4ZH4E

Crystal structure of escherichia coli rna polymerase in complex with cbrp18
Total Genus 25
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
89
structure length
89
Chain Sequence
ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Escherichia coli
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 25
structure length 89
sequence length 89
chains with identical sequence K
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2015-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4zh4E00
4G7ZE 5IP7F 2E2HF 3HKZK 4LLGE 4XSZE 4G7HE 3K7AF 4C2MF 4OIOE 3HOWF 4Y52F 1IW7E 1QKLA 3HOYF 4YFKE 3CQZF 1HQME 5E18E 4BXXF 2YU9F 3GTQF 4LJZE 4A3JF 3S1QF 4XSXE 2VUMF 2JA5F 4AYBK 1TWFF 1WCMF 3S14F 4YFXE 4MEXE 1YNJK 3HOZF 5D4CE 4A3MF 3M3YF 4A3FF 1TWCF 5BYHE 3S1MF 3S1RF 3GTLF 4OIPE 4A3DF 4A3GF 3I4NF 5IYBF 2A68E 3WODE 3S16F 4GZYE 2Y0SI 4KN7E 4OINE 3FKIF 1Y1WF 1TWHF 1I50F 2E2JF 4A93F 4YG2E 4OIQE 3PO2F 4MEYE 2NVXF 2NVYF 4C3JF 1I3QF 3S1NF 5M3MF 3GTKF 4Q5SE 4Y7NF 1K83F 5M5WF 4LK1E 3HOXF 4A3KF 3EQLE 4A3LF 5TMFE 2R92F 5IP9F 2NVTF 2BE5E 4KN4E 2JA7F 3GTJF 3RZOF 3H0GF 4Q4ZE 2WB1I 1TWAF 1SMYE 4MQ9E 5IYDF 3M4OF 3GTMF 3S2DF 2R93F 1I6VE 3H3VG 4ZH4E 2PPBE 3PO3F 5M5XF 3DXJE 2JA6F 3HOUF 2A6HE 2B63F 4BY1F 5D4DE 2O5IE 5C4XF 2NVQF 2WAQK 3I4MF 3S17F 1TWGF 5FLMF 5IPLE 5C4JF 4JK1E 5C3EF 5E17E 5M3FF 3S2HF 1ZYRE 4C3IF 2O5JE 1SFOF 5D4EE 5TMCE 4OIRE 2R7ZF 4G7OE 4BY7F 2A6EE 4A3BF 2A69E 4X6AF 3GTPF 3HOVF 1R9TF 1Y1VF 4LK0E 2JA8F 3GTGF 5M5YF 3GTOF 4KMUE 5C44F 3RZDF 4YFNE 5FJ8F 3S15F 4XLNE 1YNNK 2CW0E 5IYCF 4A3EF 4A3CF 2E2IF 4XLPE 1I6HF 4A3IF 4C3HF 4BBRF 4BBSF 2PMZK
chains in the Genus database with same CATH superfamily
4G7ZE 5IP7F 1K83E 5M5WE 2E2HF 3H3VF 3HKZK 4LLGE 3HOXE 4A3KE 4XSZE 4A3LE 4G7HE 2Y0SH 3HKZH 3K7AF 4QIWK 4C2MF 2R92E 5IP9E 2NVTE 4OIOE 2JA7E 3HOWF 3RZOE 3H0GE 4Y52F 1IW7E 1QKLA 3HOYF 1TWAE 5IYDE 4YFKE 3M4OE 3S2DE 3CQZF 3GTME 2R93E 1HQME 5E18E 4BXXF 2YU9F 3GTQF 3GTGE 3PO3E 5M5XE 4LJZE 2JA6E 2B63E 4BY1E 4A3JF 3S1QF 4XSXE 2VUMF 2E2IE 4AYBK 1TWFF 2JA5F 2NVQE 3S17E 3I4ME 5C4XE 1TWGE 5FLME 1WCMF 2WB1H 4Y7NE 3S14F 4YFXE 4MEXE 5C4JE 1YNJK 3HOZF 5C3EE 1DZFA 5D4CE 4A3MF 3M3YF 2PMZH 5M3FE 3S2HE 4A3FF 1TWCF 4C3IE 5BYHE 3S1MF 4QIWH 1SFOE 3S1RF 2R7ZE 3GTLF 4OIPE 4A3BE 4BY7E 4A3DF 3I4NF 4A3GF 4X6AE 5IYBF 3GTPE 2A68E 3HOVE 3WODE 1R9TE 3S16F 4GZYE 1Y1VE 2Y0SI 4KN7E 2JA8E 4OINE 3FKIF 5M5YE 1Y1WF 3GTOE 1I50F 1TWHF 5C44E 3RZDE 2E2JF 4YG2E 4A93F 5FJ8E 4OIQE 4MEYE 3S15E 2NVXF 3PO2F 2NVYF 5IYCE 1I3QF 4C3JF 4A3EE 3S1NF 5M3MF 3GTKF 4A3CE 4Q5SE 4AYBH 1I6HE 4Y7NF 4A3IE 4C3HE 1K83F 4BBRE 5M5WF 4BBSE 5IP7E 4LK1E 3HOXF 4A3KF 3EQLE 2E2HE 4A3LF 5TMFE 1TWCE 2R92F 5IP9F 3K7AE 2NVTF 4C2ME 2BE5E 4KN4E 2JA7F 3GTJF 3RZOF 3H0GF 4Q4ZE 3HOWE 2WB1I 1TWAF 4Y52E 1SMYE 4MQ9E 5IYDF 3HOYE 3GTMF 3M4OF 3S2DF 1I6VE 3H3VG 4ZH4E 2R93F 3CQZE 2PPBE 4BXXE 3PO3F 2YU9E 3GTQE 5M5XF 3DXJE 2JA6F 3HOUF 2A6HE 2KRXA 2B63F 4BY1F 5D4DE 2O5IE 3PO2E 5C4XF 4A3JE 2NVQF 2WAQK 1I3QE 3I4MF 2VUME 3S17F 2JA5E 1TWGF 1TWFE 5FLMF 3S1QE 5IPLE 1WCME 4JK1E 5C4JF 3S14E 5C3EF 5E17E 3HOZE 4A3ME 5M3FF 3M3YE 3S2HF 1ZYRE 4C3IF 4A3FE 3GTJE 1SFOF 2O5JE 3S1ME 5D4EE 5TMCE 4OIRE 2R7ZF 4G7OE 1EIKA 4BY7F 2A6EE 3S1RE 2A69E 4A3BF 3GTLE 4X6AF 4A3DE 4A3GE 3GTPF 3I4NE 3HOVF 5IYBE 1R9TF 3S16E 1Y1VF 4LK0E 2JA8F 3GTGF 3HOUE 5M5YF 3GTOF 4KMUE 5C44F 3RZDF 3FKIE 4YFNE 1Y1WE 1I50E 1TWHE 5FJ8F 2E2JE 4XLNE 1YNNK 2CW0E 5IYCF 4A3EF 3S15F 4A93E 4A3CF 2E2IF 2NVXE 2NVYE 4C3JE 4XLPE 3S1NE 5M3ME 3GTKE 1I6HF 2WAQH 4A3IF 4C3HF 4BBRF 4BBSF 2PMZK
chains in the Genus database with same CATH topology
4G7ZE 5IP7F 2E2HF 3HKZK 4LLGE 4XSZE 4G7HE 4QIWK 3K7AF 4C2MF 4OIOE 3HOWF 4Y52F 1IW7E 1QKLA 3HOYF 4YFKE 3CQZF 1HQME 5E18E 4BXXF 2YU9F 3GTQF 4LJZE 4A3JF 3S1QF 4XSXE 2VUMF 2JA5F 4AYBK 1TWFF 1WCMF 3S14F 4YFXE 4MEXE 1YNJK 3HOZF 5D4CE 4A3MF 3M3YF 4A3FF 1TWCF 5BYHE 3S1MF 3S1RF 3GTLF 4OIPE 4A3DF 4A3GF 3I4NF 5IYBF 2A68E 3WODE 3S16F 4GZYE 2Y0SI 4KN7E 4OINE 3FKIF 1Y1WF 1TWHF 1I50F 2E2JF 4A93F 4YG2E 4OIQE 3PO2F 4MEYE 2NVXF 2NVYF 4C3JF 1I3QF 3S1NF 5M3MF 3GTKF 4Q5SE 4Y7NF 1K83F 5M5WF 4LK1E 3HOXF 4A3KF 3EQLE 4A3LF 5TMFE 2R92F 5IP9F 2NVTF 2BE5E 4KN4E 2JA7F 3GTJF 3RZOF 3H0GF 4Q4ZE 2WB1I 1TWAF 1SMYE 4MQ9E 5IYDF 3M4OF 3GTMF 3S2DF 2R93F 1I6VE 3H3VG 4ZH4E 2PPBE 3PO3F 5M5XF 3DXJE 2JA6F 3HOUF 2A6HE 2KRXA 2B63F 4BY1F 5D4DE 2O5IE 5C4XF 2NVQF 2WAQK 3I4MF 3S17F 1TWGF 5FLMF 5IPLE 5C4JF 4JK1E 5C3EF 5E17E 5M3FF 3S2HF 1ZYRE 4C3IF 2O5JE 1SFOF 5D4EE 5TMCE 4OIRE 2R7ZF 4G7OE 4BY7F 2A6EE 4A3BF 2A69E 4X6AF 3GTPF 3HOVF 1R9TF 1Y1VF 4LK0E 2JA8F 3GTGF 5M5YF 3GTOF 4KMUE 5C44F 3RZDF 4YFNE 5FJ8F 3S15F 4XLNE 1YNNK 2CW0E 5IYCF 4A3EF 4A3CF 2E2IF 4XLPE 1I6HF 4A3IF 4C3HF 4BBRF 4BBSF 2PMZK
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G7Z E;  5IP7 F;  2E2H F;  3HKZ K;  4LLG E;  4XSZ E;  4G7H E;  3K7A F;  4C2M F;  4OIO E;  3HOW F;  4Y52 F;  1IW7 E;  1QKL A;  3HOY F;  4YFK E;  3CQZ F;  1HQM E;  5E18 E;  4BXX F;  2YU9 F;  3GTQ F;  4LJZ E;  4A3J F;  3S1Q F;  4XSX E;  2VUM F;  2JA5 F;  4AYB K;  1TWF F;  1WCM F;  3S14 F;  4YFX E;  4MEX E;  1YNJ K;  3HOZ F;  5D4C E;  4A3M F;  3M3Y F;  4A3F F;  1TWC F;  5BYH E;  3S1M F;  3S1R F;  3GTL F;  4OIP E;  4A3D F;  4A3G F;  3I4N F;  5IYB F;  2A68 E;  3WOD E;  3S16 F;  4GZY E;  2Y0S I;  4KN7 E;  4OIN E;  3FKI F;  1Y1W F;  1TWH F;  1I50 F;  2E2J F;  4A93 F;  4YG2 E;  4OIQ E;  3PO2 F;  4MEY E;  2NVX F;  2NVY F;  4C3J F;  1I3Q F;  3S1N F;  5M3M F;  3GTK F;  4Q5S E;  4Y7N F;  1K83 F;  5M5W F;  4LK1 E;  3HOX F;  4A3K F;  3EQL E;  4A3L F;  5TMF E;  2R92 F;  5IP9 F;  2NVT F;  2BE5 E;  4KN4 E;  2JA7 F;  3GTJ F;  3RZO F;  3H0G F;  4Q4Z E;  2WB1 I;  1TWA F;  1SMY E;  4MQ9 E;  5IYD F;  3M4O F;  3GTM F;  3S2D F;  2R93 F;  1I6V E;  3H3V G;  4ZH4 E;  2PPB E;  3PO3 F;  5M5X F;  3DXJ E;  2JA6 F;  3HOU F;  2A6H E;  2B63 F;  4BY1 F;  5D4D E;  2O5I E;  5C4X F;  2NVQ F;  2WAQ K;  3I4M F;  3S17 F;  1TWG F;  5FLM F;  5IPL E;  5C4J F;  4JK1 E;  5C3E F;  5E17 E;  5M3F F;  3S2H F;  1ZYR E;  4C3I F;  2O5J E;  1SFO F;  5D4E E;  5TMC E;  4OIR E;  2R7Z F;  4G7O E;  4BY7 F;  2A6E E;  4A3B F;  2A69 E;  4X6A F;  3GTP F;  3HOV F;  1R9T F;  1Y1V F;  4LK0 E;  2JA8 F;  3GTG F;  5M5Y F;  3GTO F;  4KMU E;  5C44 F;  3RZD F;  4YFN E;  5FJ8 F;  3S15 F;  4XLN E;  1YNN K;  2CW0 E;  5IYC F;  4A3E F;  4A3C F;  2E2I F;  4XLP E;  1I6H F;  4A3I F;  4C3H F;  4BBR F;  4BBS F;  2PMZ K; 
#chains in the Genus database with same CATH topology
 4G7Z E;  5IP7 F;  1K83 E;  5M5W E;  2E2H F;  3H3V F;  3HKZ K;  4LLG E;  3HOX E;  4A3K E;  4XSZ E;  4A3L E;  4G7H E;  2Y0S H;  3HKZ H;  3K7A F;  4QIW K;  4C2M F;  2R92 E;  5IP9 E;  2NVT E;  4OIO E;  2JA7 E;  3HOW F;  3RZO E;  3H0G E;  4Y52 F;  1IW7 E;  1QKL A;  3HOY F;  1TWA E;  5IYD E;  4YFK E;  3M4O E;  3S2D E;  3CQZ F;  3GTM E;  2R93 E;  1HQM E;  5E18 E;  4BXX F;  2YU9 F;  3GTQ F;  3GTG E;  3PO3 E;  5M5X E;  4LJZ E;  2JA6 E;  2B63 E;  4BY1 E;  4A3J F;  3S1Q F;  4XSX E;  2VUM F;  2E2I E;  4AYB K;  1TWF F;  2JA5 F;  2NVQ E;  3S17 E;  3I4M E;  5C4X E;  1TWG E;  5FLM E;  1WCM F;  2WB1 H;  4Y7N E;  3S14 F;  4YFX E;  4MEX E;  5C4J E;  1YNJ K;  3HOZ F;  5C3E E;  1DZF A;  5D4C E;  4A3M F;  3M3Y F;  2PMZ H;  5M3F E;  3S2H E;  4A3F F;  1TWC F;  4C3I E;  5BYH E;  3S1M F;  4QIW H;  1SFO E;  3S1R F;  2R7Z E;  3GTL F;  4OIP E;  4A3B E;  4BY7 E;  4A3D F;  3I4N F;  4A3G F;  4X6A E;  5IYB F;  3GTP E;  2A68 E;  3HOV E;  3WOD E;  1R9T E;  3S16 F;  4GZY E;  1Y1V E;  2Y0S I;  4KN7 E;  2JA8 E;  4OIN E;  3FKI F;  5M5Y E;  1Y1W F;  3GTO E;  1I50 F;  1TWH F;  5C44 E;  3RZD E;  2E2J F;  4YG2 E;  4A93 F;  5FJ8 E;  4OIQ E;  4MEY E;  3S15 E;  2NVX F;  3PO2 F;  2NVY F;  5IYC E;  1I3Q F;  4C3J F;  4A3E E;  3S1N F;  5M3M F;  3GTK F;  4A3C E;  4Q5S E;  4AYB H;  1I6H E;  4Y7N F;  4A3I E;  4C3H E;  1K83 F;  4BBR E;  5M5W F;  4BBS E;  5IP7 E;  4LK1 E;  3HOX F;  4A3K F;  3EQL E;  2E2H E;  4A3L F;  5TMF E;  1TWC E;  2R92 F;  5IP9 F;  3K7A E;  2NVT F;  4C2M E;  2BE5 E;  4KN4 E;  2JA7 F;  3GTJ F;  3RZO F;  3H0G F;  4Q4Z E;  3HOW E;  2WB1 I;  1TWA F;  4Y52 E;  1SMY E;  4MQ9 E;  5IYD F;  3HOY E;  3GTM F;  3M4O F;  3S2D F;  1I6V E;  3H3V G;  4ZH4 E;  2R93 F;  3CQZ E;  2PPB E;  4BXX E;  3PO3 F;  2YU9 E;  3GTQ E;  5M5X F;  3DXJ E;  2JA6 F;  3HOU F;  2A6H E;  2KRX A;  2B63 F;  4BY1 F;  5D4D E;  2O5I E;  3PO2 E;  5C4X F;  4A3J E;  2NVQ F;  2WAQ K;  1I3Q E;  3I4M F;  2VUM E;  3S17 F;  2JA5 E;  1TWG F;  1TWF E;  5FLM F;  3S1Q E;  5IPL E;  1WCM E;  4JK1 E;  5C4J F;  3S14 E;  5C3E F;  5E17 E;  3HOZ E;  4A3M E;  5M3F F;  3M3Y E;  3S2H F;  1ZYR E;  4C3I F;  4A3F E;  3GTJ E;  1SFO F;  2O5J E;  3S1M E;  5D4E E;  5TMC E;  4OIR E;  2R7Z F;  4G7O E;  1EIK A;  4BY7 F;  2A6E E;  3S1R E;  2A69 E;  4A3B F;  3GTL E;  4X6A F;  4A3D E;  4A3G E;  3GTP F;  3I4N E;  3HOV F;  5IYB E;  1R9T F;  3S16 E;  1Y1V F;  4LK0 E;  2JA8 F;  3GTG F;  3HOU E;  5M5Y F;  3GTO F;  4KMU E;  5C44 F;  3RZD F;  3FKI E;  4YFN E;  1Y1W E;  1I50 E;  1TWH E;  5FJ8 F;  2E2J E;  4XLN E;  1YNN K;  2CW0 E;  5IYC F;  4A3E F;  3S15 F;  4A93 E;  4A3C F;  2E2I F;  2NVX E;  2NVY E;  4C3J E;  4XLP E;  3S1N E;  5M3M E;  3GTK E;  1I6H F;  2WAQ H;  4A3I F;  4C3H F;  4BBR F;  4BBS F;  2PMZ K; 
#chains in the Genus database with same CATH homology
 4G7Z E;  5IP7 F;  2E2H F;  3HKZ K;  4LLG E;  4XSZ E;  4G7H E;  4QIW K;  3K7A F;  4C2M F;  4OIO E;  3HOW F;  4Y52 F;  1IW7 E;  1QKL A;  3HOY F;  4YFK E;  3CQZ F;  1HQM E;  5E18 E;  4BXX F;  2YU9 F;  3GTQ F;  4LJZ E;  4A3J F;  3S1Q F;  4XSX E;  2VUM F;  2JA5 F;  4AYB K;  1TWF F;  1WCM F;  3S14 F;  4YFX E;  4MEX E;  1YNJ K;  3HOZ F;  5D4C E;  4A3M F;  3M3Y F;  4A3F F;  1TWC F;  5BYH E;  3S1M F;  3S1R F;  3GTL F;  4OIP E;  4A3D F;  4A3G F;  3I4N F;  5IYB F;  2A68 E;  3WOD E;  3S16 F;  4GZY E;  2Y0S I;  4KN7 E;  4OIN E;  3FKI F;  1Y1W F;  1TWH F;  1I50 F;  2E2J F;  4A93 F;  4YG2 E;  4OIQ E;  3PO2 F;  4MEY E;  2NVX F;  2NVY F;  4C3J F;  1I3Q F;  3S1N F;  5M3M F;  3GTK F;  4Q5S E;  4Y7N F;  1K83 F;  5M5W F;  4LK1 E;  3HOX F;  4A3K F;  3EQL E;  4A3L F;  5TMF E;  2R92 F;  5IP9 F;  2NVT F;  2BE5 E;  4KN4 E;  2JA7 F;  3GTJ F;  3RZO F;  3H0G F;  4Q4Z E;  2WB1 I;  1TWA F;  1SMY E;  4MQ9 E;  5IYD F;  3M4O F;  3GTM F;  3S2D F;  2R93 F;  1I6V E;  3H3V G;  4ZH4 E;  2PPB E;  3PO3 F;  5M5X F;  3DXJ E;  2JA6 F;  3HOU F;  2A6H E;  2KRX A;  2B63 F;  4BY1 F;  5D4D E;  2O5I E;  5C4X F;  2NVQ F;  2WAQ K;  3I4M F;  3S17 F;  1TWG F;  5FLM F;  5IPL E;  5C4J F;  4JK1 E;  5C3E F;  5E17 E;  5M3F F;  3S2H F;  1ZYR E;  4C3I F;  2O5J E;  1SFO F;  5D4E E;  5TMC E;  4OIR E;  2R7Z F;  4G7O E;  4BY7 F;  2A6E E;  4A3B F;  2A69 E;  4X6A F;  3GTP F;  3HOV F;  1R9T F;  1Y1V F;  4LK0 E;  2JA8 F;  3GTG F;  5M5Y F;  3GTO F;  4KMU E;  5C44 F;  3RZD F;  4YFN E;  5FJ8 F;  3S15 F;  4XLN E;  1YNN K;  2CW0 E;  5IYC F;  4A3E F;  4A3C F;  2E2I F;  4XLP E;  1I6H F;  4A3I F;  4C3H F;  4BBR F;  4BBS F;  2PMZ K; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...