4OINE

Crystal structure of thermus thermophilus transcription initiation complex soaked with ge23077
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
94
structure length
94
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
pubmed rcsb
molecule tags Transcription, transferase/antibiotic
source organism Thermus thermophilus
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 26
structure length 94
sequence length 94
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2014-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4oinE00
3S1NF 4BY7F 4C3IF 5M3MF 4YG2E 5C44F 4A3GF 1I50F 2R93F 4G7ZE 4GZYE 2R7ZF 5D4CE 1I6HF 3RZDF 4YFXE 2O5IE 1QKLA 2A6EE 3FKIF 5M5XF 3K7AF 3S1RF 3PO3F 3S2DF 2O5JE 5IPLE 2Y0SI 2R92F 3S17F 2E2HF 5IYCF 4YFNE 3GTQF 1K83F 3WODE 4A3LF 2WB1I 5M3FF 2NVYF 1TWCF 5E18E 1ZYRE 3GTGF 4Q4ZE 3S1MF 4OIPE 1SMYE 5M5WF 4A3JF 2NVQF 3S16F 4Q5SE 4LK1E 4XSZE 2VUMF 4LLGE 5M5YF 2PPBE 3HOVF 3RZOF 3I4NF 2WAQK 4KN7E 1YNNK 4OIRE 1R9TF 4A3MF 5FLMF 2JA5F 4A3KF 2NVTF 2B63F 3HOUF 3GTKF 3GTOF 3HKZK 4KMUE 5IP7F 4G7HE 3EQLE 4BY1F 1IW7E 3S14F 4A3BF 4MEXE 4OIQE 1HQME 2E2IF 3S1QF 4XLPE 4A3EF 5C4XF 3M3YF 1Y1WF 4BBSF 4XSXE 4AYBK 4ZH4E 5D4EE 3GTMF 2CW0E 2JA7F 4MQ9E 4BBRF 2PMZK 4LJZE 5E17E 1TWHF 5IP9F 4BXXF 2A6HE 3DXJE 4KN4E 4A3FF 5FJ8F 1I3QF 1SFOF 5C4JF 3HOZF 3PO2F 3I4MF 4A93F 2BE5E 1TWAF 4LK0E 1TWFF 2E2JF 3HOYF 4JK1E 1YNJK 3CQZF 2YU9F 2A68E 3HOXF 3S2HF 5BYHE 4G7OE 4A3DF 5TMFE 4OIOE 3GTLF 3GTJF 3H0GF 4A3CF 3H3VG 1I6VE 4Y7NF 3GTPF 5TMCE 5IYDF 4X6AF 4XLNE 4Y52F 2JA6F 3S15F 2A69E 1Y1VF 5C3EF 4C3HF 1TWGF 1WCMF 4MEYE 4OINE 3M4OF 5IYBF 3HOWF 4YFKE 4A3IF 4C2MF 2NVXF 4C3JF 5D4DE 2JA8F
chains in the Genus database with same CATH superfamily
3S1QE 3S1ME 3S1NF 4BY7F 5M5WE 4C3IF 4A3JE 5M3MF 4YG2E 2NVQE 3S16E 5C44F 4A3GF 1I50F 2VUME 5M5YE 3HOVE 3RZOE 2R93F 4G7ZE 3I4NE 4GZYE 2R7ZF 1R9TE 5D4CE 4BBRE 4A3ME 1I6HF 3RZDF 4YFXE 5FLME 2O5IE 1QKLA 2A6EE 1DZFA 3FKIF 3K7AF 5M5XF 4A3KE 3S1RF 2B63E 2NVTE 3GTKE 3H3VF 3HOUE 5FJ8E 3GTOE 3S2DF 1SFOE 2Y0SI 2R92F 5IP7E 2PMZH 2E2HF 3S17F 5IYCF 4YFNE 3GTQF 1K83F 4BY1E 3WODE 4A3LF 2WB1I 5M3FF 3S14E 2NVYF 1TWCF 5E18E 1ZYRE 3GTGF 2E2IE 4QIWK 3CQZE 4Q4ZE 4OIPE 4A3EE 3S1MF 5C4XE 1SMYE 5M5WF 4A3JF 2NVQF 3M3YE 3S16F 4Q5SE 2Y0SH 4LK1E 1Y1WE 4XSZE 2VUMF 4LLGE 4BBSE 5M5YF 2PPBE 3HOVF 3RZOF 3I4NF 2O5JE 2WAQK 4KN7E 1YNNK 4OIRE 1R9TF 3GTME 4A3MF 2JA7E 5FLMF 2JA5F 4A3KF 5IPLE 1TWHE 2NVTF 2B63F 5IP9E 3GTKF 3HOUF 4BXXE 3GTOF 4A3FE 3HKZK 4KMUE 1I3QE 5IP7F 4G7HE 5C4JE 3EQLE 4BY1F 1IW7E 3HOZE 3PO2E 3I4ME 4A93E 3S14F 4A3BF 1TWAE 4MEXE 1TWFE 2E2JE 4OIQE 1HQME 2E2IF 3HOYE 3S1QF 2YU9E 4XLPE 1I50E 4A3EF 5C4XF 3HOXE 4A3DE 3S2HE 3M3YF 1Y1WF 4BBSF 4XSXE 4AYBK 3GTJE 3H0GE 3GTLE 4A3CE 2WB1H 2KRXA 4ZH4E 4Y7NE 1I6HE 3GTPE 5D4EE 5IYDE 3GTMF 2CW0E 4X6AE 2JA7F 4MQ9E 4BBRF 4Y52E 2PMZK 2JA6E 4LJZE 5E17E 3S15E 1TWHF 2R92E 1Y1VE 5C3EE 5IP9F 4BXXF 1EIKA 4C3HE 2A6HE 3DXJE 4KN4E 1TWGE 1K83E 5FJ8F 4A3FF 1I3QF 1WCME 1SFOF 3M4OE 5C4JF 5IYBE 3HOWE 3HOZF 4A3IE 4C2ME 2NVXE 4C3JE 2BE5E 3I4MF 3PO2F 4A93F 1TWAF 2JA8E 4LK0E 1TWFF 3S1NE 2E2JF 3HOYF 4BY7E 4C3IE 5M3ME 4JK1E 1YNJK 3CQZF 5C44E 2YU9F 2A68E 3HOXF 3S2HF 4QIWH 5BYHE 4G7OE 4A3DF 4A3GE 2R93E 5TMFE 4OIOE 3GTLF 3GTJF 3H0GF 3PO3F 3H3VG 4A3CF 1I6VE 2R7ZE 4Y7NF 4AYBH 2WAQH 3RZDE 2JA5E 3GTPF 5TMCE 5IYDF 4X6AF 3FKIE 3PO3E 5M5XE 3S1RE 3K7AE 4XLNE 4Y52F 3S2DE 2JA6F 3S15F 2A69E 1Y1VF 5C3EF 3S17E 2E2HE 4C3HF 5IYCE 1TWGF 3GTQE 1WCMF 4MEYE 4OINE 3M4OF 4A3LE 5M3FE 5IYBF 4A3BE 3HOWF 3HKZH 2NVYE 4YFKE 1TWCE 4A3IF 4C2MF 2NVXF 4C3JF 3GTGE 5D4DE 2JA8F
chains in the Genus database with same CATH topology
3S1NF 4BY7F 4C3IF 5M3MF 4YG2E 5C44F 4A3GF 1I50F 2R93F 4G7ZE 4GZYE 2R7ZF 5D4CE 1I6HF 3RZDF 4YFXE 2O5IE 1QKLA 2A6EE 3FKIF 5M5XF 3K7AF 3S1RF 3PO3F 3S2DF 2O5JE 5IPLE 2Y0SI 2R92F 3S17F 2E2HF 5IYCF 4YFNE 3GTQF 1K83F 3WODE 4A3LF 2WB1I 5M3FF 2NVYF 1TWCF 5E18E 1ZYRE 3GTGF 4QIWK 4Q4ZE 3S1MF 4OIPE 1SMYE 5M5WF 4A3JF 2NVQF 3S16F 4Q5SE 4LK1E 4XSZE 2VUMF 4LLGE 5M5YF 2PPBE 3HOVF 3RZOF 3I4NF 2WAQK 4KN7E 1YNNK 4OIRE 1R9TF 4A3MF 5FLMF 2JA5F 4A3KF 2NVTF 2B63F 3HOUF 3GTKF 3GTOF 3HKZK 4KMUE 5IP7F 4G7HE 3EQLE 4BY1F 1IW7E 3S14F 4A3BF 4MEXE 4OIQE 1HQME 2E2IF 3S1QF 4XLPE 4A3EF 5C4XF 3M3YF 1Y1WF 4BBSF 4XSXE 4AYBK 2KRXA 4ZH4E 5D4EE 3GTMF 2CW0E 2JA7F 4MQ9E 4BBRF 2PMZK 4LJZE 5E17E 1TWHF 5IP9F 4BXXF 2A6HE 3DXJE 4KN4E 4A3FF 5FJ8F 1I3QF 1SFOF 5C4JF 3HOZF 3PO2F 3I4MF 4A93F 2BE5E 1TWAF 4LK0E 1TWFF 2E2JF 3HOYF 4JK1E 1YNJK 3CQZF 2YU9F 2A68E 3HOXF 3S2HF 5BYHE 4G7OE 4A3DF 5TMFE 4OIOE 3GTLF 3GTJF 3H0GF 4A3CF 3H3VG 1I6VE 4Y7NF 3GTPF 5TMCE 5IYDF 4X6AF 4XLNE 4Y52F 2JA6F 3S15F 2A69E 1Y1VF 5C3EF 4C3HF 1TWGF 1WCMF 4MEYE 4OINE 3M4OF 5IYBF 3HOWF 4YFKE 4A3IF 4C2MF 2NVXF 4C3JF 5D4DE 2JA8F
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S1N F;  4BY7 F;  4C3I F;  5M3M F;  4YG2 E;  5C44 F;  4A3G F;  1I50 F;  2R93 F;  4G7Z E;  4GZY E;  2R7Z F;  5D4C E;  1I6H F;  3RZD F;  4YFX E;  2O5I E;  1QKL A;  2A6E E;  3FKI F;  5M5X F;  3K7A F;  3S1R F;  3PO3 F;  3S2D F;  2O5J E;  5IPL E;  2Y0S I;  2R92 F;  3S17 F;  2E2H F;  5IYC F;  4YFN E;  3GTQ F;  1K83 F;  3WOD E;  4A3L F;  2WB1 I;  5M3F F;  2NVY F;  1TWC F;  5E18 E;  1ZYR E;  3GTG F;  4Q4Z E;  3S1M F;  4OIP E;  1SMY E;  5M5W F;  4A3J F;  2NVQ F;  3S16 F;  4Q5S E;  4LK1 E;  4XSZ E;  2VUM F;  4LLG E;  5M5Y F;  2PPB E;  3HOV F;  3RZO F;  3I4N F;  2WAQ K;  4KN7 E;  1YNN K;  4OIR E;  1R9T F;  4A3M F;  5FLM F;  2JA5 F;  4A3K F;  2NVT F;  2B63 F;  3HOU F;  3GTK F;  3GTO F;  3HKZ K;  4KMU E;  5IP7 F;  4G7H E;  3EQL E;  4BY1 F;  1IW7 E;  3S14 F;  4A3B F;  4MEX E;  4OIQ E;  1HQM E;  2E2I F;  3S1Q F;  4XLP E;  4A3E F;  5C4X F;  3M3Y F;  1Y1W F;  4BBS F;  4XSX E;  4AYB K;  4ZH4 E;  5D4E E;  3GTM F;  2CW0 E;  2JA7 F;  4MQ9 E;  4BBR F;  2PMZ K;  4LJZ E;  5E17 E;  1TWH F;  5IP9 F;  4BXX F;  2A6H E;  3DXJ E;  4KN4 E;  4A3F F;  5FJ8 F;  1I3Q F;  1SFO F;  5C4J F;  3HOZ F;  3PO2 F;  3I4M F;  4A93 F;  2BE5 E;  1TWA F;  4LK0 E;  1TWF F;  2E2J F;  3HOY F;  4JK1 E;  1YNJ K;  3CQZ F;  2YU9 F;  2A68 E;  3HOX F;  3S2H F;  5BYH E;  4G7O E;  4A3D F;  5TMF E;  4OIO E;  3GTL F;  3GTJ F;  3H0G F;  4A3C F;  3H3V G;  1I6V E;  4Y7N F;  3GTP F;  5TMC E;  5IYD F;  4X6A F;  4XLN E;  4Y52 F;  2JA6 F;  3S15 F;  2A69 E;  1Y1V F;  5C3E F;  4C3H F;  1TWG F;  1WCM F;  4MEY E;  4OIN E;  3M4O F;  5IYB F;  3HOW F;  4YFK E;  4A3I F;  4C2M F;  2NVX F;  4C3J F;  5D4D E;  2JA8 F; 
#chains in the Genus database with same CATH topology
 3S1Q E;  3S1M E;  3S1N F;  4BY7 F;  5M5W E;  4C3I F;  4A3J E;  5M3M F;  4YG2 E;  2NVQ E;  3S16 E;  5C44 F;  4A3G F;  1I50 F;  2VUM E;  5M5Y E;  3HOV E;  3RZO E;  2R93 F;  4G7Z E;  3I4N E;  4GZY E;  2R7Z F;  1R9T E;  5D4C E;  4BBR E;  4A3M E;  1I6H F;  3RZD F;  4YFX E;  5FLM E;  2O5I E;  1QKL A;  2A6E E;  1DZF A;  3FKI F;  3K7A F;  5M5X F;  4A3K E;  3S1R F;  2B63 E;  2NVT E;  3GTK E;  3H3V F;  3HOU E;  5FJ8 E;  3GTO E;  3S2D F;  1SFO E;  2Y0S I;  2R92 F;  5IP7 E;  2PMZ H;  2E2H F;  3S17 F;  5IYC F;  4YFN E;  3GTQ F;  1K83 F;  4BY1 E;  3WOD E;  4A3L F;  2WB1 I;  5M3F F;  3S14 E;  2NVY F;  1TWC F;  5E18 E;  1ZYR E;  3GTG F;  2E2I E;  4QIW K;  3CQZ E;  4Q4Z E;  4OIP E;  4A3E E;  3S1M F;  5C4X E;  1SMY E;  5M5W F;  4A3J F;  2NVQ F;  3M3Y E;  3S16 F;  4Q5S E;  2Y0S H;  4LK1 E;  1Y1W E;  4XSZ E;  2VUM F;  4LLG E;  4BBS E;  5M5Y F;  2PPB E;  3HOV F;  3RZO F;  3I4N F;  2O5J E;  2WAQ K;  4KN7 E;  1YNN K;  4OIR E;  1R9T F;  3GTM E;  4A3M F;  2JA7 E;  5FLM F;  2JA5 F;  4A3K F;  5IPL E;  1TWH E;  2NVT F;  2B63 F;  5IP9 E;  3GTK F;  3HOU F;  4BXX E;  3GTO F;  4A3F E;  3HKZ K;  4KMU E;  1I3Q E;  5IP7 F;  4G7H E;  5C4J E;  3EQL E;  4BY1 F;  1IW7 E;  3HOZ E;  3PO2 E;  3I4M E;  4A93 E;  3S14 F;  4A3B F;  1TWA E;  4MEX E;  1TWF E;  2E2J E;  4OIQ E;  1HQM E;  2E2I F;  3HOY E;  3S1Q F;  2YU9 E;  4XLP E;  1I50 E;  4A3E F;  5C4X F;  3HOX E;  4A3D E;  3S2H E;  3M3Y F;  1Y1W F;  4BBS F;  4XSX E;  4AYB K;  3GTJ E;  3H0G E;  3GTL E;  4A3C E;  2WB1 H;  2KRX A;  4ZH4 E;  4Y7N E;  1I6H E;  3GTP E;  5D4E E;  5IYD E;  3GTM F;  2CW0 E;  4X6A E;  2JA7 F;  4MQ9 E;  4BBR F;  4Y52 E;  2PMZ K;  2JA6 E;  4LJZ E;  5E17 E;  3S15 E;  1TWH F;  2R92 E;  1Y1V E;  5C3E E;  5IP9 F;  4BXX F;  1EIK A;  4C3H E;  2A6H E;  3DXJ E;  4KN4 E;  1TWG E;  1K83 E;  5FJ8 F;  4A3F F;  1I3Q F;  1WCM E;  1SFO F;  3M4O E;  5C4J F;  5IYB E;  3HOW E;  3HOZ F;  4A3I E;  4C2M E;  2NVX E;  4C3J E;  2BE5 E;  3I4M F;  3PO2 F;  4A93 F;  1TWA F;  2JA8 E;  4LK0 E;  1TWF F;  3S1N E;  2E2J F;  3HOY F;  4BY7 E;  4C3I E;  5M3M E;  4JK1 E;  1YNJ K;  3CQZ F;  5C44 E;  2YU9 F;  2A68 E;  3HOX F;  3S2H F;  4QIW H;  5BYH E;  4G7O E;  4A3D F;  4A3G E;  2R93 E;  5TMF E;  4OIO E;  3GTL F;  3GTJ F;  3H0G F;  3PO3 F;  3H3V G;  4A3C F;  1I6V E;  2R7Z E;  4Y7N F;  4AYB H;  2WAQ H;  3RZD E;  2JA5 E;  3GTP F;  5TMC E;  5IYD F;  4X6A F;  3FKI E;  3PO3 E;  5M5X E;  3S1R E;  3K7A E;  4XLN E;  4Y52 F;  3S2D E;  2JA6 F;  3S15 F;  2A69 E;  1Y1V F;  5C3E F;  3S17 E;  2E2H E;  4C3H F;  5IYC E;  1TWG F;  3GTQ E;  1WCM F;  4MEY E;  4OIN E;  3M4O F;  4A3L E;  5M3F E;  5IYB F;  4A3B E;  3HOW F;  3HKZ H;  2NVY E;  4YFK E;  1TWC E;  4A3I F;  4C2M F;  2NVX F;  4C3J F;  3GTG E;  5D4D E;  2JA8 F; 
#chains in the Genus database with same CATH homology
 3S1N F;  4BY7 F;  4C3I F;  5M3M F;  4YG2 E;  5C44 F;  4A3G F;  1I50 F;  2R93 F;  4G7Z E;  4GZY E;  2R7Z F;  5D4C E;  1I6H F;  3RZD F;  4YFX E;  2O5I E;  1QKL A;  2A6E E;  3FKI F;  5M5X F;  3K7A F;  3S1R F;  3PO3 F;  3S2D F;  2O5J E;  5IPL E;  2Y0S I;  2R92 F;  3S17 F;  2E2H F;  5IYC F;  4YFN E;  3GTQ F;  1K83 F;  3WOD E;  4A3L F;  2WB1 I;  5M3F F;  2NVY F;  1TWC F;  5E18 E;  1ZYR E;  3GTG F;  4QIW K;  4Q4Z E;  3S1M F;  4OIP E;  1SMY E;  5M5W F;  4A3J F;  2NVQ F;  3S16 F;  4Q5S E;  4LK1 E;  4XSZ E;  2VUM F;  4LLG E;  5M5Y F;  2PPB E;  3HOV F;  3RZO F;  3I4N F;  2WAQ K;  4KN7 E;  1YNN K;  4OIR E;  1R9T F;  4A3M F;  5FLM F;  2JA5 F;  4A3K F;  2NVT F;  2B63 F;  3HOU F;  3GTK F;  3GTO F;  3HKZ K;  4KMU E;  5IP7 F;  4G7H E;  3EQL E;  4BY1 F;  1IW7 E;  3S14 F;  4A3B F;  4MEX E;  4OIQ E;  1HQM E;  2E2I F;  3S1Q F;  4XLP E;  4A3E F;  5C4X F;  3M3Y F;  1Y1W F;  4BBS F;  4XSX E;  4AYB K;  2KRX A;  4ZH4 E;  5D4E E;  3GTM F;  2CW0 E;  2JA7 F;  4MQ9 E;  4BBR F;  2PMZ K;  4LJZ E;  5E17 E;  1TWH F;  5IP9 F;  4BXX F;  2A6H E;  3DXJ E;  4KN4 E;  4A3F F;  5FJ8 F;  1I3Q F;  1SFO F;  5C4J F;  3HOZ F;  3PO2 F;  3I4M F;  4A93 F;  2BE5 E;  1TWA F;  4LK0 E;  1TWF F;  2E2J F;  3HOY F;  4JK1 E;  1YNJ K;  3CQZ F;  2YU9 F;  2A68 E;  3HOX F;  3S2H F;  5BYH E;  4G7O E;  4A3D F;  5TMF E;  4OIO E;  3GTL F;  3GTJ F;  3H0G F;  4A3C F;  3H3V G;  1I6V E;  4Y7N F;  3GTP F;  5TMC E;  5IYD F;  4X6A F;  4XLN E;  4Y52 F;  2JA6 F;  3S15 F;  2A69 E;  1Y1V F;  5C3E F;  4C3H F;  1TWG F;  1WCM F;  4MEY E;  4OIN E;  3M4O F;  5IYB F;  3HOW F;  4YFK E;  4A3I F;  4C2M F;  2NVX F;  4C3J F;  5D4D E;  2JA8 F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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