4XSZE

Crystal structure of cbr 9393 bound to escherichia coli rna polymerase holoenzyme
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
89
structure length
89
Chain Sequence
ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
pubmed doi rcsb
molecule tags Transcription/antibiotic
source organism Escherichia coli (strain k12)
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 24
structure length 89
sequence length 89
chains with identical sequence K
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2015-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4xszE00
5IP7F 4G7OE 3HOXF 1YNNK 1HQME 3GTOF 2WB1I 3M4OF 4A3IF 3S17F 2YU9F 5IP9F 1Y1VF 5M3MF 5M5XF 3RZDF 3I4NF 1QKLA 4Q4ZE 4XLPE 2Y0SI 4A93F 3DXJE 2E2IF 4A3GF 2B63F 4OIQE 5FJ8F 1Y1WF 1I6HF 4JK1E 4AYBK 4LK1E 4XSXE 2CW0E 4XSZE 3HOYF 5IPLE 1R9TF 3GTGF 5C3EF 4A3MF 5D4EE 3HOZF 1WCMF 4LJZE 4BBSF 1ZYRE 4BXXF 5C44F 4BBRF 5E18E 2VUMF 3RZOF 3HKZK 1I50F 5TMFE 3K7AF 1I6VE 1I3QF 3I4MF 3GTJF 2NVXF 4BY7F 2NVTF 3GTLF 3S1QF 4A3EF 4C2MF 3HOWF 4MQ9E 5IYCF 2PMZK 4A3LF 4OIPE 4KN4E 4YG2E 4A3DF 1TWHF 1TWCF 4C3JF 3EQLE 3CQZF 4OIOE 5IYDF 2R92F 4C3HF 1YNJK 4LLGE 1TWFF 1SFOF 3PO3F 2O5IE 2JA5F 4KN7E 3S16F 2E2JF 3HOUF 4GZYE 2O5JE 5D4CE 2BE5E 5E17E 4G7HE 3HOVF 2A6HE 4Y52F 5TMCE 2A6EE 5M5YF 3S2HF 3WODE 4YFKE 2JA8F 3FKIF 5FLMF 5M5WF 4KMUE 4YFXE 2R93F 4X6AF 3GTKF 4C3IF 5M3FF 4G7ZE 4A3CF 4Q5SE 2NVYF 2NVQF 5IYBF 1IW7E 1K83F 3S15F 2JA6F 4A3KF 4OINE 4A3JF 3S1MF 1TWAF 4MEXE 3H0GF 3PO2F 3S14F 4LK0E 4A3FF 3GTPF 1SMYE 2A68E 5BYHE 3M3YF 4MEYE 2A69E 1TWGF 5C4JF 3S1NF 5C4XF 2PPBE 4XLNE 3S1RF 4ZH4E 4OIRE 3S2DF 4BY1F 4YFNE 2WAQK 3GTMF 2R7ZF 2JA7F 5D4DE 2E2HF 3GTQF 4Y7NF 3H3VG 4A3BF
chains in the Genus database with same CATH superfamily
3HOUE 5IP7F 4G7OE 3HKZH 3HOXF 1YNNK 5C4XE 1HQME 3GTOF 3S1RE 2WB1I 3M4OF 3S2DE 4A3IF 4QIWK 3S17F 4BY1E 3GTME 2YU9F 2R7ZE 3GTKE 2JA7E 5IP9F 1Y1VF 3GTQE 2NVYE 5M3MF 4Y7NE 5M5XF 3RZDF 4A3BE 3I4NF 1QKLA 4Q4ZE 5IP7E 4XLPE 4A3KE 2Y0SI 3HOXE 4A3JE 3GTOE 4A93F 3DXJE 2E2IF 4A3GF 2B63F 3M4OE 3PO2E 4A3IE 5FJ8F 4OIQE 1Y1WF 1I6HF 4JK1E 4AYBK 4LK1E 1Y1VE 4XSXE 2CW0E 5M3ME 4XSZE 3HOYF 3RZDE 5IPLE 3I4NE 1TWGE 5C4JE 1R9TF 3GTGF 3S1NE 2E2IE 5C3EF 2B63E 4A3MF 2WB1H 2WAQH 5FJ8E 5D4EE 1Y1WE 1WCMF 4LJZE 3HOZF 4BBSF 1I6HE 1ZYRE 4BXXF 5C44F 4BBRF 5E18E 2VUMF 3RZOF 2E2HE 3HOYE 3HKZK 1I50F 3K7AF 5TMFE 1I6VE 1R9TE 1I3QF 3I4MF 3GTGE 3GTJF 2NVXF 4BY7F 2NVTF 3GTLF 3S1QF 5C3EE 4QIWH 4A3EF 4C2MF 3HOWF 3HOZE 3S17E 4BBSE 4MQ9E 5IYCF 5C44E 2PMZK 4BBRE 4OIPE 2YU9E 4A3LF 4KN4E 4YG2E 5IP9E 2VUME 1TWHF 1TWCF 3RZOE 4A3DF 4C3JF 3EQLE 1I50E 3K7AE 3CQZF 5M5XE 4OIOE 5IYDF 3I4ME 3GTJE 2R92F 2NVXE 3GTLE 4C3HF 1YNJK 3S1QE 4LLGE 1TWFF 1SFOF 4A93E 3PO3F 4A3GE 2O5IE 2KRXA 4C2ME 4AYBH 2JA5F 5IYCE 4KN7E 3S16F 2E2JF 3HOUF 4A3LE 4GZYE 5D4CE 2BE5E 4A3DE 2O5JE 1TWHE 1TWCE 4G7HE 3HOVF 2A6HE 5E17E 4Y52F 5TMCE 2A6EE 5M5YF 3CQZE 3WODE 4YFKE 2JA8F 3S2HF 3FKIF 5IYDE 5FLMF 2R92E 4C3HE 5M5WF 2Y0SH 1TWFE 4KMUE 4YFXE 1SFOE 3GTKF 3PO3E 2R93F 4A3ME 4C3IF 5M3FF 4X6AF 4G7ZE 4A3CF 4Q5SE 2NVYF 2NVQF 1WCME 5IYBF 2JA5E 1IW7E 4BXXE 1K83F 2E2JE 3S15F 2JA6F 4A3KF 4OINE 3HOVE 4A3JF 3S1MF 3S2HE 5M5YE 4Y52E 2JA8E 3FKIE 1TWAF 4MEXE 3H0GF 3PO2F 1EIKA 1I3QE 5FLME 5M5WE 2NVTE 3S14F 4BY7E 2R93E 4X6AE 4LK0E 4A3FF 3GTPF 4C3IE 5M3FE 4A3EE 1SMYE 2A68E 2NVQE 4A3CE 2PMZH 3HOWE 5IYBE 1K83E 5BYHE 4MEYE 3M3YF 2JA6E 3H3VF 2A69E 1TWGF 3S15E 5C4JF 3S1ME 4C3JE 3S1NF 2PPBE 5C4XF 4XLNE 3S1RF 3S16E 1TWAE 3H0GE 4ZH4E 4OIRE 3S2DF 4BY1F 4YFNE 2WAQK 3GTMF 3S14E 4A3FE 3GTPE 2R7ZF 2JA7F 1DZFA 5D4DE 2E2HF 3GTQF 4Y7NF 3H3VG 3M3YE 4A3BF
chains in the Genus database with same CATH topology
5IP7F 4G7OE 3HOXF 1YNNK 1HQME 3GTOF 2WB1I 3M4OF 4A3IF 4QIWK 3S17F 2YU9F 5IP9F 1Y1VF 5M3MF 5M5XF 3RZDF 3I4NF 1QKLA 4Q4ZE 4XLPE 2Y0SI 4A93F 3DXJE 2E2IF 4A3GF 2B63F 4OIQE 5FJ8F 1Y1WF 1I6HF 4JK1E 4AYBK 4LK1E 4XSXE 2CW0E 4XSZE 3HOYF 5IPLE 1R9TF 3GTGF 5C3EF 4A3MF 5D4EE 3HOZF 1WCMF 4LJZE 4BBSF 1ZYRE 4BXXF 5C44F 4BBRF 5E18E 2VUMF 3RZOF 3HKZK 1I50F 5TMFE 3K7AF 1I6VE 1I3QF 3I4MF 3GTJF 2NVXF 4BY7F 2NVTF 3GTLF 3S1QF 4A3EF 4C2MF 3HOWF 4MQ9E 5IYCF 2PMZK 4A3LF 4OIPE 4KN4E 4YG2E 4A3DF 1TWHF 1TWCF 4C3JF 3EQLE 3CQZF 4OIOE 5IYDF 2R92F 4C3HF 1YNJK 4LLGE 1TWFF 1SFOF 3PO3F 2O5IE 2KRXA 2JA5F 4KN7E 3S16F 2E2JF 3HOUF 4GZYE 2O5JE 5D4CE 2BE5E 5E17E 4G7HE 3HOVF 2A6HE 4Y52F 5TMCE 2A6EE 5M5YF 3S2HF 3WODE 4YFKE 2JA8F 3FKIF 5FLMF 5M5WF 4KMUE 4YFXE 2R93F 4X6AF 3GTKF 4C3IF 5M3FF 4G7ZE 4A3CF 4Q5SE 2NVYF 2NVQF 5IYBF 1IW7E 1K83F 3S15F 2JA6F 4A3KF 4OINE 4A3JF 3S1MF 1TWAF 4MEXE 3H0GF 3PO2F 3S14F 4LK0E 4A3FF 3GTPF 1SMYE 2A68E 5BYHE 3M3YF 4MEYE 2A69E 1TWGF 5C4JF 3S1NF 5C4XF 2PPBE 4XLNE 3S1RF 4ZH4E 4OIRE 3S2DF 4BY1F 4YFNE 2WAQK 3GTMF 2R7ZF 2JA7F 5D4DE 2E2HF 3GTQF 4Y7NF 3H3VG 4A3BF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IP7 F;  4G7O E;  3HOX F;  1YNN K;  1HQM E;  3GTO F;  2WB1 I;  3M4O F;  4A3I F;  3S17 F;  2YU9 F;  5IP9 F;  1Y1V F;  5M3M F;  5M5X F;  3RZD F;  3I4N F;  1QKL A;  4Q4Z E;  4XLP E;  2Y0S I;  4A93 F;  3DXJ E;  2E2I F;  4A3G F;  2B63 F;  4OIQ E;  5FJ8 F;  1Y1W F;  1I6H F;  4JK1 E;  4AYB K;  4LK1 E;  4XSX E;  2CW0 E;  4XSZ E;  3HOY F;  5IPL E;  1R9T F;  3GTG F;  5C3E F;  4A3M F;  5D4E E;  3HOZ F;  1WCM F;  4LJZ E;  4BBS F;  1ZYR E;  4BXX F;  5C44 F;  4BBR F;  5E18 E;  2VUM F;  3RZO F;  3HKZ K;  1I50 F;  5TMF E;  3K7A F;  1I6V E;  1I3Q F;  3I4M F;  3GTJ F;  2NVX F;  4BY7 F;  2NVT F;  3GTL F;  3S1Q F;  4A3E F;  4C2M F;  3HOW F;  4MQ9 E;  5IYC F;  2PMZ K;  4A3L F;  4OIP E;  4KN4 E;  4YG2 E;  4A3D F;  1TWH F;  1TWC F;  4C3J F;  3EQL E;  3CQZ F;  4OIO E;  5IYD F;  2R92 F;  4C3H F;  1YNJ K;  4LLG E;  1TWF F;  1SFO F;  3PO3 F;  2O5I E;  2JA5 F;  4KN7 E;  3S16 F;  2E2J F;  3HOU F;  4GZY E;  2O5J E;  5D4C E;  2BE5 E;  5E17 E;  4G7H E;  3HOV F;  2A6H E;  4Y52 F;  5TMC E;  2A6E E;  5M5Y F;  3S2H F;  3WOD E;  4YFK E;  2JA8 F;  3FKI F;  5FLM F;  5M5W F;  4KMU E;  4YFX E;  2R93 F;  4X6A F;  3GTK F;  4C3I F;  5M3F F;  4G7Z E;  4A3C F;  4Q5S E;  2NVY F;  2NVQ F;  5IYB F;  1IW7 E;  1K83 F;  3S15 F;  2JA6 F;  4A3K F;  4OIN E;  4A3J F;  3S1M F;  1TWA F;  4MEX E;  3H0G F;  3PO2 F;  3S14 F;  4LK0 E;  4A3F F;  3GTP F;  1SMY E;  2A68 E;  5BYH E;  3M3Y F;  4MEY E;  2A69 E;  1TWG F;  5C4J F;  3S1N F;  5C4X F;  2PPB E;  4XLN E;  3S1R F;  4ZH4 E;  4OIR E;  3S2D F;  4BY1 F;  4YFN E;  2WAQ K;  3GTM F;  2R7Z F;  2JA7 F;  5D4D E;  2E2H F;  3GTQ F;  4Y7N F;  3H3V G;  4A3B F; 
#chains in the Genus database with same CATH topology
 3HOU E;  5IP7 F;  4G7O E;  3HKZ H;  3HOX F;  1YNN K;  5C4X E;  1HQM E;  3GTO F;  3S1R E;  2WB1 I;  3M4O F;  3S2D E;  4A3I F;  4QIW K;  3S17 F;  4BY1 E;  3GTM E;  2YU9 F;  2R7Z E;  3GTK E;  2JA7 E;  5IP9 F;  1Y1V F;  3GTQ E;  2NVY E;  5M3M F;  4Y7N E;  5M5X F;  3RZD F;  4A3B E;  3I4N F;  1QKL A;  4Q4Z E;  5IP7 E;  4XLP E;  4A3K E;  2Y0S I;  3HOX E;  4A3J E;  3GTO E;  4A93 F;  3DXJ E;  2E2I F;  4A3G F;  2B63 F;  3M4O E;  3PO2 E;  4A3I E;  5FJ8 F;  4OIQ E;  1Y1W F;  1I6H F;  4JK1 E;  4AYB K;  4LK1 E;  1Y1V E;  4XSX E;  2CW0 E;  5M3M E;  4XSZ E;  3HOY F;  3RZD E;  5IPL E;  3I4N E;  1TWG E;  5C4J E;  1R9T F;  3GTG F;  3S1N E;  2E2I E;  5C3E F;  2B63 E;  4A3M F;  2WB1 H;  2WAQ H;  5FJ8 E;  5D4E E;  1Y1W E;  1WCM F;  4LJZ E;  3HOZ F;  4BBS F;  1I6H E;  1ZYR E;  4BXX F;  5C44 F;  4BBR F;  5E18 E;  2VUM F;  3RZO F;  2E2H E;  3HOY E;  3HKZ K;  1I50 F;  3K7A F;  5TMF E;  1I6V E;  1R9T E;  1I3Q F;  3I4M F;  3GTG E;  3GTJ F;  2NVX F;  4BY7 F;  2NVT F;  3GTL F;  3S1Q F;  5C3E E;  4QIW H;  4A3E F;  4C2M F;  3HOW F;  3HOZ E;  3S17 E;  4BBS E;  4MQ9 E;  5IYC F;  5C44 E;  2PMZ K;  4BBR E;  4OIP E;  2YU9 E;  4A3L F;  4KN4 E;  4YG2 E;  5IP9 E;  2VUM E;  1TWH F;  1TWC F;  3RZO E;  4A3D F;  4C3J F;  3EQL E;  1I50 E;  3K7A E;  3CQZ F;  5M5X E;  4OIO E;  5IYD F;  3I4M E;  3GTJ E;  2R92 F;  2NVX E;  3GTL E;  4C3H F;  1YNJ K;  3S1Q E;  4LLG E;  1TWF F;  1SFO F;  4A93 E;  3PO3 F;  4A3G E;  2O5I E;  2KRX A;  4C2M E;  4AYB H;  2JA5 F;  5IYC E;  4KN7 E;  3S16 F;  2E2J F;  3HOU F;  4A3L E;  4GZY E;  5D4C E;  2BE5 E;  4A3D E;  2O5J E;  1TWH E;  1TWC E;  4G7H E;  3HOV F;  2A6H E;  5E17 E;  4Y52 F;  5TMC E;  2A6E E;  5M5Y F;  3CQZ E;  3WOD E;  4YFK E;  2JA8 F;  3S2H F;  3FKI F;  5IYD E;  5FLM F;  2R92 E;  4C3H E;  5M5W F;  2Y0S H;  1TWF E;  4KMU E;  4YFX E;  1SFO E;  3GTK F;  3PO3 E;  2R93 F;  4A3M E;  4C3I F;  5M3F F;  4X6A F;  4G7Z E;  4A3C F;  4Q5S E;  2NVY F;  2NVQ F;  1WCM E;  5IYB F;  2JA5 E;  1IW7 E;  4BXX E;  1K83 F;  2E2J E;  3S15 F;  2JA6 F;  4A3K F;  4OIN E;  3HOV E;  4A3J F;  3S1M F;  3S2H E;  5M5Y E;  4Y52 E;  2JA8 E;  3FKI E;  1TWA F;  4MEX E;  3H0G F;  3PO2 F;  1EIK A;  1I3Q E;  5FLM E;  5M5W E;  2NVT E;  3S14 F;  4BY7 E;  2R93 E;  4X6A E;  4LK0 E;  4A3F F;  3GTP F;  4C3I E;  5M3F E;  4A3E E;  1SMY E;  2A68 E;  2NVQ E;  4A3C E;  2PMZ H;  3HOW E;  5IYB E;  1K83 E;  5BYH E;  4MEY E;  3M3Y F;  2JA6 E;  3H3V F;  2A69 E;  1TWG F;  3S15 E;  5C4J F;  3S1M E;  4C3J E;  3S1N F;  2PPB E;  5C4X F;  4XLN E;  3S1R F;  3S16 E;  1TWA E;  3H0G E;  4ZH4 E;  4OIR E;  3S2D F;  4BY1 F;  4YFN E;  2WAQ K;  3GTM F;  3S14 E;  4A3F E;  3GTP E;  2R7Z F;  2JA7 F;  1DZF A;  5D4D E;  2E2H F;  3GTQ F;  4Y7N F;  3H3V G;  3M3Y E;  4A3B F; 
#chains in the Genus database with same CATH homology
 5IP7 F;  4G7O E;  3HOX F;  1YNN K;  1HQM E;  3GTO F;  2WB1 I;  3M4O F;  4A3I F;  4QIW K;  3S17 F;  2YU9 F;  5IP9 F;  1Y1V F;  5M3M F;  5M5X F;  3RZD F;  3I4N F;  1QKL A;  4Q4Z E;  4XLP E;  2Y0S I;  4A93 F;  3DXJ E;  2E2I F;  4A3G F;  2B63 F;  4OIQ E;  5FJ8 F;  1Y1W F;  1I6H F;  4JK1 E;  4AYB K;  4LK1 E;  4XSX E;  2CW0 E;  4XSZ E;  3HOY F;  5IPL E;  1R9T F;  3GTG F;  5C3E F;  4A3M F;  5D4E E;  3HOZ F;  1WCM F;  4LJZ E;  4BBS F;  1ZYR E;  4BXX F;  5C44 F;  4BBR F;  5E18 E;  2VUM F;  3RZO F;  3HKZ K;  1I50 F;  5TMF E;  3K7A F;  1I6V E;  1I3Q F;  3I4M F;  3GTJ F;  2NVX F;  4BY7 F;  2NVT F;  3GTL F;  3S1Q F;  4A3E F;  4C2M F;  3HOW F;  4MQ9 E;  5IYC F;  2PMZ K;  4A3L F;  4OIP E;  4KN4 E;  4YG2 E;  4A3D F;  1TWH F;  1TWC F;  4C3J F;  3EQL E;  3CQZ F;  4OIO E;  5IYD F;  2R92 F;  4C3H F;  1YNJ K;  4LLG E;  1TWF F;  1SFO F;  3PO3 F;  2O5I E;  2KRX A;  2JA5 F;  4KN7 E;  3S16 F;  2E2J F;  3HOU F;  4GZY E;  2O5J E;  5D4C E;  2BE5 E;  5E17 E;  4G7H E;  3HOV F;  2A6H E;  4Y52 F;  5TMC E;  2A6E E;  5M5Y F;  3S2H F;  3WOD E;  4YFK E;  2JA8 F;  3FKI F;  5FLM F;  5M5W F;  4KMU E;  4YFX E;  2R93 F;  4X6A F;  3GTK F;  4C3I F;  5M3F F;  4G7Z E;  4A3C F;  4Q5S E;  2NVY F;  2NVQ F;  5IYB F;  1IW7 E;  1K83 F;  3S15 F;  2JA6 F;  4A3K F;  4OIN E;  4A3J F;  3S1M F;  1TWA F;  4MEX E;  3H0G F;  3PO2 F;  3S14 F;  4LK0 E;  4A3F F;  3GTP F;  1SMY E;  2A68 E;  5BYH E;  3M3Y F;  4MEY E;  2A69 E;  1TWG F;  5C4J F;  3S1N F;  5C4X F;  2PPB E;  4XLN E;  3S1R F;  4ZH4 E;  4OIR E;  3S2D F;  4BY1 F;  4YFN E;  2WAQ K;  3GTM F;  2R7Z F;  2JA7 F;  5D4D E;  2E2H F;  3GTQ F;  4Y7N F;  3H3V G;  4A3B F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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