4Y10I

Trypsin in complex with with bpti mutant (2s)-2-amino-4,4-difluorobutanoic acid
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
57
structure length
56
Chain Sequence
PDFCLEPPYTGPCARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Cationic trypsin
total genus 12
structure length 56
sequence length 57
ec nomenclature
pdb deposition date 2015-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4y10I00
1AALA 4U30W 2ZVXA 1BTHP 1YLCB 2FI3I 1DENA 2W8XA 3BTGI 2FI4I 1QLQA 1P2JI 1T7CB 9PTIA 1FAKI 3P95E 1P2QB 1TCPA 1BPTA 1TOCR 1UUAA 3AUCA 1D0DA 3L33E 3LDMA 6PTIA 1EAWB 1BHCA 1BZ5A 4ISNB 3BTEI 4Y10I 1OA55 2KNTA 4BD9B 1JV8A 4ISLB 2HEXA 4BQDA 1JV9A 3CI7A 1ADZA 1OA65 1P2OB 1LD6A 1BTIA 1KIGI 3BTHI 1EJMB 7PTIA 2R9PE 4TPII 1YKTB 3BTQI 3AUBA 2LFKA 3BTTI 1T8MB 2KCRA 2ODYE 2RA3C 2TPII 1PITA 3BTFI 1AAPA 3OFWA 4NTXB 1BRBI 4Y11I 1FANA 3TGJI 3UOUB 3AUGA 1LD5A 1KUNA 3UIRC 1B0CA 1K6UA 1T8NB 2J6DA 4Y0ZI 1P2MB 1P2II 2PTCI 3BTDI 1TPAI 1T8OB 1G6XA 3AUHA 1NAGA 1DEMA 3BTWI 1BIKA 3M7QB 3T62D 4PTIA 2DDJA 2M01A 1IRHA 4BNRI 1BPIA 1CBWD 3FP6I 2FTMB 1BRCI 2M99A 3LDJA 4NTWB 3GYMI 1ZR0B 1SHPA 1P2KI 1DTXA 2IJOI 1BZXI 5JB6A 4NTYB 2KAII 3OTJI 2LFLA 1P2NB 1F5RI 3BTMI 1YC0I 2FTLI 3D65I 3AUEA 4WXVC 1MTND 3WNYA 1BF0A 3LDIA 2UUYB 1D0DB 1TFXC 1JC6A 1CA0D 1TAPA 1Y62A 2DDIA 2FI5I 4Y0YI 1F7ZI 5C67C 1TAWB 1BUNB 1UUBA 3AUIA 1T8LB 3L3TE 4WWYC 3TPII 1FY8I 1ZJDB 2TGPI 4ISOB 5PTIA 3TGKI 3P92E 4DG4C 8PTIA 3AUDA 3FP8I 5JB7A 2JOTA 3TGII 1YLDB 1DTKA 1CO7I 5JB5A 4U32X 4DTGK 3FP7J 2CA7A 5JB4A 2ZJXA 3BTKI 3BYBA 1KNTA 2UUXA 1KTHA 3U1JE
chains in the Genus database with same CATH superfamily
1AALA 4U30W 2ZVXA 1BTHP 1YLCB 2FI3I 1DENA 2W8XA 3BTGI 2FI4I 1QLQA 1P2JI 1T7CB 9PTIA 1FAKI 3P95E 1P2QB 1TCPA 1BPTA 1TOCR 1UUAA 3AUCA 1D0DA 3L33E 3LDMA 6PTIA 1EAWB 1BHCA 1BZ5A 4ISNB 3BTEI 4Y10I 1OA55 2KNTA 4BD9B 1JV8A 4ISLB 2HEXA 4BQDA 1JV9A 3CI7A 1ADZA 1OA65 1P2OB 1LD6A 1BTIA 1KIGI 3BTHI 1EJMB 7PTIA 2R9PE 4TPII 1YKTB 3BTQI 3AUBA 2LFKA 3BTTI 1T8MB 2KCRA 2ODYE 2RA3C 2TPII 1PITA 3BTFI 1AAPA 3OFWA 4NTXB 1BRBI 4Y11I 1FANA 3TGJI 3UOUB 3AUGA 1LD5A 1KUNA 3UIRC 1B0CA 1K6UA 1T8NB 2J6DA 4Y0ZI 1P2MB 1P2II 2PTCI 3BTDI 1TPAI 1T8OB 1G6XA 3AUHA 1NAGA 1DEMA 3BTWI 1BIKA 3M7QB 3T62D 4PTIA 2DDJA 2M01A 1IRHA 4BNRI 1BPIA 1CBWD 3FP6I 2FTMB 1BRCI 2M99A 3LDJA 4NTWB 3GYMI 1ZR0B 1SHPA 1P2KI 1DTXA 2IJOI 1BZXI 5JB6A 4NTYB 2KAII 3OTJI 2LFLA 1P2NB 1F5RI 3BTMI 1YC0I 2FTLI 3D65I 3AUEA 4WXVC 1MTND 3WNYA 1BF0A 3LDIA 2UUYB 1D0DB 1TFXC 1JC6A 1CA0D 1TAPA 1Y62A 2DDIA 2FI5I 4Y0YI 1F7ZI 5C67C 1TAWB 1BUNB 1UUBA 3AUIA 1T8LB 3L3TE 4WWYC 3TPII 1FY8I 1ZJDB 2TGPI 4ISOB 5PTIA 3TGKI 3P92E 4DG4C 8PTIA 3AUDA 3FP8I 5JB7A 2JOTA 3TGII 1YLDB 1DTKA 1CO7I 5JB5A 4U32X 4DTGK 3FP7J 2CA7A 5JB4A 2ZJXA 3BTKI 3BYBA 1KNTA 2UUXA 1KTHA 3U1JE
chains in the Genus database with same CATH topology
1AALA 4U30W 2ZVXA 1BTHP 1YLCB 2FI3I 1DENA 2W8XA 3BTGI 2FI4I 1QLQA 1P2JI 1T7CB 9PTIA 1FAKI 3P95E 1P2QB 1TCPA 1BPTA 1TOCR 1UUAA 3AUCA 1D0DA 3L33E 3LDMA 6PTIA 1EAWB 1BHCA 1BZ5A 4ISNB 3BTEI 4Y10I 1OA55 2KNTA 4BD9B 1JV8A 4ISLB 2HEXA 4BQDA 1JV9A 3CI7A 1ADZA 1OA65 1P2OB 1LD6A 1BTIA 1KIGI 3BTHI 1EJMB 7PTIA 2R9PE 4TPII 1YKTB 3BTQI 3AUBA 2LFKA 3BTTI 1T8MB 2KCRA 2ODYE 2RA3C 2TPII 1PITA 3BTFI 1AAPA 3OFWA 4NTXB 1BRBI 4Y11I 1FANA 3TGJI 3UOUB 3AUGA 1LD5A 1KUNA 3UIRC 1B0CA 1K6UA 1T8NB 2J6DA 4Y0ZI 1P2MB 1P2II 2PTCI 3BTDI 1TPAI 1T8OB 1G6XA 3AUHA 1NAGA 1DEMA 3BTWI 1BIKA 3M7QB 3T62D 4PTIA 2DDJA 2M01A 1IRHA 4BNRI 1BPIA 1CBWD 3FP6I 2FTMB 1BRCI 2M99A 3LDJA 4NTWB 3GYMI 1ZR0B 1SHPA 1P2KI 1DTXA 2IJOI 1BZXI 5JB6A 4NTYB 2KAII 3OTJI 2LFLA 1P2NB 1F5RI 3BTMI 1YC0I 2FTLI 3D65I 3AUEA 4WXVC 1MTND 3WNYA 1BF0A 3LDIA 2UUYB 1D0DB 1TFXC 1JC6A 1CA0D 1TAPA 1Y62A 2DDIA 2FI5I 4Y0YI 1F7ZI 5C67C 1TAWB 1BUNB 1UUBA 3AUIA 1T8LB 3L3TE 4WWYC 3TPII 1FY8I 1ZJDB 2TGPI 4ISOB 5PTIA 3TGKI 3P92E 4DG4C 8PTIA 3AUDA 3FP8I 5JB7A 2JOTA 3TGII 1YLDB 1DTKA 1CO7I 5JB5A 4U32X 4DTGK 3FP7J 2CA7A 5JB4A 2ZJXA 3BTKI 3BYBA 1KNTA 2UUXA 1KTHA 3U1JE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AAL A;  4U30 W;  2ZVX A;  1BTH P;  1YLC B;  2FI3 I;  1DEN A;  2W8X A;  3BTG I;  2FI4 I;  1QLQ A;  1P2J I;  1T7C B;  9PTI A;  1FAK I;  3P95 E;  1P2Q B;  1TCP A;  1BPT A;  1TOC R;  1UUA A;  3AUC A;  1D0D A;  3L33 E;  3LDM A;  6PTI A;  1EAW B;  1BHC A;  1BZ5 A;  4ISN B;  3BTE I;  4Y10 I;  1OA5 5;  2KNT A;  4BD9 B;  1JV8 A;  4ISL B;  2HEX A;  4BQD A;  1JV9 A;  3CI7 A;  1ADZ A;  1OA6 5;  1P2O B;  1LD6 A;  1BTI A;  1KIG I;  3BTH I;  1EJM B;  7PTI A;  2R9P E;  4TPI I;  1YKT B;  3BTQ I;  3AUB A;  2LFK A;  3BTT I;  1T8M B;  2KCR A;  2ODY E;  2RA3 C;  2TPI I;  1PIT A;  3BTF I;  1AAP A;  3OFW A;  4NTX B;  1BRB I;  4Y11 I;  1FAN A;  3TGJ I;  3UOU B;  3AUG A;  1LD5 A;  1KUN A;  3UIR C;  1B0C A;  1K6U A;  1T8N B;  2J6D A;  4Y0Z I;  1P2M B;  1P2I I;  2PTC I;  3BTD I;  1TPA I;  1T8O B;  1G6X A;  3AUH A;  1NAG A;  1DEM A;  3BTW I;  1BIK A;  3M7Q B;  3T62 D;  4PTI A;  2DDJ A;  2M01 A;  1IRH A;  4BNR I;  1BPI A;  1CBW D;  3FP6 I;  2FTM B;  1BRC I;  2M99 A;  3LDJ A;  4NTW B;  3GYM I;  1ZR0 B;  1SHP A;  1P2K I;  1DTX A;  2IJO I;  1BZX I;  5JB6 A;  4NTY B;  2KAI I;  3OTJ I;  2LFL A;  1P2N B;  1F5R I;  3BTM I;  1YC0 I;  2FTL I;  3D65 I;  3AUE A;  4WXV C;  1MTN D;  3WNY A;  1BF0 A;  3LDI A;  2UUY B;  1D0D B;  1TFX C;  1JC6 A;  1CA0 D;  1TAP A;  1Y62 A;  2DDI A;  2FI5 I;  4Y0Y I;  1F7Z I;  5C67 C;  1TAW B;  1BUN B;  1UUB A;  3AUI A;  1T8L B;  3L3T E;  4WWY C;  3TPI I;  1FY8 I;  1ZJD B;  2TGP I;  4ISO B;  5PTI A;  3TGK I;  3P92 E;  4DG4 C;  8PTI A;  3AUD A;  3FP8 I;  5JB7 A;  2JOT A;  3TGI I;  1YLD B;  1DTK A;  1CO7 I;  5JB5 A;  4U32 X;  4DTG K;  3FP7 J;  2CA7 A;  5JB4 A;  2ZJX A;  3BTK I;  3BYB A;  1KNT A;  2UUX A;  1KTH A;  3U1J E; 
#chains in the Genus database with same CATH topology
 1AAL A;  4U30 W;  2ZVX A;  1BTH P;  1YLC B;  2FI3 I;  1DEN A;  2W8X A;  3BTG I;  2FI4 I;  1QLQ A;  1P2J I;  1T7C B;  9PTI A;  1FAK I;  3P95 E;  1P2Q B;  1TCP A;  1BPT A;  1TOC R;  1UUA A;  3AUC A;  1D0D A;  3L33 E;  3LDM A;  6PTI A;  1EAW B;  1BHC A;  1BZ5 A;  4ISN B;  3BTE I;  4Y10 I;  1OA5 5;  2KNT A;  4BD9 B;  1JV8 A;  4ISL B;  2HEX A;  4BQD A;  1JV9 A;  3CI7 A;  1ADZ A;  1OA6 5;  1P2O B;  1LD6 A;  1BTI A;  1KIG I;  3BTH I;  1EJM B;  7PTI A;  2R9P E;  4TPI I;  1YKT B;  3BTQ I;  3AUB A;  2LFK A;  3BTT I;  1T8M B;  2KCR A;  2ODY E;  2RA3 C;  2TPI I;  1PIT A;  3BTF I;  1AAP A;  3OFW A;  4NTX B;  1BRB I;  4Y11 I;  1FAN A;  3TGJ I;  3UOU B;  3AUG A;  1LD5 A;  1KUN A;  3UIR C;  1B0C A;  1K6U A;  1T8N B;  2J6D A;  4Y0Z I;  1P2M B;  1P2I I;  2PTC I;  3BTD I;  1TPA I;  1T8O B;  1G6X A;  3AUH A;  1NAG A;  1DEM A;  3BTW I;  1BIK A;  3M7Q B;  3T62 D;  4PTI A;  2DDJ A;  2M01 A;  1IRH A;  4BNR I;  1BPI A;  1CBW D;  3FP6 I;  2FTM B;  1BRC I;  2M99 A;  3LDJ A;  4NTW B;  3GYM I;  1ZR0 B;  1SHP A;  1P2K I;  1DTX A;  2IJO I;  1BZX I;  5JB6 A;  4NTY B;  2KAI I;  3OTJ I;  2LFL A;  1P2N B;  1F5R I;  3BTM I;  1YC0 I;  2FTL I;  3D65 I;  3AUE A;  4WXV C;  1MTN D;  3WNY A;  1BF0 A;  3LDI A;  2UUY B;  1D0D B;  1TFX C;  1JC6 A;  1CA0 D;  1TAP A;  1Y62 A;  2DDI A;  2FI5 I;  4Y0Y I;  1F7Z I;  5C67 C;  1TAW B;  1BUN B;  1UUB A;  3AUI A;  1T8L B;  3L3T E;  4WWY C;  3TPI I;  1FY8 I;  1ZJD B;  2TGP I;  4ISO B;  5PTI A;  3TGK I;  3P92 E;  4DG4 C;  8PTI A;  3AUD A;  3FP8 I;  5JB7 A;  2JOT A;  3TGI I;  1YLD B;  1DTK A;  1CO7 I;  5JB5 A;  4U32 X;  4DTG K;  3FP7 J;  2CA7 A;  5JB4 A;  2ZJX A;  3BTK I;  3BYB A;  1KNT A;  2UUX A;  1KTH A;  3U1J E; 
#chains in the Genus database with same CATH homology
 1AAL A;  4U30 W;  2ZVX A;  1BTH P;  1YLC B;  2FI3 I;  1DEN A;  2W8X A;  3BTG I;  2FI4 I;  1QLQ A;  1P2J I;  1T7C B;  9PTI A;  1FAK I;  3P95 E;  1P2Q B;  1TCP A;  1BPT A;  1TOC R;  1UUA A;  3AUC A;  1D0D A;  3L33 E;  3LDM A;  6PTI A;  1EAW B;  1BHC A;  1BZ5 A;  4ISN B;  3BTE I;  4Y10 I;  1OA5 5;  2KNT A;  4BD9 B;  1JV8 A;  4ISL B;  2HEX A;  4BQD A;  1JV9 A;  3CI7 A;  1ADZ A;  1OA6 5;  1P2O B;  1LD6 A;  1BTI A;  1KIG I;  3BTH I;  1EJM B;  7PTI A;  2R9P E;  4TPI I;  1YKT B;  3BTQ I;  3AUB A;  2LFK A;  3BTT I;  1T8M B;  2KCR A;  2ODY E;  2RA3 C;  2TPI I;  1PIT A;  3BTF I;  1AAP A;  3OFW A;  4NTX B;  1BRB I;  4Y11 I;  1FAN A;  3TGJ I;  3UOU B;  3AUG A;  1LD5 A;  1KUN A;  3UIR C;  1B0C A;  1K6U A;  1T8N B;  2J6D A;  4Y0Z I;  1P2M B;  1P2I I;  2PTC I;  3BTD I;  1TPA I;  1T8O B;  1G6X A;  3AUH A;  1NAG A;  1DEM A;  3BTW I;  1BIK A;  3M7Q B;  3T62 D;  4PTI A;  2DDJ A;  2M01 A;  1IRH A;  4BNR I;  1BPI A;  1CBW D;  3FP6 I;  2FTM B;  1BRC I;  2M99 A;  3LDJ A;  4NTW B;  3GYM I;  1ZR0 B;  1SHP A;  1P2K I;  1DTX A;  2IJO I;  1BZX I;  5JB6 A;  4NTY B;  2KAI I;  3OTJ I;  2LFL A;  1P2N B;  1F5R I;  3BTM I;  1YC0 I;  2FTL I;  3D65 I;  3AUE A;  4WXV C;  1MTN D;  3WNY A;  1BF0 A;  3LDI A;  2UUY B;  1D0D B;  1TFX C;  1JC6 A;  1CA0 D;  1TAP A;  1Y62 A;  2DDI A;  2FI5 I;  4Y0Y I;  1F7Z I;  5C67 C;  1TAW B;  1BUN B;  1UUB A;  3AUI A;  1T8L B;  3L3T E;  4WWY C;  3TPI I;  1FY8 I;  1ZJD B;  2TGP I;  4ISO B;  5PTI A;  3TGK I;  3P92 E;  4DG4 C;  8PTI A;  3AUD A;  3FP8 I;  5JB7 A;  2JOT A;  3TGI I;  1YLD B;  1DTK A;  1CO7 I;  5JB5 A;  4U32 X;  4DTG K;  3FP7 J;  2CA7 A;  5JB4 A;  2ZJX A;  3BTK I;  3BYB A;  1KNT A;  2UUX A;  1KTH A;  3U1J E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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