4OIOE

Crystal structure of thermus thermophilus pre-insertion substrate complex for de novo transcription initiation
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
94
structure length
94
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
pubmed rcsb
molecule tags Transcription, transferase
source organism Thermus thermophilus
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 24
structure length 94
sequence length 94
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2014-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4oioE00
4G7HE 1I6VE 2E2IF 5IPLE 1TWHF 4OIOE 2JA6F 3DXJE 4A3FF 1IW7E 3M3YF 3HOYF 4LJZE 2A6EE 3GTPF 2O5IE 5D4DE 2YU9F 5M3FF 5TMCE 3S2DF 4A3CF 4OINE 2NVTF 3H3VG 4A93F 4JK1E 3S17F 4LK1E 3GTQF 3H0GF 4C3IF 4XLNE 3I4NF 2JA7F 3K7AF 3S16F 4A3LF 5IYBF 5IYDF 1HQME 4YFXE 2B63F 3GTKF 4ZH4E 4YFKE 1Y1WF 4A3KF 4X6AF 1TWFF 3S15F 5IP7F 3S1RF 2E2HF 4LLGE 3GTMF 2PMZK 4A3BF 2NVXF 4Y7NF 5FLMF 4A3EF 3GTGF 4YG2E 5M5YF 5C4JF 4A3MF 4A3DF 3PO3F 4OIQE 5D4EE 4Y52F 2JA8F 4Q4ZE 3PO2F 2BE5E 3HOZF 3S1QF 5M3MF 4KN4E 4XSZE 1YNJK 4C3HF 5M5WF 1QKLA 4G7OE 2WAQK 4KN7E 4A3GF 4OIRE 4AYBK 3S1NF 5C44F 4C3JF 1R9TF 3RZOF 2JA5F 3HOWF 4G7ZE 2A68E 3GTLF 3M4OF 1TWGF 3S1MF 4YFNE 2VUMF 5C4XF 1YNNK 4MEXE 5E18E 3HKZK 1TWCF 3EQLE 4XLPE 5M5XF 2E2JF 5C3EF 1SFOF 3S2HF 3S14F 4MEYE 2NVQF 3GTJF 3RZDF 2WB1I 5IP9F 3HOUF 1TWAF 4KMUE 1I50F 1I3QF 4MQ9E 2CW0E 2A69E 5IYCF 5FJ8F 2NVYF 2O5JE 4GZYE 3GTOF 3FKIF 4A3IF 3HOVF 2R7ZF 4OIPE 3HOXF 2R92F 5E17E 1I6HF 5D4CE 2R93F 2PPBE 4C2MF 1SMYE 4LK0E 4BY7F 4BBSF 3I4MF 4Q5SE 1K83F 2Y0SI 4XSXE 2A6HE 5TMFE 4BBRF 4A3JF 1ZYRE 5BYHE 4BXXF 3CQZF 4BY1F 1Y1VF 1WCMF 3WODE
chains in the Genus database with same CATH superfamily
4G7HE 1I6VE 1EIKA 2E2IF 3S1NE 2WAQH 5C44E 1R9TE 5IPLE 1TWHF 3RZOE 4AYBH 4A3KE 1Y1WE 3DXJE 4A3FF 2JA5E 4OIOE 1TWFE 2JA6F 3HOWE 1IW7E 3M3YF 3M4OE 4LJZE 2E2HE 2A6EE 3HOYF 3GTPF 2O5IE 2KRXA 4Y7NE 4A3EE 4A3LE 5D4DE 4A3DE 5C4JE 5M3FF 2YU9F 2VUME 5TMCE 3S2DF 4A3CF 4OINE 2NVTF 2Y0SH 5M5XE 2E2JE 3H3VG 3HOZE 4A93F 4JK1E 3S17F 3S2HE 4LK1E 3GTQF 3S14E 3H0GF 4C3IF 4XLNE 3HKZH 3I4NF 3RZDE 4C3HE 5IP9E 5M5WE 2JA7F 3K7AF 3S16F 2WB1H 5IYBF 3HOUE 4A3LF 1I50E 5IYDF 1HQME 4YFXE 2B63F 5IYCE 3GTKF 4ZH4E 4C3JE 4YFKE 4A3KF 1Y1WF 4X6AF 3GTOE 3FKIE 1TWFF 3S15F 5IP7F 3S1RF 2E2HF 4LLGE 1DZFA 3GTMF 3GTLE 2R92E 1TWGE 2PMZK 4A3BF 2NVXF 4Y7NF 5FLMF 4A3EF 1I6HE 3GTGF 4YG2E 5M5YF 5C4JF 4A3MF 3S1ME 4A3DF 4BY7E 3I4ME 4OIQE 3PO3F 5C4XE 5D4EE 4Y52F 2JA8F 4Q4ZE 1TWCE 2BE5E 3HOZF 3PO2F 4QIWH 3S1QF 4BBRE 4KN4E 5M3MF 4XSZE 1YNJK 5C3EE 1SFOE 4BXXE 4C3HF 3CQZE 5M5WF 1QKLA 2NVQE 4G7OE 2WAQK 3GTJE 4BY1E 4KN7E 4A3GF 4OIRE 4AYBK 1TWAE 1I3QE 3S1NF 1TWHE 5C44F 4C3JF 1R9TF 5FJ8E 2NVYE 3RZOF 2JA5F 3HOWF 3HOVE 4A3IE 2R7ZE 4G7ZE 3HOYE 3M3YE 2A68E 3GTLF 3M4OF 1TWGF 3HOXE 2YU9E 5M3FE 3S1MF 3S2DE 2R93E 4YFNE 4C2ME 2VUMF 3H3VF 5C4XF 1YNNK 4MEXE 4BBSE 5E18E 3HKZK 1TWCF 3EQLE 1K83E 4XLPE 5M5XF 2E2JF 3GTQE 5C3EF 1SFOF 3S2HF 4A3JE 3S14F 4MEYE 2NVQF 3S16E 3GTJF 3RZDF 2WB1I 5IP9F 1Y1VE 3HOUF 1WCME 5IYDE 1TWAF 2B63E 4KMUE 1I50F 1I3QF 4MQ9E 2E2IE 2CW0E 3GTKE 4X6AE 2A69E 5IYCF 5FJ8F 2NVYF 3S15E 2O5JE 2JA6E 4A3FE 4GZYE 5IP7E 3S1RE 3FKIF 4A3IF 3GTOF 3HOVF 2R7ZF 3GTME 4A3GE 4A3BE 3GTPE 2NVXE 4OIPE 5FLME 3HOXF 2R92F 3GTGE 4A3ME 5M5YE 5E17E 1I6HF 5D4CE 2R93F 2PPBE 4C2MF 2PMZH 4QIWK 3PO3E 4A3CE 1SMYE 4LK0E 4BY7F 2NVTE 4Y52E 2JA8E 3I4MF 3PO2E 4Q5SE 3S1QE 1K83F 2Y0SI 4BBSF 4XSXE 5M3ME 2A6HE 4A93E 3S17E 5TMFE 4BBRF 4A3JF 3H0GE 4C3IE 3I4NE 1ZYRE 5BYHE 4BXXF 3CQZF 2JA7E 3K7AE 4BY1F 1Y1VF 5IYBE 1WCMF 3WODE
chains in the Genus database with same CATH topology
4G7HE 1I6VE 2E2IF 5IPLE 1TWHF 4OIOE 2JA6F 3DXJE 4A3FF 1IW7E 3M3YF 3HOYF 4LJZE 2A6EE 3GTPF 2O5IE 2KRXA 5D4DE 2YU9F 5M3FF 5TMCE 3S2DF 4A3CF 4OINE 2NVTF 3H3VG 4A93F 4JK1E 3S17F 4LK1E 3GTQF 3H0GF 4C3IF 4XLNE 3I4NF 2JA7F 3K7AF 3S16F 4A3LF 5IYBF 5IYDF 1HQME 4YFXE 2B63F 3GTKF 4ZH4E 4YFKE 1Y1WF 4A3KF 4X6AF 1TWFF 3S15F 5IP7F 3S1RF 2E2HF 4LLGE 3GTMF 2PMZK 4A3BF 2NVXF 4Y7NF 5FLMF 4A3EF 3GTGF 4YG2E 5M5YF 5C4JF 4A3MF 4A3DF 3PO3F 4OIQE 5D4EE 4Y52F 2JA8F 4Q4ZE 3PO2F 2BE5E 3HOZF 3S1QF 5M3MF 4KN4E 4XSZE 1YNJK 4C3HF 5M5WF 1QKLA 4G7OE 2WAQK 4KN7E 4A3GF 4OIRE 4AYBK 3S1NF 5C44F 4C3JF 1R9TF 3RZOF 2JA5F 3HOWF 4G7ZE 2A68E 3GTLF 3M4OF 1TWGF 3S1MF 4YFNE 2VUMF 5C4XF 1YNNK 4MEXE 5E18E 3HKZK 1TWCF 3EQLE 4XLPE 5M5XF 2E2JF 5C3EF 1SFOF 3S2HF 3S14F 4MEYE 2NVQF 3GTJF 3RZDF 2WB1I 5IP9F 3HOUF 1TWAF 4KMUE 1I50F 1I3QF 4MQ9E 2CW0E 2A69E 5IYCF 5FJ8F 2NVYF 2O5JE 4GZYE 3GTOF 3FKIF 4A3IF 3HOVF 2R7ZF 4OIPE 3HOXF 2R92F 5E17E 1I6HF 5D4CE 2R93F 2PPBE 4C2MF 4QIWK 1SMYE 4LK0E 4BY7F 4BBSF 3I4MF 4Q5SE 1K83F 2Y0SI 4XSXE 2A6HE 5TMFE 4BBRF 4A3JF 1ZYRE 5BYHE 4BXXF 3CQZF 4BY1F 1Y1VF 1WCMF 3WODE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G7H E;  1I6V E;  2E2I F;  5IPL E;  1TWH F;  4OIO E;  2JA6 F;  3DXJ E;  4A3F F;  1IW7 E;  3M3Y F;  3HOY F;  4LJZ E;  2A6E E;  3GTP F;  2O5I E;  5D4D E;  2YU9 F;  5M3F F;  5TMC E;  3S2D F;  4A3C F;  4OIN E;  2NVT F;  3H3V G;  4A93 F;  4JK1 E;  3S17 F;  4LK1 E;  3GTQ F;  3H0G F;  4C3I F;  4XLN E;  3I4N F;  2JA7 F;  3K7A F;  3S16 F;  4A3L F;  5IYB F;  5IYD F;  1HQM E;  4YFX E;  2B63 F;  3GTK F;  4ZH4 E;  4YFK E;  1Y1W F;  4A3K F;  4X6A F;  1TWF F;  3S15 F;  5IP7 F;  3S1R F;  2E2H F;  4LLG E;  3GTM F;  2PMZ K;  4A3B F;  2NVX F;  4Y7N F;  5FLM F;  4A3E F;  3GTG F;  4YG2 E;  5M5Y F;  5C4J F;  4A3M F;  4A3D F;  3PO3 F;  4OIQ E;  5D4E E;  4Y52 F;  2JA8 F;  4Q4Z E;  3PO2 F;  2BE5 E;  3HOZ F;  3S1Q F;  5M3M F;  4KN4 E;  4XSZ E;  1YNJ K;  4C3H F;  5M5W F;  1QKL A;  4G7O E;  2WAQ K;  4KN7 E;  4A3G F;  4OIR E;  4AYB K;  3S1N F;  5C44 F;  4C3J F;  1R9T F;  3RZO F;  2JA5 F;  3HOW F;  4G7Z E;  2A68 E;  3GTL F;  3M4O F;  1TWG F;  3S1M F;  4YFN E;  2VUM F;  5C4X F;  1YNN K;  4MEX E;  5E18 E;  3HKZ K;  1TWC F;  3EQL E;  4XLP E;  5M5X F;  2E2J F;  5C3E F;  1SFO F;  3S2H F;  3S14 F;  4MEY E;  2NVQ F;  3GTJ F;  3RZD F;  2WB1 I;  5IP9 F;  3HOU F;  1TWA F;  4KMU E;  1I50 F;  1I3Q F;  4MQ9 E;  2CW0 E;  2A69 E;  5IYC F;  5FJ8 F;  2NVY F;  2O5J E;  4GZY E;  3GTO F;  3FKI F;  4A3I F;  3HOV F;  2R7Z F;  4OIP E;  3HOX F;  2R92 F;  5E17 E;  1I6H F;  5D4C E;  2R93 F;  2PPB E;  4C2M F;  1SMY E;  4LK0 E;  4BY7 F;  4BBS F;  3I4M F;  4Q5S E;  1K83 F;  2Y0S I;  4XSX E;  2A6H E;  5TMF E;  4BBR F;  4A3J F;  1ZYR E;  5BYH E;  4BXX F;  3CQZ F;  4BY1 F;  1Y1V F;  1WCM F;  3WOD E; 
#chains in the Genus database with same CATH topology
 4G7H E;  1I6V E;  1EIK A;  2E2I F;  3S1N E;  2WAQ H;  5C44 E;  1R9T E;  5IPL E;  1TWH F;  3RZO E;  4AYB H;  4A3K E;  1Y1W E;  3DXJ E;  4A3F F;  2JA5 E;  4OIO E;  1TWF E;  2JA6 F;  3HOW E;  1IW7 E;  3M3Y F;  3M4O E;  4LJZ E;  2E2H E;  2A6E E;  3HOY F;  3GTP F;  2O5I E;  2KRX A;  4Y7N E;  4A3E E;  4A3L E;  5D4D E;  4A3D E;  5C4J E;  5M3F F;  2YU9 F;  2VUM E;  5TMC E;  3S2D F;  4A3C F;  4OIN E;  2NVT F;  2Y0S H;  5M5X E;  2E2J E;  3H3V G;  3HOZ E;  4A93 F;  4JK1 E;  3S17 F;  3S2H E;  4LK1 E;  3GTQ F;  3S14 E;  3H0G F;  4C3I F;  4XLN E;  3HKZ H;  3I4N F;  3RZD E;  4C3H E;  5IP9 E;  5M5W E;  2JA7 F;  3K7A F;  3S16 F;  2WB1 H;  5IYB F;  3HOU E;  4A3L F;  1I50 E;  5IYD F;  1HQM E;  4YFX E;  2B63 F;  5IYC E;  3GTK F;  4ZH4 E;  4C3J E;  4YFK E;  4A3K F;  1Y1W F;  4X6A F;  3GTO E;  3FKI E;  1TWF F;  3S15 F;  5IP7 F;  3S1R F;  2E2H F;  4LLG E;  1DZF A;  3GTM F;  3GTL E;  2R92 E;  1TWG E;  2PMZ K;  4A3B F;  2NVX F;  4Y7N F;  5FLM F;  4A3E F;  1I6H E;  3GTG F;  4YG2 E;  5M5Y F;  5C4J F;  4A3M F;  3S1M E;  4A3D F;  4BY7 E;  3I4M E;  4OIQ E;  3PO3 F;  5C4X E;  5D4E E;  4Y52 F;  2JA8 F;  4Q4Z E;  1TWC E;  2BE5 E;  3HOZ F;  3PO2 F;  4QIW H;  3S1Q F;  4BBR E;  4KN4 E;  5M3M F;  4XSZ E;  1YNJ K;  5C3E E;  1SFO E;  4BXX E;  4C3H F;  3CQZ E;  5M5W F;  1QKL A;  2NVQ E;  4G7O E;  2WAQ K;  3GTJ E;  4BY1 E;  4KN7 E;  4A3G F;  4OIR E;  4AYB K;  1TWA E;  1I3Q E;  3S1N F;  1TWH E;  5C44 F;  4C3J F;  1R9T F;  5FJ8 E;  2NVY E;  3RZO F;  2JA5 F;  3HOW F;  3HOV E;  4A3I E;  2R7Z E;  4G7Z E;  3HOY E;  3M3Y E;  2A68 E;  3GTL F;  3M4O F;  1TWG F;  3HOX E;  2YU9 E;  5M3F E;  3S1M F;  3S2D E;  2R93 E;  4YFN E;  4C2M E;  2VUM F;  3H3V F;  5C4X F;  1YNN K;  4MEX E;  4BBS E;  5E18 E;  3HKZ K;  1TWC F;  3EQL E;  1K83 E;  4XLP E;  5M5X F;  2E2J F;  3GTQ E;  5C3E F;  1SFO F;  3S2H F;  4A3J E;  3S14 F;  4MEY E;  2NVQ F;  3S16 E;  3GTJ F;  3RZD F;  2WB1 I;  5IP9 F;  1Y1V E;  3HOU F;  1WCM E;  5IYD E;  1TWA F;  2B63 E;  4KMU E;  1I50 F;  1I3Q F;  4MQ9 E;  2E2I E;  2CW0 E;  3GTK E;  4X6A E;  2A69 E;  5IYC F;  5FJ8 F;  2NVY F;  3S15 E;  2O5J E;  2JA6 E;  4A3F E;  4GZY E;  5IP7 E;  3S1R E;  3FKI F;  4A3I F;  3GTO F;  3HOV F;  2R7Z F;  3GTM E;  4A3G E;  4A3B E;  3GTP E;  2NVX E;  4OIP E;  5FLM E;  3HOX F;  2R92 F;  3GTG E;  4A3M E;  5M5Y E;  5E17 E;  1I6H F;  5D4C E;  2R93 F;  2PPB E;  4C2M F;  2PMZ H;  4QIW K;  3PO3 E;  4A3C E;  1SMY E;  4LK0 E;  4BY7 F;  2NVT E;  4Y52 E;  2JA8 E;  3I4M F;  3PO2 E;  4Q5S E;  3S1Q E;  1K83 F;  2Y0S I;  4BBS F;  4XSX E;  5M3M E;  2A6H E;  4A93 E;  3S17 E;  5TMF E;  4BBR F;  4A3J F;  3H0G E;  4C3I E;  3I4N E;  1ZYR E;  5BYH E;  4BXX F;  3CQZ F;  2JA7 E;  3K7A E;  4BY1 F;  1Y1V F;  5IYB E;  1WCM F;  3WOD E; 
#chains in the Genus database with same CATH homology
 4G7H E;  1I6V E;  2E2I F;  5IPL E;  1TWH F;  4OIO E;  2JA6 F;  3DXJ E;  4A3F F;  1IW7 E;  3M3Y F;  3HOY F;  4LJZ E;  2A6E E;  3GTP F;  2O5I E;  2KRX A;  5D4D E;  2YU9 F;  5M3F F;  5TMC E;  3S2D F;  4A3C F;  4OIN E;  2NVT F;  3H3V G;  4A93 F;  4JK1 E;  3S17 F;  4LK1 E;  3GTQ F;  3H0G F;  4C3I F;  4XLN E;  3I4N F;  2JA7 F;  3K7A F;  3S16 F;  4A3L F;  5IYB F;  5IYD F;  1HQM E;  4YFX E;  2B63 F;  3GTK F;  4ZH4 E;  4YFK E;  1Y1W F;  4A3K F;  4X6A F;  1TWF F;  3S15 F;  5IP7 F;  3S1R F;  2E2H F;  4LLG E;  3GTM F;  2PMZ K;  4A3B F;  2NVX F;  4Y7N F;  5FLM F;  4A3E F;  3GTG F;  4YG2 E;  5M5Y F;  5C4J F;  4A3M F;  4A3D F;  3PO3 F;  4OIQ E;  5D4E E;  4Y52 F;  2JA8 F;  4Q4Z E;  3PO2 F;  2BE5 E;  3HOZ F;  3S1Q F;  5M3M F;  4KN4 E;  4XSZ E;  1YNJ K;  4C3H F;  5M5W F;  1QKL A;  4G7O E;  2WAQ K;  4KN7 E;  4A3G F;  4OIR E;  4AYB K;  3S1N F;  5C44 F;  4C3J F;  1R9T F;  3RZO F;  2JA5 F;  3HOW F;  4G7Z E;  2A68 E;  3GTL F;  3M4O F;  1TWG F;  3S1M F;  4YFN E;  2VUM F;  5C4X F;  1YNN K;  4MEX E;  5E18 E;  3HKZ K;  1TWC F;  3EQL E;  4XLP E;  5M5X F;  2E2J F;  5C3E F;  1SFO F;  3S2H F;  3S14 F;  4MEY E;  2NVQ F;  3GTJ F;  3RZD F;  2WB1 I;  5IP9 F;  3HOU F;  1TWA F;  4KMU E;  1I50 F;  1I3Q F;  4MQ9 E;  2CW0 E;  2A69 E;  5IYC F;  5FJ8 F;  2NVY F;  2O5J E;  4GZY E;  3GTO F;  3FKI F;  4A3I F;  3HOV F;  2R7Z F;  4OIP E;  3HOX F;  2R92 F;  5E17 E;  1I6H F;  5D4C E;  2R93 F;  2PPB E;  4C2M F;  4QIW K;  1SMY E;  4LK0 E;  4BY7 F;  4BBS F;  3I4M F;  4Q5S E;  1K83 F;  2Y0S I;  4XSX E;  2A6H E;  5TMF E;  4BBR F;  4A3J F;  1ZYR E;  5BYH E;  4BXX F;  3CQZ F;  4BY1 F;  1Y1V F;  1WCM F;  3WOD E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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