4OIRE

Crystal structure of thermus thermophilus rna polymerase transcription initiation complex soaked with ge23077 and rifamycin sv
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
94
structure length
94
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
pubmed rcsb
molecule tags Transcription, transferase/antibiotic
source organism Thermus thermophilus
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 25
structure length 94
sequence length 94
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2014-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4oirE00
3S2DF 2E2HF 4KMUE 5E18E 4YFXE 2YU9F 3S15F 4BBSF 4KN7E 2NVXF 2R92F 2WB1I 4YG2E 3GTLF 2VUMF 5M5XF 1TWFF 2JA8F 3CQZF 5TMFE 4A3KF 2NVQF 4A3CF 4YFNE 1Y1VF 2E2JF 2BE5E 5IP7F 4XLNE 2PPBE 4LLGE 5IYDF 1WCMF 2Y0SI 4X6AF 5M3FF 5M3MF 3HOYF 4A3MF 3I4NF 4GZYE 2WAQK 4AYBK 3H3VG 5TMCE 5M5WF 5C4XF 4OIRE 1QKLA 3WODE 3GTGF 3S1QF 4A3DF 4A3LF 4JK1E 3GTPF 2PMZK 3HOZF 2O5JE 3S16F 3S1RF 5IP9F 3RZDF 5IYBF 3GTOF 4A3IF 2NVTF 5D4EE 2JA7F 4LK0E 4C3HF 3GTMF 3GTQF 3S1NF 3M3YF 4C2MF 5IYCF 5E17E 3S1MF 5C44F 4A3EF 3M4OF 4YFKE 4C3JF 1Y1WF 4C3IF 1SFOF 4KN4E 4A3JF 4LJZE 1YNNK 2R7ZF 4ZH4E 1HQME 4MEYE 4OIQE 4Q4ZE 2A69E 3DXJE 3HOUF 3RZOF 5BYHE 2A6HE 1TWAF 4XLPE 5D4DE 1R9TF 2JA5F 3PO3F 4G7OE 1YNJK 3HOWF 4A3GF 5C4JF 2JA6F 1ZYRE 2CW0E 4Y52F 5FLMF 4XSZE 4Q5SE 4Y7NF 3GTJF 5C3EF 1I6VE 2E2IF 3HOVF 5FJ8F 4OIOE 2B63F 4BY7F 4BXXF 3S17F 1TWGF 4BY1F 1I6HF 4A3FF 3FKIF 1I3QF 4XSXE 1TWHF 1IW7E 1I50F 2R93F 4OINE 2A6EE 2A68E 2O5IE 1TWCF 3S14F 3S2HF 4LK1E 5D4CE 3H0GF 5IPLE 1SMYE 4G7HE 3HKZK 3HOXF 4A93F 4G7ZE 5M5YF 3EQLE 4A3BF 3PO2F 4MEXE 2NVYF 1K83F 4BBRF 4MQ9E 4OIPE 3I4MF 3K7AF 3GTKF
chains in the Genus database with same CATH superfamily
1EIKA 4C2ME 5IYCE 3S2DF 3GTJE 2E2HF 4KMUE 5E18E 4YFXE 4A3EE 2E2IE 2YU9F 4KN7E 2NVXF 3M4OE 2R92F 4C3JE 2WB1I 1Y1WE 4C3IE 4YG2E 1SFOE 2VUMF 3GTLF 4A3JE 5M5XF 1TWFF 2JA8F 3CQZF 5TMFE 4A3KF 2R7ZE 2NVQF 4A3CF 4QIWH 4YFNE 1Y1VF 2E2JF 2BE5E 5IP7F 4XLNE 2PPBE 4LLGE 5IYDF 1WCMF 2Y0SI 3H3VF 4X6AF 5M3FF 5M3MF 3HOUE 3HOYF 4A3MF 2JA5E 3I4NF 2WAQK 1R9TE 3PO3E 4GZYE 4AYBK 3H3VG 5TMCE 4AYBH 5M5WF 4A3GE 5C4XF 4OIRE 1QKLA 3WODE 3GTGF 3S1QF 4A3DF 5C4JE 4A3LF 4JK1E 3GTPF 2PMZK 5FLME 3HOZF 2O5JE 3S16F 4Y52E 3S1RF 5IP9F 4Y7NE 3RZDF 5IYBF 5C3EE 4A3IF 3GTOF 2NVTF 5D4EE 2NVYE 5FJ8E 2JA7F 2B63E 4BBRE 3S15F 4LK0E 4BY7E 4BXXE 3S17E 4C3HF 3GTMF 1TWGE 4BY1E 3K7AE 3GTQF 3S1NF 1I6HE 4A3FE 3FKIE 3M3YF 4QIWK 1I3QE 4C2MF 1TWHE 5IYCF 3S1MF 5E17E 1I50E 5C44F 4A3EF 3M4OF 4YFKE 3S15E 3S2DE 2R93E 4C3JF 1Y1WF 4C3IF 1SFOF 1TWCE 4KN4E 4A3JF 4LJZE 3GTLE 4BBSF 3S14E 1YNNK 2R7ZF 4ZH4E 3S2HE 1HQME 4MEYE 4OIQE 3GTQE 3H0GE 4Q4ZE 3HOXE 2A69E 3DXJE 4A93E 3HOUF 3RZOF 5BYHE 2A6HE 1TWAF 5M3ME 5M5YE 4XLPE 5D4DE 1R9TF 2JA5F 3PO3F 3PO2E 1YNJK 3HOWF 4A3BE 4G7OE 1K83E 4A3GF 2WB1H 3I4ME 3GTGE 5C4JF 2JA6F 1ZYRE 2CW0E 4Y52F 5FLMF 3HKZH 4XSZE 3GTKE 3HOVE 4Q5SE 4Y7NF 3GTJF 5C3EF 3S1RE 1I6VE 2E2IF 3HOVF 2E2HE 3GTOE 4BBSE 5FJ8F 2YU9E 4OIOE 2B63F 2NVXE 2Y0SH 4BY7F 2JA7E 4BXXF 2R92E 3S17F 1TWGF 4BY1F 2VUME 5M5XE 1TWFE 3FKIF 4A3FF 3CQZE 1I6HF 4A3KE 1I3QF 4XSXE 1TWHF 2NVQE 2KRXA 1IW7E 1I50F 4A3CE 2R93F 5C44E 1Y1VE 2E2JE 5IP7E 4OINE 2A6EE 2A68E 5IYDE 1WCME 2O5IE 1TWCF 4X6AE 5M3FE 3HOYE 3S14F 4A3ME 3I4NE 2JA8E 3S2HF 4LK1E 1DZFA 5D4CE 3H0GF 5IPLE 5M5WE 5C4XE 1SMYE 3S1QE 4A3DE 4G7HE 3HKZK 3HOXF 4A93F 4A3LE 4G7ZE 3GTPE 3HOZE 5M5YF 3S16E 3EQLE 4A3BF 3RZOE 5IP9E 1TWAE 5IYBE 3RZDE 4MEXE 4A3IE 3PO2F 2NVYF 2WAQH 2NVTE 1K83F 4BBRF 3HOWE 4MQ9E 4OIPE 3I4MF 3K7AF 4C3HE 2JA6E 3GTME 3S1ME 3S1NE 3GTKF 3M3YE 2PMZH
chains in the Genus database with same CATH topology
3S2DF 2E2HF 4KMUE 5E18E 4YFXE 2YU9F 3S15F 4BBSF 4KN7E 2NVXF 2R92F 2WB1I 4YG2E 3GTLF 2VUMF 5M5XF 1TWFF 2JA8F 3CQZF 5TMFE 4A3KF 2NVQF 4A3CF 4YFNE 1Y1VF 2E2JF 2BE5E 5IP7F 4XLNE 2PPBE 4LLGE 5IYDF 1WCMF 2Y0SI 4X6AF 5M3FF 5M3MF 3HOYF 4A3MF 3I4NF 4GZYE 2WAQK 4AYBK 3H3VG 5TMCE 5M5WF 5C4XF 4OIRE 1QKLA 3WODE 3GTGF 3S1QF 4A3DF 4A3LF 4JK1E 3GTPF 2PMZK 3HOZF 2O5JE 3S16F 3S1RF 5IP9F 3RZDF 5IYBF 3GTOF 4A3IF 2NVTF 5D4EE 2JA7F 4LK0E 4C3HF 3GTMF 3GTQF 3S1NF 3M3YF 4QIWK 4C2MF 5IYCF 5E17E 3S1MF 5C44F 4A3EF 3M4OF 4YFKE 4C3JF 1Y1WF 4C3IF 1SFOF 4KN4E 4A3JF 4LJZE 1YNNK 2R7ZF 4ZH4E 1HQME 4MEYE 4OIQE 4Q4ZE 2A69E 3DXJE 3HOUF 3RZOF 5BYHE 2A6HE 1TWAF 4XLPE 5D4DE 1R9TF 2JA5F 3PO3F 4G7OE 1YNJK 3HOWF 4A3GF 5C4JF 2JA6F 1ZYRE 2CW0E 4Y52F 5FLMF 4XSZE 4Q5SE 4Y7NF 3GTJF 5C3EF 1I6VE 2E2IF 3HOVF 5FJ8F 4OIOE 2B63F 4BY7F 4BXXF 3S17F 1TWGF 4BY1F 1I6HF 4A3FF 3FKIF 1I3QF 4XSXE 1TWHF 2KRXA 1IW7E 1I50F 2R93F 4OINE 2A6EE 2A68E 2O5IE 1TWCF 3S14F 3S2HF 4LK1E 5D4CE 3H0GF 5IPLE 1SMYE 4G7HE 3HKZK 3HOXF 4A93F 4G7ZE 5M5YF 3EQLE 4A3BF 3PO2F 4MEXE 2NVYF 1K83F 4BBRF 4MQ9E 4OIPE 3I4MF 3K7AF 3GTKF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S2D F;  2E2H F;  4KMU E;  5E18 E;  4YFX E;  2YU9 F;  3S15 F;  4BBS F;  4KN7 E;  2NVX F;  2R92 F;  2WB1 I;  4YG2 E;  3GTL F;  2VUM F;  5M5X F;  1TWF F;  2JA8 F;  3CQZ F;  5TMF E;  4A3K F;  2NVQ F;  4A3C F;  4YFN E;  1Y1V F;  2E2J F;  2BE5 E;  5IP7 F;  4XLN E;  2PPB E;  4LLG E;  5IYD F;  1WCM F;  2Y0S I;  4X6A F;  5M3F F;  5M3M F;  3HOY F;  4A3M F;  3I4N F;  4GZY E;  2WAQ K;  4AYB K;  3H3V G;  5TMC E;  5M5W F;  5C4X F;  4OIR E;  1QKL A;  3WOD E;  3GTG F;  3S1Q F;  4A3D F;  4A3L F;  4JK1 E;  3GTP F;  2PMZ K;  3HOZ F;  2O5J E;  3S16 F;  3S1R F;  5IP9 F;  3RZD F;  5IYB F;  3GTO F;  4A3I F;  2NVT F;  5D4E E;  2JA7 F;  4LK0 E;  4C3H F;  3GTM F;  3GTQ F;  3S1N F;  3M3Y F;  4C2M F;  5IYC F;  5E17 E;  3S1M F;  5C44 F;  4A3E F;  3M4O F;  4YFK E;  4C3J F;  1Y1W F;  4C3I F;  1SFO F;  4KN4 E;  4A3J F;  4LJZ E;  1YNN K;  2R7Z F;  4ZH4 E;  1HQM E;  4MEY E;  4OIQ E;  4Q4Z E;  2A69 E;  3DXJ E;  3HOU F;  3RZO F;  5BYH E;  2A6H E;  1TWA F;  4XLP E;  5D4D E;  1R9T F;  2JA5 F;  3PO3 F;  4G7O E;  1YNJ K;  3HOW F;  4A3G F;  5C4J F;  2JA6 F;  1ZYR E;  2CW0 E;  4Y52 F;  5FLM F;  4XSZ E;  4Q5S E;  4Y7N F;  3GTJ F;  5C3E F;  1I6V E;  2E2I F;  3HOV F;  5FJ8 F;  4OIO E;  2B63 F;  4BY7 F;  4BXX F;  3S17 F;  1TWG F;  4BY1 F;  1I6H F;  4A3F F;  3FKI F;  1I3Q F;  4XSX E;  1TWH F;  1IW7 E;  1I50 F;  2R93 F;  4OIN E;  2A6E E;  2A68 E;  2O5I E;  1TWC F;  3S14 F;  3S2H F;  4LK1 E;  5D4C E;  3H0G F;  5IPL E;  1SMY E;  4G7H E;  3HKZ K;  3HOX F;  4A93 F;  4G7Z E;  5M5Y F;  3EQL E;  4A3B F;  3PO2 F;  4MEX E;  2NVY F;  1K83 F;  4BBR F;  4MQ9 E;  4OIP E;  3I4M F;  3K7A F;  3GTK F; 
#chains in the Genus database with same CATH topology
 1EIK A;  4C2M E;  5IYC E;  3S2D F;  3GTJ E;  2E2H F;  4KMU E;  5E18 E;  4YFX E;  4A3E E;  2E2I E;  2YU9 F;  4KN7 E;  2NVX F;  3M4O E;  2R92 F;  4C3J E;  2WB1 I;  1Y1W E;  4C3I E;  4YG2 E;  1SFO E;  2VUM F;  3GTL F;  4A3J E;  5M5X F;  1TWF F;  2JA8 F;  3CQZ F;  5TMF E;  4A3K F;  2R7Z E;  2NVQ F;  4A3C F;  4QIW H;  4YFN E;  1Y1V F;  2E2J F;  2BE5 E;  5IP7 F;  4XLN E;  2PPB E;  4LLG E;  5IYD F;  1WCM F;  2Y0S I;  3H3V F;  4X6A F;  5M3F F;  5M3M F;  3HOU E;  3HOY F;  4A3M F;  2JA5 E;  3I4N F;  2WAQ K;  1R9T E;  3PO3 E;  4GZY E;  4AYB K;  3H3V G;  5TMC E;  4AYB H;  5M5W F;  4A3G E;  5C4X F;  4OIR E;  1QKL A;  3WOD E;  3GTG F;  3S1Q F;  4A3D F;  5C4J E;  4A3L F;  4JK1 E;  3GTP F;  2PMZ K;  5FLM E;  3HOZ F;  2O5J E;  3S16 F;  4Y52 E;  3S1R F;  5IP9 F;  4Y7N E;  3RZD F;  5IYB F;  5C3E E;  4A3I F;  3GTO F;  2NVT F;  5D4E E;  2NVY E;  5FJ8 E;  2JA7 F;  2B63 E;  4BBR E;  3S15 F;  4LK0 E;  4BY7 E;  4BXX E;  3S17 E;  4C3H F;  3GTM F;  1TWG E;  4BY1 E;  3K7A E;  3GTQ F;  3S1N F;  1I6H E;  4A3F E;  3FKI E;  3M3Y F;  4QIW K;  1I3Q E;  4C2M F;  1TWH E;  5IYC F;  3S1M F;  5E17 E;  1I50 E;  5C44 F;  4A3E F;  3M4O F;  4YFK E;  3S15 E;  3S2D E;  2R93 E;  4C3J F;  1Y1W F;  4C3I F;  1SFO F;  1TWC E;  4KN4 E;  4A3J F;  4LJZ E;  3GTL E;  4BBS F;  3S14 E;  1YNN K;  2R7Z F;  4ZH4 E;  3S2H E;  1HQM E;  4MEY E;  4OIQ E;  3GTQ E;  3H0G E;  4Q4Z E;  3HOX E;  2A69 E;  3DXJ E;  4A93 E;  3HOU F;  3RZO F;  5BYH E;  2A6H E;  1TWA F;  5M3M E;  5M5Y E;  4XLP E;  5D4D E;  1R9T F;  2JA5 F;  3PO3 F;  3PO2 E;  1YNJ K;  3HOW F;  4A3B E;  4G7O E;  1K83 E;  4A3G F;  2WB1 H;  3I4M E;  3GTG E;  5C4J F;  2JA6 F;  1ZYR E;  2CW0 E;  4Y52 F;  5FLM F;  3HKZ H;  4XSZ E;  3GTK E;  3HOV E;  4Q5S E;  4Y7N F;  3GTJ F;  5C3E F;  3S1R E;  1I6V E;  2E2I F;  3HOV F;  2E2H E;  3GTO E;  4BBS E;  5FJ8 F;  2YU9 E;  4OIO E;  2B63 F;  2NVX E;  2Y0S H;  4BY7 F;  2JA7 E;  4BXX F;  2R92 E;  3S17 F;  1TWG F;  4BY1 F;  2VUM E;  5M5X E;  1TWF E;  3FKI F;  4A3F F;  3CQZ E;  1I6H F;  4A3K E;  1I3Q F;  4XSX E;  1TWH F;  2NVQ E;  2KRX A;  1IW7 E;  1I50 F;  4A3C E;  2R93 F;  5C44 E;  1Y1V E;  2E2J E;  5IP7 E;  4OIN E;  2A6E E;  2A68 E;  5IYD E;  1WCM E;  2O5I E;  1TWC F;  4X6A E;  5M3F E;  3HOY E;  3S14 F;  4A3M E;  3I4N E;  2JA8 E;  3S2H F;  4LK1 E;  1DZF A;  5D4C E;  3H0G F;  5IPL E;  5M5W E;  5C4X E;  1SMY E;  3S1Q E;  4A3D E;  4G7H E;  3HKZ K;  3HOX F;  4A93 F;  4A3L E;  4G7Z E;  3GTP E;  3HOZ E;  5M5Y F;  3S16 E;  3EQL E;  4A3B F;  3RZO E;  5IP9 E;  1TWA E;  5IYB E;  3RZD E;  4MEX E;  4A3I E;  3PO2 F;  2NVY F;  2WAQ H;  2NVT E;  1K83 F;  4BBR F;  3HOW E;  4MQ9 E;  4OIP E;  3I4M F;  3K7A F;  4C3H E;  2JA6 E;  3GTM E;  3S1M E;  3S1N E;  3GTK F;  3M3Y E;  2PMZ H; 
#chains in the Genus database with same CATH homology
 3S2D F;  2E2H F;  4KMU E;  5E18 E;  4YFX E;  2YU9 F;  3S15 F;  4BBS F;  4KN7 E;  2NVX F;  2R92 F;  2WB1 I;  4YG2 E;  3GTL F;  2VUM F;  5M5X F;  1TWF F;  2JA8 F;  3CQZ F;  5TMF E;  4A3K F;  2NVQ F;  4A3C F;  4YFN E;  1Y1V F;  2E2J F;  2BE5 E;  5IP7 F;  4XLN E;  2PPB E;  4LLG E;  5IYD F;  1WCM F;  2Y0S I;  4X6A F;  5M3F F;  5M3M F;  3HOY F;  4A3M F;  3I4N F;  4GZY E;  2WAQ K;  4AYB K;  3H3V G;  5TMC E;  5M5W F;  5C4X F;  4OIR E;  1QKL A;  3WOD E;  3GTG F;  3S1Q F;  4A3D F;  4A3L F;  4JK1 E;  3GTP F;  2PMZ K;  3HOZ F;  2O5J E;  3S16 F;  3S1R F;  5IP9 F;  3RZD F;  5IYB F;  3GTO F;  4A3I F;  2NVT F;  5D4E E;  2JA7 F;  4LK0 E;  4C3H F;  3GTM F;  3GTQ F;  3S1N F;  3M3Y F;  4QIW K;  4C2M F;  5IYC F;  5E17 E;  3S1M F;  5C44 F;  4A3E F;  3M4O F;  4YFK E;  4C3J F;  1Y1W F;  4C3I F;  1SFO F;  4KN4 E;  4A3J F;  4LJZ E;  1YNN K;  2R7Z F;  4ZH4 E;  1HQM E;  4MEY E;  4OIQ E;  4Q4Z E;  2A69 E;  3DXJ E;  3HOU F;  3RZO F;  5BYH E;  2A6H E;  1TWA F;  4XLP E;  5D4D E;  1R9T F;  2JA5 F;  3PO3 F;  4G7O E;  1YNJ K;  3HOW F;  4A3G F;  5C4J F;  2JA6 F;  1ZYR E;  2CW0 E;  4Y52 F;  5FLM F;  4XSZ E;  4Q5S E;  4Y7N F;  3GTJ F;  5C3E F;  1I6V E;  2E2I F;  3HOV F;  5FJ8 F;  4OIO E;  2B63 F;  4BY7 F;  4BXX F;  3S17 F;  1TWG F;  4BY1 F;  1I6H F;  4A3F F;  3FKI F;  1I3Q F;  4XSX E;  1TWH F;  2KRX A;  1IW7 E;  1I50 F;  2R93 F;  4OIN E;  2A6E E;  2A68 E;  2O5I E;  1TWC F;  3S14 F;  3S2H F;  4LK1 E;  5D4C E;  3H0G F;  5IPL E;  1SMY E;  4G7H E;  3HKZ K;  3HOX F;  4A93 F;  4G7Z E;  5M5Y F;  3EQL E;  4A3B F;  3PO2 F;  4MEX E;  2NVY F;  1K83 F;  4BBR F;  4MQ9 E;  4OIP E;  3I4M F;  3K7A F;  3GTK F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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