4Y0YI

Trypsin in complex with with bpti
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
pubmed doi rcsb
molecule tags Hydrolase\inhibitor
molecule keywords Cationic trypsin
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 2015-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4y0yI00
2FI5I 1UUAA 1F5RI 4ISLB 1P2II 1PITA 1MTND 2ZVXA 1NAGA 1B0CA 1Y62A 3LDJA 3AUCA 2RA3C 4TPII 1ZJDB 2UUXA 2HEXA 1CO7I 1T8LB 1BRCI 3LDMA 3BTFI 3GYMI 4Y0ZI 3BTWI 3UOUB 1TFXC 1JC6A 1BPTA 3L33E 2R9PE 3P92E 4BNRI 2CA7A 1TAPA 1BTIA 1BHCA 2J6DA 2TPII 1JV8A 3AUEA 3FP8I 1TCPA 1D0DB 3L3TE 1FAKI 1BRBI 1LD5A 2KNTA 1F7ZI 1FANA 1CA0D 1TPAI 2FI3I 3BYBA 1EJMB 3BTDI 2UUYB 3TGJI 1T7CB 1K6UA 3FP7J 3D65I 4DG4C 3FP6I 3AUBA 3P95E 3OTJI 1BF0A 1YC0I 4PTIA 4NTWB 4U32X 5JB4A 1YLDB 1DTXA 3BTHI 1BZ5A 5C67C 1BUNB 1D0DA 1AALA 1KIGI 1UUBA 1EAWB 2ODYE 2KAII 4ISNB 4Y11I 5JB7A 5JB5A 3BTGI 6PTIA 2M99A 1OA65 1T8NB 4ISOB 1P2JI 4WWYC 1ZR0B 1BPIA 2PTCI 3AUHA 3TPII 4DTGK 2FTLI 1P2QB 1P2NB 3U1JE 3TGII 3LDIA 7PTIA 1YKTB 3CI7A 4Y10I 2JOTA 4BD9B 3OFWA 3BTKI 4NTYB 1FY8I 1P2OB 1G6XA 2IJOI 2LFKA 1KTHA 2M01A 1DEMA 4BQDA 1P2MB 1TAWB 2FI4I 3AUIA 3T62D 1JV9A 2W8XA 2FTMB 1T8MB 3BTMI 4NTXB 3WNYA 1SHPA 1BZXI 1LD6A 3AUDA 1OA55 1IRHA 3AUGA 3BTTI 3BTQI 3BTEI 1ADZA 2ZJXA 1KUNA 1BIKA 4U30W 1DTKA 1BTHP 1CBWD 4Y0YI 2DDIA 2LFLA 1AAPA 5PTIA 1KNTA 2KCRA 1DENA 1YLCB 8PTIA 1P2KI 3M7QB 9PTIA 4WXVC 3TGKI 1T8OB 1QLQA 2TGPI 2DDJA 1TOCR 5JB6A 3UIRC
chains in the Genus database with same CATH superfamily
2FI5I 1UUAA 1F5RI 4ISLB 1P2II 1PITA 1MTND 2ZVXA 1NAGA 1B0CA 1Y62A 3LDJA 3AUCA 2RA3C 4TPII 1ZJDB 2UUXA 2HEXA 1CO7I 1T8LB 1BRCI 3LDMA 3BTFI 3GYMI 4Y0ZI 3BTWI 3UOUB 1TFXC 1JC6A 1BPTA 3L33E 2R9PE 3P92E 4BNRI 2CA7A 1TAPA 1BTIA 1BHCA 2J6DA 2TPII 1JV8A 3AUEA 3FP8I 1TCPA 1D0DB 3L3TE 1FAKI 1BRBI 1LD5A 2KNTA 1F7ZI 1FANA 1CA0D 1TPAI 2FI3I 3BYBA 1EJMB 3BTDI 2UUYB 3TGJI 1T7CB 1K6UA 3FP7J 3D65I 4DG4C 3FP6I 3AUBA 3P95E 3OTJI 1BF0A 1YC0I 4PTIA 4NTWB 4U32X 5JB4A 1YLDB 1DTXA 3BTHI 1BZ5A 5C67C 1BUNB 1D0DA 1AALA 1KIGI 1UUBA 1EAWB 2ODYE 2KAII 4ISNB 4Y11I 5JB7A 5JB5A 3BTGI 6PTIA 2M99A 1OA65 1T8NB 4ISOB 1P2JI 4WWYC 1ZR0B 1BPIA 2PTCI 3AUHA 3TPII 4DTGK 2FTLI 1P2QB 1P2NB 3U1JE 3TGII 3LDIA 7PTIA 1YKTB 3CI7A 4Y10I 2JOTA 4BD9B 3OFWA 3BTKI 4NTYB 1FY8I 1P2OB 1G6XA 2IJOI 2LFKA 1KTHA 2M01A 1DEMA 4BQDA 1P2MB 1TAWB 2FI4I 3AUIA 3T62D 1JV9A 2W8XA 2FTMB 1T8MB 3BTMI 4NTXB 3WNYA 1SHPA 1BZXI 1LD6A 3AUDA 1OA55 1IRHA 3AUGA 3BTTI 3BTQI 3BTEI 1ADZA 2ZJXA 1KUNA 1BIKA 4U30W 1DTKA 1BTHP 1CBWD 4Y0YI 2DDIA 2LFLA 1AAPA 5PTIA 1KNTA 2KCRA 1DENA 1YLCB 8PTIA 1P2KI 3M7QB 9PTIA 4WXVC 3TGKI 1T8OB 1QLQA 2TGPI 2DDJA 1TOCR 5JB6A 3UIRC
chains in the Genus database with same CATH topology
2FI5I 1UUAA 1F5RI 4ISLB 1P2II 1PITA 1MTND 2ZVXA 1NAGA 1B0CA 1Y62A 3LDJA 3AUCA 2RA3C 4TPII 1ZJDB 2UUXA 2HEXA 1CO7I 1T8LB 1BRCI 3LDMA 3BTFI 3GYMI 4Y0ZI 3BTWI 3UOUB 1TFXC 1JC6A 1BPTA 3L33E 2R9PE 3P92E 4BNRI 2CA7A 1TAPA 1BTIA 1BHCA 2J6DA 2TPII 1JV8A 3AUEA 3FP8I 1TCPA 1D0DB 3L3TE 1FAKI 1BRBI 1LD5A 2KNTA 1F7ZI 1FANA 1CA0D 1TPAI 2FI3I 3BYBA 1EJMB 3BTDI 2UUYB 3TGJI 1T7CB 1K6UA 3FP7J 3D65I 4DG4C 3FP6I 3AUBA 3P95E 3OTJI 1BF0A 1YC0I 4PTIA 4NTWB 4U32X 5JB4A 1YLDB 1DTXA 3BTHI 1BZ5A 5C67C 1BUNB 1D0DA 1AALA 1KIGI 1UUBA 1EAWB 2ODYE 2KAII 4ISNB 4Y11I 5JB7A 5JB5A 3BTGI 6PTIA 2M99A 1OA65 1T8NB 4ISOB 1P2JI 4WWYC 1ZR0B 1BPIA 2PTCI 3AUHA 3TPII 4DTGK 2FTLI 1P2QB 1P2NB 3U1JE 3TGII 3LDIA 7PTIA 1YKTB 3CI7A 4Y10I 2JOTA 4BD9B 3OFWA 3BTKI 4NTYB 1FY8I 1P2OB 1G6XA 2IJOI 2LFKA 1KTHA 2M01A 1DEMA 4BQDA 1P2MB 1TAWB 2FI4I 3AUIA 3T62D 1JV9A 2W8XA 2FTMB 1T8MB 3BTMI 4NTXB 3WNYA 1SHPA 1BZXI 1LD6A 3AUDA 1OA55 1IRHA 3AUGA 3BTTI 3BTQI 3BTEI 1ADZA 2ZJXA 1KUNA 1BIKA 4U30W 1DTKA 1BTHP 1CBWD 4Y0YI 2DDIA 2LFLA 1AAPA 5PTIA 1KNTA 2KCRA 1DENA 1YLCB 8PTIA 1P2KI 3M7QB 9PTIA 4WXVC 3TGKI 1T8OB 1QLQA 2TGPI 2DDJA 1TOCR 5JB6A 3UIRC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FI5 I;  1UUA A;  1F5R I;  4ISL B;  1P2I I;  1PIT A;  1MTN D;  2ZVX A;  1NAG A;  1B0C A;  1Y62 A;  3LDJ A;  3AUC A;  2RA3 C;  4TPI I;  1ZJD B;  2UUX A;  2HEX A;  1CO7 I;  1T8L B;  1BRC I;  3LDM A;  3BTF I;  3GYM I;  4Y0Z I;  3BTW I;  3UOU B;  1TFX C;  1JC6 A;  1BPT A;  3L33 E;  2R9P E;  3P92 E;  4BNR I;  2CA7 A;  1TAP A;  1BTI A;  1BHC A;  2J6D A;  2TPI I;  1JV8 A;  3AUE A;  3FP8 I;  1TCP A;  1D0D B;  3L3T E;  1FAK I;  1BRB I;  1LD5 A;  2KNT A;  1F7Z I;  1FAN A;  1CA0 D;  1TPA I;  2FI3 I;  3BYB A;  1EJM B;  3BTD I;  2UUY B;  3TGJ I;  1T7C B;  1K6U A;  3FP7 J;  3D65 I;  4DG4 C;  3FP6 I;  3AUB A;  3P95 E;  3OTJ I;  1BF0 A;  1YC0 I;  4PTI A;  4NTW B;  4U32 X;  5JB4 A;  1YLD B;  1DTX A;  3BTH I;  1BZ5 A;  5C67 C;  1BUN B;  1D0D A;  1AAL A;  1KIG I;  1UUB A;  1EAW B;  2ODY E;  2KAI I;  4ISN B;  4Y11 I;  5JB7 A;  5JB5 A;  3BTG I;  6PTI A;  2M99 A;  1OA6 5;  1T8N B;  4ISO B;  1P2J I;  4WWY C;  1ZR0 B;  1BPI A;  2PTC I;  3AUH A;  3TPI I;  4DTG K;  2FTL I;  1P2Q B;  1P2N B;  3U1J E;  3TGI I;  3LDI A;  7PTI A;  1YKT B;  3CI7 A;  4Y10 I;  2JOT A;  4BD9 B;  3OFW A;  3BTK I;  4NTY B;  1FY8 I;  1P2O B;  1G6X A;  2IJO I;  2LFK A;  1KTH A;  2M01 A;  1DEM A;  4BQD A;  1P2M B;  1TAW B;  2FI4 I;  3AUI A;  3T62 D;  1JV9 A;  2W8X A;  2FTM B;  1T8M B;  3BTM I;  4NTX B;  3WNY A;  1SHP A;  1BZX I;  1LD6 A;  3AUD A;  1OA5 5;  1IRH A;  3AUG A;  3BTT I;  3BTQ I;  3BTE I;  1ADZ A;  2ZJX A;  1KUN A;  1BIK A;  4U30 W;  1DTK A;  1BTH P;  1CBW D;  4Y0Y I;  2DDI A;  2LFL A;  1AAP A;  5PTI A;  1KNT A;  2KCR A;  1DEN A;  1YLC B;  8PTI A;  1P2K I;  3M7Q B;  9PTI A;  4WXV C;  3TGK I;  1T8O B;  1QLQ A;  2TGP I;  2DDJ A;  1TOC R;  5JB6 A;  3UIR C; 
#chains in the Genus database with same CATH topology
 2FI5 I;  1UUA A;  1F5R I;  4ISL B;  1P2I I;  1PIT A;  1MTN D;  2ZVX A;  1NAG A;  1B0C A;  1Y62 A;  3LDJ A;  3AUC A;  2RA3 C;  4TPI I;  1ZJD B;  2UUX A;  2HEX A;  1CO7 I;  1T8L B;  1BRC I;  3LDM A;  3BTF I;  3GYM I;  4Y0Z I;  3BTW I;  3UOU B;  1TFX C;  1JC6 A;  1BPT A;  3L33 E;  2R9P E;  3P92 E;  4BNR I;  2CA7 A;  1TAP A;  1BTI A;  1BHC A;  2J6D A;  2TPI I;  1JV8 A;  3AUE A;  3FP8 I;  1TCP A;  1D0D B;  3L3T E;  1FAK I;  1BRB I;  1LD5 A;  2KNT A;  1F7Z I;  1FAN A;  1CA0 D;  1TPA I;  2FI3 I;  3BYB A;  1EJM B;  3BTD I;  2UUY B;  3TGJ I;  1T7C B;  1K6U A;  3FP7 J;  3D65 I;  4DG4 C;  3FP6 I;  3AUB A;  3P95 E;  3OTJ I;  1BF0 A;  1YC0 I;  4PTI A;  4NTW B;  4U32 X;  5JB4 A;  1YLD B;  1DTX A;  3BTH I;  1BZ5 A;  5C67 C;  1BUN B;  1D0D A;  1AAL A;  1KIG I;  1UUB A;  1EAW B;  2ODY E;  2KAI I;  4ISN B;  4Y11 I;  5JB7 A;  5JB5 A;  3BTG I;  6PTI A;  2M99 A;  1OA6 5;  1T8N B;  4ISO B;  1P2J I;  4WWY C;  1ZR0 B;  1BPI A;  2PTC I;  3AUH A;  3TPI I;  4DTG K;  2FTL I;  1P2Q B;  1P2N B;  3U1J E;  3TGI I;  3LDI A;  7PTI A;  1YKT B;  3CI7 A;  4Y10 I;  2JOT A;  4BD9 B;  3OFW A;  3BTK I;  4NTY B;  1FY8 I;  1P2O B;  1G6X A;  2IJO I;  2LFK A;  1KTH A;  2M01 A;  1DEM A;  4BQD A;  1P2M B;  1TAW B;  2FI4 I;  3AUI A;  3T62 D;  1JV9 A;  2W8X A;  2FTM B;  1T8M B;  3BTM I;  4NTX B;  3WNY A;  1SHP A;  1BZX I;  1LD6 A;  3AUD A;  1OA5 5;  1IRH A;  3AUG A;  3BTT I;  3BTQ I;  3BTE I;  1ADZ A;  2ZJX A;  1KUN A;  1BIK A;  4U30 W;  1DTK A;  1BTH P;  1CBW D;  4Y0Y I;  2DDI A;  2LFL A;  1AAP A;  5PTI A;  1KNT A;  2KCR A;  1DEN A;  1YLC B;  8PTI A;  1P2K I;  3M7Q B;  9PTI A;  4WXV C;  3TGK I;  1T8O B;  1QLQ A;  2TGP I;  2DDJ A;  1TOC R;  5JB6 A;  3UIR C; 
#chains in the Genus database with same CATH homology
 2FI5 I;  1UUA A;  1F5R I;  4ISL B;  1P2I I;  1PIT A;  1MTN D;  2ZVX A;  1NAG A;  1B0C A;  1Y62 A;  3LDJ A;  3AUC A;  2RA3 C;  4TPI I;  1ZJD B;  2UUX A;  2HEX A;  1CO7 I;  1T8L B;  1BRC I;  3LDM A;  3BTF I;  3GYM I;  4Y0Z I;  3BTW I;  3UOU B;  1TFX C;  1JC6 A;  1BPT A;  3L33 E;  2R9P E;  3P92 E;  4BNR I;  2CA7 A;  1TAP A;  1BTI A;  1BHC A;  2J6D A;  2TPI I;  1JV8 A;  3AUE A;  3FP8 I;  1TCP A;  1D0D B;  3L3T E;  1FAK I;  1BRB I;  1LD5 A;  2KNT A;  1F7Z I;  1FAN A;  1CA0 D;  1TPA I;  2FI3 I;  3BYB A;  1EJM B;  3BTD I;  2UUY B;  3TGJ I;  1T7C B;  1K6U A;  3FP7 J;  3D65 I;  4DG4 C;  3FP6 I;  3AUB A;  3P95 E;  3OTJ I;  1BF0 A;  1YC0 I;  4PTI A;  4NTW B;  4U32 X;  5JB4 A;  1YLD B;  1DTX A;  3BTH I;  1BZ5 A;  5C67 C;  1BUN B;  1D0D A;  1AAL A;  1KIG I;  1UUB A;  1EAW B;  2ODY E;  2KAI I;  4ISN B;  4Y11 I;  5JB7 A;  5JB5 A;  3BTG I;  6PTI A;  2M99 A;  1OA6 5;  1T8N B;  4ISO B;  1P2J I;  4WWY C;  1ZR0 B;  1BPI A;  2PTC I;  3AUH A;  3TPI I;  4DTG K;  2FTL I;  1P2Q B;  1P2N B;  3U1J E;  3TGI I;  3LDI A;  7PTI A;  1YKT B;  3CI7 A;  4Y10 I;  2JOT A;  4BD9 B;  3OFW A;  3BTK I;  4NTY B;  1FY8 I;  1P2O B;  1G6X A;  2IJO I;  2LFK A;  1KTH A;  2M01 A;  1DEM A;  4BQD A;  1P2M B;  1TAW B;  2FI4 I;  3AUI A;  3T62 D;  1JV9 A;  2W8X A;  2FTM B;  1T8M B;  3BTM I;  4NTX B;  3WNY A;  1SHP A;  1BZX I;  1LD6 A;  3AUD A;  1OA5 5;  1IRH A;  3AUG A;  3BTT I;  3BTQ I;  3BTE I;  1ADZ A;  2ZJX A;  1KUN A;  1BIK A;  4U30 W;  1DTK A;  1BTH P;  1CBW D;  4Y0Y I;  2DDI A;  2LFL A;  1AAP A;  5PTI A;  1KNT A;  2KCR A;  1DEN A;  1YLC B;  8PTI A;  1P2K I;  3M7Q B;  9PTI A;  4WXV C;  3TGK I;  1T8O B;  1QLQ A;  2TGP I;  2DDJ A;  1TOC R;  5JB6 A;  3UIR C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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