5IYBE

Human core-pic in the open state
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
210
structure length
210
Chain Sequence
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transcription, transferase/dna
source organism Homo sapiens
publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 56
structure length 210
sequence length 210
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 5iybE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 5iybE02
5M5YE 3GTQE 3GTGE 3HOVE 4A3LE 1TWAE 3H3VF 2JA6E 5IYBE 3HKZH 5IP7E 4A3GE 4A3DE 3RZDE 4C3HE 4A3JE 4BBSE 2PMZH 3S1QE 2JA8E 2YU9E 1R9TE 1I50E 1TWGE 3GTLE 3PO3E 3GTPE 5IYCE 3GTKE 3HOUE 3M4OE 3FKIE 1I6HE 2NVQE 3GTJE 2JA5E 5C4XE 5M3FE 5M5XE 5IP9E 2E2JE 3CQZE 3PO2E 2WAQH 3I4NE 3K7AE 3S16E 5C3EE 2VUME 2NVXE 4A3CE 2E2IE 1K83E 3S2DE 2R92E 3I4ME 4BBRE 4C2ME 3M3YE 4A3IE 1DZFA 5M5WE 1SFOE 3S1ME 3HOZE 4C3IE 2Y0SH 3S1NE 2WB1H 4AYBH 1TWHE 3S17E 1EIKA 2JA7E 3GTME 5FJ8E 4QIWH 4A3ME 2NVYE 3HOYE 4A93E 5C44E 3S2HE 4X6AE 5FLME 3RZOE 4Y7NE 4BY7E 4BXXE 1Y1WE 3H0GE 5M3ME 3S1RE 4A3EE 1WCME 4A3FE 5C4JE 3HOWE 3HOXE 2R93E 4BY1E 3GTOE 3S15E 4A3BE 1I3QE 5IYDE 2E2HE 2B63E 4Y52E 4C3JE 2NVTE 2R7ZE 1Y1VE 1TWFE 4A3KE 3S14E 1TWCE
chains in the Genus database with same CATH superfamily
5M5YE 3GTQE 4YFNE 3GTGE 3HOVE 4A3LE 3EQLE 4A3MF 1YNJK 1TWAE 4KMUE 2NVYF 3H3VF 3HOYF 2JA6E 5IYBE 1YNNK 2CW0E 4A93F 5C44F 3HKZH 4OIOE 2O5JE 5IP7E 4OINE 4A3GE 4X6AF 4A3DE 3RZOF 3RZDE 4C3HE 4A3JE 4BBSE 2PMZH 3S1QE 2JA8E 4BY7F 4MQ9E 4Y7NF 4XLPE 3H0GF 3GTMF 2YU9E 5M3MF 3S1RF 4A3EF 1R9TE 4LLGE 1WCMF 4A3FF 1I50E 1TWGE 3GTLE 3PO3E 4OIPE 5IYBF 3GTPE 2A69E 5IYCE 5E17E 5IP7F 1SMYE 3GTKE 3HOXF 4A3DF 3HOUE 4MEYE 2A68E 4XSZE 4A3JF 3M4OE 2R93F 4G7HE 3FKIE 4Q4ZE 1I6HE 4BY1F 2NVQE 3GTJE 2JA5E 4MEXE 4KN7E 2PPBE 5C4XE 3GTOF 3S15F 4ZH4E 4A3BF 1I3QF 5IYDF 4Y52F 2E2HF 1ZYRE 5M3FE 5M5XE 4C3JF 2A6EE 5IP9E 2B63F 2NVTF 2E2JE 3CQZE 3PO2E 1Y1VF 2R7ZF 3HKZK 2WAQH 2A6HE 3I4NE 3K7AE 1TWFF 3S16E 5TMFE 5C3EE 1I6VE 2VUME 1TWCF 4A3KF 2NVXE 5M5YF 2PMZK 3M4OF 3GTQF 3S14F 3GTGF 3HOVF 4A3CE 4XLNE 4A3LF 2E2IE 5IPLE 1K83E 3GTJF 5FJ8F 4Q5SE 2WB1I 1TWAF 5TMCE 3S2DE 2R92E 2JA6F 3I4ME 4BBRE 4C2ME 3M3YE 4A3IE 1DZFA 3PO2F 5M5WE 4G7OE 1SFOE 5BYHE 3K7AF 4A3GF 4YFXE 3S1ME 3HOZE 3RZDF 4C3HF 2NVXF 4BBSF 4C3IE 4LK0E 2JA8F 3S1QF 2Y0SH 2BE5E 3S1NE 2WB1H 2YU9F 4AYBH 5D4EE 1TWHE 3S17E 4LJZE 1EIKA 1R9TF 2JA7E 1I50F 1TWGF 3GTLF 3PO3F 3GTME 5FJ8E 3GTPF 5IYCF 3GTKF 2WAQK 1IW7E 1HQME 4QIWH 5D4DE 3HOUF 4YG2E 4A3ME 3FKIF 1I6HF 2NVYE 3HOYE 2NVQF 2Y0SI 4JK1E 4A93E 2JA5F 4G7ZE 5C44E 3S2HE 5C4XF 2JA7F 4X6AE 4XSXE 5FLME 5M3FF 3RZOE 5M5XF 4OIRE 5IP9F 2O5IE 4Y7NE 2E2JF 3CQZF 4BY7E 4BXXE 4GZYE 1Y1WE 3I4NF 3H0GE 3S16F 5M3ME 3S1RE 5C3EF 2VUMF 4A3EE 3WODE 4KN4E 1WCME 4A3FE 4A3CF 5D4CE 2E2IF 1K83F 5C4JE 3HOWE 4AYBK 3S2HF 3S2DF 2R92F 3HOXE 5E18E 5FLMF 4BBRF 3I4MF 4C2MF 3M3YF 4A3IF 5M5WF 2R93E 4BXXF 4YFKE 1Y1WF 1SFOF 4BY1E 4QIWK 3S1MF 2KRXA 3HOZF 4LK1E 3GTOE 3DXJE 4C3IF 3H3VG 3S15E 4A3BE 1I3QE 5IYDE 2E2HE 2B63E 4Y52E 4C3JE 4OIQE 2NVTE 5C4JF 3HOWF 3S1NF 2R7ZE 1TWHF 1Y1VE 3S17F 1TWFE 4A3KE 3S14E 1TWCE 1QKLA
chains in the Genus database with same CATH topology
5M5YE 3GTQE 3GTGE 3HOVE 4A3LE 1TWAE 3H3VF 2JA6E 5IYBE 3HKZH 5IP7E 4A3GE 4A3DE 3RZDE 4C3HE 4A3JE 4BBSE 2PMZH 3S1QE 2JA8E 2YU9E 1R9TE 1I50E 1TWGE 3GTLE 3PO3E 3GTPE 5IYCE 3GTKE 3HOUE 3M4OE 3FKIE 1I6HE 2NVQE 3GTJE 2JA5E 5C4XE 5M3FE 5M5XE 5IP9E 2E2JE 3CQZE 3PO2E 2WAQH 3I4NE 3K7AE 3S16E 5C3EE 2VUME 2NVXE 4A3CE 2E2IE 1K83E 3S2DE 2R92E 3I4ME 4BBRE 4C2ME 3M3YE 4A3IE 1DZFA 5M5WE 1SFOE 3S1ME 3HOZE 4C3IE 2Y0SH 3S1NE 2WB1H 4AYBH 1TWHE 3S17E 1EIKA 2JA7E 3GTME 5FJ8E 4QIWH 4A3ME 2NVYE 3HOYE 4A93E 5C44E 3S2HE 4X6AE 5FLME 3RZOE 4Y7NE 4BY7E 4BXXE 1Y1WE 3H0GE 5M3ME 3S1RE 4A3EE 1WCME 4A3FE 5C4JE 3HOWE 3HOXE 2R93E 4BY1E 3GTOE 3S15E 4A3BE 1I3QE 5IYDE 2E2HE 2B63E 4Y52E 4C3JE 2NVTE 2R7ZE 1Y1VE 1TWFE 4A3KE 3S14E 1TWCE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5M5Y E;  3GTQ E;  3GTG E;  3HOV E;  4A3L E;  1TWA E;  3H3V F;  2JA6 E;  5IYB E;  3HKZ H;  5IP7 E;  4A3G E;  4A3D E;  3RZD E;  4C3H E;  4A3J E;  4BBS E;  2PMZ H;  3S1Q E;  2JA8 E;  2YU9 E;  1R9T E;  1I50 E;  1TWG E;  3GTL E;  3PO3 E;  3GTP E;  5IYC E;  3GTK E;  3HOU E;  3M4O E;  3FKI E;  1I6H E;  2NVQ E;  3GTJ E;  2JA5 E;  5C4X E;  5M3F E;  5M5X E;  5IP9 E;  2E2J E;  3CQZ E;  3PO2 E;  2WAQ H;  3I4N E;  3K7A E;  3S16 E;  5C3E E;  2VUM E;  2NVX E;  4A3C E;  2E2I E;  1K83 E;  3S2D E;  2R92 E;  3I4M E;  4BBR E;  4C2M E;  3M3Y E;  4A3I E;  1DZF A;  5M5W E;  1SFO E;  3S1M E;  3HOZ E;  4C3I E;  2Y0S H;  3S1N E;  2WB1 H;  4AYB H;  1TWH E;  3S17 E;  1EIK A;  2JA7 E;  3GTM E;  5FJ8 E;  4QIW H;  4A3M E;  2NVY E;  3HOY E;  4A93 E;  5C44 E;  3S2H E;  4X6A E;  5FLM E;  3RZO E;  4Y7N E;  4BY7 E;  4BXX E;  1Y1W E;  3H0G E;  5M3M E;  3S1R E;  4A3E E;  1WCM E;  4A3F E;  5C4J E;  3HOW E;  3HOX E;  2R93 E;  4BY1 E;  3GTO E;  3S15 E;  4A3B E;  1I3Q E;  5IYD E;  2E2H E;  2B63 E;  4Y52 E;  4C3J E;  2NVT E;  2R7Z E;  1Y1V E;  1TWF E;  4A3K E;  3S14 E;  1TWC E; 
#chains in the Genus database with same CATH topology
 5M5Y E;  3GTQ E;  4YFN E;  3GTG E;  3HOV E;  4A3L E;  3EQL E;  4A3M F;  1YNJ K;  1TWA E;  4KMU E;  2NVY F;  3H3V F;  3HOY F;  2JA6 E;  5IYB E;  1YNN K;  2CW0 E;  4A93 F;  5C44 F;  3HKZ H;  4OIO E;  2O5J E;  5IP7 E;  4OIN E;  4A3G E;  4X6A F;  4A3D E;  3RZO F;  3RZD E;  4C3H E;  4A3J E;  4BBS E;  2PMZ H;  3S1Q E;  2JA8 E;  4BY7 F;  4MQ9 E;  4Y7N F;  4XLP E;  3H0G F;  3GTM F;  2YU9 E;  5M3M F;  3S1R F;  4A3E F;  1R9T E;  4LLG E;  1WCM F;  4A3F F;  1I50 E;  1TWG E;  3GTL E;  3PO3 E;  4OIP E;  5IYB F;  3GTP E;  2A69 E;  5IYC E;  5E17 E;  5IP7 F;  1SMY E;  3GTK E;  3HOX F;  4A3D F;  3HOU E;  4MEY E;  2A68 E;  4XSZ E;  4A3J F;  3M4O E;  2R93 F;  4G7H E;  3FKI E;  4Q4Z E;  1I6H E;  4BY1 F;  2NVQ E;  3GTJ E;  2JA5 E;  4MEX E;  4KN7 E;  2PPB E;  5C4X E;  3GTO F;  3S15 F;  4ZH4 E;  4A3B F;  1I3Q F;  5IYD F;  4Y52 F;  2E2H F;  1ZYR E;  5M3F E;  5M5X E;  4C3J F;  2A6E E;  5IP9 E;  2B63 F;  2NVT F;  2E2J E;  3CQZ E;  3PO2 E;  1Y1V F;  2R7Z F;  3HKZ K;  2WAQ H;  2A6H E;  3I4N E;  3K7A E;  1TWF F;  3S16 E;  5TMF E;  5C3E E;  1I6V E;  2VUM E;  1TWC F;  4A3K F;  2NVX E;  5M5Y F;  2PMZ K;  3M4O F;  3GTQ F;  3S14 F;  3GTG F;  3HOV F;  4A3C E;  4XLN E;  4A3L F;  2E2I E;  5IPL E;  1K83 E;  3GTJ F;  5FJ8 F;  4Q5S E;  2WB1 I;  1TWA F;  5TMC E;  3S2D E;  2R92 E;  2JA6 F;  3I4M E;  4BBR E;  4C2M E;  3M3Y E;  4A3I E;  1DZF A;  3PO2 F;  5M5W E;  4G7O E;  1SFO E;  5BYH E;  3K7A F;  4A3G F;  4YFX E;  3S1M E;  3HOZ E;  3RZD F;  4C3H F;  2NVX F;  4BBS F;  4C3I E;  4LK0 E;  2JA8 F;  3S1Q F;  2Y0S H;  2BE5 E;  3S1N E;  2WB1 H;  2YU9 F;  4AYB H;  5D4E E;  1TWH E;  3S17 E;  4LJZ E;  1EIK A;  1R9T F;  2JA7 E;  1I50 F;  1TWG F;  3GTL F;  3PO3 F;  3GTM E;  5FJ8 E;  3GTP F;  5IYC F;  3GTK F;  2WAQ K;  1IW7 E;  1HQM E;  4QIW H;  5D4D E;  3HOU F;  4YG2 E;  4A3M E;  3FKI F;  1I6H F;  2NVY E;  3HOY E;  2NVQ F;  2Y0S I;  4JK1 E;  4A93 E;  2JA5 F;  4G7Z E;  5C44 E;  3S2H E;  5C4X F;  2JA7 F;  4X6A E;  4XSX E;  5FLM E;  5M3F F;  3RZO E;  5M5X F;  4OIR E;  5IP9 F;  2O5I E;  4Y7N E;  2E2J F;  3CQZ F;  4BY7 E;  4BXX E;  4GZY E;  1Y1W E;  3I4N F;  3H0G E;  3S16 F;  5M3M E;  3S1R E;  5C3E F;  2VUM F;  4A3E E;  3WOD E;  4KN4 E;  1WCM E;  4A3F E;  4A3C F;  5D4C E;  2E2I F;  1K83 F;  5C4J E;  3HOW E;  4AYB K;  3S2H F;  3S2D F;  2R92 F;  3HOX E;  5E18 E;  5FLM F;  4BBR F;  3I4M F;  4C2M F;  3M3Y F;  4A3I F;  5M5W F;  2R93 E;  4BXX F;  4YFK E;  1Y1W F;  1SFO F;  4BY1 E;  4QIW K;  3S1M F;  2KRX A;  3HOZ F;  4LK1 E;  3GTO E;  3DXJ E;  4C3I F;  3H3V G;  3S15 E;  4A3B E;  1I3Q E;  5IYD E;  2E2H E;  2B63 E;  4Y52 E;  4C3J E;  4OIQ E;  2NVT E;  5C4J F;  3HOW F;  3S1N F;  2R7Z E;  1TWH F;  1Y1V E;  3S17 F;  1TWF E;  4A3K E;  3S14 E;  1TWC E;  1QKL A; 
#chains in the Genus database with same CATH homology
 5M5Y E;  3GTQ E;  3GTG E;  3HOV E;  4A3L E;  1TWA E;  3H3V F;  2JA6 E;  5IYB E;  3HKZ H;  5IP7 E;  4A3G E;  4A3D E;  3RZD E;  4C3H E;  4A3J E;  4BBS E;  2PMZ H;  3S1Q E;  2JA8 E;  2YU9 E;  1R9T E;  1I50 E;  1TWG E;  3GTL E;  3PO3 E;  3GTP E;  5IYC E;  3GTK E;  3HOU E;  3M4O E;  3FKI E;  1I6H E;  2NVQ E;  3GTJ E;  2JA5 E;  5C4X E;  5M3F E;  5M5X E;  5IP9 E;  2E2J E;  3CQZ E;  3PO2 E;  2WAQ H;  3I4N E;  3K7A E;  3S16 E;  5C3E E;  2VUM E;  2NVX E;  4A3C E;  2E2I E;  1K83 E;  3S2D E;  2R92 E;  3I4M E;  4BBR E;  4C2M E;  3M3Y E;  4A3I E;  1DZF A;  5M5W E;  1SFO E;  3S1M E;  3HOZ E;  4C3I E;  2Y0S H;  3S1N E;  2WB1 H;  4AYB H;  1TWH E;  3S17 E;  1EIK A;  2JA7 E;  3GTM E;  5FJ8 E;  4QIW H;  4A3M E;  2NVY E;  3HOY E;  4A93 E;  5C44 E;  3S2H E;  4X6A E;  5FLM E;  3RZO E;  4Y7N E;  4BY7 E;  4BXX E;  1Y1W E;  3H0G E;  5M3M E;  3S1R E;  4A3E E;  1WCM E;  4A3F E;  5C4J E;  3HOW E;  3HOX E;  2R93 E;  4BY1 E;  3GTO E;  3S15 E;  4A3B E;  1I3Q E;  5IYD E;  2E2H E;  2B63 E;  4Y52 E;  4C3J E;  2NVT E;  2R7Z E;  1Y1V E;  1TWF E;  4A3K E;  3S14 E;  1TWC E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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