4U30W

Human mesotrypsin complexed with bikunin kunitz domain 2
Total Genus 7
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
7
sequence length
54
structure length
54
Chain Sequence
ACANLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Trypsin-3
total genus 7
structure length 54
sequence length 54
chains with identical sequence X, Y, Z
ec nomenclature
pdb deposition date 2014-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
W PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4u30W00
1AALA 1Y62A 3AUBA 2M01A 3L33E 1F7ZI 2KAII 2R9PE 1DENA 3FP6I 3UIRC 1ADZA 4BQDA 1ZR0B 5PTIA 1LD5A 1MTND 2DDIA 1BUNB 1OA65 3AUHA 3BTGI 1T8OB 2ODYE 3BTMI 1QLQA 1T7CB 2PTCI 1DEMA 5JB7A 4BD9B 4U32X 2ZVXA 2RA3C 3CI7A 2FTMB 1P2NB 3TGII 1CA0D 1AAPA 1BTIA 2FI5I 3BTKI 3BTFI 1D0DA 1F5RI 3BTQI 1BPTA 3LDIA 4TPII 4U30W 2KNTA 3TPII 1OA55 1SHPA 1BZXI 3GYMI 1BF0A 4Y0ZI 1IRHA 1EAWB 4PTIA 3LDMA 5JB4A 1P2II 1BZ5A 1TPAI 2ZJXA 3P92E 3TGJI 2FI4I 3OTJI 1P2KI 2DDJA 1P2QB 3BTTI 7PTIA 1ZJDB 8PTIA 3TGKI 1LD6A 3L3TE 1DTKA 2LFKA 3AUCA 2IJOI 2W8XA 1UUAA 1JC6A 1YLCB 1T8MB 1FY8I 4DTGK 2TGPI 1KIGI 3D65I 1DTXA 3BTEI 1PITA 1UUBA 3P95E 1D0DB 3M7QB 2FTLI 1YC0I 4ISNB 4WWYC 1BPIA 3U1JE 3UOUB 1TAPA 2HEXA 3BTHI 1BRBI 3AUGA 6PTIA 1JV8A 1JV9A 1BIKA 2FI3I 1TAWB 1NAGA 1BTHP 9PTIA 2KCRA 1B0CA 2M99A 1T8LB 3LDJA 1FANA 3AUIA 3AUDA 4Y11I 2UUYB 2JOTA 1FAKI 1TFXC 3WNYA 1P2MB 4Y0YI 1TOCR 2J6DA 3AUEA 3T62D 5JB6A 1K6UA 1YLDB 4DG4C 2TPII 3BTWI 4NTYB 1EJMB 2CA7A 1CO7I 1G6XA 1BRCI 3BYBA 1P2OB 3BTDI 1KNTA 1YKTB 1P2JI 5C67C 4Y10I 1KTHA 1T8NB 1TCPA 3FP7J 1KUNA 1BHCA 3FP8I 3OFWA 2UUXA 2LFLA 1CBWD 4ISLB 4NTWB 4ISOB 4WXVC 4BNRI 5JB5A 4NTXB
chains in the Genus database with same CATH superfamily
1AALA 1Y62A 3AUBA 2M01A 3L33E 1F7ZI 2KAII 2R9PE 1DENA 3FP6I 3UIRC 1ADZA 4BQDA 1ZR0B 5PTIA 1LD5A 1MTND 2DDIA 1BUNB 1OA65 3AUHA 3BTGI 1T8OB 2ODYE 3BTMI 1QLQA 1T7CB 2PTCI 1DEMA 5JB7A 4BD9B 4U32X 2ZVXA 2RA3C 3CI7A 2FTMB 1P2NB 3TGII 1CA0D 1AAPA 1BTIA 2FI5I 3BTKI 3BTFI 1D0DA 1F5RI 3BTQI 1BPTA 3LDIA 4TPII 4U30W 2KNTA 3TPII 1OA55 1SHPA 1BZXI 3GYMI 1BF0A 4Y0ZI 1IRHA 1EAWB 4PTIA 3LDMA 5JB4A 1P2II 1BZ5A 1TPAI 2ZJXA 3P92E 3TGJI 2FI4I 3OTJI 1P2KI 2DDJA 1P2QB 3BTTI 7PTIA 1ZJDB 8PTIA 3TGKI 1LD6A 3L3TE 1DTKA 2LFKA 3AUCA 2IJOI 2W8XA 1UUAA 1JC6A 1YLCB 1T8MB 1FY8I 4DTGK 2TGPI 1KIGI 3D65I 1DTXA 3BTEI 1PITA 1UUBA 3P95E 1D0DB 3M7QB 2FTLI 1YC0I 4ISNB 4WWYC 1BPIA 3U1JE 3UOUB 1TAPA 2HEXA 3BTHI 1BRBI 3AUGA 6PTIA 1JV8A 1JV9A 1BIKA 2FI3I 1TAWB 1NAGA 1BTHP 9PTIA 2KCRA 1B0CA 2M99A 1T8LB 3LDJA 1FANA 3AUIA 3AUDA 4Y11I 2UUYB 2JOTA 1FAKI 1TFXC 3WNYA 1P2MB 4Y0YI 1TOCR 2J6DA 3AUEA 3T62D 5JB6A 1K6UA 1YLDB 4DG4C 2TPII 3BTWI 4NTYB 1EJMB 2CA7A 1CO7I 1G6XA 1BRCI 3BYBA 1P2OB 3BTDI 1KNTA 1YKTB 1P2JI 5C67C 4Y10I 1KTHA 1T8NB 1TCPA 3FP7J 1KUNA 1BHCA 3FP8I 3OFWA 2UUXA 2LFLA 1CBWD 4ISLB 4NTWB 4ISOB 4WXVC 4BNRI 5JB5A 4NTXB
chains in the Genus database with same CATH topology
1AALA 1Y62A 3AUBA 2M01A 3L33E 1F7ZI 2KAII 2R9PE 1DENA 3FP6I 3UIRC 1ADZA 4BQDA 1ZR0B 5PTIA 1LD5A 1MTND 2DDIA 1BUNB 1OA65 3AUHA 3BTGI 1T8OB 2ODYE 3BTMI 1QLQA 1T7CB 2PTCI 1DEMA 5JB7A 4BD9B 4U32X 2ZVXA 2RA3C 3CI7A 2FTMB 1P2NB 3TGII 1CA0D 1AAPA 1BTIA 2FI5I 3BTKI 3BTFI 1D0DA 1F5RI 3BTQI 1BPTA 3LDIA 4TPII 4U30W 2KNTA 3TPII 1OA55 1SHPA 1BZXI 3GYMI 1BF0A 4Y0ZI 1IRHA 1EAWB 4PTIA 3LDMA 5JB4A 1P2II 1BZ5A 1TPAI 2ZJXA 3P92E 3TGJI 2FI4I 3OTJI 1P2KI 2DDJA 1P2QB 3BTTI 7PTIA 1ZJDB 8PTIA 3TGKI 1LD6A 3L3TE 1DTKA 2LFKA 3AUCA 2IJOI 2W8XA 1UUAA 1JC6A 1YLCB 1T8MB 1FY8I 4DTGK 2TGPI 1KIGI 3D65I 1DTXA 3BTEI 1PITA 1UUBA 3P95E 1D0DB 3M7QB 2FTLI 1YC0I 4ISNB 4WWYC 1BPIA 3U1JE 3UOUB 1TAPA 2HEXA 3BTHI 1BRBI 3AUGA 6PTIA 1JV8A 1JV9A 1BIKA 2FI3I 1TAWB 1NAGA 1BTHP 9PTIA 2KCRA 1B0CA 2M99A 1T8LB 3LDJA 1FANA 3AUIA 3AUDA 4Y11I 2UUYB 2JOTA 1FAKI 1TFXC 3WNYA 1P2MB 4Y0YI 1TOCR 2J6DA 3AUEA 3T62D 5JB6A 1K6UA 1YLDB 4DG4C 2TPII 3BTWI 4NTYB 1EJMB 2CA7A 1CO7I 1G6XA 1BRCI 3BYBA 1P2OB 3BTDI 1KNTA 1YKTB 1P2JI 5C67C 4Y10I 1KTHA 1T8NB 1TCPA 3FP7J 1KUNA 1BHCA 3FP8I 3OFWA 2UUXA 2LFLA 1CBWD 4ISLB 4NTWB 4ISOB 4WXVC 4BNRI 5JB5A 4NTXB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AAL A;  1Y62 A;  3AUB A;  2M01 A;  3L33 E;  1F7Z I;  2KAI I;  2R9P E;  1DEN A;  3FP6 I;  3UIR C;  1ADZ A;  4BQD A;  1ZR0 B;  5PTI A;  1LD5 A;  1MTN D;  2DDI A;  1BUN B;  1OA6 5;  3AUH A;  3BTG I;  1T8O B;  2ODY E;  3BTM I;  1QLQ A;  1T7C B;  2PTC I;  1DEM A;  5JB7 A;  4BD9 B;  4U32 X;  2ZVX A;  2RA3 C;  3CI7 A;  2FTM B;  1P2N B;  3TGI I;  1CA0 D;  1AAP A;  1BTI A;  2FI5 I;  3BTK I;  3BTF I;  1D0D A;  1F5R I;  3BTQ I;  1BPT A;  3LDI A;  4TPI I;  4U30 W;  2KNT A;  3TPI I;  1OA5 5;  1SHP A;  1BZX I;  3GYM I;  1BF0 A;  4Y0Z I;  1IRH A;  1EAW B;  4PTI A;  3LDM A;  5JB4 A;  1P2I I;  1BZ5 A;  1TPA I;  2ZJX A;  3P92 E;  3TGJ I;  2FI4 I;  3OTJ I;  1P2K I;  2DDJ A;  1P2Q B;  3BTT I;  7PTI A;  1ZJD B;  8PTI A;  3TGK I;  1LD6 A;  3L3T E;  1DTK A;  2LFK A;  3AUC A;  2IJO I;  2W8X A;  1UUA A;  1JC6 A;  1YLC B;  1T8M B;  1FY8 I;  4DTG K;  2TGP I;  1KIG I;  3D65 I;  1DTX A;  3BTE I;  1PIT A;  1UUB A;  3P95 E;  1D0D B;  3M7Q B;  2FTL I;  1YC0 I;  4ISN B;  4WWY C;  1BPI A;  3U1J E;  3UOU B;  1TAP A;  2HEX A;  3BTH I;  1BRB I;  3AUG A;  6PTI A;  1JV8 A;  1JV9 A;  1BIK A;  2FI3 I;  1TAW B;  1NAG A;  1BTH P;  9PTI A;  2KCR A;  1B0C A;  2M99 A;  1T8L B;  3LDJ A;  1FAN A;  3AUI A;  3AUD A;  4Y11 I;  2UUY B;  2JOT A;  1FAK I;  1TFX C;  3WNY A;  1P2M B;  4Y0Y I;  1TOC R;  2J6D A;  3AUE A;  3T62 D;  5JB6 A;  1K6U A;  1YLD B;  4DG4 C;  2TPI I;  3BTW I;  4NTY B;  1EJM B;  2CA7 A;  1CO7 I;  1G6X A;  1BRC I;  3BYB A;  1P2O B;  3BTD I;  1KNT A;  1YKT B;  1P2J I;  5C67 C;  4Y10 I;  1KTH A;  1T8N B;  1TCP A;  3FP7 J;  1KUN A;  1BHC A;  3FP8 I;  3OFW A;  2UUX A;  2LFL A;  1CBW D;  4ISL B;  4NTW B;  4ISO B;  4WXV C;  4BNR I;  5JB5 A;  4NTX B; 
#chains in the Genus database with same CATH topology
 1AAL A;  1Y62 A;  3AUB A;  2M01 A;  3L33 E;  1F7Z I;  2KAI I;  2R9P E;  1DEN A;  3FP6 I;  3UIR C;  1ADZ A;  4BQD A;  1ZR0 B;  5PTI A;  1LD5 A;  1MTN D;  2DDI A;  1BUN B;  1OA6 5;  3AUH A;  3BTG I;  1T8O B;  2ODY E;  3BTM I;  1QLQ A;  1T7C B;  2PTC I;  1DEM A;  5JB7 A;  4BD9 B;  4U32 X;  2ZVX A;  2RA3 C;  3CI7 A;  2FTM B;  1P2N B;  3TGI I;  1CA0 D;  1AAP A;  1BTI A;  2FI5 I;  3BTK I;  3BTF I;  1D0D A;  1F5R I;  3BTQ I;  1BPT A;  3LDI A;  4TPI I;  4U30 W;  2KNT A;  3TPI I;  1OA5 5;  1SHP A;  1BZX I;  3GYM I;  1BF0 A;  4Y0Z I;  1IRH A;  1EAW B;  4PTI A;  3LDM A;  5JB4 A;  1P2I I;  1BZ5 A;  1TPA I;  2ZJX A;  3P92 E;  3TGJ I;  2FI4 I;  3OTJ I;  1P2K I;  2DDJ A;  1P2Q B;  3BTT I;  7PTI A;  1ZJD B;  8PTI A;  3TGK I;  1LD6 A;  3L3T E;  1DTK A;  2LFK A;  3AUC A;  2IJO I;  2W8X A;  1UUA A;  1JC6 A;  1YLC B;  1T8M B;  1FY8 I;  4DTG K;  2TGP I;  1KIG I;  3D65 I;  1DTX A;  3BTE I;  1PIT A;  1UUB A;  3P95 E;  1D0D B;  3M7Q B;  2FTL I;  1YC0 I;  4ISN B;  4WWY C;  1BPI A;  3U1J E;  3UOU B;  1TAP A;  2HEX A;  3BTH I;  1BRB I;  3AUG A;  6PTI A;  1JV8 A;  1JV9 A;  1BIK A;  2FI3 I;  1TAW B;  1NAG A;  1BTH P;  9PTI A;  2KCR A;  1B0C A;  2M99 A;  1T8L B;  3LDJ A;  1FAN A;  3AUI A;  3AUD A;  4Y11 I;  2UUY B;  2JOT A;  1FAK I;  1TFX C;  3WNY A;  1P2M B;  4Y0Y I;  1TOC R;  2J6D A;  3AUE A;  3T62 D;  5JB6 A;  1K6U A;  1YLD B;  4DG4 C;  2TPI I;  3BTW I;  4NTY B;  1EJM B;  2CA7 A;  1CO7 I;  1G6X A;  1BRC I;  3BYB A;  1P2O B;  3BTD I;  1KNT A;  1YKT B;  1P2J I;  5C67 C;  4Y10 I;  1KTH A;  1T8N B;  1TCP A;  3FP7 J;  1KUN A;  1BHC A;  3FP8 I;  3OFW A;  2UUX A;  2LFL A;  1CBW D;  4ISL B;  4NTW B;  4ISO B;  4WXV C;  4BNR I;  5JB5 A;  4NTX B; 
#chains in the Genus database with same CATH homology
 1AAL A;  1Y62 A;  3AUB A;  2M01 A;  3L33 E;  1F7Z I;  2KAI I;  2R9P E;  1DEN A;  3FP6 I;  3UIR C;  1ADZ A;  4BQD A;  1ZR0 B;  5PTI A;  1LD5 A;  1MTN D;  2DDI A;  1BUN B;  1OA6 5;  3AUH A;  3BTG I;  1T8O B;  2ODY E;  3BTM I;  1QLQ A;  1T7C B;  2PTC I;  1DEM A;  5JB7 A;  4BD9 B;  4U32 X;  2ZVX A;  2RA3 C;  3CI7 A;  2FTM B;  1P2N B;  3TGI I;  1CA0 D;  1AAP A;  1BTI A;  2FI5 I;  3BTK I;  3BTF I;  1D0D A;  1F5R I;  3BTQ I;  1BPT A;  3LDI A;  4TPI I;  4U30 W;  2KNT A;  3TPI I;  1OA5 5;  1SHP A;  1BZX I;  3GYM I;  1BF0 A;  4Y0Z I;  1IRH A;  1EAW B;  4PTI A;  3LDM A;  5JB4 A;  1P2I I;  1BZ5 A;  1TPA I;  2ZJX A;  3P92 E;  3TGJ I;  2FI4 I;  3OTJ I;  1P2K I;  2DDJ A;  1P2Q B;  3BTT I;  7PTI A;  1ZJD B;  8PTI A;  3TGK I;  1LD6 A;  3L3T E;  1DTK A;  2LFK A;  3AUC A;  2IJO I;  2W8X A;  1UUA A;  1JC6 A;  1YLC B;  1T8M B;  1FY8 I;  4DTG K;  2TGP I;  1KIG I;  3D65 I;  1DTX A;  3BTE I;  1PIT A;  1UUB A;  3P95 E;  1D0D B;  3M7Q B;  2FTL I;  1YC0 I;  4ISN B;  4WWY C;  1BPI A;  3U1J E;  3UOU B;  1TAP A;  2HEX A;  3BTH I;  1BRB I;  3AUG A;  6PTI A;  1JV8 A;  1JV9 A;  1BIK A;  2FI3 I;  1TAW B;  1NAG A;  1BTH P;  9PTI A;  2KCR A;  1B0C A;  2M99 A;  1T8L B;  3LDJ A;  1FAN A;  3AUI A;  3AUD A;  4Y11 I;  2UUY B;  2JOT A;  1FAK I;  1TFX C;  3WNY A;  1P2M B;  4Y0Y I;  1TOC R;  2J6D A;  3AUE A;  3T62 D;  5JB6 A;  1K6U A;  1YLD B;  4DG4 C;  2TPI I;  3BTW I;  4NTY B;  1EJM B;  2CA7 A;  1CO7 I;  1G6X A;  1BRC I;  3BYB A;  1P2O B;  3BTD I;  1KNT A;  1YKT B;  1P2J I;  5C67 C;  4Y10 I;  1KTH A;  1T8N B;  1TCP A;  3FP7 J;  1KUN A;  1BHC A;  3FP8 I;  3OFW A;  2UUX A;  2LFL A;  1CBW D;  4ISL B;  4NTW B;  4ISO B;  4WXV C;  4BNR I;  5JB5 A;  4NTX B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...