tags Transferase
source organism Escherichia coli
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 23
structure length 89
sequence length 89
chains with identical sequence K
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2013-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4meyE00
2PMZK 3HOXF 4KN7E 4A3MF 4C2MF 4G7HE 3HOUF 4A3LF 1WCMF 2NVQF 2NVYF 3I4NF 2VUMF 4A93F 5BYHE 4G7OE 4A3GF 2NVTF 3GTPF 4BY1F 4LJZE 2R92F 3S16F 1Y1VF 4XLNE 4MQ9E 4LK0E 4X6AF 3S1QF 3WODE 4Q5SE 2BE5E 4C3JF 1TWAF 4OIOE 4A3BF 2JA8F 4ZH4E 1SMYE 3K7AF 1IW7E 5E17E 3FKIF 3HOVF 4A3DF 5D4EE 4A3CF 4A3KF 3S1NF 1K83F 4MEYE 2O5IE 4Q4ZE 3S2DF 4YG2E 4BBRF 1TWFF 3HOWF 4GZYE 3GTOF 5M3MF 3M4OF 1TWCF 3CQZF 2E2IF 2WB1I 3GTKF 4Y7NF 2JA5F 1TWGF 4OINE 4YFKE 5TMCE 3S14F 4XSXE 1I6HF 1I3QF 3M3YF 3GTGF 3S2HF 3GTJF 1QKLA 5C4JF 3H3VG 4LLGE 5IYCF 4C3HF 4A3FF 2A69E 4OIPE 2Y0SI 4BY7F 1Y1WF 2B63F 1I6VE 3DXJE 5M3FF 2E2JF 4YFNE 5TMFE 3RZDF 4G7ZE 3HOYF 1I50F 4JK1E 3S1RF 1TWHF 2A68E 3GTLF 3PO3F 3H0GF 4LK1E 3S1MF 4YFXE 4BXXF 3S15F 5IYDF 2NVXF 3S17F 1R9TF 2WAQK 4Y52F 4A3IF 4OIRE 3PO2F 2YU9F 2JA7F 4A3EF 2R93F 2R7ZF 5M5XF 4A3JF 4C3IF 5IPLE 3I4MF 2A6HE 5D4DE 2A6EE 1ZYRE 3RZOF 5C3EF 1YNJK 3HKZK 4KN4E 5M5YF 4KMUE 3HOZF 5C44F 5IYBF 2E2HF 4BBSF 4OIQE 4XSZE 1HQME 1YNNK 5IP7F 5E18E 2CW0E 5D4CE 4XLPE 4AYBK 5IP9F 3EQLE 3GTQF 2PPBE 2JA6F 4MEXE 5FJ8F 3GTMF 5FLMF 5M5WF 5C4XF 2O5JE 1SFOF
chains in the Genus database with same CATH superfamily
2PMZK 3HOXF 4KN7E 4A3MF 4C2MF 4G7HE 4X6AE 3HOUF 3S1QE 4A3LF 1I6HE 1WCMF 2NVQF 2NVYF 3I4NF 5C4JE 2VUMF 4A93F 4C3JE 4C3HE 5BYHE 3H3VF 3S15E 4A3BE 4G7OE 4A3GF 2JA8E 2NVTF 2Y0SH 3GTPF 4BY1F 3FKIE 4LJZE 2R92F 3HOVE 4A3DE 3S16F 1Y1VF 4XLNE 4A3CE 4A3KE 3S1NE 4MQ9E 4LK0E 4X6AF 3S1QF 3WODE 4Q5SE 3S2DE 4BBRE 1TWFE 2BE5E 5M3ME 3M4OE 1TWCE 1TWHE 4C3JF 2R92E 1TWAF 2E2IE 4OIOE 4A3BF 2JA8F 3GTKE 4Y7NE 2JA5E 1TWGE 4ZH4E 1SMYE 3K7AF 4BXXE 1IW7E 5E17E 3FKIF 3S14E 3HOVF 4A3DF 4Y52E 3M3YE 1I3QE 5D4EE 3GTGE 3S2HE 4A3CF 3GTJE 4A3KF 3S1NF 1K83F 4MEYE 2YU9E 2JA7E 2O5IE 4Q4ZE 2R93E 3S2DF 4YG2E 5IYCE 1TWFF 4BBRF 3HOWF 3GTOF 5M3MF 4A3FE 4GZYE 3M4OF 1TWCF 1DZFA 3CQZF 4BY7E 1Y1WE 2B63E 2E2IF 5M3FE 2WB1I 2KRXA 4Y7NF 2E2JE 2JA5F 3GTKF 1TWGF 4OINE 4YFKE 3RZDE 5TMCE 3S14F 4XSXE 1I50E 3HOYE 1I6HF 1I3QF 3S1RE 3M3YF 3GTGF 3S2HF 5IP7E 3GTJF 2WAQH 1QKLA 5C4JF 3H3VG 4LLGE 5IYCF 3GTLE 4C3HF 4A3FF 3PO3E 3H0GE 2JA6E 2A69E 4OIPE 2Y0SI 3S1ME 4BY7F 5IYDE 2NVXE 5M5WE 1Y1WF 1I6VE 2B63F 3DXJE 5M3FF 1R9TE 3S17E 4A3IE 5C4XE 1SFOE 2E2JF 4YFNE 3PO2E 5TMFE 3HOXE 3RZDF 4G7ZE 4A3ME 4A3EE 3HOYF 1I50F 3HKZH 4JK1E 2R7ZE 3S1RF 5M5XE 4A3JE 4C3IE 3I4ME 1TWHF 2A68E 2VUME 3GTLF 3RZOE 3PO3F 5C3EE 3H0GF 4LK1E 1EIKA 3S1MF 4YFXE 5M5YE 4BXXF 3S15F 5IYDF 2NVXF 3HOZE 5C44E 3S17F 5IYBE 1R9TF 2WAQK 4Y52F 4A3IF 2E2HE 4BY1E 4OIRE 4BBSE 3PO2F 2YU9F 2JA7F 4A3EF 2R93F 5IP9E 2R7ZF 2PMZH 3GTQE 5M5XF 4A3JF 4C3IF 5IPLE 4QIWK 5FJ8E 3I4MF 3GTME 2A6HE 5FLME 5D4DE 2A6EE 1ZYRE 4QIWH 3RZOF 1TWAE 5C3EF 1YNJK 3HKZK 4KN4E 5M5YF 4KMUE 3K7AE 3HOZF 5C44F 5IYBF 4C2ME 2E2HF 4BBSF 3HOUE 4A3LE 4OIQE 4XSZE 1HQME 1WCME 1YNNK 2NVYE 5IP7F 2CW0E 5E18E 4XLPE 5D4CE 2NVQE 4AYBK 3I4NE 1K83E 5IP9F 3EQLE 4A93E 3HOWE 3GTQF 2PPBE 4AYBH 3GTOE 2JA6F 4MEXE 5FJ8F 4A3GE 3GTMF 2NVTE 5FLMF 3GTPE 3CQZE 5M5WF 5C4XF 2O5JE 2WB1H 1SFOF 3S16E 1Y1VE
chains in the Genus database with same CATH topology
2PMZK 3HOXF 4KN7E 4A3MF 4C2MF 4G7HE 3HOUF 4A3LF 1WCMF 2NVQF 2NVYF 3I4NF 2VUMF 4A93F 5BYHE 4G7OE 4A3GF 2NVTF 3GTPF 4BY1F 4LJZE 2R92F 3S16F 1Y1VF 4XLNE 4MQ9E 4LK0E 4X6AF 3S1QF 3WODE 4Q5SE 2BE5E 4C3JF 1TWAF 4OIOE 4A3BF 2JA8F 4ZH4E 1SMYE 3K7AF 1IW7E 5E17E 3FKIF 3HOVF 4A3DF 5D4EE 4A3CF 4A3KF 3S1NF 1K83F 4MEYE 2O5IE 4Q4ZE 3S2DF 4YG2E 4BBRF 1TWFF 3HOWF 4GZYE 3GTOF 5M3MF 3M4OF 1TWCF 3CQZF 2E2IF 2WB1I 2KRXA 4Y7NF 2JA5F 3GTKF 1TWGF 4OINE 4YFKE 5TMCE 3S14F 4XSXE 1I6HF 1I3QF 3M3YF 3GTGF 3S2HF 3GTJF 1QKLA 5C4JF 3H3VG 4LLGE 5IYCF 4C3HF 4A3FF 2A69E 4OIPE 2Y0SI 4BY7F 1Y1WF 2B63F 1I6VE 3DXJE 5M3FF 2E2JF 4YFNE 5TMFE 3RZDF 4G7ZE 3HOYF 1I50F 4JK1E 3S1RF 1TWHF 2A68E 3GTLF 3PO3F 3H0GF 4LK1E 3S1MF 4YFXE 4BXXF 3S15F 5IYDF 2NVXF 3S17F 1R9TF 2WAQK 4Y52F 4A3IF 4OIRE 3PO2F 2YU9F 2JA7F 4A3EF 2R93F 2R7ZF 5M5XF 4A3JF 4C3IF 5IPLE 4QIWK 3I4MF 2A6HE 5D4DE 2A6EE 1ZYRE 3RZOF 5C3EF 1YNJK 3HKZK 4KN4E 5M5YF 4KMUE 3HOZF 5C44F 5IYBF 2E2HF 4BBSF 4OIQE 4XSZE 1HQME 1YNNK 5IP7F 5E18E 2CW0E 5D4CE 4XLPE 4AYBK 5IP9F 3EQLE 3GTQF 2PPBE 2JA6F 4MEXE 5FJ8F 3GTMF 5FLMF 5M5WF 5C4XF 2O5JE 1SFOF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PMZ K;  3HOX F;  4KN7 E;  4A3M F;  4C2M F;  4G7H E;  3HOU F;  4A3L F;  1WCM F;  2NVQ F;  2NVY F;  3I4N F;  2VUM F;  4A93 F;  5BYH E;  4G7O E;  4A3G F;  2NVT F;  3GTP F;  4BY1 F;  4LJZ E;  2R92 F;  3S16 F;  1Y1V F;  4XLN E;  4MQ9 E;  4LK0 E;  4X6A F;  3S1Q F;  3WOD E;  4Q5S E;  2BE5 E;  4C3J F;  1TWA F;  4OIO E;  4A3B F;  2JA8 F;  4ZH4 E;  1SMY E;  3K7A F;  1IW7 E;  5E17 E;  3FKI F;  3HOV F;  4A3D F;  5D4E E;  4A3C F;  4A3K F;  3S1N F;  1K83 F;  4MEY E;  2O5I E;  4Q4Z E;  3S2D F;  4YG2 E;  4BBR F;  1TWF F;  3HOW F;  4GZY E;  3GTO F;  5M3M F;  3M4O F;  1TWC F;  3CQZ F;  2E2I F;  2WB1 I;  3GTK F;  4Y7N F;  2JA5 F;  1TWG F;  4OIN E;  4YFK E;  5TMC E;  3S14 F;  4XSX E;  1I6H F;  1I3Q F;  3M3Y F;  3GTG F;  3S2H F;  3GTJ F;  1QKL A;  5C4J F;  3H3V G;  4LLG E;  5IYC F;  4C3H F;  4A3F F;  2A69 E;  4OIP E;  2Y0S I;  4BY7 F;  1Y1W F;  2B63 F;  1I6V E;  3DXJ E;  5M3F F;  2E2J F;  4YFN E;  5TMF E;  3RZD F;  4G7Z E;  3HOY F;  1I50 F;  4JK1 E;  3S1R F;  1TWH F;  2A68 E;  3GTL F;  3PO3 F;  3H0G F;  4LK1 E;  3S1M F;  4YFX E;  4BXX F;  3S15 F;  5IYD F;  2NVX F;  3S17 F;  1R9T F;  2WAQ K;  4Y52 F;  4A3I F;  4OIR E;  3PO2 F;  2YU9 F;  2JA7 F;  4A3E F;  2R93 F;  2R7Z F;  5M5X F;  4A3J F;  4C3I F;  5IPL E;  3I4M F;  2A6H E;  5D4D E;  2A6E E;  1ZYR E;  3RZO F;  5C3E F;  1YNJ K;  3HKZ K;  4KN4 E;  5M5Y F;  4KMU E;  3HOZ F;  5C44 F;  5IYB F;  2E2H F;  4BBS F;  4OIQ E;  4XSZ E;  1HQM E;  1YNN K;  5IP7 F;  5E18 E;  2CW0 E;  5D4C E;  4XLP E;  4AYB K;  5IP9 F;  3EQL E;  3GTQ F;  2PPB E;  2JA6 F;  4MEX E;  5FJ8 F;  3GTM F;  5FLM F;  5M5W F;  5C4X F;  2O5J E;  1SFO F; 
#chains in the Genus database with same CATH topology
 2PMZ K;  3HOX F;  4KN7 E;  4A3M F;  4C2M F;  4G7H E;  4X6A E;  3HOU F;  3S1Q E;  4A3L F;  1I6H E;  1WCM F;  2NVQ F;  2NVY F;  3I4N F;  5C4J E;  2VUM F;  4A93 F;  4C3J E;  4C3H E;  5BYH E;  3H3V F;  3S15 E;  4A3B E;  4G7O E;  4A3G F;  2JA8 E;  2NVT F;  2Y0S H;  3GTP F;  4BY1 F;  3FKI E;  4LJZ E;  2R92 F;  3HOV E;  4A3D E;  3S16 F;  1Y1V F;  4XLN E;  4A3C E;  4A3K E;  3S1N E;  4MQ9 E;  4LK0 E;  4X6A F;  3S1Q F;  3WOD E;  4Q5S E;  3S2D E;  4BBR E;  1TWF E;  2BE5 E;  5M3M E;  3M4O E;  1TWC E;  1TWH E;  4C3J F;  2R92 E;  1TWA F;  2E2I E;  4OIO E;  4A3B F;  2JA8 F;  3GTK E;  4Y7N E;  2JA5 E;  1TWG E;  4ZH4 E;  1SMY E;  3K7A F;  4BXX E;  1IW7 E;  5E17 E;  3FKI F;  3S14 E;  3HOV F;  4A3D F;  4Y52 E;  3M3Y E;  1I3Q E;  5D4E E;  3GTG E;  3S2H E;  4A3C F;  3GTJ E;  4A3K F;  3S1N F;  1K83 F;  4MEY E;  2YU9 E;  2JA7 E;  2O5I E;  4Q4Z E;  2R93 E;  3S2D F;  4YG2 E;  5IYC E;  1TWF F;  4BBR F;  3HOW F;  3GTO F;  5M3M F;  4A3F E;  4GZY E;  3M4O F;  1TWC F;  1DZF A;  3CQZ F;  4BY7 E;  1Y1W E;  2B63 E;  2E2I F;  5M3F E;  2WB1 I;  2KRX A;  4Y7N F;  2E2J E;  2JA5 F;  3GTK F;  1TWG F;  4OIN E;  4YFK E;  3RZD E;  5TMC E;  3S14 F;  4XSX E;  1I50 E;  3HOY E;  1I6H F;  1I3Q F;  3S1R E;  3M3Y F;  3GTG F;  3S2H F;  5IP7 E;  3GTJ F;  2WAQ H;  1QKL A;  5C4J F;  3H3V G;  4LLG E;  5IYC F;  3GTL E;  4C3H F;  4A3F F;  3PO3 E;  3H0G E;  2JA6 E;  2A69 E;  4OIP E;  2Y0S I;  3S1M E;  4BY7 F;  5IYD E;  2NVX E;  5M5W E;  1Y1W F;  1I6V E;  2B63 F;  3DXJ E;  5M3F F;  1R9T E;  3S17 E;  4A3I E;  5C4X E;  1SFO E;  2E2J F;  4YFN E;  3PO2 E;  5TMF E;  3HOX E;  3RZD F;  4G7Z E;  4A3M E;  4A3E E;  3HOY F;  1I50 F;  3HKZ H;  4JK1 E;  2R7Z E;  3S1R F;  5M5X E;  4A3J E;  4C3I E;  3I4M E;  1TWH F;  2A68 E;  2VUM E;  3GTL F;  3RZO E;  3PO3 F;  5C3E E;  3H0G F;  4LK1 E;  1EIK A;  3S1M F;  4YFX E;  5M5Y E;  4BXX F;  3S15 F;  5IYD F;  2NVX F;  3HOZ E;  5C44 E;  3S17 F;  5IYB E;  1R9T F;  2WAQ K;  4Y52 F;  4A3I F;  2E2H E;  4BY1 E;  4OIR E;  4BBS E;  3PO2 F;  2YU9 F;  2JA7 F;  4A3E F;  2R93 F;  5IP9 E;  2R7Z F;  2PMZ H;  3GTQ E;  5M5X F;  4A3J F;  4C3I F;  5IPL E;  4QIW K;  5FJ8 E;  3I4M F;  3GTM E;  2A6H E;  5FLM E;  5D4D E;  2A6E E;  1ZYR E;  4QIW H;  3RZO F;  1TWA E;  5C3E F;  1YNJ K;  3HKZ K;  4KN4 E;  5M5Y F;  4KMU E;  3K7A E;  3HOZ F;  5C44 F;  5IYB F;  4C2M E;  2E2H F;  4BBS F;  3HOU E;  4A3L E;  4OIQ E;  4XSZ E;  1HQM E;  1WCM E;  1YNN K;  2NVY E;  5IP7 F;  2CW0 E;  5E18 E;  4XLP E;  5D4C E;  2NVQ E;  4AYB K;  3I4N E;  1K83 E;  5IP9 F;  3EQL E;  4A93 E;  3HOW E;  3GTQ F;  2PPB E;  4AYB H;  3GTO E;  2JA6 F;  4MEX E;  5FJ8 F;  4A3G E;  3GTM F;  2NVT E;  5FLM F;  3GTP E;  3CQZ E;  5M5W F;  5C4X F;  2O5J E;  2WB1 H;  1SFO F;  3S16 E;  1Y1V E; 
#chains in the Genus database with same CATH homology
 2PMZ K;  3HOX F;  4KN7 E;  4A3M F;  4C2M F;  4G7H E;  3HOU F;  4A3L F;  1WCM F;  2NVQ F;  2NVY F;  3I4N F;  2VUM F;  4A93 F;  5BYH E;  4G7O E;  4A3G F;  2NVT F;  3GTP F;  4BY1 F;  4LJZ E;  2R92 F;  3S16 F;  1Y1V F;  4XLN E;  4MQ9 E;  4LK0 E;  4X6A F;  3S1Q F;  3WOD E;  4Q5S E;  2BE5 E;  4C3J F;  1TWA F;  4OIO E;  4A3B F;  2JA8 F;  4ZH4 E;  1SMY E;  3K7A F;  1IW7 E;  5E17 E;  3FKI F;  3HOV F;  4A3D F;  5D4E E;  4A3C F;  4A3K F;  3S1N F;  1K83 F;  4MEY E;  2O5I E;  4Q4Z E;  3S2D F;  4YG2 E;  4BBR F;  1TWF F;  3HOW F;  4GZY E;  3GTO F;  5M3M F;  3M4O F;  1TWC F;  3CQZ F;  2E2I F;  2WB1 I;  2KRX A;  4Y7N F;  2JA5 F;  3GTK F;  1TWG F;  4OIN E;  4YFK E;  5TMC E;  3S14 F;  4XSX E;  1I6H F;  1I3Q F;  3M3Y F;  3GTG F;  3S2H F;  3GTJ F;  1QKL A;  5C4J F;  3H3V G;  4LLG E;  5IYC F;  4C3H F;  4A3F F;  2A69 E;  4OIP E;  2Y0S I;  4BY7 F;  1Y1W F;  2B63 F;  1I6V E;  3DXJ E;  5M3F F;  2E2J F;  4YFN E;  5TMF E;  3RZD F;  4G7Z E;  3HOY F;  1I50 F;  4JK1 E;  3S1R F;  1TWH F;  2A68 E;  3GTL F;  3PO3 F;  3H0G F;  4LK1 E;  3S1M F;  4YFX E;  4BXX F;  3S15 F;  5IYD F;  2NVX F;  3S17 F;  1R9T F;  2WAQ K;  4Y52 F;  4A3I F;  4OIR E;  3PO2 F;  2YU9 F;  2JA7 F;  4A3E F;  2R93 F;  2R7Z F;  5M5X F;  4A3J F;  4C3I F;  5IPL E;  4QIW K;  3I4M F;  2A6H E;  5D4D E;  2A6E E;  1ZYR E;  3RZO F;  5C3E F;  1YNJ K;  3HKZ K;  4KN4 E;  5M5Y F;  4KMU E;  3HOZ F;  5C44 F;  5IYB F;  2E2H F;  4BBS F;  4OIQ E;  4XSZ E;  1HQM E;  1YNN K;  5IP7 F;  5E18 E;  2CW0 E;  5D4C E;  4XLP E;  4AYB K;  5IP9 F;  3EQL E;  3GTQ F;  2PPB E;  2JA6 F;  4MEX E;  5FJ8 F;  3GTM F;  5FLM F;  5M5W F;  5C4X F;  2O5J E;  1SFO F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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