5IYCE

Human core-pic in the initial transcribing state
Total Genus 56
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
210
structure length
210
Chain Sequence
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule tags Transcription, transferase/dna
source organism Homo sapiens
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 56
structure length 210
sequence length 210
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 5iycE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 5iycE02
4X6AE 4A93E 2R92E 2JA8E 1TWHE 1SFOE 5IYBE 1Y1WE 4BXXE 1I50E 3S1ME 3S15E 4A3BE 5M3FE 3H3VF 3S2HE 4A3DE 1TWAE 5IYCE 2YU9E 3M4OE 2Y0SH 4A3LE 4A3FE 3HOUE 3CQZE 3HOZE 3HOXE 2E2HE 1TWFE 2NVQE 5C44E 3FKIE 3GTKE 3GTQE 1WCME 1Y1VE 3GTOE 3S14E 4Y52E 3S1RE 5IYDE 4A3ME 4A3KE 3I4NE 3M3YE 3H0GE 3S1NE 4A3JE 2NVXE 4BBSE 5M5XE 3HKZH 1DZFA 4C2ME 2WAQH 2WB1H 2NVTE 5M3ME 4A3IE 5IP9E 2JA5E 2JA6E 4AYBH 1TWCE 3RZOE 4Y7NE 3HOYE 3GTLE 2R93E 5C4XE 4C3JE 3GTPE 3S17E 4C3HE 2B63E 3GTME 3PO3E 5IP7E 2E2JE 3S2DE 5FLME 3K7AE 1K83E 3GTGE 4C3IE 5C3EE 4QIWH 3RZDE 4BBRE 2R7ZE 4BY7E 1I3QE 3S16E 5M5YE 1TWGE 1EIKA 2JA7E 3I4ME 4A3CE 2VUME 3HOWE 2PMZH 3PO2E 4A3GE 1R9TE 5M5WE 5FJ8E 2NVYE 3GTJE 5C4JE 4A3EE 4BY1E 2E2IE 3S1QE 1I6HE 3HOVE
chains in the Genus database with same CATH superfamily
4X6AE 2YU9F 4OIOE 3M4OF 3PO2F 4A93E 2R92E 4LLGE 4AYBK 2JA8E 3DXJE 1TWHE 5M5WF 3GTJF 2NVYF 4A3FF 1SFOE 5IYBE 2WB1I 5C4JF 4BY1F 2O5JE 2E2IF 1Y1WE 1I6HF 4BXXE 5D4EE 1I50E 3HOXF 2E2HF 4A93F 3S1ME 2R92F 4KMUE 5C44F 3S15E 4A3BE 3FKIF 5M3FE 3H3VF 5IYBF 1SFOF 1Y1WF 4GZYE 3S2HE 1I50F 1Y1VF 4G7ZE 3S1RF 4A3DE 1TWAE 5IYDF 4A3MF 4A3KF 5IYCE 2YU9E 3M4OE 2Y0SH 3S15F 4A3BF 3H0GF 5M3FF 4A3LE 4Q4ZE 4QIWK 3S2HF 4A3FE 3HOUE 2A6HE 3CQZE 3HOZE 3S1NF 2BE5E 4OIPE 4A3DF 1TWAF 4ZH4E 1QKLA 5IYCF 2NVXF 3HOXE 2E2HE 1TWFE 1HQME 4YG2E 4A3LF 2NVQE 5C44E 5M5XF 4KN7E 3FKIE 1ZYRE 1YNNK 2KRXA 3CQZF 3HOUF 3GTKE 3GTQE 3HOZF 1WCME 5E17E 2NVTF 4XLNE 1Y1VE 3GTOE 3S14E 4Y52E 3S1RE 1TWFF 4LJZE 5IP9F 5IYDE 4A3ME 2NVQF 4A3KE 2JA6F 3I4NE 3M3YE 3H0GE 3GTKF 3GTQF 1YNJK 1WCMF 2PMZK 4Y7NF 3HOYF 2R93F 5C4XF 1I6VE 4C3JF 3GTOF 3S14F 3S1NE 4Y52F 3GTPF 3S17F 4A3JE 4C3HF 2NVXE 3I4NF 3M3YF 3PO3F 2E2JF 4BBSE 4YFKE 2PPBE 5M5XE 3HKZH 1DZFA 3K7AF 4C2ME 4OIQE 3GTGF 2WAQH 2WB1H 2NVTE 4A3JF 4XSZE 5M3ME 4A3IE 5IP9E 4BBSF 2JA5E 4XSXE 2JA6E 4AYBH 4JK1E 1TWCE 3RZOE 4Y7NE 3HOYE 5E18E 3GTLE 2R93E 5IPLE 5C4XE 4OINE 4C3JE 4MEXE 5M3MF 4A3IF 3GTPE 3S17E 4BBRF 4XLPE 4BY7F 2JA5F 4C3HE 2B63E 1TWCF 3GTME 3PO3E 5IP7E 2E2JE 3RZOF 3S2DE 1IW7E 1SMYE 5TMFE 5M5YF 3GTLF 5FLME 1TWGF 4OIRE 3K7AE 3I4MF 1K83E 3GTGE 4KN4E 4G7OE 4C3IE 4A3CF 3WODE 2B63F 5C3EE 2VUMF 3GTMF 4Q5SE 5IP7F 3S2DF 4QIWH 5D4CE 5FLMF 4A3GF 4MEYE 5BYHE 4LK0E 1K83F 3RZDE 1R9TF 4YFXE 4C3IF 5FJ8F 2O5IE 4A3EF 5C3EF 4C2MF 3S1QF 3HOVF 4X6AF 4BBRE 2R7ZE 4BY7E 4MQ9E 1I3QE 3S16E 5M5YE 3RZDF 1TWHF 2A69E 2Y0SI 4G7HE 1TWGE 2JA8F 1EIKA 2JA7E 5TMCE 4LK1E 3I4ME 2A68E 4BXXF 3EQLE 4A3CE 4YFNE 2R7ZF 2VUME 1I3QF 3S1MF 5D4DE 2CW0E 3S16F 3HOWE 2PMZH 3PO2E 4A3GE 2JA7F 3HKZK 2A6EE 1R9TE 5M5WE 5FJ8E 2NVYE 3GTJE 3H3VG 5C4JE 4A3EE 4BY1E 2E2IE 2WAQK 3S1QE 1I6HE 3HOWF 3HOVE
chains in the Genus database with same CATH topology
4X6AE 4A93E 2R92E 2JA8E 1TWHE 1SFOE 5IYBE 1Y1WE 4BXXE 1I50E 3S1ME 3S15E 4A3BE 5M3FE 3H3VF 3S2HE 4A3DE 1TWAE 5IYCE 2YU9E 3M4OE 2Y0SH 4A3LE 4A3FE 3HOUE 3CQZE 3HOZE 3HOXE 2E2HE 1TWFE 2NVQE 5C44E 3FKIE 3GTKE 3GTQE 1WCME 1Y1VE 3GTOE 3S14E 4Y52E 3S1RE 5IYDE 4A3ME 4A3KE 3I4NE 3M3YE 3H0GE 3S1NE 4A3JE 2NVXE 4BBSE 5M5XE 3HKZH 1DZFA 4C2ME 2WAQH 2WB1H 2NVTE 5M3ME 4A3IE 5IP9E 2JA5E 2JA6E 4AYBH 1TWCE 3RZOE 4Y7NE 3HOYE 3GTLE 2R93E 5C4XE 4C3JE 3GTPE 3S17E 4C3HE 2B63E 3GTME 3PO3E 5IP7E 2E2JE 3S2DE 5FLME 3K7AE 1K83E 3GTGE 4C3IE 5C3EE 4QIWH 3RZDE 4BBRE 2R7ZE 4BY7E 1I3QE 3S16E 5M5YE 1TWGE 1EIKA 2JA7E 3I4ME 4A3CE 2VUME 3HOWE 2PMZH 3PO2E 4A3GE 1R9TE 5M5WE 5FJ8E 2NVYE 3GTJE 5C4JE 4A3EE 4BY1E 2E2IE 3S1QE 1I6HE 3HOVE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X6A E;  4A93 E;  2R92 E;  2JA8 E;  1TWH E;  1SFO E;  5IYB E;  1Y1W E;  4BXX E;  1I50 E;  3S1M E;  3S15 E;  4A3B E;  5M3F E;  3H3V F;  3S2H E;  4A3D E;  1TWA E;  5IYC E;  2YU9 E;  3M4O E;  2Y0S H;  4A3L E;  4A3F E;  3HOU E;  3CQZ E;  3HOZ E;  3HOX E;  2E2H E;  1TWF E;  2NVQ E;  5C44 E;  3FKI E;  3GTK E;  3GTQ E;  1WCM E;  1Y1V E;  3GTO E;  3S14 E;  4Y52 E;  3S1R E;  5IYD E;  4A3M E;  4A3K E;  3I4N E;  3M3Y E;  3H0G E;  3S1N E;  4A3J E;  2NVX E;  4BBS E;  5M5X E;  3HKZ H;  1DZF A;  4C2M E;  2WAQ H;  2WB1 H;  2NVT E;  5M3M E;  4A3I E;  5IP9 E;  2JA5 E;  2JA6 E;  4AYB H;  1TWC E;  3RZO E;  4Y7N E;  3HOY E;  3GTL E;  2R93 E;  5C4X E;  4C3J E;  3GTP E;  3S17 E;  4C3H E;  2B63 E;  3GTM E;  3PO3 E;  5IP7 E;  2E2J E;  3S2D E;  5FLM E;  3K7A E;  1K83 E;  3GTG E;  4C3I E;  5C3E E;  4QIW H;  3RZD E;  4BBR E;  2R7Z E;  4BY7 E;  1I3Q E;  3S16 E;  5M5Y E;  1TWG E;  1EIK A;  2JA7 E;  3I4M E;  4A3C E;  2VUM E;  3HOW E;  2PMZ H;  3PO2 E;  4A3G E;  1R9T E;  5M5W E;  5FJ8 E;  2NVY E;  3GTJ E;  5C4J E;  4A3E E;  4BY1 E;  2E2I E;  3S1Q E;  1I6H E;  3HOV E; 
#chains in the Genus database with same CATH topology
 4X6A E;  2YU9 F;  4OIO E;  3M4O F;  3PO2 F;  4A93 E;  2R92 E;  4LLG E;  4AYB K;  2JA8 E;  3DXJ E;  1TWH E;  5M5W F;  3GTJ F;  2NVY F;  4A3F F;  1SFO E;  5IYB E;  2WB1 I;  5C4J F;  4BY1 F;  2O5J E;  2E2I F;  1Y1W E;  1I6H F;  4BXX E;  5D4E E;  1I50 E;  3HOX F;  2E2H F;  4A93 F;  3S1M E;  2R92 F;  4KMU E;  5C44 F;  3S15 E;  4A3B E;  3FKI F;  5M3F E;  3H3V F;  5IYB F;  1SFO F;  1Y1W F;  4GZY E;  3S2H E;  1I50 F;  1Y1V F;  4G7Z E;  3S1R F;  4A3D E;  1TWA E;  5IYD F;  4A3M F;  4A3K F;  5IYC E;  2YU9 E;  3M4O E;  2Y0S H;  3S15 F;  4A3B F;  3H0G F;  5M3F F;  4A3L E;  4Q4Z E;  4QIW K;  3S2H F;  4A3F E;  3HOU E;  2A6H E;  3CQZ E;  3HOZ E;  3S1N F;  2BE5 E;  4OIP E;  4A3D F;  1TWA F;  4ZH4 E;  1QKL A;  5IYC F;  2NVX F;  3HOX E;  2E2H E;  1TWF E;  1HQM E;  4YG2 E;  4A3L F;  2NVQ E;  5C44 E;  5M5X F;  4KN7 E;  3FKI E;  1ZYR E;  1YNN K;  2KRX A;  3CQZ F;  3HOU F;  3GTK E;  3GTQ E;  3HOZ F;  1WCM E;  5E17 E;  2NVT F;  4XLN E;  1Y1V E;  3GTO E;  3S14 E;  4Y52 E;  3S1R E;  1TWF F;  4LJZ E;  5IP9 F;  5IYD E;  4A3M E;  2NVQ F;  4A3K E;  2JA6 F;  3I4N E;  3M3Y E;  3H0G E;  3GTK F;  3GTQ F;  1YNJ K;  1WCM F;  2PMZ K;  4Y7N F;  3HOY F;  2R93 F;  5C4X F;  1I6V E;  4C3J F;  3GTO F;  3S14 F;  3S1N E;  4Y52 F;  3GTP F;  3S17 F;  4A3J E;  4C3H F;  2NVX E;  3I4N F;  3M3Y F;  3PO3 F;  2E2J F;  4BBS E;  4YFK E;  2PPB E;  5M5X E;  3HKZ H;  1DZF A;  3K7A F;  4C2M E;  4OIQ E;  3GTG F;  2WAQ H;  2WB1 H;  2NVT E;  4A3J F;  4XSZ E;  5M3M E;  4A3I E;  5IP9 E;  4BBS F;  2JA5 E;  4XSX E;  2JA6 E;  4AYB H;  4JK1 E;  1TWC E;  3RZO E;  4Y7N E;  3HOY E;  5E18 E;  3GTL E;  2R93 E;  5IPL E;  5C4X E;  4OIN E;  4C3J E;  4MEX E;  5M3M F;  4A3I F;  3GTP E;  3S17 E;  4BBR F;  4XLP E;  4BY7 F;  2JA5 F;  4C3H E;  2B63 E;  1TWC F;  3GTM E;  3PO3 E;  5IP7 E;  2E2J E;  3RZO F;  3S2D E;  1IW7 E;  1SMY E;  5TMF E;  5M5Y F;  3GTL F;  5FLM E;  1TWG F;  4OIR E;  3K7A E;  3I4M F;  1K83 E;  3GTG E;  4KN4 E;  4G7O E;  4C3I E;  4A3C F;  3WOD E;  2B63 F;  5C3E E;  2VUM F;  3GTM F;  4Q5S E;  5IP7 F;  3S2D F;  4QIW H;  5D4C E;  5FLM F;  4A3G F;  4MEY E;  5BYH E;  4LK0 E;  1K83 F;  3RZD E;  1R9T F;  4YFX E;  4C3I F;  5FJ8 F;  2O5I E;  4A3E F;  5C3E F;  4C2M F;  3S1Q F;  3HOV F;  4X6A F;  4BBR E;  2R7Z E;  4BY7 E;  4MQ9 E;  1I3Q E;  3S16 E;  5M5Y E;  3RZD F;  1TWH F;  2A69 E;  2Y0S I;  4G7H E;  1TWG E;  2JA8 F;  1EIK A;  2JA7 E;  5TMC E;  4LK1 E;  3I4M E;  2A68 E;  4BXX F;  3EQL E;  4A3C E;  4YFN E;  2R7Z F;  2VUM E;  1I3Q F;  3S1M F;  5D4D E;  2CW0 E;  3S16 F;  3HOW E;  2PMZ H;  3PO2 E;  4A3G E;  2JA7 F;  3HKZ K;  2A6E E;  1R9T E;  5M5W E;  5FJ8 E;  2NVY E;  3GTJ E;  3H3V G;  5C4J E;  4A3E E;  4BY1 E;  2E2I E;  2WAQ K;  3S1Q E;  1I6H E;  3HOW F;  3HOV E; 
#chains in the Genus database with same CATH homology
 4X6A E;  4A93 E;  2R92 E;  2JA8 E;  1TWH E;  1SFO E;  5IYB E;  1Y1W E;  4BXX E;  1I50 E;  3S1M E;  3S15 E;  4A3B E;  5M3F E;  3H3V F;  3S2H E;  4A3D E;  1TWA E;  5IYC E;  2YU9 E;  3M4O E;  2Y0S H;  4A3L E;  4A3F E;  3HOU E;  3CQZ E;  3HOZ E;  3HOX E;  2E2H E;  1TWF E;  2NVQ E;  5C44 E;  3FKI E;  3GTK E;  3GTQ E;  1WCM E;  1Y1V E;  3GTO E;  3S14 E;  4Y52 E;  3S1R E;  5IYD E;  4A3M E;  4A3K E;  3I4N E;  3M3Y E;  3H0G E;  3S1N E;  4A3J E;  2NVX E;  4BBS E;  5M5X E;  3HKZ H;  1DZF A;  4C2M E;  2WAQ H;  2WB1 H;  2NVT E;  5M3M E;  4A3I E;  5IP9 E;  2JA5 E;  2JA6 E;  4AYB H;  1TWC E;  3RZO E;  4Y7N E;  3HOY E;  3GTL E;  2R93 E;  5C4X E;  4C3J E;  3GTP E;  3S17 E;  4C3H E;  2B63 E;  3GTM E;  3PO3 E;  5IP7 E;  2E2J E;  3S2D E;  5FLM E;  3K7A E;  1K83 E;  3GTG E;  4C3I E;  5C3E E;  4QIW H;  3RZD E;  4BBR E;  2R7Z E;  4BY7 E;  1I3Q E;  3S16 E;  5M5Y E;  1TWG E;  1EIK A;  2JA7 E;  3I4M E;  4A3C E;  2VUM E;  3HOW E;  2PMZ H;  3PO2 E;  4A3G E;  1R9T E;  5M5W E;  5FJ8 E;  2NVY E;  3GTJ E;  5C4J E;  4A3E E;  4BY1 E;  2E2I E;  3S1Q E;  1I6H E;  3HOV E; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...