4U32X

Human mesotrypsin complexed with hai-2 kunitz domain 1
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
54
structure length
54
Chain Sequence
HDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Kunitz-type protease inhibitor 2
total genus 12
structure length 54
sequence length 54
ec nomenclature
pdb deposition date 2014-07-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4u32X00
1DENA 3LDIA 3BTMI 1BIKA 1BRCI 1D0DB 1SHPA 1BTIA 3OTJI 1TAPA 3BTKI 4DTGK 2JOTA 1BPIA 1OA55 2ODYE 1LD5A 2RA3C 1QLQA 2M01A 9PTIA 4BNRI 1P2QB 3L3TE 1B0CA 3AUGA 2TGPI 2ZJXA 2DDIA 3TGJI 4TPII 1P2OB 3TPII 5JB4A 3WNYA 2KAII 2M99A 1YC0I 1P2JI 2FI4I 1BHCA 1ADZA 3AUCA 1PITA 3AUEA 1UUAA 3BTHI 4ISLB 3GYMI 3BTTI 1IRHA 3LDJA 3CI7A 4Y0YI 1BUNB 3FP7J 4BQDA 1P2KI 1EJMB 1KTHA 2J6DA 3L33E 1ZR0B 4NTYB 3FP8I 1TAWB 1FY8I 5JB5A 1TFXC 1NAGA 1TOCR 3BTWI 4U30W 1BRBI 2TPII 3P92E 3BYBA 1OA65 1JV8A 1CO7I 1ZJDB 1BZ5A 3UOUB 1DTKA 1CBWD 2W8XA 1YLDB 2ZVXA 1YLCB 2FI3I 1F7ZI 1BPTA 3LDMA 2LFLA 3P95E 7PTIA 4WXVC 3UIRC 6PTIA 4PTIA 1AALA 2R9PE 3AUIA 3TGII 3TGKI 5JB6A 1KUNA 1P2NB 2IJOI 2FTMB 1D0DA 1YKTB 1T8NB 4WWYC 5JB7A 3AUHA 3OFWA 1P2MB 1G6XA 1T8OB 4Y0ZI 3AUDA 3BTFI 1BZXI 2DDJA 2KCRA 4ISOB 3T62D 1TPAI 1F5RI 1T7CB 4ISNB 4BD9B 1P2II 2PTCI 3BTQI 3BTDI 4Y10I 1CA0D 1UUBA 1DEMA 4Y11I 1JV9A 3AUBA 1BF0A 2KNTA 1TCPA 1KIGI 4U32X 5PTIA 1FAKI 3BTGI 2HEXA 1AAPA 1EAWB 1KNTA 1BTHP 4NTWB 3FP6I 3M7QB 1T8MB 1MTND 2UUYB 1DTXA 1Y62A 2FI5I 3D65I 1LD6A 3U1JE 1T8LB 4NTXB 1K6UA 4DG4C 2UUXA 1FANA 2LFKA 8PTIA 1JC6A 3BTEI 2CA7A 5C67C 2FTLI
chains in the Genus database with same CATH superfamily
1DENA 3LDIA 3BTMI 1BIKA 1BRCI 1D0DB 1SHPA 1BTIA 3OTJI 1TAPA 3BTKI 4DTGK 2JOTA 1BPIA 1OA55 2ODYE 1LD5A 2RA3C 1QLQA 2M01A 9PTIA 4BNRI 1P2QB 3L3TE 1B0CA 3AUGA 2TGPI 2ZJXA 2DDIA 3TGJI 4TPII 1P2OB 3TPII 5JB4A 3WNYA 2KAII 2M99A 1YC0I 1P2JI 2FI4I 1BHCA 1ADZA 3AUCA 1PITA 3AUEA 1UUAA 3BTHI 4ISLB 3GYMI 3BTTI 1IRHA 3LDJA 3CI7A 4Y0YI 1BUNB 3FP7J 4BQDA 1P2KI 1EJMB 1KTHA 2J6DA 3L33E 1ZR0B 4NTYB 3FP8I 1TAWB 1FY8I 5JB5A 1TFXC 1NAGA 1TOCR 3BTWI 4U30W 1BRBI 2TPII 3P92E 3BYBA 1OA65 1JV8A 1CO7I 1ZJDB 1BZ5A 3UOUB 1DTKA 1CBWD 2W8XA 1YLDB 2ZVXA 1YLCB 2FI3I 1F7ZI 1BPTA 3LDMA 2LFLA 3P95E 7PTIA 4WXVC 3UIRC 6PTIA 4PTIA 1AALA 2R9PE 3AUIA 3TGII 3TGKI 5JB6A 1KUNA 1P2NB 2IJOI 2FTMB 1D0DA 1YKTB 1T8NB 4WWYC 5JB7A 3AUHA 3OFWA 1P2MB 1G6XA 1T8OB 4Y0ZI 3AUDA 3BTFI 1BZXI 2DDJA 2KCRA 4ISOB 3T62D 1TPAI 1F5RI 1T7CB 4ISNB 4BD9B 1P2II 2PTCI 3BTQI 3BTDI 4Y10I 1CA0D 1UUBA 1DEMA 4Y11I 1JV9A 3AUBA 1BF0A 2KNTA 1TCPA 1KIGI 4U32X 5PTIA 1FAKI 3BTGI 2HEXA 1AAPA 1EAWB 1KNTA 1BTHP 4NTWB 3FP6I 3M7QB 1T8MB 1MTND 2UUYB 1DTXA 1Y62A 2FI5I 3D65I 1LD6A 3U1JE 1T8LB 4NTXB 1K6UA 4DG4C 2UUXA 1FANA 2LFKA 8PTIA 1JC6A 3BTEI 2CA7A 5C67C 2FTLI
chains in the Genus database with same CATH topology
1DENA 3LDIA 3BTMI 1BIKA 1BRCI 1D0DB 1SHPA 1BTIA 3OTJI 1TAPA 3BTKI 4DTGK 2JOTA 1BPIA 1OA55 2ODYE 1LD5A 2RA3C 1QLQA 2M01A 9PTIA 4BNRI 1P2QB 3L3TE 1B0CA 3AUGA 2TGPI 2ZJXA 2DDIA 3TGJI 4TPII 1P2OB 3TPII 5JB4A 3WNYA 2KAII 2M99A 1YC0I 1P2JI 2FI4I 1BHCA 1ADZA 3AUCA 1PITA 3AUEA 1UUAA 3BTHI 4ISLB 3GYMI 3BTTI 1IRHA 3LDJA 3CI7A 4Y0YI 1BUNB 3FP7J 4BQDA 1P2KI 1EJMB 1KTHA 2J6DA 3L33E 1ZR0B 4NTYB 3FP8I 1TAWB 1FY8I 5JB5A 1TFXC 1NAGA 1TOCR 3BTWI 4U30W 1BRBI 2TPII 3P92E 3BYBA 1OA65 1JV8A 1CO7I 1ZJDB 1BZ5A 3UOUB 1DTKA 1CBWD 2W8XA 1YLDB 2ZVXA 1YLCB 2FI3I 1F7ZI 1BPTA 3LDMA 2LFLA 3P95E 7PTIA 4WXVC 3UIRC 6PTIA 4PTIA 1AALA 2R9PE 3AUIA 3TGII 3TGKI 5JB6A 1KUNA 1P2NB 2IJOI 2FTMB 1D0DA 1YKTB 1T8NB 4WWYC 5JB7A 3AUHA 3OFWA 1P2MB 1G6XA 1T8OB 4Y0ZI 3AUDA 3BTFI 1BZXI 2DDJA 2KCRA 4ISOB 3T62D 1TPAI 1F5RI 1T7CB 4ISNB 4BD9B 1P2II 2PTCI 3BTQI 3BTDI 4Y10I 1CA0D 1UUBA 1DEMA 4Y11I 1JV9A 3AUBA 1BF0A 2KNTA 1TCPA 1KIGI 4U32X 5PTIA 1FAKI 3BTGI 2HEXA 1AAPA 1EAWB 1KNTA 1BTHP 4NTWB 3FP6I 3M7QB 1T8MB 1MTND 2UUYB 1DTXA 1Y62A 2FI5I 3D65I 1LD6A 3U1JE 1T8LB 4NTXB 1K6UA 4DG4C 2UUXA 1FANA 2LFKA 8PTIA 1JC6A 3BTEI 2CA7A 5C67C 2FTLI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DEN A;  3LDI A;  3BTM I;  1BIK A;  1BRC I;  1D0D B;  1SHP A;  1BTI A;  3OTJ I;  1TAP A;  3BTK I;  4DTG K;  2JOT A;  1BPI A;  1OA5 5;  2ODY E;  1LD5 A;  2RA3 C;  1QLQ A;  2M01 A;  9PTI A;  4BNR I;  1P2Q B;  3L3T E;  1B0C A;  3AUG A;  2TGP I;  2ZJX A;  2DDI A;  3TGJ I;  4TPI I;  1P2O B;  3TPI I;  5JB4 A;  3WNY A;  2KAI I;  2M99 A;  1YC0 I;  1P2J I;  2FI4 I;  1BHC A;  1ADZ A;  3AUC A;  1PIT A;  3AUE A;  1UUA A;  3BTH I;  4ISL B;  3GYM I;  3BTT I;  1IRH A;  3LDJ A;  3CI7 A;  4Y0Y I;  1BUN B;  3FP7 J;  4BQD A;  1P2K I;  1EJM B;  1KTH A;  2J6D A;  3L33 E;  1ZR0 B;  4NTY B;  3FP8 I;  1TAW B;  1FY8 I;  5JB5 A;  1TFX C;  1NAG A;  1TOC R;  3BTW I;  4U30 W;  1BRB I;  2TPI I;  3P92 E;  3BYB A;  1OA6 5;  1JV8 A;  1CO7 I;  1ZJD B;  1BZ5 A;  3UOU B;  1DTK A;  1CBW D;  2W8X A;  1YLD B;  2ZVX A;  1YLC B;  2FI3 I;  1F7Z I;  1BPT A;  3LDM A;  2LFL A;  3P95 E;  7PTI A;  4WXV C;  3UIR C;  6PTI A;  4PTI A;  1AAL A;  2R9P E;  3AUI A;  3TGI I;  3TGK I;  5JB6 A;  1KUN A;  1P2N B;  2IJO I;  2FTM B;  1D0D A;  1YKT B;  1T8N B;  4WWY C;  5JB7 A;  3AUH A;  3OFW A;  1P2M B;  1G6X A;  1T8O B;  4Y0Z I;  3AUD A;  3BTF I;  1BZX I;  2DDJ A;  2KCR A;  4ISO B;  3T62 D;  1TPA I;  1F5R I;  1T7C B;  4ISN B;  4BD9 B;  1P2I I;  2PTC I;  3BTQ I;  3BTD I;  4Y10 I;  1CA0 D;  1UUB A;  1DEM A;  4Y11 I;  1JV9 A;  3AUB A;  1BF0 A;  2KNT A;  1TCP A;  1KIG I;  4U32 X;  5PTI A;  1FAK I;  3BTG I;  2HEX A;  1AAP A;  1EAW B;  1KNT A;  1BTH P;  4NTW B;  3FP6 I;  3M7Q B;  1T8M B;  1MTN D;  2UUY B;  1DTX A;  1Y62 A;  2FI5 I;  3D65 I;  1LD6 A;  3U1J E;  1T8L B;  4NTX B;  1K6U A;  4DG4 C;  2UUX A;  1FAN A;  2LFK A;  8PTI A;  1JC6 A;  3BTE I;  2CA7 A;  5C67 C;  2FTL I; 
#chains in the Genus database with same CATH topology
 1DEN A;  3LDI A;  3BTM I;  1BIK A;  1BRC I;  1D0D B;  1SHP A;  1BTI A;  3OTJ I;  1TAP A;  3BTK I;  4DTG K;  2JOT A;  1BPI A;  1OA5 5;  2ODY E;  1LD5 A;  2RA3 C;  1QLQ A;  2M01 A;  9PTI A;  4BNR I;  1P2Q B;  3L3T E;  1B0C A;  3AUG A;  2TGP I;  2ZJX A;  2DDI A;  3TGJ I;  4TPI I;  1P2O B;  3TPI I;  5JB4 A;  3WNY A;  2KAI I;  2M99 A;  1YC0 I;  1P2J I;  2FI4 I;  1BHC A;  1ADZ A;  3AUC A;  1PIT A;  3AUE A;  1UUA A;  3BTH I;  4ISL B;  3GYM I;  3BTT I;  1IRH A;  3LDJ A;  3CI7 A;  4Y0Y I;  1BUN B;  3FP7 J;  4BQD A;  1P2K I;  1EJM B;  1KTH A;  2J6D A;  3L33 E;  1ZR0 B;  4NTY B;  3FP8 I;  1TAW B;  1FY8 I;  5JB5 A;  1TFX C;  1NAG A;  1TOC R;  3BTW I;  4U30 W;  1BRB I;  2TPI I;  3P92 E;  3BYB A;  1OA6 5;  1JV8 A;  1CO7 I;  1ZJD B;  1BZ5 A;  3UOU B;  1DTK A;  1CBW D;  2W8X A;  1YLD B;  2ZVX A;  1YLC B;  2FI3 I;  1F7Z I;  1BPT A;  3LDM A;  2LFL A;  3P95 E;  7PTI A;  4WXV C;  3UIR C;  6PTI A;  4PTI A;  1AAL A;  2R9P E;  3AUI A;  3TGI I;  3TGK I;  5JB6 A;  1KUN A;  1P2N B;  2IJO I;  2FTM B;  1D0D A;  1YKT B;  1T8N B;  4WWY C;  5JB7 A;  3AUH A;  3OFW A;  1P2M B;  1G6X A;  1T8O B;  4Y0Z I;  3AUD A;  3BTF I;  1BZX I;  2DDJ A;  2KCR A;  4ISO B;  3T62 D;  1TPA I;  1F5R I;  1T7C B;  4ISN B;  4BD9 B;  1P2I I;  2PTC I;  3BTQ I;  3BTD I;  4Y10 I;  1CA0 D;  1UUB A;  1DEM A;  4Y11 I;  1JV9 A;  3AUB A;  1BF0 A;  2KNT A;  1TCP A;  1KIG I;  4U32 X;  5PTI A;  1FAK I;  3BTG I;  2HEX A;  1AAP A;  1EAW B;  1KNT A;  1BTH P;  4NTW B;  3FP6 I;  3M7Q B;  1T8M B;  1MTN D;  2UUY B;  1DTX A;  1Y62 A;  2FI5 I;  3D65 I;  1LD6 A;  3U1J E;  1T8L B;  4NTX B;  1K6U A;  4DG4 C;  2UUX A;  1FAN A;  2LFK A;  8PTI A;  1JC6 A;  3BTE I;  2CA7 A;  5C67 C;  2FTL I; 
#chains in the Genus database with same CATH homology
 1DEN A;  3LDI A;  3BTM I;  1BIK A;  1BRC I;  1D0D B;  1SHP A;  1BTI A;  3OTJ I;  1TAP A;  3BTK I;  4DTG K;  2JOT A;  1BPI A;  1OA5 5;  2ODY E;  1LD5 A;  2RA3 C;  1QLQ A;  2M01 A;  9PTI A;  4BNR I;  1P2Q B;  3L3T E;  1B0C A;  3AUG A;  2TGP I;  2ZJX A;  2DDI A;  3TGJ I;  4TPI I;  1P2O B;  3TPI I;  5JB4 A;  3WNY A;  2KAI I;  2M99 A;  1YC0 I;  1P2J I;  2FI4 I;  1BHC A;  1ADZ A;  3AUC A;  1PIT A;  3AUE A;  1UUA A;  3BTH I;  4ISL B;  3GYM I;  3BTT I;  1IRH A;  3LDJ A;  3CI7 A;  4Y0Y I;  1BUN B;  3FP7 J;  4BQD A;  1P2K I;  1EJM B;  1KTH A;  2J6D A;  3L33 E;  1ZR0 B;  4NTY B;  3FP8 I;  1TAW B;  1FY8 I;  5JB5 A;  1TFX C;  1NAG A;  1TOC R;  3BTW I;  4U30 W;  1BRB I;  2TPI I;  3P92 E;  3BYB A;  1OA6 5;  1JV8 A;  1CO7 I;  1ZJD B;  1BZ5 A;  3UOU B;  1DTK A;  1CBW D;  2W8X A;  1YLD B;  2ZVX A;  1YLC B;  2FI3 I;  1F7Z I;  1BPT A;  3LDM A;  2LFL A;  3P95 E;  7PTI A;  4WXV C;  3UIR C;  6PTI A;  4PTI A;  1AAL A;  2R9P E;  3AUI A;  3TGI I;  3TGK I;  5JB6 A;  1KUN A;  1P2N B;  2IJO I;  2FTM B;  1D0D A;  1YKT B;  1T8N B;  4WWY C;  5JB7 A;  3AUH A;  3OFW A;  1P2M B;  1G6X A;  1T8O B;  4Y0Z I;  3AUD A;  3BTF I;  1BZX I;  2DDJ A;  2KCR A;  4ISO B;  3T62 D;  1TPA I;  1F5R I;  1T7C B;  4ISN B;  4BD9 B;  1P2I I;  2PTC I;  3BTQ I;  3BTD I;  4Y10 I;  1CA0 D;  1UUB A;  1DEM A;  4Y11 I;  1JV9 A;  3AUB A;  1BF0 A;  2KNT A;  1TCP A;  1KIG I;  4U32 X;  5PTI A;  1FAK I;  3BTG I;  2HEX A;  1AAP A;  1EAW B;  1KNT A;  1BTH P;  4NTW B;  3FP6 I;  3M7Q B;  1T8M B;  1MTN D;  2UUY B;  1DTX A;  1Y62 A;  2FI5 I;  3D65 I;  1LD6 A;  3U1J E;  1T8L B;  4NTX B;  1K6U A;  4DG4 C;  2UUX A;  1FAN A;  2LFK A;  8PTI A;  1JC6 A;  3BTE I;  2CA7 A;  5C67 C;  2FTL I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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