5JB5A

A simplified bpti variant containing 22 alanines out of 58 residues
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
57
structure length
57
Chain Sequence
RPAFCLEPPYAGPGAAAIIRYFYNAAAGAAQAFVYGGVAAKRNNFASAADALAACAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Bos taurus
molecule keywords Pancreatic trypsin inhibitor
total genus 9
structure length 57
sequence length 57
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2016-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 5jb5A00
3FP6I 4Y10I 1YKTB 3GYMI 2KCRA 4WWYC 4TPII 3BTGI 1FANA 1JV9A 2R9PE 3TGJI 3AUCA 3LDJA 4ISNB 1Y62A 1CA0D 3AUHA 2LFKA 3FP8I 4NTYB 1LD5A 1P2II 4WXVC 1TCPA 3TGKI 1OA65 2FI5I 3L3TE 1ZJDB 2LFLA 3BTTI 4ISOB 1LD6A 4NTXB 3AUIA 2ZVXA 1PITA 2UUYB 1P2NB 2RA3C 1FY8I 3BTKI 3BTDI 4DTGK 1K6UA 1P2MB 9PTIA 2HEXA 5JB4A 2IJOI 1BRCI 2JOTA 1T8NB 6PTIA 4Y11I 3BTMI 2FI4I 1P2KI 3AUGA 1CO7I 1T8LB 2M01A 1DTKA 3OTJI 1EJMB 2W8XA 1P2OB 2PTCI 1UUBA 1KTHA 4U32X 3TPII 3AUBA 4DG4C 3L33E 3U1JE 3UOUB 4PTIA 4NTWB 3D65I 3OFWA 1T8OB 3BTHI 3P92E 1JV8A 1KUNA 1CBWD 2FI3I 3BTFI 3FP7J 1DENA 1P2QB 1YC0I 1BZXI 1T7CB 1TAWB 2UUXA 3T62D 1OA55 5JB6A 1DEMA 4Y0ZI 4BD9B 1EAWB 3BTWI 2M99A 1DTXA 1F7ZI 1BTHP 1NAGA 3BTQI 2TPII 1F5RI 2DDIA 2CA7A 4U30W 5JB7A 2TGPI 5JB5A 1AALA 1AAPA 1ZR0B 1D0DB 1P2JI 3LDMA 1BPTA 1BHCA 3WNYA 1BTIA 1KNTA 3AUEA 3M7QB 8PTIA 3AUDA 1YLCB 3CI7A 1ADZA 4BQDA 2FTLI 1BF0A 4ISLB 2J6DA 1BZ5A 2ZJXA 2DDJA 1KIGI 2KAII 1BIKA 1YLDB 1SHPA 3BYBA 5C67C 4BNRI 1G6XA 1IRHA 2ODYE 1UUAA 5PTIA 1D0DA 1T8MB 1BPIA 1TFXC 1TOCR 3TGII 2FTMB 4Y0YI 1TAPA 1QLQA 1B0CA 3BTEI 2KNTA 3P95E 1MTND 1JC6A 1BRBI 1TPAI 3UIRC 7PTIA 1FAKI 1BUNB 3LDIA
chains in the Genus database with same CATH superfamily
3FP6I 4Y10I 1YKTB 3GYMI 2KCRA 4WWYC 4TPII 3BTGI 1FANA 1JV9A 2R9PE 3TGJI 3AUCA 3LDJA 4ISNB 1Y62A 1CA0D 3AUHA 2LFKA 3FP8I 4NTYB 1LD5A 1P2II 4WXVC 1TCPA 3TGKI 1OA65 2FI5I 3L3TE 1ZJDB 2LFLA 3BTTI 4ISOB 1LD6A 4NTXB 3AUIA 2ZVXA 1PITA 2UUYB 1P2NB 2RA3C 1FY8I 3BTKI 3BTDI 4DTGK 1K6UA 1P2MB 9PTIA 2HEXA 5JB4A 2IJOI 1BRCI 2JOTA 1T8NB 6PTIA 4Y11I 3BTMI 2FI4I 1P2KI 3AUGA 1CO7I 1T8LB 2M01A 1DTKA 3OTJI 1EJMB 2W8XA 1P2OB 2PTCI 1UUBA 1KTHA 4U32X 3TPII 3AUBA 4DG4C 3L33E 3U1JE 3UOUB 4PTIA 4NTWB 3D65I 3OFWA 1T8OB 3BTHI 3P92E 1JV8A 1KUNA 1CBWD 2FI3I 3BTFI 3FP7J 1DENA 1P2QB 1YC0I 1BZXI 1T7CB 1TAWB 2UUXA 3T62D 1OA55 5JB6A 1DEMA 4Y0ZI 4BD9B 1EAWB 3BTWI 2M99A 1DTXA 1F7ZI 1BTHP 1NAGA 3BTQI 2TPII 1F5RI 2DDIA 2CA7A 4U30W 5JB7A 2TGPI 5JB5A 1AALA 1AAPA 1ZR0B 1D0DB 1P2JI 3LDMA 1BPTA 1BHCA 3WNYA 1BTIA 1KNTA 3AUEA 3M7QB 8PTIA 3AUDA 1YLCB 3CI7A 1ADZA 4BQDA 2FTLI 1BF0A 4ISLB 2J6DA 1BZ5A 2ZJXA 2DDJA 1KIGI 2KAII 1BIKA 1YLDB 1SHPA 3BYBA 5C67C 4BNRI 1G6XA 1IRHA 2ODYE 1UUAA 5PTIA 1D0DA 1T8MB 1BPIA 1TFXC 1TOCR 3TGII 2FTMB 4Y0YI 1TAPA 1QLQA 1B0CA 3BTEI 2KNTA 3P95E 1MTND 1JC6A 1BRBI 1TPAI 3UIRC 7PTIA 1FAKI 1BUNB 3LDIA
chains in the Genus database with same CATH topology
3FP6I 4Y10I 1YKTB 3GYMI 2KCRA 4WWYC 4TPII 3BTGI 1FANA 1JV9A 2R9PE 3TGJI 3AUCA 3LDJA 4ISNB 1Y62A 1CA0D 3AUHA 2LFKA 3FP8I 4NTYB 1LD5A 1P2II 4WXVC 1TCPA 3TGKI 1OA65 2FI5I 3L3TE 1ZJDB 2LFLA 3BTTI 4ISOB 1LD6A 4NTXB 3AUIA 2ZVXA 1PITA 2UUYB 1P2NB 2RA3C 1FY8I 3BTKI 3BTDI 4DTGK 1K6UA 1P2MB 9PTIA 2HEXA 5JB4A 2IJOI 1BRCI 2JOTA 1T8NB 6PTIA 4Y11I 3BTMI 2FI4I 1P2KI 3AUGA 1CO7I 1T8LB 2M01A 1DTKA 3OTJI 1EJMB 2W8XA 1P2OB 2PTCI 1UUBA 1KTHA 4U32X 3TPII 3AUBA 4DG4C 3L33E 3U1JE 3UOUB 4PTIA 4NTWB 3D65I 3OFWA 1T8OB 3BTHI 3P92E 1JV8A 1KUNA 1CBWD 2FI3I 3BTFI 3FP7J 1DENA 1P2QB 1YC0I 1BZXI 1T7CB 1TAWB 2UUXA 3T62D 1OA55 5JB6A 1DEMA 4Y0ZI 4BD9B 1EAWB 3BTWI 2M99A 1DTXA 1F7ZI 1BTHP 1NAGA 3BTQI 2TPII 1F5RI 2DDIA 2CA7A 4U30W 5JB7A 2TGPI 5JB5A 1AALA 1AAPA 1ZR0B 1D0DB 1P2JI 3LDMA 1BPTA 1BHCA 3WNYA 1BTIA 1KNTA 3AUEA 3M7QB 8PTIA 3AUDA 1YLCB 3CI7A 1ADZA 4BQDA 2FTLI 1BF0A 4ISLB 2J6DA 1BZ5A 2ZJXA 2DDJA 1KIGI 2KAII 1BIKA 1YLDB 1SHPA 3BYBA 5C67C 4BNRI 1G6XA 1IRHA 2ODYE 1UUAA 5PTIA 1D0DA 1T8MB 1BPIA 1TFXC 1TOCR 3TGII 2FTMB 4Y0YI 1TAPA 1QLQA 1B0CA 3BTEI 2KNTA 3P95E 1MTND 1JC6A 1BRBI 1TPAI 3UIRC 7PTIA 1FAKI 1BUNB 3LDIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FP6 I;  4Y10 I;  1YKT B;  3GYM I;  2KCR A;  4WWY C;  4TPI I;  3BTG I;  1FAN A;  1JV9 A;  2R9P E;  3TGJ I;  3AUC A;  3LDJ A;  4ISN B;  1Y62 A;  1CA0 D;  3AUH A;  2LFK A;  3FP8 I;  4NTY B;  1LD5 A;  1P2I I;  4WXV C;  1TCP A;  3TGK I;  1OA6 5;  2FI5 I;  3L3T E;  1ZJD B;  2LFL A;  3BTT I;  4ISO B;  1LD6 A;  4NTX B;  3AUI A;  2ZVX A;  1PIT A;  2UUY B;  1P2N B;  2RA3 C;  1FY8 I;  3BTK I;  3BTD I;  4DTG K;  1K6U A;  1P2M B;  9PTI A;  2HEX A;  5JB4 A;  2IJO I;  1BRC I;  2JOT A;  1T8N B;  6PTI A;  4Y11 I;  3BTM I;  2FI4 I;  1P2K I;  3AUG A;  1CO7 I;  1T8L B;  2M01 A;  1DTK A;  3OTJ I;  1EJM B;  2W8X A;  1P2O B;  2PTC I;  1UUB A;  1KTH A;  4U32 X;  3TPI I;  3AUB A;  4DG4 C;  3L33 E;  3U1J E;  3UOU B;  4PTI A;  4NTW B;  3D65 I;  3OFW A;  1T8O B;  3BTH I;  3P92 E;  1JV8 A;  1KUN A;  1CBW D;  2FI3 I;  3BTF I;  3FP7 J;  1DEN A;  1P2Q B;  1YC0 I;  1BZX I;  1T7C B;  1TAW B;  2UUX A;  3T62 D;  1OA5 5;  5JB6 A;  1DEM A;  4Y0Z I;  4BD9 B;  1EAW B;  3BTW I;  2M99 A;  1DTX A;  1F7Z I;  1BTH P;  1NAG A;  3BTQ I;  2TPI I;  1F5R I;  2DDI A;  2CA7 A;  4U30 W;  5JB7 A;  2TGP I;  5JB5 A;  1AAL A;  1AAP A;  1ZR0 B;  1D0D B;  1P2J I;  3LDM A;  1BPT A;  1BHC A;  3WNY A;  1BTI A;  1KNT A;  3AUE A;  3M7Q B;  8PTI A;  3AUD A;  1YLC B;  3CI7 A;  1ADZ A;  4BQD A;  2FTL I;  1BF0 A;  4ISL B;  2J6D A;  1BZ5 A;  2ZJX A;  2DDJ A;  1KIG I;  2KAI I;  1BIK A;  1YLD B;  1SHP A;  3BYB A;  5C67 C;  4BNR I;  1G6X A;  1IRH A;  2ODY E;  1UUA A;  5PTI A;  1D0D A;  1T8M B;  1BPI A;  1TFX C;  1TOC R;  3TGI I;  2FTM B;  4Y0Y I;  1TAP A;  1QLQ A;  1B0C A;  3BTE I;  2KNT A;  3P95 E;  1MTN D;  1JC6 A;  1BRB I;  1TPA I;  3UIR C;  7PTI A;  1FAK I;  1BUN B;  3LDI A; 
#chains in the Genus database with same CATH topology
 3FP6 I;  4Y10 I;  1YKT B;  3GYM I;  2KCR A;  4WWY C;  4TPI I;  3BTG I;  1FAN A;  1JV9 A;  2R9P E;  3TGJ I;  3AUC A;  3LDJ A;  4ISN B;  1Y62 A;  1CA0 D;  3AUH A;  2LFK A;  3FP8 I;  4NTY B;  1LD5 A;  1P2I I;  4WXV C;  1TCP A;  3TGK I;  1OA6 5;  2FI5 I;  3L3T E;  1ZJD B;  2LFL A;  3BTT I;  4ISO B;  1LD6 A;  4NTX B;  3AUI A;  2ZVX A;  1PIT A;  2UUY B;  1P2N B;  2RA3 C;  1FY8 I;  3BTK I;  3BTD I;  4DTG K;  1K6U A;  1P2M B;  9PTI A;  2HEX A;  5JB4 A;  2IJO I;  1BRC I;  2JOT A;  1T8N B;  6PTI A;  4Y11 I;  3BTM I;  2FI4 I;  1P2K I;  3AUG A;  1CO7 I;  1T8L B;  2M01 A;  1DTK A;  3OTJ I;  1EJM B;  2W8X A;  1P2O B;  2PTC I;  1UUB A;  1KTH A;  4U32 X;  3TPI I;  3AUB A;  4DG4 C;  3L33 E;  3U1J E;  3UOU B;  4PTI A;  4NTW B;  3D65 I;  3OFW A;  1T8O B;  3BTH I;  3P92 E;  1JV8 A;  1KUN A;  1CBW D;  2FI3 I;  3BTF I;  3FP7 J;  1DEN A;  1P2Q B;  1YC0 I;  1BZX I;  1T7C B;  1TAW B;  2UUX A;  3T62 D;  1OA5 5;  5JB6 A;  1DEM A;  4Y0Z I;  4BD9 B;  1EAW B;  3BTW I;  2M99 A;  1DTX A;  1F7Z I;  1BTH P;  1NAG A;  3BTQ I;  2TPI I;  1F5R I;  2DDI A;  2CA7 A;  4U30 W;  5JB7 A;  2TGP I;  5JB5 A;  1AAL A;  1AAP A;  1ZR0 B;  1D0D B;  1P2J I;  3LDM A;  1BPT A;  1BHC A;  3WNY A;  1BTI A;  1KNT A;  3AUE A;  3M7Q B;  8PTI A;  3AUD A;  1YLC B;  3CI7 A;  1ADZ A;  4BQD A;  2FTL I;  1BF0 A;  4ISL B;  2J6D A;  1BZ5 A;  2ZJX A;  2DDJ A;  1KIG I;  2KAI I;  1BIK A;  1YLD B;  1SHP A;  3BYB A;  5C67 C;  4BNR I;  1G6X A;  1IRH A;  2ODY E;  1UUA A;  5PTI A;  1D0D A;  1T8M B;  1BPI A;  1TFX C;  1TOC R;  3TGI I;  2FTM B;  4Y0Y I;  1TAP A;  1QLQ A;  1B0C A;  3BTE I;  2KNT A;  3P95 E;  1MTN D;  1JC6 A;  1BRB I;  1TPA I;  3UIR C;  7PTI A;  1FAK I;  1BUN B;  3LDI A; 
#chains in the Genus database with same CATH homology
 3FP6 I;  4Y10 I;  1YKT B;  3GYM I;  2KCR A;  4WWY C;  4TPI I;  3BTG I;  1FAN A;  1JV9 A;  2R9P E;  3TGJ I;  3AUC A;  3LDJ A;  4ISN B;  1Y62 A;  1CA0 D;  3AUH A;  2LFK A;  3FP8 I;  4NTY B;  1LD5 A;  1P2I I;  4WXV C;  1TCP A;  3TGK I;  1OA6 5;  2FI5 I;  3L3T E;  1ZJD B;  2LFL A;  3BTT I;  4ISO B;  1LD6 A;  4NTX B;  3AUI A;  2ZVX A;  1PIT A;  2UUY B;  1P2N B;  2RA3 C;  1FY8 I;  3BTK I;  3BTD I;  4DTG K;  1K6U A;  1P2M B;  9PTI A;  2HEX A;  5JB4 A;  2IJO I;  1BRC I;  2JOT A;  1T8N B;  6PTI A;  4Y11 I;  3BTM I;  2FI4 I;  1P2K I;  3AUG A;  1CO7 I;  1T8L B;  2M01 A;  1DTK A;  3OTJ I;  1EJM B;  2W8X A;  1P2O B;  2PTC I;  1UUB A;  1KTH A;  4U32 X;  3TPI I;  3AUB A;  4DG4 C;  3L33 E;  3U1J E;  3UOU B;  4PTI A;  4NTW B;  3D65 I;  3OFW A;  1T8O B;  3BTH I;  3P92 E;  1JV8 A;  1KUN A;  1CBW D;  2FI3 I;  3BTF I;  3FP7 J;  1DEN A;  1P2Q B;  1YC0 I;  1BZX I;  1T7C B;  1TAW B;  2UUX A;  3T62 D;  1OA5 5;  5JB6 A;  1DEM A;  4Y0Z I;  4BD9 B;  1EAW B;  3BTW I;  2M99 A;  1DTX A;  1F7Z I;  1BTH P;  1NAG A;  3BTQ I;  2TPI I;  1F5R I;  2DDI A;  2CA7 A;  4U30 W;  5JB7 A;  2TGP I;  5JB5 A;  1AAL A;  1AAP A;  1ZR0 B;  1D0D B;  1P2J I;  3LDM A;  1BPT A;  1BHC A;  3WNY A;  1BTI A;  1KNT A;  3AUE A;  3M7Q B;  8PTI A;  3AUD A;  1YLC B;  3CI7 A;  1ADZ A;  4BQD A;  2FTL I;  1BF0 A;  4ISL B;  2J6D A;  1BZ5 A;  2ZJX A;  2DDJ A;  1KIG I;  2KAI I;  1BIK A;  1YLD B;  1SHP A;  3BYB A;  5C67 C;  4BNR I;  1G6X A;  1IRH A;  2ODY E;  1UUA A;  5PTI A;  1D0D A;  1T8M B;  1BPI A;  1TFX C;  1TOC R;  3TGI I;  2FTM B;  4Y0Y I;  1TAP A;  1QLQ A;  1B0C A;  3BTE I;  2KNT A;  3P95 E;  1MTN D;  1JC6 A;  1BRB I;  1TPA I;  3UIR C;  7PTI A;  1FAK I;  1BUN B;  3LDI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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