4Y0ZI

Trypsin in complex with with bpti mutant aminobutyric acid
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
57
structure length
56
Chain Sequence
PDFCLEPPYTGPCARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor complex
molecule keywords Cationic trypsin
total genus 11
structure length 56
sequence length 57
ec nomenclature
pdb deposition date 2015-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4y0zI00
5C67C 4BQDA 5JB7A 1T7CB 3P92E 6PTIA 1P2OB 1KIGI 2TPII 3BTTI 3LDMA 3U1JE 1T8OB 1BIKA 2UUXA 3BTMI 4NTYB 3D65I 1ADZA 1P2JI 2M99A 3BTHI 1MTND 1EJMB 1Y62A 1BRCI 1TAPA 1KUNA 4NTXB 1BHCA 1YLDB 9PTIA 1FY8I 3GYMI 2IJOI 3LDIA 1DTXA 3BYBA 2ODYE 1JV8A 2R9PE 7PTIA 1P2II 1UUBA 1K6UA 3AUIA 4ISNB 1IRHA 1KTHA 5JB4A 4U30W 1ZR0B 2RA3C 1DTKA 2UUYB 1JC6A 1P2KI 1YLCB 2ZVXA 3AUBA 3AUCA 4PTIA 3TGJI 3FP8I 2M01A 1BZXI 3UOUB 3CI7A 3TPII 2DDJA 1BPTA 2FI3I 3AUEA 3AUHA 3LDJA 3UIRC 1BPIA 1KNTA 2ZJXA 3BTWI 1FAKI 2HEXA 1BZ5A 1LD6A 1YKTB 4Y0ZI 1TCPA 1SHPA 2J6DA 2FTLI 2KCRA 4Y11I 1CO7I 1BUNB 1T8LB 1P2MB 4ISLB 5PTIA 1AAPA 1FANA 1TAWB 3BTKI 3BTQI 2PTCI 3L3TE 3M7QB 1P2QB 4ISOB 4Y10I 1UUAA 4Y0YI 1LD5A 3L33E 5JB6A 1DEMA 1TFXC 3BTEI 1AALA 1OA55 1PITA 3TGII 1BRBI 1F5RI 1EAWB 1D0DB 2FI5I 1DENA 2CA7A 4TPII 3AUGA 3WNYA 3OTJI 1YC0I 3OFWA 4NTWB 1G6XA 1ZJDB 1TPAI 3TGKI 4WWYC 1BF0A 3BTGI 2KAII 4BD9B 1BTIA 1BTHP 1NAGA 2W8XA 1TOCR 1D0DA 5JB5A 1CA0D 2FTMB 1JV9A 2KNTA 3FP7J 3BTDI 4U32X 4DG4C 4DTGK 2FI4I 8PTIA 4BNRI 1T8NB 1CBWD 2TGPI 1P2NB 1OA65 1F7ZI 2LFKA 2LFLA 3AUDA 1B0CA 3T62D 1T8MB 3FP6I 2DDIA 3P95E 4WXVC 3BTFI 2JOTA 1QLQA
chains in the Genus database with same CATH superfamily
5C67C 4BQDA 5JB7A 1T7CB 3P92E 6PTIA 1P2OB 1KIGI 2TPII 3BTTI 3LDMA 3U1JE 1T8OB 1BIKA 2UUXA 3BTMI 4NTYB 3D65I 1ADZA 1P2JI 2M99A 3BTHI 1MTND 1EJMB 1Y62A 1BRCI 1TAPA 1KUNA 4NTXB 1BHCA 1YLDB 9PTIA 1FY8I 3GYMI 2IJOI 3LDIA 1DTXA 3BYBA 2ODYE 1JV8A 2R9PE 7PTIA 1P2II 1UUBA 1K6UA 3AUIA 4ISNB 1IRHA 1KTHA 5JB4A 4U30W 1ZR0B 2RA3C 1DTKA 2UUYB 1JC6A 1P2KI 1YLCB 2ZVXA 3AUBA 3AUCA 4PTIA 3TGJI 3FP8I 2M01A 1BZXI 3UOUB 3CI7A 3TPII 2DDJA 1BPTA 2FI3I 3AUEA 3AUHA 3LDJA 3UIRC 1BPIA 1KNTA 2ZJXA 3BTWI 1FAKI 2HEXA 1BZ5A 1LD6A 1YKTB 4Y0ZI 1TCPA 1SHPA 2J6DA 2FTLI 2KCRA 4Y11I 1CO7I 1BUNB 1T8LB 1P2MB 4ISLB 5PTIA 1AAPA 1FANA 1TAWB 3BTKI 3BTQI 2PTCI 3L3TE 3M7QB 1P2QB 4ISOB 4Y10I 1UUAA 4Y0YI 1LD5A 3L33E 5JB6A 1DEMA 1TFXC 3BTEI 1AALA 1OA55 1PITA 3TGII 1BRBI 1F5RI 1EAWB 1D0DB 2FI5I 1DENA 2CA7A 4TPII 3AUGA 3WNYA 3OTJI 1YC0I 3OFWA 4NTWB 1G6XA 1ZJDB 1TPAI 3TGKI 4WWYC 1BF0A 3BTGI 2KAII 4BD9B 1BTIA 1BTHP 1NAGA 2W8XA 1TOCR 1D0DA 5JB5A 1CA0D 2FTMB 1JV9A 2KNTA 3FP7J 3BTDI 4U32X 4DG4C 4DTGK 2FI4I 8PTIA 4BNRI 1T8NB 1CBWD 2TGPI 1P2NB 1OA65 1F7ZI 2LFKA 2LFLA 3AUDA 1B0CA 3T62D 1T8MB 3FP6I 2DDIA 3P95E 4WXVC 3BTFI 2JOTA 1QLQA
chains in the Genus database with same CATH topology
5C67C 4BQDA 5JB7A 1T7CB 3P92E 6PTIA 1P2OB 1KIGI 2TPII 3BTTI 3LDMA 3U1JE 1T8OB 1BIKA 2UUXA 3BTMI 4NTYB 3D65I 1ADZA 1P2JI 2M99A 3BTHI 1MTND 1EJMB 1Y62A 1BRCI 1TAPA 1KUNA 4NTXB 1BHCA 1YLDB 9PTIA 1FY8I 3GYMI 2IJOI 3LDIA 1DTXA 3BYBA 2ODYE 1JV8A 2R9PE 7PTIA 1P2II 1UUBA 1K6UA 3AUIA 4ISNB 1IRHA 1KTHA 5JB4A 4U30W 1ZR0B 2RA3C 1DTKA 2UUYB 1JC6A 1P2KI 1YLCB 2ZVXA 3AUBA 3AUCA 4PTIA 3TGJI 3FP8I 2M01A 1BZXI 3UOUB 3CI7A 3TPII 2DDJA 1BPTA 2FI3I 3AUEA 3AUHA 3LDJA 3UIRC 1BPIA 1KNTA 2ZJXA 3BTWI 1FAKI 2HEXA 1BZ5A 1LD6A 1YKTB 4Y0ZI 1TCPA 1SHPA 2J6DA 2FTLI 2KCRA 4Y11I 1CO7I 1BUNB 1T8LB 1P2MB 4ISLB 5PTIA 1AAPA 1FANA 1TAWB 3BTKI 3BTQI 2PTCI 3L3TE 3M7QB 1P2QB 4ISOB 4Y10I 1UUAA 4Y0YI 1LD5A 3L33E 5JB6A 1DEMA 1TFXC 3BTEI 1AALA 1OA55 1PITA 3TGII 1BRBI 1F5RI 1EAWB 1D0DB 2FI5I 1DENA 2CA7A 4TPII 3AUGA 3WNYA 3OTJI 1YC0I 3OFWA 4NTWB 1G6XA 1ZJDB 1TPAI 3TGKI 4WWYC 1BF0A 3BTGI 2KAII 4BD9B 1BTIA 1BTHP 1NAGA 2W8XA 1TOCR 1D0DA 5JB5A 1CA0D 2FTMB 1JV9A 2KNTA 3FP7J 3BTDI 4U32X 4DG4C 4DTGK 2FI4I 8PTIA 4BNRI 1T8NB 1CBWD 2TGPI 1P2NB 1OA65 1F7ZI 2LFKA 2LFLA 3AUDA 1B0CA 3T62D 1T8MB 3FP6I 2DDIA 3P95E 4WXVC 3BTFI 2JOTA 1QLQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C67 C;  4BQD A;  5JB7 A;  1T7C B;  3P92 E;  6PTI A;  1P2O B;  1KIG I;  2TPI I;  3BTT I;  3LDM A;  3U1J E;  1T8O B;  1BIK A;  2UUX A;  3BTM I;  4NTY B;  3D65 I;  1ADZ A;  1P2J I;  2M99 A;  3BTH I;  1MTN D;  1EJM B;  1Y62 A;  1BRC I;  1TAP A;  1KUN A;  4NTX B;  1BHC A;  1YLD B;  9PTI A;  1FY8 I;  3GYM I;  2IJO I;  3LDI A;  1DTX A;  3BYB A;  2ODY E;  1JV8 A;  2R9P E;  7PTI A;  1P2I I;  1UUB A;  1K6U A;  3AUI A;  4ISN B;  1IRH A;  1KTH A;  5JB4 A;  4U30 W;  1ZR0 B;  2RA3 C;  1DTK A;  2UUY B;  1JC6 A;  1P2K I;  1YLC B;  2ZVX A;  3AUB A;  3AUC A;  4PTI A;  3TGJ I;  3FP8 I;  2M01 A;  1BZX I;  3UOU B;  3CI7 A;  3TPI I;  2DDJ A;  1BPT A;  2FI3 I;  3AUE A;  3AUH A;  3LDJ A;  3UIR C;  1BPI A;  1KNT A;  2ZJX A;  3BTW I;  1FAK I;  2HEX A;  1BZ5 A;  1LD6 A;  1YKT B;  4Y0Z I;  1TCP A;  1SHP A;  2J6D A;  2FTL I;  2KCR A;  4Y11 I;  1CO7 I;  1BUN B;  1T8L B;  1P2M B;  4ISL B;  5PTI A;  1AAP A;  1FAN A;  1TAW B;  3BTK I;  3BTQ I;  2PTC I;  3L3T E;  3M7Q B;  1P2Q B;  4ISO B;  4Y10 I;  1UUA A;  4Y0Y I;  1LD5 A;  3L33 E;  5JB6 A;  1DEM A;  1TFX C;  3BTE I;  1AAL A;  1OA5 5;  1PIT A;  3TGI I;  1BRB I;  1F5R I;  1EAW B;  1D0D B;  2FI5 I;  1DEN A;  2CA7 A;  4TPI I;  3AUG A;  3WNY A;  3OTJ I;  1YC0 I;  3OFW A;  4NTW B;  1G6X A;  1ZJD B;  1TPA I;  3TGK I;  4WWY C;  1BF0 A;  3BTG I;  2KAI I;  4BD9 B;  1BTI A;  1BTH P;  1NAG A;  2W8X A;  1TOC R;  1D0D A;  5JB5 A;  1CA0 D;  2FTM B;  1JV9 A;  2KNT A;  3FP7 J;  3BTD I;  4U32 X;  4DG4 C;  4DTG K;  2FI4 I;  8PTI A;  4BNR I;  1T8N B;  1CBW D;  2TGP I;  1P2N B;  1OA6 5;  1F7Z I;  2LFK A;  2LFL A;  3AUD A;  1B0C A;  3T62 D;  1T8M B;  3FP6 I;  2DDI A;  3P95 E;  4WXV C;  3BTF I;  2JOT A;  1QLQ A; 
#chains in the Genus database with same CATH topology
 5C67 C;  4BQD A;  5JB7 A;  1T7C B;  3P92 E;  6PTI A;  1P2O B;  1KIG I;  2TPI I;  3BTT I;  3LDM A;  3U1J E;  1T8O B;  1BIK A;  2UUX A;  3BTM I;  4NTY B;  3D65 I;  1ADZ A;  1P2J I;  2M99 A;  3BTH I;  1MTN D;  1EJM B;  1Y62 A;  1BRC I;  1TAP A;  1KUN A;  4NTX B;  1BHC A;  1YLD B;  9PTI A;  1FY8 I;  3GYM I;  2IJO I;  3LDI A;  1DTX A;  3BYB A;  2ODY E;  1JV8 A;  2R9P E;  7PTI A;  1P2I I;  1UUB A;  1K6U A;  3AUI A;  4ISN B;  1IRH A;  1KTH A;  5JB4 A;  4U30 W;  1ZR0 B;  2RA3 C;  1DTK A;  2UUY B;  1JC6 A;  1P2K I;  1YLC B;  2ZVX A;  3AUB A;  3AUC A;  4PTI A;  3TGJ I;  3FP8 I;  2M01 A;  1BZX I;  3UOU B;  3CI7 A;  3TPI I;  2DDJ A;  1BPT A;  2FI3 I;  3AUE A;  3AUH A;  3LDJ A;  3UIR C;  1BPI A;  1KNT A;  2ZJX A;  3BTW I;  1FAK I;  2HEX A;  1BZ5 A;  1LD6 A;  1YKT B;  4Y0Z I;  1TCP A;  1SHP A;  2J6D A;  2FTL I;  2KCR A;  4Y11 I;  1CO7 I;  1BUN B;  1T8L B;  1P2M B;  4ISL B;  5PTI A;  1AAP A;  1FAN A;  1TAW B;  3BTK I;  3BTQ I;  2PTC I;  3L3T E;  3M7Q B;  1P2Q B;  4ISO B;  4Y10 I;  1UUA A;  4Y0Y I;  1LD5 A;  3L33 E;  5JB6 A;  1DEM A;  1TFX C;  3BTE I;  1AAL A;  1OA5 5;  1PIT A;  3TGI I;  1BRB I;  1F5R I;  1EAW B;  1D0D B;  2FI5 I;  1DEN A;  2CA7 A;  4TPI I;  3AUG A;  3WNY A;  3OTJ I;  1YC0 I;  3OFW A;  4NTW B;  1G6X A;  1ZJD B;  1TPA I;  3TGK I;  4WWY C;  1BF0 A;  3BTG I;  2KAI I;  4BD9 B;  1BTI A;  1BTH P;  1NAG A;  2W8X A;  1TOC R;  1D0D A;  5JB5 A;  1CA0 D;  2FTM B;  1JV9 A;  2KNT A;  3FP7 J;  3BTD I;  4U32 X;  4DG4 C;  4DTG K;  2FI4 I;  8PTI A;  4BNR I;  1T8N B;  1CBW D;  2TGP I;  1P2N B;  1OA6 5;  1F7Z I;  2LFK A;  2LFL A;  3AUD A;  1B0C A;  3T62 D;  1T8M B;  3FP6 I;  2DDI A;  3P95 E;  4WXV C;  3BTF I;  2JOT A;  1QLQ A; 
#chains in the Genus database with same CATH homology
 5C67 C;  4BQD A;  5JB7 A;  1T7C B;  3P92 E;  6PTI A;  1P2O B;  1KIG I;  2TPI I;  3BTT I;  3LDM A;  3U1J E;  1T8O B;  1BIK A;  2UUX A;  3BTM I;  4NTY B;  3D65 I;  1ADZ A;  1P2J I;  2M99 A;  3BTH I;  1MTN D;  1EJM B;  1Y62 A;  1BRC I;  1TAP A;  1KUN A;  4NTX B;  1BHC A;  1YLD B;  9PTI A;  1FY8 I;  3GYM I;  2IJO I;  3LDI A;  1DTX A;  3BYB A;  2ODY E;  1JV8 A;  2R9P E;  7PTI A;  1P2I I;  1UUB A;  1K6U A;  3AUI A;  4ISN B;  1IRH A;  1KTH A;  5JB4 A;  4U30 W;  1ZR0 B;  2RA3 C;  1DTK A;  2UUY B;  1JC6 A;  1P2K I;  1YLC B;  2ZVX A;  3AUB A;  3AUC A;  4PTI A;  3TGJ I;  3FP8 I;  2M01 A;  1BZX I;  3UOU B;  3CI7 A;  3TPI I;  2DDJ A;  1BPT A;  2FI3 I;  3AUE A;  3AUH A;  3LDJ A;  3UIR C;  1BPI A;  1KNT A;  2ZJX A;  3BTW I;  1FAK I;  2HEX A;  1BZ5 A;  1LD6 A;  1YKT B;  4Y0Z I;  1TCP A;  1SHP A;  2J6D A;  2FTL I;  2KCR A;  4Y11 I;  1CO7 I;  1BUN B;  1T8L B;  1P2M B;  4ISL B;  5PTI A;  1AAP A;  1FAN A;  1TAW B;  3BTK I;  3BTQ I;  2PTC I;  3L3T E;  3M7Q B;  1P2Q B;  4ISO B;  4Y10 I;  1UUA A;  4Y0Y I;  1LD5 A;  3L33 E;  5JB6 A;  1DEM A;  1TFX C;  3BTE I;  1AAL A;  1OA5 5;  1PIT A;  3TGI I;  1BRB I;  1F5R I;  1EAW B;  1D0D B;  2FI5 I;  1DEN A;  2CA7 A;  4TPI I;  3AUG A;  3WNY A;  3OTJ I;  1YC0 I;  3OFW A;  4NTW B;  1G6X A;  1ZJD B;  1TPA I;  3TGK I;  4WWY C;  1BF0 A;  3BTG I;  2KAI I;  4BD9 B;  1BTI A;  1BTH P;  1NAG A;  2W8X A;  1TOC R;  1D0D A;  5JB5 A;  1CA0 D;  2FTM B;  1JV9 A;  2KNT A;  3FP7 J;  3BTD I;  4U32 X;  4DG4 C;  4DTG K;  2FI4 I;  8PTI A;  4BNR I;  1T8N B;  1CBW D;  2TGP I;  1P2N B;  1OA6 5;  1F7Z I;  2LFK A;  2LFL A;  3AUD A;  1B0C A;  3T62 D;  1T8M B;  3FP6 I;  2DDI A;  3P95 E;  4WXV C;  3BTF I;  2JOT A;  1QLQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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