5ADQB

Crystal structure of human tankyrase 2 in complex with jw55
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
AHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TANKYRASE-2
total genus 1
structure length 46
sequence length 46
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-08-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 5adqB00
4L09C 4L10C 4L0VC 4L0BC 5ADRB 4L2FC 4HLFC 4L34C 4UI5C 4UI6C 4KZQC 4UI3C 4UI8C 4L0SC 4L0TC 4UI7C 4L33C 5FPFC 4HKKB 4UI4C 5C5QC 4KZUC 4L2GC 4HKIC 4HKNC 5C5PC 4KZLC 4HLMC 5ADSB 4UVPB 4L32C 4L31C 4HLKC 4HLHC 5ADTB 4HL5C 4HMHC 4L0IC 5C5RC 5ADQB 4L2KC 4HLGC
chains in the Genus database with same CATH superfamily
2A6QA 4L09C 4L10C 4L0VC 3CTOA 4L0BC 5ADRB 4L2FC 4HLFC 3HRYA 4L34C 4UI5C 4UI6C 4KZQC 4UI3C 4UI8C 4ZM2A 4L0SC 4L0TC 2ODKA 3KH2E 4UI7C 4L33C 5FPFC 3HS2A 4HKKB 4UI4C 2ZIXB 5C5QC 4KZUC 4HKIC 4L2GC 4ZM0A 3HJ6A 3K6QA 4HKNC 5C5PC 4KZLC 4HLMC 5ADSB 3OEIA 4UVPB 4L32C 3K33B 4L31C 4ZLXA 3G5OA 3D55A 4HLKC 4HLHC 5ADTB 4HL5C 4HMHC 4L0IC 5C5RC 3OEIE 5ADQB 4L2KC 4HLGC
chains in the Genus database with same CATH topology
4L09C 4L10C 4L0VC 4L0BC 5ADRB 4L2FC 4HLFC 4L34C 4UI5C 4UI6C 4KZQC 4UI3C 4UI8C 4L0SC 4L0TC 4UI7C 4L33C 5FPFC 4HKKB 4UI4C 2ZIXB 5C5QC 4KZUC 4L2GC 4HKIC 3HJ6A 4HKNC 5C5PC 4KZLC 4HLMC 5ADSB 4UVPB 4L32C 4L31C 4HLKC 4HLHC 5ADTB 4HL5C 4HMHC 4L0IC 5C5RC 5ADQB 4L2KC 4HLGC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L09 C;  4L10 C;  4L0V C;  4L0B C;  5ADR B;  4L2F C;  4HLF C;  4L34 C;  4UI5 C;  4UI6 C;  4KZQ C;  4UI3 C;  4UI8 C;  4L0S C;  4L0T C;  4UI7 C;  4L33 C;  5FPF C;  4HKK B;  4UI4 C;  5C5Q C;  4KZU C;  4L2G C;  4HKI C;  4HKN C;  5C5P C;  4KZL C;  4HLM C;  5ADS B;  4UVP B;  4L32 C;  4L31 C;  4HLK C;  4HLH C;  5ADT B;  4HL5 C;  4HMH C;  4L0I C;  5C5R C;  5ADQ B;  4L2K C;  4HLG C; 
#chains in the Genus database with same CATH topology
 2A6Q A;  4L09 C;  4L10 C;  4L0V C;  3CTO A;  4L0B C;  5ADR B;  4L2F C;  4HLF C;  3HRY A;  4L34 C;  4UI5 C;  4UI6 C;  4KZQ C;  4UI3 C;  4UI8 C;  4ZM2 A;  4L0S C;  4L0T C;  2ODK A;  3KH2 E;  4UI7 C;  4L33 C;  5FPF C;  3HS2 A;  4HKK B;  4UI4 C;  2ZIX B;  5C5Q C;  4KZU C;  4HKI C;  4L2G C;  4ZM0 A;  3HJ6 A;  3K6Q A;  4HKN C;  5C5P C;  4KZL C;  4HLM C;  5ADS B;  3OEI A;  4UVP B;  4L32 C;  3K33 B;  4L31 C;  4ZLX A;  3G5O A;  3D55 A;  4HLK C;  4HLH C;  5ADT B;  4HL5 C;  4HMH C;  4L0I C;  5C5R C;  3OEI E;  5ADQ B;  4L2K C;  4HLG C; 
#chains in the Genus database with same CATH homology
 4L09 C;  4L10 C;  4L0V C;  4L0B C;  5ADR B;  4L2F C;  4HLF C;  4L34 C;  4UI5 C;  4UI6 C;  4KZQ C;  4UI3 C;  4UI8 C;  4L0S C;  4L0T C;  4UI7 C;  4L33 C;  5FPF C;  4HKK B;  4UI4 C;  2ZIX B;  5C5Q C;  4KZU C;  4L2G C;  4HKI C;  3HJ6 A;  4HKN C;  5C5P C;  4KZL C;  4HLM C;  5ADS B;  4UVP B;  4L32 C;  4L31 C;  4HLK C;  4HLH C;  5ADT B;  4HL5 C;  4HMH C;  4L0I C;  5C5R C;  5ADQ B;  4L2K C;  4HLG C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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