5C5PC

Crystal structure of human tankyrase-2 in complex with a pyranopyridone inhibitor
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
AHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 46
sequence length 46
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-06-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 5c5pC00
4KZQC 4HKNC 5ADRB 4L2KC 4L0BC 4KZUC 4UI7C 5C5RC 4L09C 4UI5C 4UI6C 5C5QC 4L0SC 4HLMC 4HKIC 4L34C 4L31C 4L10C 4L0VC 4L2FC 4UI4C 4HL5C 4UVPB 4L2GC 4KZLC 4HLGC 4L33C 5ADTB 5C5PC 5ADSB 4HKKB 4UI3C 4UI8C 5ADQB 4L0IC 4HLFC 4HLKC 4HLHC 4L32C 4L0TC 5FPFC 4HMHC
chains in the Genus database with same CATH superfamily
4KZQC 3HS2A 3HJ6A 3OEIA 4HKNC 5ADRB 4L2KC 2ZIXB 4L0BC 4KZUC 4UI7C 5C5RC 3CTOA 4L09C 4UI5C 4UI6C 5C5QC 4L0SC 4HKIC 4HLMC 4L34C 4L31C 4L10C 4L0VC 4ZM0A 4L2FC 4UI4C 4HL5C 4UVPB 4L2GC 4KZLC 3G5OA 2A6QA 4HLGC 4L33C 5ADTB 3OEIE 5C5PC 5ADSB 2ODKA 4ZM2A 4HKKB 4UI3C 3D55A 4HMHC 4UI8C 4ZLXA 5ADQB 4L0IC 4HLFC 4HLKC 4HLHC 3HRYA 3K33B 4L32C 4L0TC 5FPFC 3KH2E 3K6QA
chains in the Genus database with same CATH topology
4KZQC 3HJ6A 4HKNC 5ADRB 4L2KC 2ZIXB 4L0BC 4KZUC 4UI7C 5C5RC 4L09C 4UI5C 4UI6C 5C5QC 4L0SC 4HKIC 4HLMC 4L34C 4L31C 4L10C 4L0VC 4L2FC 4UI4C 4HL5C 4UVPB 4L2GC 4KZLC 4HLGC 4L33C 5ADTB 5C5PC 5ADSB 4HKKB 4UI3C 4UI8C 5ADQB 4L0IC 4HLFC 4HLKC 4HLHC 4L32C 4L0TC 5FPFC 4HMHC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KZQ C;  4HKN C;  5ADR B;  4L2K C;  4L0B C;  4KZU C;  4UI7 C;  5C5R C;  4L09 C;  4UI5 C;  4UI6 C;  5C5Q C;  4L0S C;  4HLM C;  4HKI C;  4L34 C;  4L31 C;  4L10 C;  4L0V C;  4L2F C;  4UI4 C;  4HL5 C;  4UVP B;  4L2G C;  4KZL C;  4HLG C;  4L33 C;  5ADT B;  5C5P C;  5ADS B;  4HKK B;  4UI3 C;  4UI8 C;  5ADQ B;  4L0I C;  4HLF C;  4HLK C;  4HLH C;  4L32 C;  4L0T C;  5FPF C;  4HMH C; 
#chains in the Genus database with same CATH topology
 4KZQ C;  3HS2 A;  3HJ6 A;  3OEI A;  4HKN C;  5ADR B;  4L2K C;  2ZIX B;  4L0B C;  4KZU C;  4UI7 C;  5C5R C;  3CTO A;  4L09 C;  4UI5 C;  4UI6 C;  5C5Q C;  4L0S C;  4HKI C;  4HLM C;  4L34 C;  4L31 C;  4L10 C;  4L0V C;  4ZM0 A;  4L2F C;  4UI4 C;  4HL5 C;  4UVP B;  4L2G C;  4KZL C;  3G5O A;  2A6Q A;  4HLG C;  4L33 C;  5ADT B;  3OEI E;  5C5P C;  5ADS B;  2ODK A;  4ZM2 A;  4HKK B;  4UI3 C;  3D55 A;  4HMH C;  4UI8 C;  4ZLX A;  5ADQ B;  4L0I C;  4HLF C;  4HLK C;  4HLH C;  3HRY A;  3K33 B;  4L32 C;  4L0T C;  5FPF C;  3KH2 E;  3K6Q A; 
#chains in the Genus database with same CATH homology
 4KZQ C;  3HJ6 A;  4HKN C;  5ADR B;  4L2K C;  2ZIX B;  4L0B C;  4KZU C;  4UI7 C;  5C5R C;  4L09 C;  4UI5 C;  4UI6 C;  5C5Q C;  4L0S C;  4HKI C;  4HLM C;  4L34 C;  4L31 C;  4L10 C;  4L0V C;  4L2F C;  4UI4 C;  4HL5 C;  4UVP B;  4L2G C;  4KZL C;  4HLG C;  4L33 C;  5ADT B;  5C5P C;  5ADS B;  4HKK B;  4UI3 C;  4UI8 C;  5ADQ B;  4L0I C;  4HLF C;  4HLK C;  4HLH C;  4L32 C;  4L0T C;  5FPF C;  4HMH C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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