4TPII

The refined 2.2-angstroms (0.22-nm) x-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the arg15 analogue of bovine pancreatic trypsin inhibitor
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCRARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords TRYPSINOGEN
total genus 12
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1985-06-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4tpiI00
1IRHA 5JB6A 3D65I 5JB4A 3BTDI 1B0CA 3BTFI 3OFWA 1DTKA 1BTIA 3AUGA 1BUNB 1CBWD 1F5RI 1SHPA 1PITA 1UUAA 2FTLI 3WNYA 2TGPI 3TGKI 2UUYB 1P2II 2IJOI 4NTXB 3M7QB 1OA55 1AALA 1BZ5A 1AAPA 1DTXA 1F7ZI 3FP8I 2JOTA 5C67C 2ZVXA 1DEMA 2UUXA 3P92E 5JB5A 1CA0D 1TFXC 3T62D 1ADZA 4BD9B 3U1JE 4ISLB 1CO7I 1P2KI 1P2QB 4U30W 1UUBA 2W8XA 3P95E 1EJMB 1TCPA 3BTHI 1DENA 1YC0I 1KIGI 5PTIA 1T8NB 1EAWB 2M01A 4Y0ZI 1T7CB 1T8LB 1FAKI 3UOUB 1TPAI 3LDIA 4ISOB 1P2NB 1TAPA 2FI4I 3TGJI 1P2OB 3BTWI 3L33E 1BPIA 4Y10I 1BTHP 1OA65 3AUHA 2DDIA 2ZJXA 2FI3I 3AUEA 4WXVC 5JB7A 1P2JI 4PTIA 1KTHA 3FP6I 1ZR0B 1G6XA 3L3TE 8PTIA 2KCRA 7PTIA 4DG4C 1D0DA 1YLCB 1BZXI 3AUCA 1T8OB 1BHCA 4Y11I 1BRBI 3CI7A 3AUDA 1KNTA 1MTND 3AUIA 1T8MB 3GYMI 2PTCI 3BTMI 2ODYE 1KUNA 4U32X 1LD6A 3BTKI 2KNTA 3FP7J 2DDJA 4ISNB 1LD5A 3LDJA 6PTIA 1NAGA 2FI5I 1D0DB 4DTGK 1FY8I 2HEXA 2TPII 9PTIA 1TAWB 3TPII 1K6UA 3BYBA 1QLQA 1JC6A 4TPII 1BF0A 1FANA 1ZJDB 2RA3C 3BTEI 4Y0YI 3BTTI 2KAII 3OTJI 3TGII 2LFKA 1Y62A 1JV9A 1YLDB 3BTQI 3UIRC 1BRCI 3AUBA 1JV8A 4BQDA 2J6DA 4BNRI 4WWYC 2R9PE 2LFLA 1BIKA 1BPTA 2M99A 2FTMB 1TOCR 1P2MB 1YKTB 2CA7A 3LDMA 3BTGI 4NTWB 4NTYB
chains in the Genus database with same CATH superfamily
1IRHA 5JB6A 3D65I 5JB4A 3BTDI 1B0CA 3BTFI 3OFWA 1DTKA 1BTIA 3AUGA 1BUNB 1CBWD 1F5RI 1SHPA 1PITA 1UUAA 2FTLI 3WNYA 2TGPI 3TGKI 2UUYB 1P2II 2IJOI 4NTXB 3M7QB 1OA55 1AALA 1BZ5A 1AAPA 1DTXA 1F7ZI 3FP8I 2JOTA 5C67C 2ZVXA 1DEMA 2UUXA 3P92E 5JB5A 1CA0D 1TFXC 3T62D 1ADZA 4BD9B 3U1JE 4ISLB 1CO7I 1P2KI 1P2QB 4U30W 1UUBA 2W8XA 3P95E 1EJMB 1TCPA 3BTHI 1DENA 1YC0I 1KIGI 5PTIA 1T8NB 1EAWB 2M01A 4Y0ZI 1T7CB 1T8LB 1FAKI 3UOUB 1TPAI 3LDIA 4ISOB 1P2NB 1TAPA 2FI4I 3TGJI 1P2OB 3BTWI 3L33E 1BPIA 4Y10I 1BTHP 1OA65 3AUHA 2DDIA 2ZJXA 2FI3I 3AUEA 4WXVC 5JB7A 1P2JI 4PTIA 1KTHA 3FP6I 1ZR0B 1G6XA 3L3TE 8PTIA 2KCRA 7PTIA 4DG4C 1D0DA 1YLCB 1BZXI 3AUCA 1T8OB 1BHCA 4Y11I 1BRBI 3CI7A 3AUDA 1KNTA 1MTND 3AUIA 1T8MB 3GYMI 2PTCI 3BTMI 2ODYE 1KUNA 4U32X 1LD6A 3BTKI 2KNTA 3FP7J 2DDJA 4ISNB 1LD5A 3LDJA 6PTIA 1NAGA 2FI5I 1D0DB 4DTGK 1FY8I 2HEXA 2TPII 9PTIA 1TAWB 3TPII 1K6UA 3BYBA 1QLQA 1JC6A 4TPII 1BF0A 1FANA 1ZJDB 2RA3C 3BTEI 4Y0YI 3BTTI 2KAII 3OTJI 3TGII 2LFKA 1Y62A 1JV9A 1YLDB 3BTQI 3UIRC 1BRCI 3AUBA 1JV8A 4BQDA 2J6DA 4BNRI 4WWYC 2R9PE 2LFLA 1BIKA 1BPTA 2M99A 2FTMB 1TOCR 1P2MB 1YKTB 2CA7A 3LDMA 3BTGI 4NTWB 4NTYB
chains in the Genus database with same CATH topology
1IRHA 5JB6A 3D65I 5JB4A 3BTDI 1B0CA 3BTFI 3OFWA 1DTKA 1BTIA 3AUGA 1BUNB 1CBWD 1F5RI 1SHPA 1PITA 1UUAA 2FTLI 3WNYA 2TGPI 3TGKI 2UUYB 1P2II 2IJOI 4NTXB 3M7QB 1OA55 1AALA 1BZ5A 1AAPA 1DTXA 1F7ZI 3FP8I 2JOTA 5C67C 2ZVXA 1DEMA 2UUXA 3P92E 5JB5A 1CA0D 1TFXC 3T62D 1ADZA 4BD9B 3U1JE 4ISLB 1CO7I 1P2KI 1P2QB 4U30W 1UUBA 2W8XA 3P95E 1EJMB 1TCPA 3BTHI 1DENA 1YC0I 1KIGI 5PTIA 1T8NB 1EAWB 2M01A 4Y0ZI 1T7CB 1T8LB 1FAKI 3UOUB 1TPAI 3LDIA 4ISOB 1P2NB 1TAPA 2FI4I 3TGJI 1P2OB 3BTWI 3L33E 1BPIA 4Y10I 1BTHP 1OA65 3AUHA 2DDIA 2ZJXA 2FI3I 3AUEA 4WXVC 5JB7A 1P2JI 4PTIA 1KTHA 3FP6I 1ZR0B 1G6XA 3L3TE 8PTIA 2KCRA 7PTIA 4DG4C 1D0DA 1YLCB 1BZXI 3AUCA 1T8OB 1BHCA 4Y11I 1BRBI 3CI7A 3AUDA 1KNTA 1MTND 3AUIA 1T8MB 3GYMI 2PTCI 3BTMI 2ODYE 1KUNA 4U32X 1LD6A 3BTKI 2KNTA 3FP7J 2DDJA 4ISNB 1LD5A 3LDJA 6PTIA 1NAGA 2FI5I 1D0DB 4DTGK 1FY8I 2HEXA 2TPII 9PTIA 1TAWB 3TPII 1K6UA 3BYBA 1QLQA 1JC6A 4TPII 1BF0A 1FANA 1ZJDB 2RA3C 3BTEI 4Y0YI 3BTTI 2KAII 3OTJI 3TGII 2LFKA 1Y62A 1JV9A 1YLDB 3BTQI 3UIRC 1BRCI 3AUBA 1JV8A 4BQDA 2J6DA 4BNRI 4WWYC 2R9PE 2LFLA 1BIKA 1BPTA 2M99A 2FTMB 1TOCR 1P2MB 1YKTB 2CA7A 3LDMA 3BTGI 4NTWB 4NTYB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IRH A;  5JB6 A;  3D65 I;  5JB4 A;  3BTD I;  1B0C A;  3BTF I;  3OFW A;  1DTK A;  1BTI A;  3AUG A;  1BUN B;  1CBW D;  1F5R I;  1SHP A;  1PIT A;  1UUA A;  2FTL I;  3WNY A;  2TGP I;  3TGK I;  2UUY B;  1P2I I;  2IJO I;  4NTX B;  3M7Q B;  1OA5 5;  1AAL A;  1BZ5 A;  1AAP A;  1DTX A;  1F7Z I;  3FP8 I;  2JOT A;  5C67 C;  2ZVX A;  1DEM A;  2UUX A;  3P92 E;  5JB5 A;  1CA0 D;  1TFX C;  3T62 D;  1ADZ A;  4BD9 B;  3U1J E;  4ISL B;  1CO7 I;  1P2K I;  1P2Q B;  4U30 W;  1UUB A;  2W8X A;  3P95 E;  1EJM B;  1TCP A;  3BTH I;  1DEN A;  1YC0 I;  1KIG I;  5PTI A;  1T8N B;  1EAW B;  2M01 A;  4Y0Z I;  1T7C B;  1T8L B;  1FAK I;  3UOU B;  1TPA I;  3LDI A;  4ISO B;  1P2N B;  1TAP A;  2FI4 I;  3TGJ I;  1P2O B;  3BTW I;  3L33 E;  1BPI A;  4Y10 I;  1BTH P;  1OA6 5;  3AUH A;  2DDI A;  2ZJX A;  2FI3 I;  3AUE A;  4WXV C;  5JB7 A;  1P2J I;  4PTI A;  1KTH A;  3FP6 I;  1ZR0 B;  1G6X A;  3L3T E;  8PTI A;  2KCR A;  7PTI A;  4DG4 C;  1D0D A;  1YLC B;  1BZX I;  3AUC A;  1T8O B;  1BHC A;  4Y11 I;  1BRB I;  3CI7 A;  3AUD A;  1KNT A;  1MTN D;  3AUI A;  1T8M B;  3GYM I;  2PTC I;  3BTM I;  2ODY E;  1KUN A;  4U32 X;  1LD6 A;  3BTK I;  2KNT A;  3FP7 J;  2DDJ A;  4ISN B;  1LD5 A;  3LDJ A;  6PTI A;  1NAG A;  2FI5 I;  1D0D B;  4DTG K;  1FY8 I;  2HEX A;  2TPI I;  9PTI A;  1TAW B;  3TPI I;  1K6U A;  3BYB A;  1QLQ A;  1JC6 A;  4TPI I;  1BF0 A;  1FAN A;  1ZJD B;  2RA3 C;  3BTE I;  4Y0Y I;  3BTT I;  2KAI I;  3OTJ I;  3TGI I;  2LFK A;  1Y62 A;  1JV9 A;  1YLD B;  3BTQ I;  3UIR C;  1BRC I;  3AUB A;  1JV8 A;  4BQD A;  2J6D A;  4BNR I;  4WWY C;  2R9P E;  2LFL A;  1BIK A;  1BPT A;  2M99 A;  2FTM B;  1TOC R;  1P2M B;  1YKT B;  2CA7 A;  3LDM A;  3BTG I;  4NTW B;  4NTY B; 
#chains in the Genus database with same CATH topology
 1IRH A;  5JB6 A;  3D65 I;  5JB4 A;  3BTD I;  1B0C A;  3BTF I;  3OFW A;  1DTK A;  1BTI A;  3AUG A;  1BUN B;  1CBW D;  1F5R I;  1SHP A;  1PIT A;  1UUA A;  2FTL I;  3WNY A;  2TGP I;  3TGK I;  2UUY B;  1P2I I;  2IJO I;  4NTX B;  3M7Q B;  1OA5 5;  1AAL A;  1BZ5 A;  1AAP A;  1DTX A;  1F7Z I;  3FP8 I;  2JOT A;  5C67 C;  2ZVX A;  1DEM A;  2UUX A;  3P92 E;  5JB5 A;  1CA0 D;  1TFX C;  3T62 D;  1ADZ A;  4BD9 B;  3U1J E;  4ISL B;  1CO7 I;  1P2K I;  1P2Q B;  4U30 W;  1UUB A;  2W8X A;  3P95 E;  1EJM B;  1TCP A;  3BTH I;  1DEN A;  1YC0 I;  1KIG I;  5PTI A;  1T8N B;  1EAW B;  2M01 A;  4Y0Z I;  1T7C B;  1T8L B;  1FAK I;  3UOU B;  1TPA I;  3LDI A;  4ISO B;  1P2N B;  1TAP A;  2FI4 I;  3TGJ I;  1P2O B;  3BTW I;  3L33 E;  1BPI A;  4Y10 I;  1BTH P;  1OA6 5;  3AUH A;  2DDI A;  2ZJX A;  2FI3 I;  3AUE A;  4WXV C;  5JB7 A;  1P2J I;  4PTI A;  1KTH A;  3FP6 I;  1ZR0 B;  1G6X A;  3L3T E;  8PTI A;  2KCR A;  7PTI A;  4DG4 C;  1D0D A;  1YLC B;  1BZX I;  3AUC A;  1T8O B;  1BHC A;  4Y11 I;  1BRB I;  3CI7 A;  3AUD A;  1KNT A;  1MTN D;  3AUI A;  1T8M B;  3GYM I;  2PTC I;  3BTM I;  2ODY E;  1KUN A;  4U32 X;  1LD6 A;  3BTK I;  2KNT A;  3FP7 J;  2DDJ A;  4ISN B;  1LD5 A;  3LDJ A;  6PTI A;  1NAG A;  2FI5 I;  1D0D B;  4DTG K;  1FY8 I;  2HEX A;  2TPI I;  9PTI A;  1TAW B;  3TPI I;  1K6U A;  3BYB A;  1QLQ A;  1JC6 A;  4TPI I;  1BF0 A;  1FAN A;  1ZJD B;  2RA3 C;  3BTE I;  4Y0Y I;  3BTT I;  2KAI I;  3OTJ I;  3TGI I;  2LFK A;  1Y62 A;  1JV9 A;  1YLD B;  3BTQ I;  3UIR C;  1BRC I;  3AUB A;  1JV8 A;  4BQD A;  2J6D A;  4BNR I;  4WWY C;  2R9P E;  2LFL A;  1BIK A;  1BPT A;  2M99 A;  2FTM B;  1TOC R;  1P2M B;  1YKT B;  2CA7 A;  3LDM A;  3BTG I;  4NTW B;  4NTY B; 
#chains in the Genus database with same CATH homology
 1IRH A;  5JB6 A;  3D65 I;  5JB4 A;  3BTD I;  1B0C A;  3BTF I;  3OFW A;  1DTK A;  1BTI A;  3AUG A;  1BUN B;  1CBW D;  1F5R I;  1SHP A;  1PIT A;  1UUA A;  2FTL I;  3WNY A;  2TGP I;  3TGK I;  2UUY B;  1P2I I;  2IJO I;  4NTX B;  3M7Q B;  1OA5 5;  1AAL A;  1BZ5 A;  1AAP A;  1DTX A;  1F7Z I;  3FP8 I;  2JOT A;  5C67 C;  2ZVX A;  1DEM A;  2UUX A;  3P92 E;  5JB5 A;  1CA0 D;  1TFX C;  3T62 D;  1ADZ A;  4BD9 B;  3U1J E;  4ISL B;  1CO7 I;  1P2K I;  1P2Q B;  4U30 W;  1UUB A;  2W8X A;  3P95 E;  1EJM B;  1TCP A;  3BTH I;  1DEN A;  1YC0 I;  1KIG I;  5PTI A;  1T8N B;  1EAW B;  2M01 A;  4Y0Z I;  1T7C B;  1T8L B;  1FAK I;  3UOU B;  1TPA I;  3LDI A;  4ISO B;  1P2N B;  1TAP A;  2FI4 I;  3TGJ I;  1P2O B;  3BTW I;  3L33 E;  1BPI A;  4Y10 I;  1BTH P;  1OA6 5;  3AUH A;  2DDI A;  2ZJX A;  2FI3 I;  3AUE A;  4WXV C;  5JB7 A;  1P2J I;  4PTI A;  1KTH A;  3FP6 I;  1ZR0 B;  1G6X A;  3L3T E;  8PTI A;  2KCR A;  7PTI A;  4DG4 C;  1D0D A;  1YLC B;  1BZX I;  3AUC A;  1T8O B;  1BHC A;  4Y11 I;  1BRB I;  3CI7 A;  3AUD A;  1KNT A;  1MTN D;  3AUI A;  1T8M B;  3GYM I;  2PTC I;  3BTM I;  2ODY E;  1KUN A;  4U32 X;  1LD6 A;  3BTK I;  2KNT A;  3FP7 J;  2DDJ A;  4ISN B;  1LD5 A;  3LDJ A;  6PTI A;  1NAG A;  2FI5 I;  1D0D B;  4DTG K;  1FY8 I;  2HEX A;  2TPI I;  9PTI A;  1TAW B;  3TPI I;  1K6U A;  3BYB A;  1QLQ A;  1JC6 A;  4TPI I;  1BF0 A;  1FAN A;  1ZJD B;  2RA3 C;  3BTE I;  4Y0Y I;  3BTT I;  2KAI I;  3OTJ I;  3TGI I;  2LFK A;  1Y62 A;  1JV9 A;  1YLD B;  3BTQ I;  3UIR C;  1BRC I;  3AUB A;  1JV8 A;  4BQD A;  2J6D A;  4BNR I;  4WWY C;  2R9P E;  2LFL A;  1BIK A;  1BPT A;  2M99 A;  2FTM B;  1TOC R;  1P2M B;  1YKT B;  2CA7 A;  3LDM A;  3BTG I;  4NTW B;  4NTY B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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