4NTXB

Structure of acid-sensing ion channel in complex with snake toxin and amiloride
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
60
structure length
60
Chain Sequence
EIRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
pubmed doi rcsb
molecule tags Transport protein/toxin
source organism Gallus gallus
molecule keywords Acid-sensing ion channel 1
total genus 14
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 2013-12-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4ntxB00
3GYMI 5JB7A 9PTIA 3TPII 4DG4C 1YLCB 3LDIA 1TOCR 3OFWA 2W8XA 1EJMB 1P2OB 3AUIA 2UUYB 2ZJXA 1FANA 1EAWB 2CA7A 1UUBA 3L33E 1P2MB 7PTIA 5PTIA 2ZVXA 3UOUB 1T8OB 2KAII 4NTXB 1TAPA 3AUEA 1D0DB 2TGPI 2LFLA 1T8LB 2R9PE 4PTIA 4WWYC 2LFKA 5JB6A 1CA0D 4ISLB 1P2NB 1BZ5A 1SHPA 4BD9B 1T8MB 4U30W 1BPTA 1D0DA 1BF0A 1BTHP 1BTIA 1TAWB 3P95E 4BQDA 1BIKA 1CO7I 1UUAA 3M7QB 3UIRC 1ZR0B 1YC0I 1DTXA 2J6DA 3CI7A 5JB5A 1DTKA 1LD5A 1JV9A 3T62D 4NTWB 1BRCI 5JB4A 1DEMA 1TPAI 3BTMI 1F5RI 3BTEI 2M01A 3BTFI 3L3TE 1P2KI 3TGJI 1T8NB 1ADZA 4Y10I 1YKTB 3WNYA 1JC6A 2FTMB 4DTGK 2FI3I 2ODYE 1KNTA 1YLDB 3LDMA 1Y62A 3AUHA 1LD6A 1QLQA 2DDIA 2DDJA 3BTGI 3LDJA 8PTIA 2TPII 1AALA 1P2JI 2RA3C 3FP7J 4Y11I 5C67C 1G6XA 1TFXC 3BYBA 3D65I 3AUBA 3BTDI 4NTYB 4BNRI 3BTQI 1OA55 2UUXA 4Y0YI 2KCRA 1P2QB 1OA65 2FI4I 3OTJI 3FP8I 1KTHA 1B0CA 1FY8I 1P2II 3AUDA 4Y0ZI 3AUGA 4U32X 1T7CB 4WXVC 1KUNA 1BHCA 2IJOI 3FP6I 2JOTA 3AUCA 4ISNB 2HEXA 1BZXI 1CBWD 2KNTA 3U1JE 1K6UA 1JV8A 1KIGI 1BPIA 1BRBI 3TGII 2M99A 3BTKI 2FTLI 3P92E 1MTND 1AAPA 2PTCI 1FAKI 1F7ZI 1ZJDB 6PTIA 1PITA 4TPII 1IRHA 1DENA 1NAGA 4ISOB 3BTWI 3BTHI 1TCPA 2FI5I 1BUNB 3TGKI 3BTTI
chains in the Genus database with same CATH superfamily
3GYMI 5JB7A 9PTIA 3TPII 4DG4C 1YLCB 3LDIA 1TOCR 3OFWA 2W8XA 1EJMB 1P2OB 3AUIA 2UUYB 2ZJXA 1FANA 1EAWB 2CA7A 1UUBA 3L33E 1P2MB 7PTIA 5PTIA 2ZVXA 3UOUB 1T8OB 2KAII 4NTXB 1TAPA 3AUEA 1D0DB 2TGPI 2LFLA 1T8LB 2R9PE 4PTIA 4WWYC 2LFKA 5JB6A 1CA0D 4ISLB 1P2NB 1BZ5A 1SHPA 4BD9B 1T8MB 4U30W 1BPTA 1D0DA 1BF0A 1BTHP 1BTIA 1TAWB 3P95E 4BQDA 1BIKA 1CO7I 1UUAA 3M7QB 3UIRC 1ZR0B 1YC0I 1DTXA 2J6DA 3CI7A 5JB5A 1DTKA 1LD5A 1JV9A 3T62D 4NTWB 1BRCI 5JB4A 1DEMA 1TPAI 3BTMI 1F5RI 3BTEI 2M01A 3BTFI 3L3TE 1P2KI 3TGJI 1T8NB 1ADZA 4Y10I 1YKTB 3WNYA 1JC6A 2FTMB 4DTGK 2FI3I 2ODYE 1KNTA 1YLDB 3LDMA 1Y62A 3AUHA 1LD6A 1QLQA 2DDIA 2DDJA 3BTGI 3LDJA 8PTIA 2TPII 1AALA 1P2JI 2RA3C 3FP7J 4Y11I 5C67C 1G6XA 1TFXC 3BYBA 3D65I 3AUBA 3BTDI 4NTYB 4BNRI 3BTQI 1OA55 2UUXA 4Y0YI 2KCRA 1P2QB 1OA65 2FI4I 3OTJI 3FP8I 1KTHA 1B0CA 1FY8I 1P2II 3AUDA 4Y0ZI 3AUGA 4U32X 1T7CB 4WXVC 1KUNA 1BHCA 2IJOI 3FP6I 2JOTA 3AUCA 4ISNB 2HEXA 1BZXI 1CBWD 2KNTA 3U1JE 1K6UA 1JV8A 1KIGI 1BPIA 1BRBI 3TGII 2M99A 3BTKI 2FTLI 3P92E 1MTND 1AAPA 2PTCI 1FAKI 1F7ZI 1ZJDB 6PTIA 1PITA 4TPII 1IRHA 1DENA 1NAGA 4ISOB 3BTWI 3BTHI 1TCPA 2FI5I 1BUNB 3TGKI 3BTTI
chains in the Genus database with same CATH topology
3GYMI 5JB7A 9PTIA 3TPII 4DG4C 1YLCB 3LDIA 1TOCR 3OFWA 2W8XA 1EJMB 1P2OB 3AUIA 2UUYB 2ZJXA 1FANA 1EAWB 2CA7A 1UUBA 3L33E 1P2MB 7PTIA 5PTIA 2ZVXA 3UOUB 1T8OB 2KAII 4NTXB 1TAPA 3AUEA 1D0DB 2TGPI 2LFLA 1T8LB 2R9PE 4PTIA 4WWYC 2LFKA 5JB6A 1CA0D 4ISLB 1P2NB 1BZ5A 1SHPA 4BD9B 1T8MB 4U30W 1BPTA 1D0DA 1BF0A 1BTHP 1BTIA 1TAWB 3P95E 4BQDA 1BIKA 1CO7I 1UUAA 3M7QB 3UIRC 1ZR0B 1YC0I 1DTXA 2J6DA 3CI7A 5JB5A 1DTKA 1LD5A 1JV9A 3T62D 4NTWB 1BRCI 5JB4A 1DEMA 1TPAI 3BTMI 1F5RI 3BTEI 2M01A 3BTFI 3L3TE 1P2KI 3TGJI 1T8NB 1ADZA 4Y10I 1YKTB 3WNYA 1JC6A 2FTMB 4DTGK 2FI3I 2ODYE 1KNTA 1YLDB 3LDMA 1Y62A 3AUHA 1LD6A 1QLQA 2DDIA 2DDJA 3BTGI 3LDJA 8PTIA 2TPII 1AALA 1P2JI 2RA3C 3FP7J 4Y11I 5C67C 1G6XA 1TFXC 3BYBA 3D65I 3AUBA 3BTDI 4NTYB 4BNRI 3BTQI 1OA55 2UUXA 4Y0YI 2KCRA 1P2QB 1OA65 2FI4I 3OTJI 3FP8I 1KTHA 1B0CA 1FY8I 1P2II 3AUDA 4Y0ZI 3AUGA 4U32X 1T7CB 4WXVC 1KUNA 1BHCA 2IJOI 3FP6I 2JOTA 3AUCA 4ISNB 2HEXA 1BZXI 1CBWD 2KNTA 3U1JE 1K6UA 1JV8A 1KIGI 1BPIA 1BRBI 3TGII 2M99A 3BTKI 2FTLI 3P92E 1MTND 1AAPA 2PTCI 1FAKI 1F7ZI 1ZJDB 6PTIA 1PITA 4TPII 1IRHA 1DENA 1NAGA 4ISOB 3BTWI 3BTHI 1TCPA 2FI5I 1BUNB 3TGKI 3BTTI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GYM I;  5JB7 A;  9PTI A;  3TPI I;  4DG4 C;  1YLC B;  3LDI A;  1TOC R;  3OFW A;  2W8X A;  1EJM B;  1P2O B;  3AUI A;  2UUY B;  2ZJX A;  1FAN A;  1EAW B;  2CA7 A;  1UUB A;  3L33 E;  1P2M B;  7PTI A;  5PTI A;  2ZVX A;  3UOU B;  1T8O B;  2KAI I;  4NTX B;  1TAP A;  3AUE A;  1D0D B;  2TGP I;  2LFL A;  1T8L B;  2R9P E;  4PTI A;  4WWY C;  2LFK A;  5JB6 A;  1CA0 D;  4ISL B;  1P2N B;  1BZ5 A;  1SHP A;  4BD9 B;  1T8M B;  4U30 W;  1BPT A;  1D0D A;  1BF0 A;  1BTH P;  1BTI A;  1TAW B;  3P95 E;  4BQD A;  1BIK A;  1CO7 I;  1UUA A;  3M7Q B;  3UIR C;  1ZR0 B;  1YC0 I;  1DTX A;  2J6D A;  3CI7 A;  5JB5 A;  1DTK A;  1LD5 A;  1JV9 A;  3T62 D;  4NTW B;  1BRC I;  5JB4 A;  1DEM A;  1TPA I;  3BTM I;  1F5R I;  3BTE I;  2M01 A;  3BTF I;  3L3T E;  1P2K I;  3TGJ I;  1T8N B;  1ADZ A;  4Y10 I;  1YKT B;  3WNY A;  1JC6 A;  2FTM B;  4DTG K;  2FI3 I;  2ODY E;  1KNT A;  1YLD B;  3LDM A;  1Y62 A;  3AUH A;  1LD6 A;  1QLQ A;  2DDI A;  2DDJ A;  3BTG I;  3LDJ A;  8PTI A;  2TPI I;  1AAL A;  1P2J I;  2RA3 C;  3FP7 J;  4Y11 I;  5C67 C;  1G6X A;  1TFX C;  3BYB A;  3D65 I;  3AUB A;  3BTD I;  4NTY B;  4BNR I;  3BTQ I;  1OA5 5;  2UUX A;  4Y0Y I;  2KCR A;  1P2Q B;  1OA6 5;  2FI4 I;  3OTJ I;  3FP8 I;  1KTH A;  1B0C A;  1FY8 I;  1P2I I;  3AUD A;  4Y0Z I;  3AUG A;  4U32 X;  1T7C B;  4WXV C;  1KUN A;  1BHC A;  2IJO I;  3FP6 I;  2JOT A;  3AUC A;  4ISN B;  2HEX A;  1BZX I;  1CBW D;  2KNT A;  3U1J E;  1K6U A;  1JV8 A;  1KIG I;  1BPI A;  1BRB I;  3TGI I;  2M99 A;  3BTK I;  2FTL I;  3P92 E;  1MTN D;  1AAP A;  2PTC I;  1FAK I;  1F7Z I;  1ZJD B;  6PTI A;  1PIT A;  4TPI I;  1IRH A;  1DEN A;  1NAG A;  4ISO B;  3BTW I;  3BTH I;  1TCP A;  2FI5 I;  1BUN B;  3TGK I;  3BTT I; 
#chains in the Genus database with same CATH topology
 3GYM I;  5JB7 A;  9PTI A;  3TPI I;  4DG4 C;  1YLC B;  3LDI A;  1TOC R;  3OFW A;  2W8X A;  1EJM B;  1P2O B;  3AUI A;  2UUY B;  2ZJX A;  1FAN A;  1EAW B;  2CA7 A;  1UUB A;  3L33 E;  1P2M B;  7PTI A;  5PTI A;  2ZVX A;  3UOU B;  1T8O B;  2KAI I;  4NTX B;  1TAP A;  3AUE A;  1D0D B;  2TGP I;  2LFL A;  1T8L B;  2R9P E;  4PTI A;  4WWY C;  2LFK A;  5JB6 A;  1CA0 D;  4ISL B;  1P2N B;  1BZ5 A;  1SHP A;  4BD9 B;  1T8M B;  4U30 W;  1BPT A;  1D0D A;  1BF0 A;  1BTH P;  1BTI A;  1TAW B;  3P95 E;  4BQD A;  1BIK A;  1CO7 I;  1UUA A;  3M7Q B;  3UIR C;  1ZR0 B;  1YC0 I;  1DTX A;  2J6D A;  3CI7 A;  5JB5 A;  1DTK A;  1LD5 A;  1JV9 A;  3T62 D;  4NTW B;  1BRC I;  5JB4 A;  1DEM A;  1TPA I;  3BTM I;  1F5R I;  3BTE I;  2M01 A;  3BTF I;  3L3T E;  1P2K I;  3TGJ I;  1T8N B;  1ADZ A;  4Y10 I;  1YKT B;  3WNY A;  1JC6 A;  2FTM B;  4DTG K;  2FI3 I;  2ODY E;  1KNT A;  1YLD B;  3LDM A;  1Y62 A;  3AUH A;  1LD6 A;  1QLQ A;  2DDI A;  2DDJ A;  3BTG I;  3LDJ A;  8PTI A;  2TPI I;  1AAL A;  1P2J I;  2RA3 C;  3FP7 J;  4Y11 I;  5C67 C;  1G6X A;  1TFX C;  3BYB A;  3D65 I;  3AUB A;  3BTD I;  4NTY B;  4BNR I;  3BTQ I;  1OA5 5;  2UUX A;  4Y0Y I;  2KCR A;  1P2Q B;  1OA6 5;  2FI4 I;  3OTJ I;  3FP8 I;  1KTH A;  1B0C A;  1FY8 I;  1P2I I;  3AUD A;  4Y0Z I;  3AUG A;  4U32 X;  1T7C B;  4WXV C;  1KUN A;  1BHC A;  2IJO I;  3FP6 I;  2JOT A;  3AUC A;  4ISN B;  2HEX A;  1BZX I;  1CBW D;  2KNT A;  3U1J E;  1K6U A;  1JV8 A;  1KIG I;  1BPI A;  1BRB I;  3TGI I;  2M99 A;  3BTK I;  2FTL I;  3P92 E;  1MTN D;  1AAP A;  2PTC I;  1FAK I;  1F7Z I;  1ZJD B;  6PTI A;  1PIT A;  4TPI I;  1IRH A;  1DEN A;  1NAG A;  4ISO B;  3BTW I;  3BTH I;  1TCP A;  2FI5 I;  1BUN B;  3TGK I;  3BTT I; 
#chains in the Genus database with same CATH homology
 3GYM I;  5JB7 A;  9PTI A;  3TPI I;  4DG4 C;  1YLC B;  3LDI A;  1TOC R;  3OFW A;  2W8X A;  1EJM B;  1P2O B;  3AUI A;  2UUY B;  2ZJX A;  1FAN A;  1EAW B;  2CA7 A;  1UUB A;  3L33 E;  1P2M B;  7PTI A;  5PTI A;  2ZVX A;  3UOU B;  1T8O B;  2KAI I;  4NTX B;  1TAP A;  3AUE A;  1D0D B;  2TGP I;  2LFL A;  1T8L B;  2R9P E;  4PTI A;  4WWY C;  2LFK A;  5JB6 A;  1CA0 D;  4ISL B;  1P2N B;  1BZ5 A;  1SHP A;  4BD9 B;  1T8M B;  4U30 W;  1BPT A;  1D0D A;  1BF0 A;  1BTH P;  1BTI A;  1TAW B;  3P95 E;  4BQD A;  1BIK A;  1CO7 I;  1UUA A;  3M7Q B;  3UIR C;  1ZR0 B;  1YC0 I;  1DTX A;  2J6D A;  3CI7 A;  5JB5 A;  1DTK A;  1LD5 A;  1JV9 A;  3T62 D;  4NTW B;  1BRC I;  5JB4 A;  1DEM A;  1TPA I;  3BTM I;  1F5R I;  3BTE I;  2M01 A;  3BTF I;  3L3T E;  1P2K I;  3TGJ I;  1T8N B;  1ADZ A;  4Y10 I;  1YKT B;  3WNY A;  1JC6 A;  2FTM B;  4DTG K;  2FI3 I;  2ODY E;  1KNT A;  1YLD B;  3LDM A;  1Y62 A;  3AUH A;  1LD6 A;  1QLQ A;  2DDI A;  2DDJ A;  3BTG I;  3LDJ A;  8PTI A;  2TPI I;  1AAL A;  1P2J I;  2RA3 C;  3FP7 J;  4Y11 I;  5C67 C;  1G6X A;  1TFX C;  3BYB A;  3D65 I;  3AUB A;  3BTD I;  4NTY B;  4BNR I;  3BTQ I;  1OA5 5;  2UUX A;  4Y0Y I;  2KCR A;  1P2Q B;  1OA6 5;  2FI4 I;  3OTJ I;  3FP8 I;  1KTH A;  1B0C A;  1FY8 I;  1P2I I;  3AUD A;  4Y0Z I;  3AUG A;  4U32 X;  1T7C B;  4WXV C;  1KUN A;  1BHC A;  2IJO I;  3FP6 I;  2JOT A;  3AUC A;  4ISN B;  2HEX A;  1BZX I;  1CBW D;  2KNT A;  3U1J E;  1K6U A;  1JV8 A;  1KIG I;  1BPI A;  1BRB I;  3TGI I;  2M99 A;  3BTK I;  2FTL I;  3P92 E;  1MTN D;  1AAP A;  2PTC I;  1FAK I;  1F7Z I;  1ZJD B;  6PTI A;  1PIT A;  4TPI I;  1IRH A;  1DEN A;  1NAG A;  4ISO B;  3BTW I;  3BTH I;  1TCP A;  2FI5 I;  1BUN B;  3TGK I;  3BTT I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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