4X6AF

Crystal structure of yeast rna polymerase ii encountering oxidative cyclopurine dna lesions
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
84
structure length
84
Chain Sequence
KAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions.
pubmed doi rcsb
molecule tags Transcription/dna
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 17
structure length 84
sequence length 84
ec nomenclature
pdb deposition date 2014-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4x6aF00
2E2JF 3H3VG 4OIQE 3GTOF 3PO2F 1Y1VF 1ZYRE 4OINE 4KMUE 5E17E 5M5XF 5D4CE 4A3BF 2E2IF 3EQLE 4XSXE 4Y7NF 4Y52F 2JA6F 5IYCF 3GTMF 4OIOE 2O5IE 3WODE 1QKLA 4KN7E 5D4EE 1YNJK 4YFXE 2VUMF 5TMCE 2YU9F 4A3CF 2R93F 2NVTF 3FKIF 1IW7E 5FJ8F 3DXJE 5C44F 3RZDF 3PO3F 2E2HF 4JK1E 5IYBF 4BY7F 4A3LF 4XSZE 4AYBK 4OIRE 3HOYF 5IPLE 3HOUF 4X6AF 4ZH4E 1SFOF 5M5WF 2NVQF 4G7HE 3HOVF 1R9TF 3I4NF 4MQ9E 4YG2E 4A3KF 3H0GF 4A3EF 1SMYE 1I6HF 1YNNK 2A69E 3GTQF 4LJZE 5IYDF 1Y1WF 5BYHE 4G7OE 2JA7F 4GZYE 3HOZF 3HKZK 4YFNE 3S2DF 4OIPE 4LK1E 3K7AF 5E18E 1K83F 4A3MF 5C4XF 4A3GF 2O5JE 1I6VE 5C4JF 2NVYF 3S1NF 3S1MF 3GTPF 4A3DF 3RZOF 3GTJF 3GTLF 4A3JF 2BE5E 5IP7F 2JA8F 2A68E 1TWGF 1I50F 3I4MF 5TMFE 3GTKF 2B63F 4BBRF 2A6HE 4C3HF 4BBSF 5M3FF 1TWFF 4Q5SE 3M4OF 2R7ZF 3S2HF 4KN4E 2PMZK 2A6EE 3S16F 5D4DE 5FLMF 5C3EF 3S17F 2R92F 4Q4ZE 4XLPE 3HOXF 3M3YF 2CW0E 5M3MF 5M5YF 2PPBE 4XLNE 4MEYE 4MEXE 1HQME 3CQZF 4BY1F 4YFKE 3S1RF 2JA5F 1TWHF 1TWAF 4C3IF 3GTGF 4G7ZE 2WB1I 4A3FF 3HOWF 4BXXF 3S14F 1WCMF 2Y0SI 3S1QF 1TWCF 4LLGE 5IP9F 4C2MF 4LK0E 4A93F 3S15F 2WAQK 1I3QF 4A3IF 4C3JF 2NVXF
chains in the Genus database with same CATH superfamily
2E2JF 4QIWH 4BBRE 4C3HE 2B63E 3H3VG 4OIQE 3GTOF 3PO2F 1EIKA 3GTKE 1Y1VF 1ZYRE 4OINE 5M3FE 4BBSE 4KMUE 5E17E 5M5XF 1TWFE 2KRXA 5D4CE 4A3BF 2E2IF 3M4OE 3S2HE 3EQLE 3S16E 4XSXE 5C3EE 3S17E 5C4XE 4Y7NF 4Y52F 2JA6F 5IYCF 3GTMF 3HOXE 4OIOE 2O5IE 3M3YE 3WODE 1QKLA 3HKZH 5M3ME 5M5YE 3S1ME 4KN7E 2WB1H 5D4EE 1YNJK 4BY1E 2JA5E 2Y0SH 4YFXE 4C3IE 5TMCE 2YU9F 2VUMF 1TWGE 3GTGE 4A3CF 2R93F 4A3FE 3HOWE 4BXXE 2NVTF 3S14E 1DZFA 1WCME 3FKIF 1IW7E 3S1QE 1TWCE 4C2ME 5IP9E 5FJ8F 4A93E 3DXJE 5C44F 3RZDF 3S15E 3PO3F 2E2HF 1I3QE 4JK1E 5IYBF 4BY7F 4A3LF 4XSZE 4AYBK 4OIRE 2R7ZE 3HOYF 4C3JE 5IPLE 2NVXE 2E2JE 4ZH4E 1SFOF 5M5WF 3HOUF 2NVQF 4G7HE 3HOVF 3GTOE 1R9TF 3PO2E 1Y1VE 5FLME 3I4NF 4MQ9E 4YG2E 4A3KF 3H0GF 4A3EF 1SMYE 1I6HF 2R92E 1YNNK 4A3BE 2A69E 2E2IE 3S1QF 3GTQF 4LJZE 5IYDF 1Y1WF 5BYHE 4G7OE 2JA7F 4GZYE 3HOZF 3HKZK 4YFNE 3S2DF 2PMZH 4OIPE 3CQZE 4Y7NE 3S1RE 5IYCE 4LK1E 3K7AF 2JA6E 5E18E 3GTME 1TWHE 4Y52E 1TWAE 1K83F 4A3MF 5C4XF 4QIWK 4A3GF 2O5JE 1I6VE 5C4JF 2NVYF 3S1NF 2VUME 4A3CE 2YU9E 3S1MF 2R93E 3GTPF 4A3DF 3RZOF 3GTJF 4A3IE 2NVTE 3FKIE 3GTLF 4A3JF 2BE5E 5IP7F 5FJ8E 2JA8F 2A68E 5C44E 3RZDE 1TWGF 3PO3E 1I50F 2E2HE 3I4MF 5TMFE 5M5XE 5IYBE 3GTKF 4A3LE 2B63F 4BBRF 2A6HE 4C3HF 4BY7E 3HOUE 4X6AE 1SFOE 5M5WE 3HOVE 4BBSF 2WAQH 5M3FF 1R9TE 3I4NE 4A3EE 4A3KE 1TWFF 3H0GE 4Q5SE 3M4OF 2R7ZF 3S2HF 1I6HE 4KN4E 2PMZK 2A6EE 3S16F 3GTQE 5D4DE 5IYDE 5FLMF 5C3EF 1Y1WE 2JA7E 3S17F 3HOZE 2R92F 4Q4ZE 4AYBH 3S2DE 4XLPE 3HOXF 3M3YF 3K7AE 2CW0E 5M3MF 5M5YF 2PPBE 1K83E 4XLNE 4MEYE 4A3ME 4MEXE 1HQME 3CQZF 4BY1F 4YFKE 3S1RF 3I4ME 2JA5F 4A3GE 1TWHF 1TWAF 4C3IF 3GTGF 4X6AF 5C4JE 2NVYE 2WB1I 4G7ZE 4A3FF 3HOWF 4BXXF 3S1NE 3S14F 1WCMF 3GTPE 4A3DE 3RZOE 2Y0SI 3GTJE 1TWCF 4LLGE 5IP9F 4C2MF 4LK0E 3GTLE 3HOYE 4A3JE 5IP7E 3H3VF 2NVQE 3S15F 2JA8E 2WAQK 1I3QF 1I50E 4A93F 4A3IF 4C3JF 2NVXF
chains in the Genus database with same CATH topology
2E2JF 3H3VG 4OIQE 3GTOF 3PO2F 1Y1VF 1ZYRE 4OINE 4KMUE 5E17E 5M5XF 2KRXA 5D4CE 4A3BF 2E2IF 3EQLE 4XSXE 4Y7NF 4Y52F 2JA6F 5IYCF 3GTMF 4OIOE 2O5IE 3WODE 1QKLA 4KN7E 5D4EE 1YNJK 4YFXE 2VUMF 5TMCE 2YU9F 4A3CF 2R93F 2NVTF 3FKIF 1IW7E 5FJ8F 3DXJE 5C44F 3RZDF 3PO3F 2E2HF 4JK1E 5IYBF 4BY7F 4A3LF 4XSZE 4AYBK 4OIRE 3HOYF 5IPLE 3HOUF 4X6AF 4ZH4E 1SFOF 5M5WF 2NVQF 4G7HE 3HOVF 1R9TF 3I4NF 4MQ9E 4YG2E 4A3KF 3H0GF 4A3EF 1SMYE 1I6HF 1YNNK 2A69E 3GTQF 4LJZE 5IYDF 1Y1WF 5BYHE 4G7OE 2JA7F 4GZYE 3HOZF 3HKZK 4YFNE 3S2DF 4OIPE 4LK1E 3K7AF 5E18E 1K83F 4A3MF 5C4XF 4QIWK 4A3GF 2O5JE 1I6VE 5C4JF 2NVYF 3S1NF 3S1MF 3GTPF 4A3DF 3RZOF 3GTJF 3GTLF 4A3JF 2BE5E 5IP7F 2JA8F 2A68E 1TWGF 1I50F 3I4MF 5TMFE 3GTKF 2B63F 4BBRF 2A6HE 4C3HF 4BBSF 5M3FF 1TWFF 4Q5SE 3M4OF 2R7ZF 3S2HF 4KN4E 2PMZK 2A6EE 3S16F 5D4DE 5FLMF 5C3EF 3S17F 2R92F 4Q4ZE 4XLPE 3HOXF 3M3YF 2CW0E 5M3MF 5M5YF 2PPBE 4XLNE 4MEYE 4MEXE 1HQME 3CQZF 4BY1F 4YFKE 3S1RF 2JA5F 1TWHF 1TWAF 4C3IF 3GTGF 4G7ZE 2WB1I 4A3FF 3HOWF 4BXXF 3S14F 1WCMF 2Y0SI 3S1QF 1TWCF 4LLGE 5IP9F 4C2MF 4LK0E 4A93F 3S15F 2WAQK 1I3QF 4A3IF 4C3JF 2NVXF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E2J F;  3H3V G;  4OIQ E;  3GTO F;  3PO2 F;  1Y1V F;  1ZYR E;  4OIN E;  4KMU E;  5E17 E;  5M5X F;  5D4C E;  4A3B F;  2E2I F;  3EQL E;  4XSX E;  4Y7N F;  4Y52 F;  2JA6 F;  5IYC F;  3GTM F;  4OIO E;  2O5I E;  3WOD E;  1QKL A;  4KN7 E;  5D4E E;  1YNJ K;  4YFX E;  2VUM F;  5TMC E;  2YU9 F;  4A3C F;  2R93 F;  2NVT F;  3FKI F;  1IW7 E;  5FJ8 F;  3DXJ E;  5C44 F;  3RZD F;  3PO3 F;  2E2H F;  4JK1 E;  5IYB F;  4BY7 F;  4A3L F;  4XSZ E;  4AYB K;  4OIR E;  3HOY F;  5IPL E;  3HOU F;  4X6A F;  4ZH4 E;  1SFO F;  5M5W F;  2NVQ F;  4G7H E;  3HOV F;  1R9T F;  3I4N F;  4MQ9 E;  4YG2 E;  4A3K F;  3H0G F;  4A3E F;  1SMY E;  1I6H F;  1YNN K;  2A69 E;  3GTQ F;  4LJZ E;  5IYD F;  1Y1W F;  5BYH E;  4G7O E;  2JA7 F;  4GZY E;  3HOZ F;  3HKZ K;  4YFN E;  3S2D F;  4OIP E;  4LK1 E;  3K7A F;  5E18 E;  1K83 F;  4A3M F;  5C4X F;  4A3G F;  2O5J E;  1I6V E;  5C4J F;  2NVY F;  3S1N F;  3S1M F;  3GTP F;  4A3D F;  3RZO F;  3GTJ F;  3GTL F;  4A3J F;  2BE5 E;  5IP7 F;  2JA8 F;  2A68 E;  1TWG F;  1I50 F;  3I4M F;  5TMF E;  3GTK F;  2B63 F;  4BBR F;  2A6H E;  4C3H F;  4BBS F;  5M3F F;  1TWF F;  4Q5S E;  3M4O F;  2R7Z F;  3S2H F;  4KN4 E;  2PMZ K;  2A6E E;  3S16 F;  5D4D E;  5FLM F;  5C3E F;  3S17 F;  2R92 F;  4Q4Z E;  4XLP E;  3HOX F;  3M3Y F;  2CW0 E;  5M3M F;  5M5Y F;  2PPB E;  4XLN E;  4MEY E;  4MEX E;  1HQM E;  3CQZ F;  4BY1 F;  4YFK E;  3S1R F;  2JA5 F;  1TWH F;  1TWA F;  4C3I F;  3GTG F;  4G7Z E;  2WB1 I;  4A3F F;  3HOW F;  4BXX F;  3S14 F;  1WCM F;  2Y0S I;  3S1Q F;  1TWC F;  4LLG E;  5IP9 F;  4C2M F;  4LK0 E;  4A93 F;  3S15 F;  2WAQ K;  1I3Q F;  4A3I F;  4C3J F;  2NVX F; 
#chains in the Genus database with same CATH topology
 2E2J F;  4QIW H;  4BBR E;  4C3H E;  2B63 E;  3H3V G;  4OIQ E;  3GTO F;  3PO2 F;  1EIK A;  3GTK E;  1Y1V F;  1ZYR E;  4OIN E;  5M3F E;  4BBS E;  4KMU E;  5E17 E;  5M5X F;  1TWF E;  2KRX A;  5D4C E;  4A3B F;  2E2I F;  3M4O E;  3S2H E;  3EQL E;  3S16 E;  4XSX E;  5C3E E;  3S17 E;  5C4X E;  4Y7N F;  4Y52 F;  2JA6 F;  5IYC F;  3GTM F;  3HOX E;  4OIO E;  2O5I E;  3M3Y E;  3WOD E;  1QKL A;  3HKZ H;  5M3M E;  5M5Y E;  3S1M E;  4KN7 E;  2WB1 H;  5D4E E;  1YNJ K;  4BY1 E;  2JA5 E;  2Y0S H;  4YFX E;  4C3I E;  5TMC E;  2YU9 F;  2VUM F;  1TWG E;  3GTG E;  4A3C F;  2R93 F;  4A3F E;  3HOW E;  4BXX E;  2NVT F;  3S14 E;  1DZF A;  1WCM E;  3FKI F;  1IW7 E;  3S1Q E;  1TWC E;  4C2M E;  5IP9 E;  5FJ8 F;  4A93 E;  3DXJ E;  5C44 F;  3RZD F;  3S15 E;  3PO3 F;  2E2H F;  1I3Q E;  4JK1 E;  5IYB F;  4BY7 F;  4A3L F;  4XSZ E;  4AYB K;  4OIR E;  2R7Z E;  3HOY F;  4C3J E;  5IPL E;  2NVX E;  2E2J E;  4ZH4 E;  1SFO F;  5M5W F;  3HOU F;  2NVQ F;  4G7H E;  3HOV F;  3GTO E;  1R9T F;  3PO2 E;  1Y1V E;  5FLM E;  3I4N F;  4MQ9 E;  4YG2 E;  4A3K F;  3H0G F;  4A3E F;  1SMY E;  1I6H F;  2R92 E;  1YNN K;  4A3B E;  2A69 E;  2E2I E;  3S1Q F;  3GTQ F;  4LJZ E;  5IYD F;  1Y1W F;  5BYH E;  4G7O E;  2JA7 F;  4GZY E;  3HOZ F;  3HKZ K;  4YFN E;  3S2D F;  2PMZ H;  4OIP E;  3CQZ E;  4Y7N E;  3S1R E;  5IYC E;  4LK1 E;  3K7A F;  2JA6 E;  5E18 E;  3GTM E;  1TWH E;  4Y52 E;  1TWA E;  1K83 F;  4A3M F;  5C4X F;  4QIW K;  4A3G F;  2O5J E;  1I6V E;  5C4J F;  2NVY F;  3S1N F;  2VUM E;  4A3C E;  2YU9 E;  3S1M F;  2R93 E;  3GTP F;  4A3D F;  3RZO F;  3GTJ F;  4A3I E;  2NVT E;  3FKI E;  3GTL F;  4A3J F;  2BE5 E;  5IP7 F;  5FJ8 E;  2JA8 F;  2A68 E;  5C44 E;  3RZD E;  1TWG F;  3PO3 E;  1I50 F;  2E2H E;  3I4M F;  5TMF E;  5M5X E;  5IYB E;  3GTK F;  4A3L E;  2B63 F;  4BBR F;  2A6H E;  4C3H F;  4BY7 E;  3HOU E;  4X6A E;  1SFO E;  5M5W E;  3HOV E;  4BBS F;  2WAQ H;  5M3F F;  1R9T E;  3I4N E;  4A3E E;  4A3K E;  1TWF F;  3H0G E;  4Q5S E;  3M4O F;  2R7Z F;  3S2H F;  1I6H E;  4KN4 E;  2PMZ K;  2A6E E;  3S16 F;  3GTQ E;  5D4D E;  5IYD E;  5FLM F;  5C3E F;  1Y1W E;  2JA7 E;  3S17 F;  3HOZ E;  2R92 F;  4Q4Z E;  4AYB H;  3S2D E;  4XLP E;  3HOX F;  3M3Y F;  3K7A E;  2CW0 E;  5M3M F;  5M5Y F;  2PPB E;  1K83 E;  4XLN E;  4MEY E;  4A3M E;  4MEX E;  1HQM E;  3CQZ F;  4BY1 F;  4YFK E;  3S1R F;  3I4M E;  2JA5 F;  4A3G E;  1TWH F;  1TWA F;  4C3I F;  3GTG F;  4X6A F;  5C4J E;  2NVY E;  2WB1 I;  4G7Z E;  4A3F F;  3HOW F;  4BXX F;  3S1N E;  3S14 F;  1WCM F;  3GTP E;  4A3D E;  3RZO E;  2Y0S I;  3GTJ E;  1TWC F;  4LLG E;  5IP9 F;  4C2M F;  4LK0 E;  3GTL E;  3HOY E;  4A3J E;  5IP7 E;  3H3V F;  2NVQ E;  3S15 F;  2JA8 E;  2WAQ K;  1I3Q F;  1I50 E;  4A93 F;  4A3I F;  4C3J F;  2NVX F; 
#chains in the Genus database with same CATH homology
 2E2J F;  3H3V G;  4OIQ E;  3GTO F;  3PO2 F;  1Y1V F;  1ZYR E;  4OIN E;  4KMU E;  5E17 E;  5M5X F;  2KRX A;  5D4C E;  4A3B F;  2E2I F;  3EQL E;  4XSX E;  4Y7N F;  4Y52 F;  2JA6 F;  5IYC F;  3GTM F;  4OIO E;  2O5I E;  3WOD E;  1QKL A;  4KN7 E;  5D4E E;  1YNJ K;  4YFX E;  2VUM F;  5TMC E;  2YU9 F;  4A3C F;  2R93 F;  2NVT F;  3FKI F;  1IW7 E;  5FJ8 F;  3DXJ E;  5C44 F;  3RZD F;  3PO3 F;  2E2H F;  4JK1 E;  5IYB F;  4BY7 F;  4A3L F;  4XSZ E;  4AYB K;  4OIR E;  3HOY F;  5IPL E;  3HOU F;  4X6A F;  4ZH4 E;  1SFO F;  5M5W F;  2NVQ F;  4G7H E;  3HOV F;  1R9T F;  3I4N F;  4MQ9 E;  4YG2 E;  4A3K F;  3H0G F;  4A3E F;  1SMY E;  1I6H F;  1YNN K;  2A69 E;  3GTQ F;  4LJZ E;  5IYD F;  1Y1W F;  5BYH E;  4G7O E;  2JA7 F;  4GZY E;  3HOZ F;  3HKZ K;  4YFN E;  3S2D F;  4OIP E;  4LK1 E;  3K7A F;  5E18 E;  1K83 F;  4A3M F;  5C4X F;  4QIW K;  4A3G F;  2O5J E;  1I6V E;  5C4J F;  2NVY F;  3S1N F;  3S1M F;  3GTP F;  4A3D F;  3RZO F;  3GTJ F;  3GTL F;  4A3J F;  2BE5 E;  5IP7 F;  2JA8 F;  2A68 E;  1TWG F;  1I50 F;  3I4M F;  5TMF E;  3GTK F;  2B63 F;  4BBR F;  2A6H E;  4C3H F;  4BBS F;  5M3F F;  1TWF F;  4Q5S E;  3M4O F;  2R7Z F;  3S2H F;  4KN4 E;  2PMZ K;  2A6E E;  3S16 F;  5D4D E;  5FLM F;  5C3E F;  3S17 F;  2R92 F;  4Q4Z E;  4XLP E;  3HOX F;  3M3Y F;  2CW0 E;  5M3M F;  5M5Y F;  2PPB E;  4XLN E;  4MEY E;  4MEX E;  1HQM E;  3CQZ F;  4BY1 F;  4YFK E;  3S1R F;  2JA5 F;  1TWH F;  1TWA F;  4C3I F;  3GTG F;  4G7Z E;  2WB1 I;  4A3F F;  3HOW F;  4BXX F;  3S14 F;  1WCM F;  2Y0S I;  3S1Q F;  1TWC F;  4LLG E;  5IP9 F;  4C2M F;  4LK0 E;  4A93 F;  3S15 F;  2WAQ K;  1I3Q F;  4A3I F;  4C3J F;  2NVX F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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