5IYBE

Human core-pic in the open state
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
210
structure length
210
Chain Sequence
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule tags Transcription, transferase/dna
source organism Homo sapiens
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 56
structure length 210
sequence length 210
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 5iybE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 5iybE02
3I4ME 4A3LE 5M3FE 4C3IE 2YU9E 4BXXE 2E2HE 1I6HE 3H3VF 3HOYE 4A3DE 4A3ME 3S2HE 3GTKE 4Y52E 3CQZE 4BY7E 4C3HE 3M4OE 1DZFA 1Y1WE 2JA5E 5M5XE 3HOUE 3H0GE 2JA6E 1SFOE 3GTLE 5IYDE 3S1QE 4AYBH 1TWAE 4BBRE 5M3ME 5FLME 3GTJE 1Y1VE 3I4NE 2NVYE 4Y7NE 4A3IE 3GTPE 3S16E 1TWGE 2R7ZE 4A93E 4BY1E 2PMZH 4C2ME 4C3JE 3GTGE 3GTQE 1K83E 1TWCE 2WAQH 2R92E 2NVTE 5C3EE 1I3QE 5IP7E 2E2IE 3HOZE 1TWHE 3S17E 5M5YE 5C44E 3S1RE 2JA8E 3RZDE 2WB1H 1I50E 3PO2E 1WCME 3S2DE 3PO3E 3RZOE 5IYCE 3HOVE 3FKIE 3GTME 5C4JE 3GTOE 1R9TE 5FJ8E 2NVQE 2JA7E 3K7AE 5M5WE 3S14E 4QIWH 2R93E 4X6AE 3S1NE 4A3JE 3M3YE 3HOWE 2E2JE 1TWFE 3HOXE 2Y0SH 5IYBE 2B63E 4A3CE 4A3FE 5IP9E 3S15E 5C4XE 1EIKA 4A3KE 4A3GE 4A3EE 2VUME 3HKZH 4A3BE 3S1ME 2NVXE 4BBSE
chains in the Genus database with same CATH superfamily
4A3MF 2Y0SI 2O5JE 4G7ZE 3I4ME 3S2HF 5E18E 3GTKF 4A3LE 5M3FE 4C3IE 2YU9E 4KN7E 4BXXE 2E2HE 1HQME 1I6HE 3H3VF 3HOYE 3CQZF 4Y52F 4OIOE 4A3DE 4A3ME 4BY7F 4C3HF 3S2HE 3M4OF 3GTKE 4Q4ZE 2O5IE 2A69E 4MEYE 1Y1WF 3H3VG 4Y52E 3CQZE 4BY7E 4C3HE 2WAQK 5M5XF 2E2IF 3HOUF 3M4OE 1DZFA 3H0GF 2JA6F 1SFOF 1Y1WE 5IYDF 3S1QF 4MEXE 4OINE 2CW0E 1TWAF 4ZH4E 2JA5E 5M5XE 3HOUE 4BBRF 3H0GE 5M3MF 2PPBE 2JA6E 1SFOE 3GTLE 2A68E 5BYHE 1Y1VF 5FLMF 5IYDE 3S1QE 2NVYF 4Y7NF 3I4NF 4A3IF 4AYBH 3GTPF 1TWAE 3S16F 1TWGF 4BBRE 5M3ME 2R7ZF 4A93F 5FLME 4BY1F 3GTJE 1Y1VE 3I4NE 4C2MF 2NVYE 4Y7NE 4C3JF 4XLNE 3GTGF 4A3IE 2BE5E 3GTQF 3HOYF 5IPLE 3GTPE 1K83F 4LJZE 3S16E 1TWGE 2R7ZE 4A93E 4BY1E 4KN4E 2PMZH 4C2ME 4C3JE 3GTGE 3GTQE 2JA7F 1K83E 1TWCF 2R92F 4KMUE 1I3QF 5IP7F 5C3EF 2NVTF 3HOZF 1TWHF 1YNNK 4QIWK 2A6HE 4MQ9E 3S17F 5M5YF 4XSZE 5E17E 5C44F 3HOWF 3S1RF 3S14F 1TWCE 2WAQH 2R92E 2NVTE 5C3EE 1I3QE 5IP7E 2E2IE 3HOZE 1TWHE 3RZDF 4OIRE 2JA8F 3S17E 1I50F 5M5YE 5D4EE 1WCMF 3PO2F 4LLGE 3S2DF 5C44E 3PO3F 3S1RE 3RZOF 5IYCF 2JA8E 3RZDE 4XLPE 3HOVF 2WB1H 3FKIF 5D4DE 3GTMF 1I50E 3PO2E 5C4JF 1WCME 1R9TF 5FJ8F 2NVQF 3S2DE 3GTOF 3PO3E 5TMCE 3RZOE 5IYCE 4JK1E 3HOVE 2A6EE 4LK0E 3EQLE 4A3BF 3FKIE 3GTME 3HKZK 5C4JE 3GTOE 1R9TE 5FJ8E 2NVQE 4YFKE 3K7AF 1ZYRE 4AYBK 5M5WF 4Q5SE 2R93F 4GZYE 4X6AF 4OIQE 3DXJE 3S1NF 4A3JF 4A3DF 3M3YF 4YG2E 2E2HF 2E2JF 2JA7E 2WB1I 3K7AE 5M5WE 3S14E 2KRXA 4QIWH 2R93E 5D4CE 1TWFF 4X6AE 3HOXF 3S1NE 4A3JE 5IYBF 3M3YE 4LK1E 3HOWE 2E2JE 2PMZK 2B63F 1TWFE 4A3CF 3HOXE 2Y0SH 1IW7E 5IYBE 4A3FF 4G7OE 5IP9F 5TMFE 3S15F 5C4XF 2B63E 1I6VE 4A3KF 4YFXE 4A3GF 4A3EF 2VUMF 4A3CE 2JA5F 4G7HE 3S1MF 4A3FE 4YFNE 3GTLF 5IP9E 3S15E 1SMYE 5C4XE 1EIKA 4A3KE 4A3GE 2NVXF 4A3EE 4BBSF 2VUME 3HKZH 4A3BE 3S1ME 3I4MF 1YNJK 4A3LF 1QKLA 4C3IF 3GTJF 5M3FF 2YU9F 4BXXF 1I6HF 2NVXE 3WODE 4XSXE 4OIPE 4BBSE
chains in the Genus database with same CATH topology
3I4ME 4A3LE 5M3FE 4C3IE 2YU9E 4BXXE 2E2HE 1I6HE 3H3VF 3HOYE 4A3DE 4A3ME 3S2HE 3GTKE 4Y52E 3CQZE 4BY7E 4C3HE 3M4OE 1DZFA 1Y1WE 2JA5E 5M5XE 3HOUE 3H0GE 2JA6E 1SFOE 3GTLE 5IYDE 3S1QE 4AYBH 1TWAE 4BBRE 5M3ME 5FLME 3GTJE 1Y1VE 3I4NE 2NVYE 4Y7NE 4A3IE 3GTPE 3S16E 1TWGE 2R7ZE 4A93E 4BY1E 2PMZH 4C2ME 4C3JE 3GTGE 3GTQE 1K83E 1TWCE 2WAQH 2R92E 2NVTE 5C3EE 1I3QE 5IP7E 2E2IE 3HOZE 1TWHE 3S17E 5M5YE 5C44E 3S1RE 2JA8E 3RZDE 2WB1H 1I50E 3PO2E 1WCME 3S2DE 3PO3E 3RZOE 5IYCE 3HOVE 3FKIE 3GTME 5C4JE 3GTOE 1R9TE 5FJ8E 2NVQE 2JA7E 3K7AE 5M5WE 3S14E 4QIWH 2R93E 4X6AE 3S1NE 4A3JE 3M3YE 3HOWE 2E2JE 1TWFE 3HOXE 2Y0SH 5IYBE 2B63E 4A3CE 4A3FE 5IP9E 3S15E 5C4XE 1EIKA 4A3KE 4A3GE 4A3EE 2VUME 3HKZH 4A3BE 3S1ME 2NVXE 4BBSE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I4M E;  4A3L E;  5M3F E;  4C3I E;  2YU9 E;  4BXX E;  2E2H E;  1I6H E;  3H3V F;  3HOY E;  4A3D E;  4A3M E;  3S2H E;  3GTK E;  4Y52 E;  3CQZ E;  4BY7 E;  4C3H E;  3M4O E;  1DZF A;  1Y1W E;  2JA5 E;  5M5X E;  3HOU E;  3H0G E;  2JA6 E;  1SFO E;  3GTL E;  5IYD E;  3S1Q E;  4AYB H;  1TWA E;  4BBR E;  5M3M E;  5FLM E;  3GTJ E;  1Y1V E;  3I4N E;  2NVY E;  4Y7N E;  4A3I E;  3GTP E;  3S16 E;  1TWG E;  2R7Z E;  4A93 E;  4BY1 E;  2PMZ H;  4C2M E;  4C3J E;  3GTG E;  3GTQ E;  1K83 E;  1TWC E;  2WAQ H;  2R92 E;  2NVT E;  5C3E E;  1I3Q E;  5IP7 E;  2E2I E;  3HOZ E;  1TWH E;  3S17 E;  5M5Y E;  5C44 E;  3S1R E;  2JA8 E;  3RZD E;  2WB1 H;  1I50 E;  3PO2 E;  1WCM E;  3S2D E;  3PO3 E;  3RZO E;  5IYC E;  3HOV E;  3FKI E;  3GTM E;  5C4J E;  3GTO E;  1R9T E;  5FJ8 E;  2NVQ E;  2JA7 E;  3K7A E;  5M5W E;  3S14 E;  4QIW H;  2R93 E;  4X6A E;  3S1N E;  4A3J E;  3M3Y E;  3HOW E;  2E2J E;  1TWF E;  3HOX E;  2Y0S H;  5IYB E;  2B63 E;  4A3C E;  4A3F E;  5IP9 E;  3S15 E;  5C4X E;  1EIK A;  4A3K E;  4A3G E;  4A3E E;  2VUM E;  3HKZ H;  4A3B E;  3S1M E;  2NVX E;  4BBS E; 
#chains in the Genus database with same CATH topology
 4A3M F;  2Y0S I;  2O5J E;  4G7Z E;  3I4M E;  3S2H F;  5E18 E;  3GTK F;  4A3L E;  5M3F E;  4C3I E;  2YU9 E;  4KN7 E;  4BXX E;  2E2H E;  1HQM E;  1I6H E;  3H3V F;  3HOY E;  3CQZ F;  4Y52 F;  4OIO E;  4A3D E;  4A3M E;  4BY7 F;  4C3H F;  3S2H E;  3M4O F;  3GTK E;  4Q4Z E;  2O5I E;  2A69 E;  4MEY E;  1Y1W F;  3H3V G;  4Y52 E;  3CQZ E;  4BY7 E;  4C3H E;  2WAQ K;  5M5X F;  2E2I F;  3HOU F;  3M4O E;  1DZF A;  3H0G F;  2JA6 F;  1SFO F;  1Y1W E;  5IYD F;  3S1Q F;  4MEX E;  4OIN E;  2CW0 E;  1TWA F;  4ZH4 E;  2JA5 E;  5M5X E;  3HOU E;  4BBR F;  3H0G E;  5M3M F;  2PPB E;  2JA6 E;  1SFO E;  3GTL E;  2A68 E;  5BYH E;  1Y1V F;  5FLM F;  5IYD E;  3S1Q E;  2NVY F;  4Y7N F;  3I4N F;  4A3I F;  4AYB H;  3GTP F;  1TWA E;  3S16 F;  1TWG F;  4BBR E;  5M3M E;  2R7Z F;  4A93 F;  5FLM E;  4BY1 F;  3GTJ E;  1Y1V E;  3I4N E;  4C2M F;  2NVY E;  4Y7N E;  4C3J F;  4XLN E;  3GTG F;  4A3I E;  2BE5 E;  3GTQ F;  3HOY F;  5IPL E;  3GTP E;  1K83 F;  4LJZ E;  3S16 E;  1TWG E;  2R7Z E;  4A93 E;  4BY1 E;  4KN4 E;  2PMZ H;  4C2M E;  4C3J E;  3GTG E;  3GTQ E;  2JA7 F;  1K83 E;  1TWC F;  2R92 F;  4KMU E;  1I3Q F;  5IP7 F;  5C3E F;  2NVT F;  3HOZ F;  1TWH F;  1YNN K;  4QIW K;  2A6H E;  4MQ9 E;  3S17 F;  5M5Y F;  4XSZ E;  5E17 E;  5C44 F;  3HOW F;  3S1R F;  3S14 F;  1TWC E;  2WAQ H;  2R92 E;  2NVT E;  5C3E E;  1I3Q E;  5IP7 E;  2E2I E;  3HOZ E;  1TWH E;  3RZD F;  4OIR E;  2JA8 F;  3S17 E;  1I50 F;  5M5Y E;  5D4E E;  1WCM F;  3PO2 F;  4LLG E;  3S2D F;  5C44 E;  3PO3 F;  3S1R E;  3RZO F;  5IYC F;  2JA8 E;  3RZD E;  4XLP E;  3HOV F;  2WB1 H;  3FKI F;  5D4D E;  3GTM F;  1I50 E;  3PO2 E;  5C4J F;  1WCM E;  1R9T F;  5FJ8 F;  2NVQ F;  3S2D E;  3GTO F;  3PO3 E;  5TMC E;  3RZO E;  5IYC E;  4JK1 E;  3HOV E;  2A6E E;  4LK0 E;  3EQL E;  4A3B F;  3FKI E;  3GTM E;  3HKZ K;  5C4J E;  3GTO E;  1R9T E;  5FJ8 E;  2NVQ E;  4YFK E;  3K7A F;  1ZYR E;  4AYB K;  5M5W F;  4Q5S E;  2R93 F;  4GZY E;  4X6A F;  4OIQ E;  3DXJ E;  3S1N F;  4A3J F;  4A3D F;  3M3Y F;  4YG2 E;  2E2H F;  2E2J F;  2JA7 E;  2WB1 I;  3K7A E;  5M5W E;  3S14 E;  2KRX A;  4QIW H;  2R93 E;  5D4C E;  1TWF F;  4X6A E;  3HOX F;  3S1N E;  4A3J E;  5IYB F;  3M3Y E;  4LK1 E;  3HOW E;  2E2J E;  2PMZ K;  2B63 F;  1TWF E;  4A3C F;  3HOX E;  2Y0S H;  1IW7 E;  5IYB E;  4A3F F;  4G7O E;  5IP9 F;  5TMF E;  3S15 F;  5C4X F;  2B63 E;  1I6V E;  4A3K F;  4YFX E;  4A3G F;  4A3E F;  2VUM F;  4A3C E;  2JA5 F;  4G7H E;  3S1M F;  4A3F E;  4YFN E;  3GTL F;  5IP9 E;  3S15 E;  1SMY E;  5C4X E;  1EIK A;  4A3K E;  4A3G E;  2NVX F;  4A3E E;  4BBS F;  2VUM E;  3HKZ H;  4A3B E;  3S1M E;  3I4M F;  1YNJ K;  4A3L F;  1QKL A;  4C3I F;  3GTJ F;  5M3F F;  2YU9 F;  4BXX F;  1I6H F;  2NVX E;  3WOD E;  4XSX E;  4OIP E;  4BBS E; 
#chains in the Genus database with same CATH homology
 3I4M E;  4A3L E;  5M3F E;  4C3I E;  2YU9 E;  4BXX E;  2E2H E;  1I6H E;  3H3V F;  3HOY E;  4A3D E;  4A3M E;  3S2H E;  3GTK E;  4Y52 E;  3CQZ E;  4BY7 E;  4C3H E;  3M4O E;  1DZF A;  1Y1W E;  2JA5 E;  5M5X E;  3HOU E;  3H0G E;  2JA6 E;  1SFO E;  3GTL E;  5IYD E;  3S1Q E;  4AYB H;  1TWA E;  4BBR E;  5M3M E;  5FLM E;  3GTJ E;  1Y1V E;  3I4N E;  2NVY E;  4Y7N E;  4A3I E;  3GTP E;  3S16 E;  1TWG E;  2R7Z E;  4A93 E;  4BY1 E;  2PMZ H;  4C2M E;  4C3J E;  3GTG E;  3GTQ E;  1K83 E;  1TWC E;  2WAQ H;  2R92 E;  2NVT E;  5C3E E;  1I3Q E;  5IP7 E;  2E2I E;  3HOZ E;  1TWH E;  3S17 E;  5M5Y E;  5C44 E;  3S1R E;  2JA8 E;  3RZD E;  2WB1 H;  1I50 E;  3PO2 E;  1WCM E;  3S2D E;  3PO3 E;  3RZO E;  5IYC E;  3HOV E;  3FKI E;  3GTM E;  5C4J E;  3GTO E;  1R9T E;  5FJ8 E;  2NVQ E;  2JA7 E;  3K7A E;  5M5W E;  3S14 E;  4QIW H;  2R93 E;  4X6A E;  3S1N E;  4A3J E;  3M3Y E;  3HOW E;  2E2J E;  1TWF E;  3HOX E;  2Y0S H;  5IYB E;  2B63 E;  4A3C E;  4A3F E;  5IP9 E;  3S15 E;  5C4X E;  1EIK A;  4A3K E;  4A3G E;  4A3E E;  2VUM E;  3HKZ H;  4A3B E;  3S1M E;  2NVX E;  4BBS E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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