4OIQE

Crystal structure of thermus thermophilus transcription initiation complex soaked with ge23077 and rifampicin
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
94
structure length
94
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
pubmed rcsb
molecule tags Transcription, transferase/antibiotic
source organism Thermus thermophilus
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 26
structure length 94
sequence length 94
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2014-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4oiqE00
4BY1F 3GTOF 2NVYF 4Y52F 4MEXE 2E2HF 1K83F 1I3QF 4KN7E 5M3MF 1WCMF 3HOWF 3WODE 3CQZF 3HOXF 3S15F 3S16F 4YFKE 4G7ZE 1TWHF 4OINE 3PO2F 3HOYF 4C3JF 2WB1I 1TWGF 2JA5F 2Y0SI 5C4JF 2NVXF 1TWFF 2A6HE 4OIOE 3GTMF 3I4MF 5IP9F 3HOVF 5M5WF 3S17F 5IYBF 2NVTF 4XLPE 4AYBK 1R9TF 1QKLA 2WAQK 5M5XF 4KMUE 1HQME 3HKZK 4A93F 3DXJE 4A3KF 3M3YF 4A3LF 4A3JF 1SFOF 4A3MF 3GTJF 4LLGE 2PPBE 2CW0E 1I6VE 5IYCF 4G7HE 4OIQE 3S2DF 3HOZF 4Q4ZE 5M3FF 2R92F 3S1RF 5C4XF 5D4EE 3S1MF 4X6AF 1YNJK 5FJ8F 4OIRE 4KN4E 4LK0E 5M5YF 2A6EE 4OIPE 4YFXE 2E2JF 4A3DF 1TWCF 4XSXE 2YU9F 5E17E 4A3FF 4YG2E 3S2HF 4LK1E 5IPLE 3I4NF 4A3BF 2A69E 3GTGF 3S1NF 4C3HF 5TMFE 3GTLF 1I50F 4G7OE 3S1QF 4A3CF 4MQ9E 4XSZE 5IP7F 4LJZE 4Y7NF 2NVQF 3H0GF 5TMCE 2B63F 4BXXF 4MEYE 3M4OF 5E18E 2JA6F 2O5JE 3RZOF 4C2MF 2BE5E 2E2IF 2VUMF 4C3IF 5D4CE 2A68E 3RZDF 2PMZK 2R93F 4ZH4E 3FKIF 4A3IF 4Q5SE 3H3VG 5C44F 5D4DE 1TWAF 2R7ZF 2O5IE 4GZYE 4BBRF 3GTPF 1ZYRE 4A3EF 4YFNE 1Y1VF 4BY7F 1Y1WF 5IYDF 3EQLE 2JA7F 2JA8F 4A3GF 4XLNE 4BBSF 5FLMF 1SMYE 3HOUF 1IW7E 3K7AF 5BYHE 1I6HF 1YNNK 5C3EF 3GTKF 3S14F 4JK1E 3PO3F 3GTQF
chains in the Genus database with same CATH superfamily
4BY1F 3GTOF 3S2HE 2NVYF 4Y52F 4MEXE 3GTPE 2E2HF 1K83F 1I3QF 3GTGE 3S1NE 4C3HE 1Y1VE 4BY7E 4KN7E 5M3MF 5IYDE 3S1QE 4A3CE 1WCMF 3HOWF 3WODE 3CQZF 4Y7NE 3HOXF 2JA7E 3H0GE 3S15F 3S16F 4YFKE 4A3GE 4G7ZE 1TWHF 4AYBH 4OINE 2B63E 3PO2F 3HOYF 2WAQH 4BXXE 2WB1H 3HOUE 4C3JF 2WB1I 1TWGF 2JA5F 2Y0SI 4C2ME 1I6HE 2E2IE 5C4JF 2NVXF 3GTKE 1TWFF 2A6HE 4OIOE 3GTMF 3I4MF 3S14E 1DZFA 2R93E 5IP9F 3HOVF 5M5WF 3S17F 3GTQE 5IYBF 5C44E 4BY1E 2NVTF 3GTOE 1TWAE 2NVYE 4AYBK 4XLPE 1R9TF 4BBRE 2E2HE 1QKLA 2WAQK 5M5XF 4A3EE 4KMUE 1HQME 3HKZK 4A93F 3DXJE 4A3KF 1Y1WE 3M3YF 4A3JF 4A3LF 1SFOF 4A3MF 3GTJF 4LLGE 2PPBE 2CW0E 3HOWE 1I6VE 3CQZE 5IYCF 3HOXE 4G7HE 4OIQE 3S15E 3S2DF 3H3VF 2JA8E 3HOZF 3PO2E 4Q4ZE 5M3FF 3HOYE 4BBSE 2R92F 5FLME 3S1RF 5C4XF 5D4EE 3S1MF 4X6AF 1YNJK 5FJ8F 2Y0SH 3K7AE 4KN4E 4LK0E 5C4JE 4OIRE 2KRXA 5C3EE 5M5YF 3GTME 2A6EE 4OIPE 4YFXE 2E2JF 4A3DF 1TWCF 4XSXE 3GTQF 5IP9E 4QIWH 5M5WE 3S17E 2YU9F 5E17E 3PO3E 4A3FF 4YG2E 3S2HF 4LK1E 5IPLE 3I4NF 4A3BF 2A69E 3GTGF 3S1NF 4C3HF 5TMFE 4Y52E 3GTLF 1I50F 1K83E 1I3QE 4G7OE 2PMZH 3S1QF 5M3ME 4A3JE 4A3CF 4MQ9E 4XSZE 4LJZE 4Y7NF 5IP7F 2NVQF 3H0GF 1WCME 5TMCE 4QIWK 2B63F 3S2DE 4BXXF 4MEYE 3HOZE 3S16E 5M3FE 1TWHE 3M4OF 5E18E 2JA6F 2R92E 2O5JE 5C4XE 3RZOF 4C2MF 2BE5E 4C3JE 2E2IF 2VUMF 4C3IF 5D4CE 3S1ME 1TWGE 2A68E 3RZDF 2JA5E 2PMZK 2NVXE 5M5YE 1TWFE 4A3DE 2R93F 4ZH4E 3I4ME 3FKIF 4A3IF 4Q5SE 3H3VG 2YU9E 5C44F 4A3FE 3HOVE 5D4DE 1TWAF 2R7ZF 2O5IE 3I4NE 4BBRF 4GZYE 4A3BE 5IYBE 2NVTE 3GTPF 1ZYRE 4A3EF 1R9TE 3GTLE 4YFNE 1I50E 1Y1VF 4BY7F 5M5XE 1Y1WF 5IYDF 4A93E 4A3KE 3M3YE 4A3LE 5IP7E 1SFOE 4A3ME 2NVQE 3EQLE 3GTJE 2JA7F 2JA8F 4A3GF 5IYCE 4XLNE 4BBSF 5FLMF 1SMYE 3HOUF 2JA6E 3M4OE 1EIKA 3HKZH 1IW7E 3RZOE 3K7AF 3S1RE 2VUME 4C3IE 5BYHE 1I6HF 1YNNK 5C3EF 3RZDE 5FJ8E 3GTKF 3S14F 4JK1E 2E2JE 3FKIE 4A3IE 4X6AE 3PO3F 1TWCE 2R7ZE
chains in the Genus database with same CATH topology
4BY1F 3GTOF 2NVYF 4Y52F 4MEXE 2E2HF 1K83F 1I3QF 4KN7E 5M3MF 1WCMF 3HOWF 3WODE 3CQZF 3HOXF 3S15F 3S16F 4YFKE 4G7ZE 1TWHF 4OINE 3PO2F 3HOYF 4C3JF 2WB1I 1TWGF 2JA5F 2Y0SI 5C4JF 2NVXF 1TWFF 2A6HE 4OIOE 3GTMF 3I4MF 5IP9F 3HOVF 5M5WF 3S17F 5IYBF 2NVTF 4XLPE 4AYBK 1R9TF 1QKLA 2WAQK 5M5XF 4KMUE 1HQME 3HKZK 4A93F 3DXJE 4A3KF 3M3YF 4A3LF 4A3JF 1SFOF 4A3MF 3GTJF 4LLGE 2PPBE 2CW0E 1I6VE 5IYCF 4G7HE 4OIQE 3S2DF 3HOZF 4Q4ZE 5M3FF 2R92F 3S1RF 5C4XF 5D4EE 3S1MF 4X6AF 1YNJK 5FJ8F 4OIRE 4KN4E 4LK0E 2KRXA 5M5YF 2A6EE 4OIPE 4YFXE 2E2JF 4A3DF 1TWCF 4XSXE 2YU9F 5E17E 4A3FF 4YG2E 3S2HF 4LK1E 5IPLE 3I4NF 4A3BF 2A69E 3GTGF 3S1NF 4C3HF 5TMFE 3GTLF 1I50F 4G7OE 3S1QF 4A3CF 4MQ9E 4XSZE 5IP7F 4LJZE 4Y7NF 2NVQF 3H0GF 5TMCE 4QIWK 2B63F 4BXXF 4MEYE 3M4OF 5E18E 2JA6F 2O5JE 3RZOF 4C2MF 2BE5E 2E2IF 2VUMF 4C3IF 5D4CE 2A68E 3RZDF 2PMZK 2R93F 4ZH4E 3FKIF 4A3IF 4Q5SE 3H3VG 5C44F 5D4DE 1TWAF 2R7ZF 2O5IE 4GZYE 4BBRF 3GTPF 1ZYRE 4A3EF 4YFNE 1Y1VF 4BY7F 1Y1WF 5IYDF 3EQLE 2JA7F 2JA8F 4A3GF 4XLNE 4BBSF 5FLMF 1SMYE 3HOUF 1IW7E 3K7AF 5BYHE 1I6HF 1YNNK 5C3EF 3GTKF 3S14F 4JK1E 3PO3F 3GTQF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BY1 F;  3GTO F;  2NVY F;  4Y52 F;  4MEX E;  2E2H F;  1K83 F;  1I3Q F;  4KN7 E;  5M3M F;  1WCM F;  3HOW F;  3WOD E;  3CQZ F;  3HOX F;  3S15 F;  3S16 F;  4YFK E;  4G7Z E;  1TWH F;  4OIN E;  3PO2 F;  3HOY F;  4C3J F;  2WB1 I;  1TWG F;  2JA5 F;  2Y0S I;  5C4J F;  2NVX F;  1TWF F;  2A6H E;  4OIO E;  3GTM F;  3I4M F;  5IP9 F;  3HOV F;  5M5W F;  3S17 F;  5IYB F;  2NVT F;  4XLP E;  4AYB K;  1R9T F;  1QKL A;  2WAQ K;  5M5X F;  4KMU E;  1HQM E;  3HKZ K;  4A93 F;  3DXJ E;  4A3K F;  3M3Y F;  4A3L F;  4A3J F;  1SFO F;  4A3M F;  3GTJ F;  4LLG E;  2PPB E;  2CW0 E;  1I6V E;  5IYC F;  4G7H E;  4OIQ E;  3S2D F;  3HOZ F;  4Q4Z E;  5M3F F;  2R92 F;  3S1R F;  5C4X F;  5D4E E;  3S1M F;  4X6A F;  1YNJ K;  5FJ8 F;  4OIR E;  4KN4 E;  4LK0 E;  5M5Y F;  2A6E E;  4OIP E;  4YFX E;  2E2J F;  4A3D F;  1TWC F;  4XSX E;  2YU9 F;  5E17 E;  4A3F F;  4YG2 E;  3S2H F;  4LK1 E;  5IPL E;  3I4N F;  4A3B F;  2A69 E;  3GTG F;  3S1N F;  4C3H F;  5TMF E;  3GTL F;  1I50 F;  4G7O E;  3S1Q F;  4A3C F;  4MQ9 E;  4XSZ E;  5IP7 F;  4LJZ E;  4Y7N F;  2NVQ F;  3H0G F;  5TMC E;  2B63 F;  4BXX F;  4MEY E;  3M4O F;  5E18 E;  2JA6 F;  2O5J E;  3RZO F;  4C2M F;  2BE5 E;  2E2I F;  2VUM F;  4C3I F;  5D4C E;  2A68 E;  3RZD F;  2PMZ K;  2R93 F;  4ZH4 E;  3FKI F;  4A3I F;  4Q5S E;  3H3V G;  5C44 F;  5D4D E;  1TWA F;  2R7Z F;  2O5I E;  4GZY E;  4BBR F;  3GTP F;  1ZYR E;  4A3E F;  4YFN E;  1Y1V F;  4BY7 F;  1Y1W F;  5IYD F;  3EQL E;  2JA7 F;  2JA8 F;  4A3G F;  4XLN E;  4BBS F;  5FLM F;  1SMY E;  3HOU F;  1IW7 E;  3K7A F;  5BYH E;  1I6H F;  1YNN K;  5C3E F;  3GTK F;  3S14 F;  4JK1 E;  3PO3 F;  3GTQ F; 
#chains in the Genus database with same CATH topology
 4BY1 F;  3GTO F;  3S2H E;  2NVY F;  4Y52 F;  4MEX E;  3GTP E;  2E2H F;  1K83 F;  1I3Q F;  3GTG E;  3S1N E;  4C3H E;  1Y1V E;  4BY7 E;  4KN7 E;  5M3M F;  5IYD E;  3S1Q E;  4A3C E;  1WCM F;  3HOW F;  3WOD E;  3CQZ F;  4Y7N E;  3HOX F;  2JA7 E;  3H0G E;  3S15 F;  3S16 F;  4YFK E;  4A3G E;  4G7Z E;  1TWH F;  4AYB H;  4OIN E;  2B63 E;  3PO2 F;  3HOY F;  2WAQ H;  4BXX E;  2WB1 H;  3HOU E;  4C3J F;  2WB1 I;  1TWG F;  2JA5 F;  2Y0S I;  4C2M E;  1I6H E;  2E2I E;  5C4J F;  2NVX F;  3GTK E;  1TWF F;  2A6H E;  4OIO E;  3GTM F;  3I4M F;  3S14 E;  1DZF A;  2R93 E;  5IP9 F;  3HOV F;  5M5W F;  3S17 F;  3GTQ E;  5IYB F;  5C44 E;  4BY1 E;  2NVT F;  3GTO E;  1TWA E;  2NVY E;  4AYB K;  4XLP E;  1R9T F;  4BBR E;  2E2H E;  1QKL A;  2WAQ K;  5M5X F;  4A3E E;  4KMU E;  1HQM E;  3HKZ K;  4A93 F;  3DXJ E;  4A3K F;  1Y1W E;  3M3Y F;  4A3J F;  4A3L F;  1SFO F;  4A3M F;  3GTJ F;  4LLG E;  2PPB E;  2CW0 E;  3HOW E;  1I6V E;  3CQZ E;  5IYC F;  3HOX E;  4G7H E;  4OIQ E;  3S15 E;  3S2D F;  3H3V F;  2JA8 E;  3HOZ F;  3PO2 E;  4Q4Z E;  5M3F F;  3HOY E;  4BBS E;  2R92 F;  5FLM E;  3S1R F;  5C4X F;  5D4E E;  3S1M F;  4X6A F;  1YNJ K;  5FJ8 F;  2Y0S H;  3K7A E;  4KN4 E;  4LK0 E;  5C4J E;  4OIR E;  2KRX A;  5C3E E;  5M5Y F;  3GTM E;  2A6E E;  4OIP E;  4YFX E;  2E2J F;  4A3D F;  1TWC F;  4XSX E;  3GTQ F;  5IP9 E;  4QIW H;  5M5W E;  3S17 E;  2YU9 F;  5E17 E;  3PO3 E;  4A3F F;  4YG2 E;  3S2H F;  4LK1 E;  5IPL E;  3I4N F;  4A3B F;  2A69 E;  3GTG F;  3S1N F;  4C3H F;  5TMF E;  4Y52 E;  3GTL F;  1I50 F;  1K83 E;  1I3Q E;  4G7O E;  2PMZ H;  3S1Q F;  5M3M E;  4A3J E;  4A3C F;  4MQ9 E;  4XSZ E;  4LJZ E;  4Y7N F;  5IP7 F;  2NVQ F;  3H0G F;  1WCM E;  5TMC E;  4QIW K;  2B63 F;  3S2D E;  4BXX F;  4MEY E;  3HOZ E;  3S16 E;  5M3F E;  1TWH E;  3M4O F;  5E18 E;  2JA6 F;  2R92 E;  2O5J E;  5C4X E;  3RZO F;  4C2M F;  2BE5 E;  4C3J E;  2E2I F;  2VUM F;  4C3I F;  5D4C E;  3S1M E;  1TWG E;  2A68 E;  3RZD F;  2JA5 E;  2PMZ K;  2NVX E;  5M5Y E;  1TWF E;  4A3D E;  2R93 F;  4ZH4 E;  3I4M E;  3FKI F;  4A3I F;  4Q5S E;  3H3V G;  2YU9 E;  5C44 F;  4A3F E;  3HOV E;  5D4D E;  1TWA F;  2R7Z F;  2O5I E;  3I4N E;  4BBR F;  4GZY E;  4A3B E;  5IYB E;  2NVT E;  3GTP F;  1ZYR E;  4A3E F;  1R9T E;  3GTL E;  4YFN E;  1I50 E;  1Y1V F;  4BY7 F;  5M5X E;  1Y1W F;  5IYD F;  4A93 E;  4A3K E;  3M3Y E;  4A3L E;  5IP7 E;  1SFO E;  4A3M E;  2NVQ E;  3EQL E;  3GTJ E;  2JA7 F;  2JA8 F;  4A3G F;  5IYC E;  4XLN E;  4BBS F;  5FLM F;  1SMY E;  3HOU F;  2JA6 E;  3M4O E;  1EIK A;  3HKZ H;  1IW7 E;  3RZO E;  3K7A F;  3S1R E;  2VUM E;  4C3I E;  5BYH E;  1I6H F;  1YNN K;  5C3E F;  3RZD E;  5FJ8 E;  3GTK F;  3S14 F;  4JK1 E;  2E2J E;  3FKI E;  4A3I E;  4X6A E;  3PO3 F;  1TWC E;  2R7Z E; 
#chains in the Genus database with same CATH homology
 4BY1 F;  3GTO F;  2NVY F;  4Y52 F;  4MEX E;  2E2H F;  1K83 F;  1I3Q F;  4KN7 E;  5M3M F;  1WCM F;  3HOW F;  3WOD E;  3CQZ F;  3HOX F;  3S15 F;  3S16 F;  4YFK E;  4G7Z E;  1TWH F;  4OIN E;  3PO2 F;  3HOY F;  4C3J F;  2WB1 I;  1TWG F;  2JA5 F;  2Y0S I;  5C4J F;  2NVX F;  1TWF F;  2A6H E;  4OIO E;  3GTM F;  3I4M F;  5IP9 F;  3HOV F;  5M5W F;  3S17 F;  5IYB F;  2NVT F;  4XLP E;  4AYB K;  1R9T F;  1QKL A;  2WAQ K;  5M5X F;  4KMU E;  1HQM E;  3HKZ K;  4A93 F;  3DXJ E;  4A3K F;  3M3Y F;  4A3L F;  4A3J F;  1SFO F;  4A3M F;  3GTJ F;  4LLG E;  2PPB E;  2CW0 E;  1I6V E;  5IYC F;  4G7H E;  4OIQ E;  3S2D F;  3HOZ F;  4Q4Z E;  5M3F F;  2R92 F;  3S1R F;  5C4X F;  5D4E E;  3S1M F;  4X6A F;  1YNJ K;  5FJ8 F;  4OIR E;  4KN4 E;  4LK0 E;  2KRX A;  5M5Y F;  2A6E E;  4OIP E;  4YFX E;  2E2J F;  4A3D F;  1TWC F;  4XSX E;  2YU9 F;  5E17 E;  4A3F F;  4YG2 E;  3S2H F;  4LK1 E;  5IPL E;  3I4N F;  4A3B F;  2A69 E;  3GTG F;  3S1N F;  4C3H F;  5TMF E;  3GTL F;  1I50 F;  4G7O E;  3S1Q F;  4A3C F;  4MQ9 E;  4XSZ E;  5IP7 F;  4LJZ E;  4Y7N F;  2NVQ F;  3H0G F;  5TMC E;  4QIW K;  2B63 F;  4BXX F;  4MEY E;  3M4O F;  5E18 E;  2JA6 F;  2O5J E;  3RZO F;  4C2M F;  2BE5 E;  2E2I F;  2VUM F;  4C3I F;  5D4C E;  2A68 E;  3RZD F;  2PMZ K;  2R93 F;  4ZH4 E;  3FKI F;  4A3I F;  4Q5S E;  3H3V G;  5C44 F;  5D4D E;  1TWA F;  2R7Z F;  2O5I E;  4GZY E;  4BBR F;  3GTP F;  1ZYR E;  4A3E F;  4YFN E;  1Y1V F;  4BY7 F;  1Y1W F;  5IYD F;  3EQL E;  2JA7 F;  2JA8 F;  4A3G F;  4XLN E;  4BBS F;  5FLM F;  1SMY E;  3HOU F;  1IW7 E;  3K7A F;  5BYH E;  1I6H F;  1YNN K;  5C3E F;  3GTK F;  3S14 F;  4JK1 E;  3PO3 F;  3GTQ F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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