4PTIA

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
molecule tags Proteinase inhibitor (trypsin)
source organism Bos taurus
molecule keywords TRYPSIN INHIBITOR
total genus 10
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4ptiA00
1BTHP 1LD5A 1MTND 3M7QB 1JV9A 1ZR0B 3P92E 1P2JI 2HEXA 4BQDA 3AUIA 9PTIA 3FP8I 3OTJI 1T8OB 4ISNB 2FTLI 3LDIA 1OA55 1BIKA 2LFKA 3CI7A 2M01A 4NTYB 3TGII 3T62D 4NTWB 1JC6A 1TPAI 1BZ5A 1BPTA 1DEMA 1TAPA 1NAGA 3BTQI 3TGKI 1F5RI 1P2QB 3LDMA 1K6UA 1F7ZI 1BRBI 2W8XA 2M99A 3L3TE 2LFLA 2KNTA 1DTXA 1BF0A 1LD6A 1FY8I 2FI5I 1JV8A 2JOTA 1T7CB 4DTGK 1AALA 1G6XA 1YLCB 3GYMI 2UUYB 3BTEI 8PTIA 3BTGI 1P2KI 1KTHA 1TFXC 3FP7J 1ADZA 2ODYE 1BUNB 1BTIA 4TPII 1D0DA 4DG4C 1BRCI 3AUGA 1P2NB 3FP6I 5JB7A 2DDIA 4U30W 2FI4I 1P2MB 4WXVC 3BTMI 3P95E 4ISLB 4PTIA 1CA0D 3AUCA 1QLQA 2ZJXA 1OA65 1BZXI 3D65I 3TPII 4BD9B 3UIRC 5JB4A 4NTXB 2R9PE 1AAPA 5C67C 1ZJDB 1T8NB 2TGPI 1DENA 3WNYA 3BTTI 1PITA 1T8MB 1BPIA 1Y62A 2ZVXA 4WWYC 1EJMB 2PTCI 3BTFI 2DDJA 3BTHI 3UOUB 1UUBA 6PTIA 7PTIA 3LDJA 2CA7A 5JB6A 1KUNA 4Y0YI 1KNTA 2J6DA 1FAKI 1YLDB 2IJOI 4Y0ZI 5PTIA 4Y11I 2FTMB 1P2OB 1YKTB 3BTKI 1D0DB 1DTKA 1T8LB 2TPII 4Y10I 1CBWD 1TAWB 1TCPA 1KIGI 4BNRI 5JB5A 1TOCR 1SHPA 3BTDI 3L33E 2FI3I 3OFWA 3TGJI 3AUBA 3U1JE 1YC0I 1BHCA 3BTWI 1IRHA 2UUXA 1B0CA 1CO7I 3AUEA 1EAWB 1P2II 3AUHA 1UUAA 2KCRA 4ISOB 2RA3C 3AUDA 3BYBA 1FANA 2KAII 4U32X
chains in the Genus database with same CATH superfamily
1BTHP 1LD5A 1MTND 3M7QB 1JV9A 1ZR0B 3P92E 1P2JI 2HEXA 4BQDA 3AUIA 9PTIA 3FP8I 3OTJI 1T8OB 4ISNB 2FTLI 3LDIA 1OA55 1BIKA 2LFKA 3CI7A 2M01A 4NTYB 3TGII 3T62D 4NTWB 1JC6A 1TPAI 1BZ5A 1BPTA 1DEMA 1TAPA 1NAGA 3BTQI 3TGKI 1F5RI 1P2QB 3LDMA 1K6UA 1F7ZI 1BRBI 2W8XA 2M99A 3L3TE 2LFLA 2KNTA 1DTXA 1BF0A 1LD6A 1FY8I 2FI5I 1JV8A 2JOTA 1T7CB 4DTGK 1AALA 1G6XA 1YLCB 3GYMI 2UUYB 3BTEI 8PTIA 3BTGI 1P2KI 1KTHA 1TFXC 3FP7J 1ADZA 2ODYE 1BUNB 1BTIA 4TPII 1D0DA 4DG4C 1BRCI 3AUGA 1P2NB 3FP6I 5JB7A 2DDIA 4U30W 2FI4I 1P2MB 4WXVC 3BTMI 3P95E 4ISLB 4PTIA 1CA0D 3AUCA 1QLQA 2ZJXA 1OA65 1BZXI 3D65I 3TPII 4BD9B 3UIRC 5JB4A 4NTXB 2R9PE 1AAPA 5C67C 1ZJDB 1T8NB 2TGPI 1DENA 3WNYA 3BTTI 1PITA 1T8MB 1BPIA 1Y62A 2ZVXA 4WWYC 1EJMB 2PTCI 3BTFI 2DDJA 3BTHI 3UOUB 1UUBA 6PTIA 7PTIA 3LDJA 2CA7A 5JB6A 1KUNA 4Y0YI 1KNTA 2J6DA 1FAKI 1YLDB 2IJOI 4Y0ZI 5PTIA 4Y11I 2FTMB 1P2OB 1YKTB 3BTKI 1D0DB 1DTKA 1T8LB 2TPII 4Y10I 1CBWD 1TAWB 1TCPA 1KIGI 4BNRI 5JB5A 1TOCR 1SHPA 3BTDI 3L33E 2FI3I 3OFWA 3TGJI 3AUBA 3U1JE 1YC0I 1BHCA 3BTWI 1IRHA 2UUXA 1B0CA 1CO7I 3AUEA 1EAWB 1P2II 3AUHA 1UUAA 2KCRA 4ISOB 2RA3C 3AUDA 3BYBA 1FANA 2KAII 4U32X
chains in the Genus database with same CATH topology
1BTHP 1LD5A 1MTND 3M7QB 1JV9A 1ZR0B 3P92E 1P2JI 2HEXA 4BQDA 3AUIA 9PTIA 3FP8I 3OTJI 1T8OB 4ISNB 2FTLI 3LDIA 1OA55 1BIKA 2LFKA 3CI7A 2M01A 4NTYB 3TGII 3T62D 4NTWB 1JC6A 1TPAI 1BZ5A 1BPTA 1DEMA 1TAPA 1NAGA 3BTQI 3TGKI 1F5RI 1P2QB 3LDMA 1K6UA 1F7ZI 1BRBI 2W8XA 2M99A 3L3TE 2LFLA 2KNTA 1DTXA 1BF0A 1LD6A 1FY8I 2FI5I 1JV8A 2JOTA 1T7CB 4DTGK 1AALA 1G6XA 1YLCB 3GYMI 2UUYB 3BTEI 8PTIA 3BTGI 1P2KI 1KTHA 1TFXC 3FP7J 1ADZA 2ODYE 1BUNB 1BTIA 4TPII 1D0DA 4DG4C 1BRCI 3AUGA 1P2NB 3FP6I 5JB7A 2DDIA 4U30W 2FI4I 1P2MB 4WXVC 3BTMI 3P95E 4ISLB 4PTIA 1CA0D 3AUCA 1QLQA 2ZJXA 1OA65 1BZXI 3D65I 3TPII 4BD9B 3UIRC 5JB4A 4NTXB 2R9PE 1AAPA 5C67C 1ZJDB 1T8NB 2TGPI 1DENA 3WNYA 3BTTI 1PITA 1T8MB 1BPIA 1Y62A 2ZVXA 4WWYC 1EJMB 2PTCI 3BTFI 2DDJA 3BTHI 3UOUB 1UUBA 6PTIA 7PTIA 3LDJA 2CA7A 5JB6A 1KUNA 4Y0YI 1KNTA 2J6DA 1FAKI 1YLDB 2IJOI 4Y0ZI 5PTIA 4Y11I 2FTMB 1P2OB 1YKTB 3BTKI 1D0DB 1DTKA 1T8LB 2TPII 4Y10I 1CBWD 1TAWB 1TCPA 1KIGI 4BNRI 5JB5A 1TOCR 1SHPA 3BTDI 3L33E 2FI3I 3OFWA 3TGJI 3AUBA 3U1JE 1YC0I 1BHCA 3BTWI 1IRHA 2UUXA 1B0CA 1CO7I 3AUEA 1EAWB 1P2II 3AUHA 1UUAA 2KCRA 4ISOB 2RA3C 3AUDA 3BYBA 1FANA 2KAII 4U32X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BTH P;  1LD5 A;  1MTN D;  3M7Q B;  1JV9 A;  1ZR0 B;  3P92 E;  1P2J I;  2HEX A;  4BQD A;  3AUI A;  9PTI A;  3FP8 I;  3OTJ I;  1T8O B;  4ISN B;  2FTL I;  3LDI A;  1OA5 5;  1BIK A;  2LFK A;  3CI7 A;  2M01 A;  4NTY B;  3TGI I;  3T62 D;  4NTW B;  1JC6 A;  1TPA I;  1BZ5 A;  1BPT A;  1DEM A;  1TAP A;  1NAG A;  3BTQ I;  3TGK I;  1F5R I;  1P2Q B;  3LDM A;  1K6U A;  1F7Z I;  1BRB I;  2W8X A;  2M99 A;  3L3T E;  2LFL A;  2KNT A;  1DTX A;  1BF0 A;  1LD6 A;  1FY8 I;  2FI5 I;  1JV8 A;  2JOT A;  1T7C B;  4DTG K;  1AAL A;  1G6X A;  1YLC B;  3GYM I;  2UUY B;  3BTE I;  8PTI A;  3BTG I;  1P2K I;  1KTH A;  1TFX C;  3FP7 J;  1ADZ A;  2ODY E;  1BUN B;  1BTI A;  4TPI I;  1D0D A;  4DG4 C;  1BRC I;  3AUG A;  1P2N B;  3FP6 I;  5JB7 A;  2DDI A;  4U30 W;  2FI4 I;  1P2M B;  4WXV C;  3BTM I;  3P95 E;  4ISL B;  4PTI A;  1CA0 D;  3AUC A;  1QLQ A;  2ZJX A;  1OA6 5;  1BZX I;  3D65 I;  3TPI I;  4BD9 B;  3UIR C;  5JB4 A;  4NTX B;  2R9P E;  1AAP A;  5C67 C;  1ZJD B;  1T8N B;  2TGP I;  1DEN A;  3WNY A;  3BTT I;  1PIT A;  1T8M B;  1BPI A;  1Y62 A;  2ZVX A;  4WWY C;  1EJM B;  2PTC I;  3BTF I;  2DDJ A;  3BTH I;  3UOU B;  1UUB A;  6PTI A;  7PTI A;  3LDJ A;  2CA7 A;  5JB6 A;  1KUN A;  4Y0Y I;  1KNT A;  2J6D A;  1FAK I;  1YLD B;  2IJO I;  4Y0Z I;  5PTI A;  4Y11 I;  2FTM B;  1P2O B;  1YKT B;  3BTK I;  1D0D B;  1DTK A;  1T8L B;  2TPI I;  4Y10 I;  1CBW D;  1TAW B;  1TCP A;  1KIG I;  4BNR I;  5JB5 A;  1TOC R;  1SHP A;  3BTD I;  3L33 E;  2FI3 I;  3OFW A;  3TGJ I;  3AUB A;  3U1J E;  1YC0 I;  1BHC A;  3BTW I;  1IRH A;  2UUX A;  1B0C A;  1CO7 I;  3AUE A;  1EAW B;  1P2I I;  3AUH A;  1UUA A;  2KCR A;  4ISO B;  2RA3 C;  3AUD A;  3BYB A;  1FAN A;  2KAI I;  4U32 X; 
#chains in the Genus database with same CATH topology
 1BTH P;  1LD5 A;  1MTN D;  3M7Q B;  1JV9 A;  1ZR0 B;  3P92 E;  1P2J I;  2HEX A;  4BQD A;  3AUI A;  9PTI A;  3FP8 I;  3OTJ I;  1T8O B;  4ISN B;  2FTL I;  3LDI A;  1OA5 5;  1BIK A;  2LFK A;  3CI7 A;  2M01 A;  4NTY B;  3TGI I;  3T62 D;  4NTW B;  1JC6 A;  1TPA I;  1BZ5 A;  1BPT A;  1DEM A;  1TAP A;  1NAG A;  3BTQ I;  3TGK I;  1F5R I;  1P2Q B;  3LDM A;  1K6U A;  1F7Z I;  1BRB I;  2W8X A;  2M99 A;  3L3T E;  2LFL A;  2KNT A;  1DTX A;  1BF0 A;  1LD6 A;  1FY8 I;  2FI5 I;  1JV8 A;  2JOT A;  1T7C B;  4DTG K;  1AAL A;  1G6X A;  1YLC B;  3GYM I;  2UUY B;  3BTE I;  8PTI A;  3BTG I;  1P2K I;  1KTH A;  1TFX C;  3FP7 J;  1ADZ A;  2ODY E;  1BUN B;  1BTI A;  4TPI I;  1D0D A;  4DG4 C;  1BRC I;  3AUG A;  1P2N B;  3FP6 I;  5JB7 A;  2DDI A;  4U30 W;  2FI4 I;  1P2M B;  4WXV C;  3BTM I;  3P95 E;  4ISL B;  4PTI A;  1CA0 D;  3AUC A;  1QLQ A;  2ZJX A;  1OA6 5;  1BZX I;  3D65 I;  3TPI I;  4BD9 B;  3UIR C;  5JB4 A;  4NTX B;  2R9P E;  1AAP A;  5C67 C;  1ZJD B;  1T8N B;  2TGP I;  1DEN A;  3WNY A;  3BTT I;  1PIT A;  1T8M B;  1BPI A;  1Y62 A;  2ZVX A;  4WWY C;  1EJM B;  2PTC I;  3BTF I;  2DDJ A;  3BTH I;  3UOU B;  1UUB A;  6PTI A;  7PTI A;  3LDJ A;  2CA7 A;  5JB6 A;  1KUN A;  4Y0Y I;  1KNT A;  2J6D A;  1FAK I;  1YLD B;  2IJO I;  4Y0Z I;  5PTI A;  4Y11 I;  2FTM B;  1P2O B;  1YKT B;  3BTK I;  1D0D B;  1DTK A;  1T8L B;  2TPI I;  4Y10 I;  1CBW D;  1TAW B;  1TCP A;  1KIG I;  4BNR I;  5JB5 A;  1TOC R;  1SHP A;  3BTD I;  3L33 E;  2FI3 I;  3OFW A;  3TGJ I;  3AUB A;  3U1J E;  1YC0 I;  1BHC A;  3BTW I;  1IRH A;  2UUX A;  1B0C A;  1CO7 I;  3AUE A;  1EAW B;  1P2I I;  3AUH A;  1UUA A;  2KCR A;  4ISO B;  2RA3 C;  3AUD A;  3BYB A;  1FAN A;  2KAI I;  4U32 X; 
#chains in the Genus database with same CATH homology
 1BTH P;  1LD5 A;  1MTN D;  3M7Q B;  1JV9 A;  1ZR0 B;  3P92 E;  1P2J I;  2HEX A;  4BQD A;  3AUI A;  9PTI A;  3FP8 I;  3OTJ I;  1T8O B;  4ISN B;  2FTL I;  3LDI A;  1OA5 5;  1BIK A;  2LFK A;  3CI7 A;  2M01 A;  4NTY B;  3TGI I;  3T62 D;  4NTW B;  1JC6 A;  1TPA I;  1BZ5 A;  1BPT A;  1DEM A;  1TAP A;  1NAG A;  3BTQ I;  3TGK I;  1F5R I;  1P2Q B;  3LDM A;  1K6U A;  1F7Z I;  1BRB I;  2W8X A;  2M99 A;  3L3T E;  2LFL A;  2KNT A;  1DTX A;  1BF0 A;  1LD6 A;  1FY8 I;  2FI5 I;  1JV8 A;  2JOT A;  1T7C B;  4DTG K;  1AAL A;  1G6X A;  1YLC B;  3GYM I;  2UUY B;  3BTE I;  8PTI A;  3BTG I;  1P2K I;  1KTH A;  1TFX C;  3FP7 J;  1ADZ A;  2ODY E;  1BUN B;  1BTI A;  4TPI I;  1D0D A;  4DG4 C;  1BRC I;  3AUG A;  1P2N B;  3FP6 I;  5JB7 A;  2DDI A;  4U30 W;  2FI4 I;  1P2M B;  4WXV C;  3BTM I;  3P95 E;  4ISL B;  4PTI A;  1CA0 D;  3AUC A;  1QLQ A;  2ZJX A;  1OA6 5;  1BZX I;  3D65 I;  3TPI I;  4BD9 B;  3UIR C;  5JB4 A;  4NTX B;  2R9P E;  1AAP A;  5C67 C;  1ZJD B;  1T8N B;  2TGP I;  1DEN A;  3WNY A;  3BTT I;  1PIT A;  1T8M B;  1BPI A;  1Y62 A;  2ZVX A;  4WWY C;  1EJM B;  2PTC I;  3BTF I;  2DDJ A;  3BTH I;  3UOU B;  1UUB A;  6PTI A;  7PTI A;  3LDJ A;  2CA7 A;  5JB6 A;  1KUN A;  4Y0Y I;  1KNT A;  2J6D A;  1FAK I;  1YLD B;  2IJO I;  4Y0Z I;  5PTI A;  4Y11 I;  2FTM B;  1P2O B;  1YKT B;  3BTK I;  1D0D B;  1DTK A;  1T8L B;  2TPI I;  4Y10 I;  1CBW D;  1TAW B;  1TCP A;  1KIG I;  4BNR I;  5JB5 A;  1TOC R;  1SHP A;  3BTD I;  3L33 E;  2FI3 I;  3OFW A;  3TGJ I;  3AUB A;  3U1J E;  1YC0 I;  1BHC A;  3BTW I;  1IRH A;  2UUX A;  1B0C A;  1CO7 I;  3AUE A;  1EAW B;  1P2I I;  3AUH A;  1UUA A;  2KCR A;  4ISO B;  2RA3 C;  3AUD A;  3BYB A;  1FAN A;  2KAI I;  4U32 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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