5C4JE

Crystal structure of a transcribing rna polymerase ii complex reveals a complete transcription bubble
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
212
structure length
212
Chain Sequence
ENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
pubmed doi rcsb
molecule tags Transferase/dna/rna
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 46
structure length 212
sequence length 212
ec nomenclature
pdb deposition date 2015-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 5c4jE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 5c4jE02
5C3EE 2R93E 1I50E 4A3GE 1EIKA 5IYBE 4A3DE 4A3LE 1TWFE 2E2JE 2YU9E 2VUME 3S1ME 1Y1VE 1TWCE 1K83E 4A3KE 4BBSE 3HOVE 3S2DE 4C3HE 5IP7E 5M5WE 4QIWH 3S1QE 3S17E 4A3BE 3GTGE 2R92E 3GTLE 1DZFA 5M5XE 1R9TE 5FJ8E 5M3FE 2PMZH 4A3CE 1WCME 3GTME 2E2IE 5IP9E 3GTKE 3GTQE 3GTOE 4BXXE 1I6HE 3PO3E 1SFOE 5C4JE 2NVQE 3I4ME 2JA7E 3M4OE 5C4XE 3PO2E 2NVXE 4A3FE 5FLME 3HOZE 4A3ME 3HOYE 2E2HE 1TWAE 2JA5E 4BY7E 3CQZE 5C44E 4Y7NE 4A3JE 5M5YE 4AYBH 3HOXE 4A3EE 4BY1E 3S16E 3GTPE 2R7ZE 4Y52E 3S1NE 1TWHE 4C2ME 3M3YE 3RZDE 2WB1H 3HOWE 3S15E 4A93E 3H0GE 2WAQH 3GTJE 2JA8E 3HKZH 1Y1WE 1TWGE 3FKIE 3S1RE 4BBRE 3S14E 4C3IE 4X6AE 3RZOE 2Y0SH 4A3IE 3S2HE 3K7AE 5M3ME 3HOUE 2NVYE 3I4NE 1I3QE 3H3VF 2NVTE 2B63E 4C3JE 5IYDE 5IYCE 2JA6E
chains in the Genus database with same CATH superfamily
3GTKF 5C3EE 4KMUE 2R93E 3GTQF 4BXXF 1I50E 4A3GE 4G7OE 4YFKE 1SFOF 1EIKA 2JA7F 5IYBE 1K83F 2NVXF 3PO2F 5FLMF 4A3DE 5E18E 4A3LE 1TWFE 2E2JE 2PPBE 2YU9E 2VUME 3S2DF 4BBSF 4C3HF 5IP7F 5M5WF 2E2HF 3S1ME 2A6HE 4XLNE 4BY7F 3S1QF 5C44F 1Y1VE 1TWCE 2A69E 4LK0E 3GTGF 1K83E 4LK1E 3GTLF 4MEYE 4A3KE 4XSZE 4BBSE 3HOVE 3S2DE 4Q5SE 4YFNE 5D4EE 1I6VE 4C3HE 5IP7E 5M5WE 5M5YF 5FJ8F 5IPLE 1WCMF 3DXJE 3HOXF 3GTMF 4QIWH 3S1QE 3S17E 4A3BE 1IW7E 4MEXE 3GTPF 3GTGE 2R92E 1TWHF 2E2IF 5IP9F 5TMCE 3GTOF 3M3YF 4OIOE 1I6HF 4JK1E 2WB1I 3PO3F 3GTLE 1DZFA 5M5XE 1R9TE 5FJ8E 5M3FE 2PMZH 4A3CE 4YG2E 5C4JF 4MQ9E 1WCME 2NVQF 4A3FF 1YNNK 1R9TF 3GTME 3HOZF 3M4OF 4A3MF 3HOYF 2JA8F 2E2IE 1TWAF 1Y1WF 5IP9E 3GTKE 3GTQE 3GTOE 4BXXE 4QIWK 2JA5F 2O5JE 1I6HE 5M5XF 3PO3E 3CQZF 3S1RF 5TMFE 1SFOE 4LLGE 5C4JE 2NVQE 3I4ME 2JA7E 3M4OE 5C4XE 3PO2E 2NVXE 4LJZE 4A3FE 5FLME 4Y7NF 3HOZE 1YNJK 4KN4E 2KRXA 4A3JF 2Y0SI 4A3ME 3HOYE 2PMZK 4A3IF 2E2HE 1TWAE 2JA5E 5M3MF 4BY1F 4BY7E 4A3EF 3CQZE 2NVYF 5C44E 3HOUF 3S16F 4Y52F 2R7ZF 3S1NF 2A68E 3S1MF 4Y7NE 4C2MF 3RZDF 4XLPE 4A3JE 3HOWF 3S15F 5M5YE 4A93F 4AYBH 2B63F 4OIRE 3H0GF 3HOXE 4A3EE 4BY1E 2BE5E 3S16E 3GTPE 2R7ZE 4Y52E 3GTJF 3S1NE 1TWHE 1TWGF 2O5IE 4C2ME 4YFXE 2R93F 3FKIF 3M3YE 3RZDE 2WB1H 5D4DE 3HOWE 3S15E 4BBRF 4G7HE 4A93E 3S14F 3H0GE 4GZYE 4OIQE 4C3IF 2WAQH 4A3LF 1TWFF 3WODE 2E2JF 3GTJE 4OIPE 4AYBK 2JA8E 2YU9F 3S2HF 3HKZH 1Y1WE 1TWGE 3K7AF 3FKIE 4X6AF 3S1RE 1Y1VF 4BBRE 1TWCF 4G7ZE 5C4XF 3I4NF 1ZYRE 3S14E 1I3QF 4C3IE 4OINE 2A6EE 4A3KF 4X6AE 3RZOE 2Y0SH 4A3IE 2NVTF 3HOVF 3S2HE 5E17E 4ZH4E 2WAQK 3K7AE 5M3ME 4C3JF 5BYHE 3HOUE 4XSXE 2NVYE 3S17F 2CW0E 4A3BF 3HKZK 3I4MF 5IYDF 3I4NE 2R92F 5IYCF 2JA6F 1I3QE 5C3EF 1HQME 1I50F 3H3VF 4Q4ZE 3RZOF 4A3GF 1QKLA 2NVTE 5D4CE 5M3FF 2B63E 4A3CF 5IYBF 4C3JE 3H3VG 4A3DF 3EQLE 4KN7E 2VUMF 5IYDE 1SMYE 5IYCE 2JA6E
chains in the Genus database with same CATH topology
5C3EE 2R93E 1I50E 4A3GE 1EIKA 5IYBE 4A3DE 4A3LE 1TWFE 2E2JE 2YU9E 2VUME 3S1ME 1Y1VE 1TWCE 1K83E 4A3KE 4BBSE 3HOVE 3S2DE 4C3HE 5IP7E 5M5WE 4QIWH 3S1QE 3S17E 4A3BE 3GTGE 2R92E 3GTLE 1DZFA 5M5XE 1R9TE 5FJ8E 5M3FE 2PMZH 4A3CE 1WCME 3GTME 2E2IE 5IP9E 3GTKE 3GTQE 3GTOE 4BXXE 1I6HE 3PO3E 1SFOE 5C4JE 2NVQE 3I4ME 2JA7E 3M4OE 5C4XE 3PO2E 2NVXE 4A3FE 5FLME 3HOZE 4A3ME 3HOYE 2E2HE 1TWAE 2JA5E 4BY7E 3CQZE 5C44E 4Y7NE 4A3JE 5M5YE 4AYBH 3HOXE 4A3EE 4BY1E 3S16E 3GTPE 2R7ZE 4Y52E 3S1NE 1TWHE 4C2ME 3M3YE 3RZDE 2WB1H 3HOWE 3S15E 4A93E 3H0GE 2WAQH 3GTJE 2JA8E 3HKZH 1Y1WE 1TWGE 3FKIE 3S1RE 4BBRE 3S14E 4C3IE 4X6AE 3RZOE 2Y0SH 4A3IE 3S2HE 3K7AE 5M3ME 3HOUE 2NVYE 3I4NE 1I3QE 3H3VF 2NVTE 2B63E 4C3JE 5IYDE 5IYCE 2JA6E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C3E E;  2R93 E;  1I50 E;  4A3G E;  1EIK A;  5IYB E;  4A3D E;  4A3L E;  1TWF E;  2E2J E;  2YU9 E;  2VUM E;  3S1M E;  1Y1V E;  1TWC E;  1K83 E;  4A3K E;  4BBS E;  3HOV E;  3S2D E;  4C3H E;  5IP7 E;  5M5W E;  4QIW H;  3S1Q E;  3S17 E;  4A3B E;  3GTG E;  2R92 E;  3GTL E;  1DZF A;  5M5X E;  1R9T E;  5FJ8 E;  5M3F E;  2PMZ H;  4A3C E;  1WCM E;  3GTM E;  2E2I E;  5IP9 E;  3GTK E;  3GTQ E;  3GTO E;  4BXX E;  1I6H E;  3PO3 E;  1SFO E;  5C4J E;  2NVQ E;  3I4M E;  2JA7 E;  3M4O E;  5C4X E;  3PO2 E;  2NVX E;  4A3F E;  5FLM E;  3HOZ E;  4A3M E;  3HOY E;  2E2H E;  1TWA E;  2JA5 E;  4BY7 E;  3CQZ E;  5C44 E;  4Y7N E;  4A3J E;  5M5Y E;  4AYB H;  3HOX E;  4A3E E;  4BY1 E;  3S16 E;  3GTP E;  2R7Z E;  4Y52 E;  3S1N E;  1TWH E;  4C2M E;  3M3Y E;  3RZD E;  2WB1 H;  3HOW E;  3S15 E;  4A93 E;  3H0G E;  2WAQ H;  3GTJ E;  2JA8 E;  3HKZ H;  1Y1W E;  1TWG E;  3FKI E;  3S1R E;  4BBR E;  3S14 E;  4C3I E;  4X6A E;  3RZO E;  2Y0S H;  4A3I E;  3S2H E;  3K7A E;  5M3M E;  3HOU E;  2NVY E;  3I4N E;  1I3Q E;  3H3V F;  2NVT E;  2B63 E;  4C3J E;  5IYD E;  5IYC E;  2JA6 E; 
#chains in the Genus database with same CATH topology
 3GTK F;  5C3E E;  4KMU E;  2R93 E;  3GTQ F;  4BXX F;  1I50 E;  4A3G E;  4G7O E;  4YFK E;  1SFO F;  1EIK A;  2JA7 F;  5IYB E;  1K83 F;  2NVX F;  3PO2 F;  5FLM F;  4A3D E;  5E18 E;  4A3L E;  1TWF E;  2E2J E;  2PPB E;  2YU9 E;  2VUM E;  3S2D F;  4BBS F;  4C3H F;  5IP7 F;  5M5W F;  2E2H F;  3S1M E;  2A6H E;  4XLN E;  4BY7 F;  3S1Q F;  5C44 F;  1Y1V E;  1TWC E;  2A69 E;  4LK0 E;  3GTG F;  1K83 E;  4LK1 E;  3GTL F;  4MEY E;  4A3K E;  4XSZ E;  4BBS E;  3HOV E;  3S2D E;  4Q5S E;  4YFN E;  5D4E E;  1I6V E;  4C3H E;  5IP7 E;  5M5W E;  5M5Y F;  5FJ8 F;  5IPL E;  1WCM F;  3DXJ E;  3HOX F;  3GTM F;  4QIW H;  3S1Q E;  3S17 E;  4A3B E;  1IW7 E;  4MEX E;  3GTP F;  3GTG E;  2R92 E;  1TWH F;  2E2I F;  5IP9 F;  5TMC E;  3GTO F;  3M3Y F;  4OIO E;  1I6H F;  4JK1 E;  2WB1 I;  3PO3 F;  3GTL E;  1DZF A;  5M5X E;  1R9T E;  5FJ8 E;  5M3F E;  2PMZ H;  4A3C E;  4YG2 E;  5C4J F;  4MQ9 E;  1WCM E;  2NVQ F;  4A3F F;  1YNN K;  1R9T F;  3GTM E;  3HOZ F;  3M4O F;  4A3M F;  3HOY F;  2JA8 F;  2E2I E;  1TWA F;  1Y1W F;  5IP9 E;  3GTK E;  3GTQ E;  3GTO E;  4BXX E;  4QIW K;  2JA5 F;  2O5J E;  1I6H E;  5M5X F;  3PO3 E;  3CQZ F;  3S1R F;  5TMF E;  1SFO E;  4LLG E;  5C4J E;  2NVQ E;  3I4M E;  2JA7 E;  3M4O E;  5C4X E;  3PO2 E;  2NVX E;  4LJZ E;  4A3F E;  5FLM E;  4Y7N F;  3HOZ E;  1YNJ K;  4KN4 E;  2KRX A;  4A3J F;  2Y0S I;  4A3M E;  3HOY E;  2PMZ K;  4A3I F;  2E2H E;  1TWA E;  2JA5 E;  5M3M F;  4BY1 F;  4BY7 E;  4A3E F;  3CQZ E;  2NVY F;  5C44 E;  3HOU F;  3S16 F;  4Y52 F;  2R7Z F;  3S1N F;  2A68 E;  3S1M F;  4Y7N E;  4C2M F;  3RZD F;  4XLP E;  4A3J E;  3HOW F;  3S15 F;  5M5Y E;  4A93 F;  4AYB H;  2B63 F;  4OIR E;  3H0G F;  3HOX E;  4A3E E;  4BY1 E;  2BE5 E;  3S16 E;  3GTP E;  2R7Z E;  4Y52 E;  3GTJ F;  3S1N E;  1TWH E;  1TWG F;  2O5I E;  4C2M E;  4YFX E;  2R93 F;  3FKI F;  3M3Y E;  3RZD E;  2WB1 H;  5D4D E;  3HOW E;  3S15 E;  4BBR F;  4G7H E;  4A93 E;  3S14 F;  3H0G E;  4GZY E;  4OIQ E;  4C3I F;  2WAQ H;  4A3L F;  1TWF F;  3WOD E;  2E2J F;  3GTJ E;  4OIP E;  4AYB K;  2JA8 E;  2YU9 F;  3S2H F;  3HKZ H;  1Y1W E;  1TWG E;  3K7A F;  3FKI E;  4X6A F;  3S1R E;  1Y1V F;  4BBR E;  1TWC F;  4G7Z E;  5C4X F;  3I4N F;  1ZYR E;  3S14 E;  1I3Q F;  4C3I E;  4OIN E;  2A6E E;  4A3K F;  4X6A E;  3RZO E;  2Y0S H;  4A3I E;  2NVT F;  3HOV F;  3S2H E;  5E17 E;  4ZH4 E;  2WAQ K;  3K7A E;  5M3M E;  4C3J F;  5BYH E;  3HOU E;  4XSX E;  2NVY E;  3S17 F;  2CW0 E;  4A3B F;  3HKZ K;  3I4M F;  5IYD F;  3I4N E;  2R92 F;  5IYC F;  2JA6 F;  1I3Q E;  5C3E F;  1HQM E;  1I50 F;  3H3V F;  4Q4Z E;  3RZO F;  4A3G F;  1QKL A;  2NVT E;  5D4C E;  5M3F F;  2B63 E;  4A3C F;  5IYB F;  4C3J E;  3H3V G;  4A3D F;  3EQL E;  4KN7 E;  2VUM F;  5IYD E;  1SMY E;  5IYC E;  2JA6 E; 
#chains in the Genus database with same CATH homology
 5C3E E;  2R93 E;  1I50 E;  4A3G E;  1EIK A;  5IYB E;  4A3D E;  4A3L E;  1TWF E;  2E2J E;  2YU9 E;  2VUM E;  3S1M E;  1Y1V E;  1TWC E;  1K83 E;  4A3K E;  4BBS E;  3HOV E;  3S2D E;  4C3H E;  5IP7 E;  5M5W E;  4QIW H;  3S1Q E;  3S17 E;  4A3B E;  3GTG E;  2R92 E;  3GTL E;  1DZF A;  5M5X E;  1R9T E;  5FJ8 E;  5M3F E;  2PMZ H;  4A3C E;  1WCM E;  3GTM E;  2E2I E;  5IP9 E;  3GTK E;  3GTQ E;  3GTO E;  4BXX E;  1I6H E;  3PO3 E;  1SFO E;  5C4J E;  2NVQ E;  3I4M E;  2JA7 E;  3M4O E;  5C4X E;  3PO2 E;  2NVX E;  4A3F E;  5FLM E;  3HOZ E;  4A3M E;  3HOY E;  2E2H E;  1TWA E;  2JA5 E;  4BY7 E;  3CQZ E;  5C44 E;  4Y7N E;  4A3J E;  5M5Y E;  4AYB H;  3HOX E;  4A3E E;  4BY1 E;  3S16 E;  3GTP E;  2R7Z E;  4Y52 E;  3S1N E;  1TWH E;  4C2M E;  3M3Y E;  3RZD E;  2WB1 H;  3HOW E;  3S15 E;  4A93 E;  3H0G E;  2WAQ H;  3GTJ E;  2JA8 E;  3HKZ H;  1Y1W E;  1TWG E;  3FKI E;  3S1R E;  4BBR E;  3S14 E;  4C3I E;  4X6A E;  3RZO E;  2Y0S H;  4A3I E;  3S2H E;  3K7A E;  5M3M E;  3HOU E;  2NVY E;  3I4N E;  1I3Q E;  3H3V F;  2NVT E;  2B63 E;  4C3J E;  5IYD E;  5IYC E;  2JA6 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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