4Y11I

Trypsin in complex with with bpti mutant (2s)-2-amino-4,4,4-trifluorobutanoic acid
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
57
structure length
56
Chain Sequence
PDFCLEPPYTGPCARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Cationic trypsin
total genus 11
structure length 56
sequence length 57
ec nomenclature
pdb deposition date 2015-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4y11I00
4TPII 1UUBA 4Y10I 1P2QB 9PTIA 2ZVXA 1FY8I 2LFKA 1IRHA 1YLDB 2J6DA 1CBWD 3AUEA 1JV8A 1MTND 2JOTA 1BTIA 2DDIA 3TGKI 3TGII 3TPII 3BTFI 1B0CA 1BIKA 1LD6A 1TAPA 2LFLA 4BD9B 1DTXA 4NTYB 3M7QB 1JC6A 1BRCI 3T62D 1P2NB 3AUIA 1P2JI 1AAPA 3AUDA 1TCPA 3UIRC 1T8LB 1NAGA 1F5RI 1ZJDB 1BZ5A 3OTJI 3BTMI 1YC0I 1OA55 2M01A 4DG4C 1P2II 1YLCB 2ZJXA 2W8XA 1TOCR 4NTXB 1BHCA 3AUCA 4BNRI 3FP7J 3CI7A 2KCRA 4U32X 2TPII 1EAWB 1YKTB 1BPIA 1T8OB 1TAWB 3BTHI 3BTEI 4ISLB 3AUBA 4Y0ZI 3UOUB 1LD5A 2ODYE 3BYBA 1P2OB 1SHPA 2FI4I 1OA65 2TGPI 5PTIA 1BF0A 2UUYB 1D0DB 1TFXC 3BTDI 4WWYC 2M99A 5JB4A 4BQDA 1DENA 1T8MB 1P2MB 2CA7A 5C67C 2KNTA 2FTMB 6PTIA 3L3TE 2FI3I 2RA3C 1TPAI 2FI5I 3AUGA 1Y62A 4U30W 3GYMI 3OFWA 3D65I 3L33E 4WXVC 8PTIA 1BZXI 4NTWB 1AALA 2IJOI 1DEMA 4DTGK 3FP6I 4PTIA 1KTHA 4Y11I 1T8NB 3BTTI 1KUNA 1BTHP 3WNYA 3P95E 1P2KI 1EJMB 5JB7A 3P92E 3BTWI 3LDIA 3LDJA 1G6XA 2UUXA 1CA0D 1K6UA 2FTLI 3U1JE 2PTCI 3LDMA 2KAII 1KNTA 1ZR0B 7PTIA 1FANA 3TGJI 1PITA 3BTGI 1DTKA 4Y0YI 2DDJA 4ISNB 1QLQA 1CO7I 3AUHA 1BUNB 1BPTA 2R9PE 4ISOB 1BRBI 5JB6A 1D0DA 1JV9A 2HEXA 1KIGI 3BTQI 1T7CB 3BTKI 3FP8I 1ADZA 1FAKI 1UUAA 1F7ZI 5JB5A
chains in the Genus database with same CATH superfamily
4TPII 1UUBA 4Y10I 1P2QB 9PTIA 2ZVXA 1FY8I 2LFKA 1IRHA 1YLDB 2J6DA 1CBWD 3AUEA 1JV8A 1MTND 2JOTA 1BTIA 2DDIA 3TGKI 3TGII 3TPII 3BTFI 1B0CA 1BIKA 1LD6A 1TAPA 2LFLA 4BD9B 1DTXA 4NTYB 3M7QB 1JC6A 1BRCI 3T62D 1P2NB 3AUIA 1P2JI 1AAPA 3AUDA 1TCPA 3UIRC 1T8LB 1NAGA 1F5RI 1ZJDB 1BZ5A 3OTJI 3BTMI 1YC0I 1OA55 2M01A 4DG4C 1P2II 1YLCB 2ZJXA 2W8XA 1TOCR 4NTXB 1BHCA 3AUCA 4BNRI 3FP7J 3CI7A 2KCRA 4U32X 2TPII 1EAWB 1YKTB 1BPIA 1T8OB 1TAWB 3BTHI 3BTEI 4ISLB 3AUBA 4Y0ZI 3UOUB 1LD5A 2ODYE 3BYBA 1P2OB 1SHPA 2FI4I 1OA65 2TGPI 5PTIA 1BF0A 2UUYB 1D0DB 1TFXC 3BTDI 4WWYC 2M99A 5JB4A 4BQDA 1DENA 1T8MB 1P2MB 2CA7A 5C67C 2KNTA 2FTMB 6PTIA 3L3TE 2FI3I 2RA3C 1TPAI 2FI5I 3AUGA 1Y62A 4U30W 3GYMI 3OFWA 3D65I 3L33E 4WXVC 8PTIA 1BZXI 4NTWB 1AALA 2IJOI 1DEMA 4DTGK 3FP6I 4PTIA 1KTHA 4Y11I 1T8NB 3BTTI 1KUNA 1BTHP 3WNYA 3P95E 1P2KI 1EJMB 5JB7A 3P92E 3BTWI 3LDIA 3LDJA 1G6XA 2UUXA 1CA0D 1K6UA 2FTLI 3U1JE 2PTCI 3LDMA 2KAII 1KNTA 1ZR0B 7PTIA 1FANA 3TGJI 1PITA 3BTGI 1DTKA 4Y0YI 2DDJA 4ISNB 1QLQA 1CO7I 3AUHA 1BUNB 1BPTA 2R9PE 4ISOB 1BRBI 5JB6A 1D0DA 1JV9A 2HEXA 1KIGI 3BTQI 1T7CB 3BTKI 3FP8I 1ADZA 1FAKI 1UUAA 1F7ZI 5JB5A
chains in the Genus database with same CATH topology
4TPII 1UUBA 4Y10I 1P2QB 9PTIA 2ZVXA 1FY8I 2LFKA 1IRHA 1YLDB 2J6DA 1CBWD 3AUEA 1JV8A 1MTND 2JOTA 1BTIA 2DDIA 3TGKI 3TGII 3TPII 3BTFI 1B0CA 1BIKA 1LD6A 1TAPA 2LFLA 4BD9B 1DTXA 4NTYB 3M7QB 1JC6A 1BRCI 3T62D 1P2NB 3AUIA 1P2JI 1AAPA 3AUDA 1TCPA 3UIRC 1T8LB 1NAGA 1F5RI 1ZJDB 1BZ5A 3OTJI 3BTMI 1YC0I 1OA55 2M01A 4DG4C 1P2II 1YLCB 2ZJXA 2W8XA 1TOCR 4NTXB 1BHCA 3AUCA 4BNRI 3FP7J 3CI7A 2KCRA 4U32X 2TPII 1EAWB 1YKTB 1BPIA 1T8OB 1TAWB 3BTHI 3BTEI 4ISLB 3AUBA 4Y0ZI 3UOUB 1LD5A 2ODYE 3BYBA 1P2OB 1SHPA 2FI4I 1OA65 2TGPI 5PTIA 1BF0A 2UUYB 1D0DB 1TFXC 3BTDI 4WWYC 2M99A 5JB4A 4BQDA 1DENA 1T8MB 1P2MB 2CA7A 5C67C 2KNTA 2FTMB 6PTIA 3L3TE 2FI3I 2RA3C 1TPAI 2FI5I 3AUGA 1Y62A 4U30W 3GYMI 3OFWA 3D65I 3L33E 4WXVC 8PTIA 1BZXI 4NTWB 1AALA 2IJOI 1DEMA 4DTGK 3FP6I 4PTIA 1KTHA 4Y11I 1T8NB 3BTTI 1KUNA 1BTHP 3WNYA 3P95E 1P2KI 1EJMB 5JB7A 3P92E 3BTWI 3LDIA 3LDJA 1G6XA 2UUXA 1CA0D 1K6UA 2FTLI 3U1JE 2PTCI 3LDMA 2KAII 1KNTA 1ZR0B 7PTIA 1FANA 3TGJI 1PITA 3BTGI 1DTKA 4Y0YI 2DDJA 4ISNB 1QLQA 1CO7I 3AUHA 1BUNB 1BPTA 2R9PE 4ISOB 1BRBI 5JB6A 1D0DA 1JV9A 2HEXA 1KIGI 3BTQI 1T7CB 3BTKI 3FP8I 1ADZA 1FAKI 1UUAA 1F7ZI 5JB5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TPI I;  1UUB A;  4Y10 I;  1P2Q B;  9PTI A;  2ZVX A;  1FY8 I;  2LFK A;  1IRH A;  1YLD B;  2J6D A;  1CBW D;  3AUE A;  1JV8 A;  1MTN D;  2JOT A;  1BTI A;  2DDI A;  3TGK I;  3TGI I;  3TPI I;  3BTF I;  1B0C A;  1BIK A;  1LD6 A;  1TAP A;  2LFL A;  4BD9 B;  1DTX A;  4NTY B;  3M7Q B;  1JC6 A;  1BRC I;  3T62 D;  1P2N B;  3AUI A;  1P2J I;  1AAP A;  3AUD A;  1TCP A;  3UIR C;  1T8L B;  1NAG A;  1F5R I;  1ZJD B;  1BZ5 A;  3OTJ I;  3BTM I;  1YC0 I;  1OA5 5;  2M01 A;  4DG4 C;  1P2I I;  1YLC B;  2ZJX A;  2W8X A;  1TOC R;  4NTX B;  1BHC A;  3AUC A;  4BNR I;  3FP7 J;  3CI7 A;  2KCR A;  4U32 X;  2TPI I;  1EAW B;  1YKT B;  1BPI A;  1T8O B;  1TAW B;  3BTH I;  3BTE I;  4ISL B;  3AUB A;  4Y0Z I;  3UOU B;  1LD5 A;  2ODY E;  3BYB A;  1P2O B;  1SHP A;  2FI4 I;  1OA6 5;  2TGP I;  5PTI A;  1BF0 A;  2UUY B;  1D0D B;  1TFX C;  3BTD I;  4WWY C;  2M99 A;  5JB4 A;  4BQD A;  1DEN A;  1T8M B;  1P2M B;  2CA7 A;  5C67 C;  2KNT A;  2FTM B;  6PTI A;  3L3T E;  2FI3 I;  2RA3 C;  1TPA I;  2FI5 I;  3AUG A;  1Y62 A;  4U30 W;  3GYM I;  3OFW A;  3D65 I;  3L33 E;  4WXV C;  8PTI A;  1BZX I;  4NTW B;  1AAL A;  2IJO I;  1DEM A;  4DTG K;  3FP6 I;  4PTI A;  1KTH A;  4Y11 I;  1T8N B;  3BTT I;  1KUN A;  1BTH P;  3WNY A;  3P95 E;  1P2K I;  1EJM B;  5JB7 A;  3P92 E;  3BTW I;  3LDI A;  3LDJ A;  1G6X A;  2UUX A;  1CA0 D;  1K6U A;  2FTL I;  3U1J E;  2PTC I;  3LDM A;  2KAI I;  1KNT A;  1ZR0 B;  7PTI A;  1FAN A;  3TGJ I;  1PIT A;  3BTG I;  1DTK A;  4Y0Y I;  2DDJ A;  4ISN B;  1QLQ A;  1CO7 I;  3AUH A;  1BUN B;  1BPT A;  2R9P E;  4ISO B;  1BRB I;  5JB6 A;  1D0D A;  1JV9 A;  2HEX A;  1KIG I;  3BTQ I;  1T7C B;  3BTK I;  3FP8 I;  1ADZ A;  1FAK I;  1UUA A;  1F7Z I;  5JB5 A; 
#chains in the Genus database with same CATH topology
 4TPI I;  1UUB A;  4Y10 I;  1P2Q B;  9PTI A;  2ZVX A;  1FY8 I;  2LFK A;  1IRH A;  1YLD B;  2J6D A;  1CBW D;  3AUE A;  1JV8 A;  1MTN D;  2JOT A;  1BTI A;  2DDI A;  3TGK I;  3TGI I;  3TPI I;  3BTF I;  1B0C A;  1BIK A;  1LD6 A;  1TAP A;  2LFL A;  4BD9 B;  1DTX A;  4NTY B;  3M7Q B;  1JC6 A;  1BRC I;  3T62 D;  1P2N B;  3AUI A;  1P2J I;  1AAP A;  3AUD A;  1TCP A;  3UIR C;  1T8L B;  1NAG A;  1F5R I;  1ZJD B;  1BZ5 A;  3OTJ I;  3BTM I;  1YC0 I;  1OA5 5;  2M01 A;  4DG4 C;  1P2I I;  1YLC B;  2ZJX A;  2W8X A;  1TOC R;  4NTX B;  1BHC A;  3AUC A;  4BNR I;  3FP7 J;  3CI7 A;  2KCR A;  4U32 X;  2TPI I;  1EAW B;  1YKT B;  1BPI A;  1T8O B;  1TAW B;  3BTH I;  3BTE I;  4ISL B;  3AUB A;  4Y0Z I;  3UOU B;  1LD5 A;  2ODY E;  3BYB A;  1P2O B;  1SHP A;  2FI4 I;  1OA6 5;  2TGP I;  5PTI A;  1BF0 A;  2UUY B;  1D0D B;  1TFX C;  3BTD I;  4WWY C;  2M99 A;  5JB4 A;  4BQD A;  1DEN A;  1T8M B;  1P2M B;  2CA7 A;  5C67 C;  2KNT A;  2FTM B;  6PTI A;  3L3T E;  2FI3 I;  2RA3 C;  1TPA I;  2FI5 I;  3AUG A;  1Y62 A;  4U30 W;  3GYM I;  3OFW A;  3D65 I;  3L33 E;  4WXV C;  8PTI A;  1BZX I;  4NTW B;  1AAL A;  2IJO I;  1DEM A;  4DTG K;  3FP6 I;  4PTI A;  1KTH A;  4Y11 I;  1T8N B;  3BTT I;  1KUN A;  1BTH P;  3WNY A;  3P95 E;  1P2K I;  1EJM B;  5JB7 A;  3P92 E;  3BTW I;  3LDI A;  3LDJ A;  1G6X A;  2UUX A;  1CA0 D;  1K6U A;  2FTL I;  3U1J E;  2PTC I;  3LDM A;  2KAI I;  1KNT A;  1ZR0 B;  7PTI A;  1FAN A;  3TGJ I;  1PIT A;  3BTG I;  1DTK A;  4Y0Y I;  2DDJ A;  4ISN B;  1QLQ A;  1CO7 I;  3AUH A;  1BUN B;  1BPT A;  2R9P E;  4ISO B;  1BRB I;  5JB6 A;  1D0D A;  1JV9 A;  2HEX A;  1KIG I;  3BTQ I;  1T7C B;  3BTK I;  3FP8 I;  1ADZ A;  1FAK I;  1UUA A;  1F7Z I;  5JB5 A; 
#chains in the Genus database with same CATH homology
 4TPI I;  1UUB A;  4Y10 I;  1P2Q B;  9PTI A;  2ZVX A;  1FY8 I;  2LFK A;  1IRH A;  1YLD B;  2J6D A;  1CBW D;  3AUE A;  1JV8 A;  1MTN D;  2JOT A;  1BTI A;  2DDI A;  3TGK I;  3TGI I;  3TPI I;  3BTF I;  1B0C A;  1BIK A;  1LD6 A;  1TAP A;  2LFL A;  4BD9 B;  1DTX A;  4NTY B;  3M7Q B;  1JC6 A;  1BRC I;  3T62 D;  1P2N B;  3AUI A;  1P2J I;  1AAP A;  3AUD A;  1TCP A;  3UIR C;  1T8L B;  1NAG A;  1F5R I;  1ZJD B;  1BZ5 A;  3OTJ I;  3BTM I;  1YC0 I;  1OA5 5;  2M01 A;  4DG4 C;  1P2I I;  1YLC B;  2ZJX A;  2W8X A;  1TOC R;  4NTX B;  1BHC A;  3AUC A;  4BNR I;  3FP7 J;  3CI7 A;  2KCR A;  4U32 X;  2TPI I;  1EAW B;  1YKT B;  1BPI A;  1T8O B;  1TAW B;  3BTH I;  3BTE I;  4ISL B;  3AUB A;  4Y0Z I;  3UOU B;  1LD5 A;  2ODY E;  3BYB A;  1P2O B;  1SHP A;  2FI4 I;  1OA6 5;  2TGP I;  5PTI A;  1BF0 A;  2UUY B;  1D0D B;  1TFX C;  3BTD I;  4WWY C;  2M99 A;  5JB4 A;  4BQD A;  1DEN A;  1T8M B;  1P2M B;  2CA7 A;  5C67 C;  2KNT A;  2FTM B;  6PTI A;  3L3T E;  2FI3 I;  2RA3 C;  1TPA I;  2FI5 I;  3AUG A;  1Y62 A;  4U30 W;  3GYM I;  3OFW A;  3D65 I;  3L33 E;  4WXV C;  8PTI A;  1BZX I;  4NTW B;  1AAL A;  2IJO I;  1DEM A;  4DTG K;  3FP6 I;  4PTI A;  1KTH A;  4Y11 I;  1T8N B;  3BTT I;  1KUN A;  1BTH P;  3WNY A;  3P95 E;  1P2K I;  1EJM B;  5JB7 A;  3P92 E;  3BTW I;  3LDI A;  3LDJ A;  1G6X A;  2UUX A;  1CA0 D;  1K6U A;  2FTL I;  3U1J E;  2PTC I;  3LDM A;  2KAI I;  1KNT A;  1ZR0 B;  7PTI A;  1FAN A;  3TGJ I;  1PIT A;  3BTG I;  1DTK A;  4Y0Y I;  2DDJ A;  4ISN B;  1QLQ A;  1CO7 I;  3AUH A;  1BUN B;  1BPT A;  2R9P E;  4ISO B;  1BRB I;  5JB6 A;  1D0D A;  1JV9 A;  2HEX A;  1KIG I;  3BTQ I;  1T7C B;  3BTK I;  3FP8 I;  1ADZ A;  1FAK I;  1UUA A;  1F7Z I;  5JB5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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