5C4XE

Crystal structure of a transcribing rna polymerase ii complex reveals a complete transcription bubble
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
pubmed doi rcsb
molecule tags Transferase/rna/dna
source organism Saccharomyces cerevisiae (strain atcc 204508 / s288c)
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 54
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2015-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 5c4xE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 5c4xE02
5M3ME 3S1ME 3K7AE 3GTLE 3GTQE 3S14E 1K83E 5IYDE 2JA6E 2R7ZE 4X6AE 2JA7E 4A3IE 5C44E 5IP9E 1Y1WE 3HOWE 3M3YE 4A3LE 5C4JE 4A3GE 2E2HE 2NVYE 3S2DE 3HOYE 4BY7E 2B63E 2JA8E 1TWCE 2E2IE 5FJ8E 5IYCE 5M3FE 3PO3E 4C3JE 2Y0SH 1WCME 3S1NE 3H3VF 1I6HE 2WAQH 2NVTE 5M5YE 4BBRE 1I3QE 2NVQE 2R92E 3HKZH 3RZOE 2R93E 5M5XE 3RZDE 3CQZE 2NVXE 1SFOE 3HOVE 4BBSE 4C3IE 2E2JE 3FKIE 4A3CE 1DZFA 3M4OE 4AYBH 3PO2E 3S16E 4A3DE 4QIWH 2VUME 3I4NE 1I50E 1TWGE 2YU9E 4A3EE 4C2ME 3S17E 2JA5E 3H0GE 1EIKA 4BXXE 4A3BE 3GTGE 4A93E 5IYBE 5C4XE 3S1RE 3GTME 4C3HE 1TWAE 1Y1VE 5IP7E 4Y7NE 1TWHE 1TWFE 4A3ME 3HOXE 4A3FE 2WB1H 2PMZH 4A3JE 3GTJE 4A3KE 4Y52E 3S15E 1R9TE 5FLME 3S2HE 3GTOE 5M5WE 3HOUE 5C3EE 3HOZE 3S1QE 4BY1E 3I4ME 3GTPE 3GTKE
chains in the Genus database with same CATH superfamily
5M3ME 3S1ME 5IP9F 1Y1WF 3K7AE 3GTLE 3GTQE 3S14E 4KN7E 3HOWF 3M3YF 4A3LF 1K83E 5C4JF 5IYDE 2JA6E 2R7ZE 4A3GF 5IPLE 2E2HF 4X6AE 2NVYF 4LK1E 2CW0E 3S2DF 4AYBK 2JA7E 4G7ZE 4BY7F 3HOYF 4LK0E 2B63F 2JA8F 4A3IE 1TWCF 5C44E 4QIWK 5FJ8F 2E2IF 2O5IE 4KN4E 5IP9E 1Y1WE 5IYCF 5M3FF 5M3MF 3PO3F 2O5JE 3HOWE 2A6HE 2KRXA 4KMUE 3M3YE 4A3LE 4C3JF 5C4JE 4A3GE 4Q4ZE 2E2HE 1WCMF 2NVYE 4OIQE 4LJZE 3S2DE 4YFNE 4XLPE 3HOYE 4BY7E 2B63E 2JA8E 4OIRE 2JA7F 1TWCE 2E2IE 5FJ8E 4G7OE 1I6HF 5IYCE 5M3FE 3DXJE 2NVTF 5M5YF 4BBRF 3PO3E 4GZYE 4C3JE 1I3QF 2NVQF 2R92F 3RZOF 4XSXE 2Y0SH 5M5XF 2R93F 1WCME 3S1NE 3RZDF 1SMYE 3H3VF 2PMZK 4OIOE 1I6HE 3CQZF 2WAQH 2NVTE 5M5YE 4BBRE 2NVXF 3EQLE 1SFOF 3HOVF 4BBSF 1I3QE 2NVQE 2Y0SI 4YFKE 4C3IF 2R92E 3HKZH 2E2JF 3RZOE 2R93E 5M5XE 1ZYRE 5E18E 1YNNK 1QKLA 3RZDE 3FKIF 4A3CF 2A68E 3S1NF 2BE5E 5E17E 3M4OF 3PO2F 3S16F 3CQZE 2NVXE 4A3DF 2VUMF 1SFOE 3HOVE 4BBSE 3I4NF 4JK1E 1HQME 4C3IE 1I50F 2E2JE 1TWGF 4OINE 2YU9F 4A3EF 4MEXE 4C2MF 1IW7E 3S17F 2JA5F 3FKIE 3H0GF 4A3CE 4BXXF 4A3BF 1DZFA 3GTGF 4A93F 4G7HE 4XSZE 5IYBF 3M4OE 4AYBH 3PO2E 3S16E 5C4XF 4ZH4E 4A3DE 3HKZK 4QIWH 3S1RF 2VUME 3GTMF 3I4NE 4Q5SE 5BYHE 4C3HF 4LLGE 1I50E 1TWAF 5D4EE 1Y1VF 1TWGE 4MEYE 4Y7NF 2YU9E 5IP7F 4A3EE 2PPBE 4C2ME 3S17E 1TWHF 1TWFF 2JA5E 3H0GE 1YNJK 1EIKA 4BXXE 4A3BE 3GTGE 4A93E 4A3MF 5IYBE 3HOXF 2A6EE 3WODE 5C4XE 4MQ9E 4A3JF 3S1RE 3GTJF 4A3KF 3GTME 2A69E 4Y52F 4XLNE 4C3HE 5D4CE 1TWAE 3S15F 1Y1VE 5IP7E 4Y7NE 5FLMF 1R9TF 3S2HF 1TWHE 3GTOF 1TWFE 5M5WF 3HOUF 5TMCE 4OIPE 5C3EF 5D4DE 3HOZF 4YFXE 4A3ME 3S1QF 4BY1F 3HOXE 4A3FE 2WB1H 2WAQK 3I4MF 3GTPF 3GTKF 4YG2E 2PMZH 3S1MF 4A3JE 1I6VE 3K7AF 5TMFE 3GTJE 4A3KE 3GTLF 4Y52E 3GTQF 3S14F 1K83F 3H3VG 3S15E 5IYDF 1R9TE 5FLME 2JA6F 2R7ZF 3S2HE 4X6AF 3GTOE 5M5WE 3HOUE 5C3EE 2WB1I 3HOZE 3S1QE 4BY1E 4A3IF 3I4ME 5C44F 3GTPE 3GTKE 4A3FF
chains in the Genus database with same CATH topology
5M3ME 3S1ME 3K7AE 3GTLE 3GTQE 3S14E 1K83E 5IYDE 2JA6E 2R7ZE 4X6AE 2JA7E 4A3IE 5C44E 5IP9E 1Y1WE 3HOWE 3M3YE 4A3LE 5C4JE 4A3GE 2E2HE 2NVYE 3S2DE 3HOYE 4BY7E 2B63E 2JA8E 1TWCE 2E2IE 5FJ8E 5IYCE 5M3FE 3PO3E 4C3JE 2Y0SH 1WCME 3S1NE 3H3VF 1I6HE 2WAQH 2NVTE 5M5YE 4BBRE 1I3QE 2NVQE 2R92E 3HKZH 3RZOE 2R93E 5M5XE 3RZDE 3CQZE 2NVXE 1SFOE 3HOVE 4BBSE 4C3IE 2E2JE 3FKIE 4A3CE 1DZFA 3M4OE 4AYBH 3PO2E 3S16E 4A3DE 4QIWH 2VUME 3I4NE 1I50E 1TWGE 2YU9E 4A3EE 4C2ME 3S17E 2JA5E 3H0GE 1EIKA 4BXXE 4A3BE 3GTGE 4A93E 5IYBE 5C4XE 3S1RE 3GTME 4C3HE 1TWAE 1Y1VE 5IP7E 4Y7NE 1TWHE 1TWFE 4A3ME 3HOXE 4A3FE 2WB1H 2PMZH 4A3JE 3GTJE 4A3KE 4Y52E 3S15E 1R9TE 5FLME 3S2HE 3GTOE 5M5WE 3HOUE 5C3EE 3HOZE 3S1QE 4BY1E 3I4ME 3GTPE 3GTKE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5M3M E;  3S1M E;  3K7A E;  3GTL E;  3GTQ E;  3S14 E;  1K83 E;  5IYD E;  2JA6 E;  2R7Z E;  4X6A E;  2JA7 E;  4A3I E;  5C44 E;  5IP9 E;  1Y1W E;  3HOW E;  3M3Y E;  4A3L E;  5C4J E;  4A3G E;  2E2H E;  2NVY E;  3S2D E;  3HOY E;  4BY7 E;  2B63 E;  2JA8 E;  1TWC E;  2E2I E;  5FJ8 E;  5IYC E;  5M3F E;  3PO3 E;  4C3J E;  2Y0S H;  1WCM E;  3S1N E;  3H3V F;  1I6H E;  2WAQ H;  2NVT E;  5M5Y E;  4BBR E;  1I3Q E;  2NVQ E;  2R92 E;  3HKZ H;  3RZO E;  2R93 E;  5M5X E;  3RZD E;  3CQZ E;  2NVX E;  1SFO E;  3HOV E;  4BBS E;  4C3I E;  2E2J E;  3FKI E;  4A3C E;  1DZF A;  3M4O E;  4AYB H;  3PO2 E;  3S16 E;  4A3D E;  4QIW H;  2VUM E;  3I4N E;  1I50 E;  1TWG E;  2YU9 E;  4A3E E;  4C2M E;  3S17 E;  2JA5 E;  3H0G E;  1EIK A;  4BXX E;  4A3B E;  3GTG E;  4A93 E;  5IYB E;  5C4X E;  3S1R E;  3GTM E;  4C3H E;  1TWA E;  1Y1V E;  5IP7 E;  4Y7N E;  1TWH E;  1TWF E;  4A3M E;  3HOX E;  4A3F E;  2WB1 H;  2PMZ H;  4A3J E;  3GTJ E;  4A3K E;  4Y52 E;  3S15 E;  1R9T E;  5FLM E;  3S2H E;  3GTO E;  5M5W E;  3HOU E;  5C3E E;  3HOZ E;  3S1Q E;  4BY1 E;  3I4M E;  3GTP E;  3GTK E; 
#chains in the Genus database with same CATH topology
 5M3M E;  3S1M E;  5IP9 F;  1Y1W F;  3K7A E;  3GTL E;  3GTQ E;  3S14 E;  4KN7 E;  3HOW F;  3M3Y F;  4A3L F;  1K83 E;  5C4J F;  5IYD E;  2JA6 E;  2R7Z E;  4A3G F;  5IPL E;  2E2H F;  4X6A E;  2NVY F;  4LK1 E;  2CW0 E;  3S2D F;  4AYB K;  2JA7 E;  4G7Z E;  4BY7 F;  3HOY F;  4LK0 E;  2B63 F;  2JA8 F;  4A3I E;  1TWC F;  5C44 E;  4QIW K;  5FJ8 F;  2E2I F;  2O5I E;  4KN4 E;  5IP9 E;  1Y1W E;  5IYC F;  5M3F F;  5M3M F;  3PO3 F;  2O5J E;  3HOW E;  2A6H E;  2KRX A;  4KMU E;  3M3Y E;  4A3L E;  4C3J F;  5C4J E;  4A3G E;  4Q4Z E;  2E2H E;  1WCM F;  2NVY E;  4OIQ E;  4LJZ E;  3S2D E;  4YFN E;  4XLP E;  3HOY E;  4BY7 E;  2B63 E;  2JA8 E;  4OIR E;  2JA7 F;  1TWC E;  2E2I E;  5FJ8 E;  4G7O E;  1I6H F;  5IYC E;  5M3F E;  3DXJ E;  2NVT F;  5M5Y F;  4BBR F;  3PO3 E;  4GZY E;  4C3J E;  1I3Q F;  2NVQ F;  2R92 F;  3RZO F;  4XSX E;  2Y0S H;  5M5X F;  2R93 F;  1WCM E;  3S1N E;  3RZD F;  1SMY E;  3H3V F;  2PMZ K;  4OIO E;  1I6H E;  3CQZ F;  2WAQ H;  2NVT E;  5M5Y E;  4BBR E;  2NVX F;  3EQL E;  1SFO F;  3HOV F;  4BBS F;  1I3Q E;  2NVQ E;  2Y0S I;  4YFK E;  4C3I F;  2R92 E;  3HKZ H;  2E2J F;  3RZO E;  2R93 E;  5M5X E;  1ZYR E;  5E18 E;  1YNN K;  1QKL A;  3RZD E;  3FKI F;  4A3C F;  2A68 E;  3S1N F;  2BE5 E;  5E17 E;  3M4O F;  3PO2 F;  3S16 F;  3CQZ E;  2NVX E;  4A3D F;  2VUM F;  1SFO E;  3HOV E;  4BBS E;  3I4N F;  4JK1 E;  1HQM E;  4C3I E;  1I50 F;  2E2J E;  1TWG F;  4OIN E;  2YU9 F;  4A3E F;  4MEX E;  4C2M F;  1IW7 E;  3S17 F;  2JA5 F;  3FKI E;  3H0G F;  4A3C E;  4BXX F;  4A3B F;  1DZF A;  3GTG F;  4A93 F;  4G7H E;  4XSZ E;  5IYB F;  3M4O E;  4AYB H;  3PO2 E;  3S16 E;  5C4X F;  4ZH4 E;  4A3D E;  3HKZ K;  4QIW H;  3S1R F;  2VUM E;  3GTM F;  3I4N E;  4Q5S E;  5BYH E;  4C3H F;  4LLG E;  1I50 E;  1TWA F;  5D4E E;  1Y1V F;  1TWG E;  4MEY E;  4Y7N F;  2YU9 E;  5IP7 F;  4A3E E;  2PPB E;  4C2M E;  3S17 E;  1TWH F;  1TWF F;  2JA5 E;  3H0G E;  1YNJ K;  1EIK A;  4BXX E;  4A3B E;  3GTG E;  4A93 E;  4A3M F;  5IYB E;  3HOX F;  2A6E E;  3WOD E;  5C4X E;  4MQ9 E;  4A3J F;  3S1R E;  3GTJ F;  4A3K F;  3GTM E;  2A69 E;  4Y52 F;  4XLN E;  4C3H E;  5D4C E;  1TWA E;  3S15 F;  1Y1V E;  5IP7 E;  4Y7N E;  5FLM F;  1R9T F;  3S2H F;  1TWH E;  3GTO F;  1TWF E;  5M5W F;  3HOU F;  5TMC E;  4OIP E;  5C3E F;  5D4D E;  3HOZ F;  4YFX E;  4A3M E;  3S1Q F;  4BY1 F;  3HOX E;  4A3F E;  2WB1 H;  2WAQ K;  3I4M F;  3GTP F;  3GTK F;  4YG2 E;  2PMZ H;  3S1M F;  4A3J E;  1I6V E;  3K7A F;  5TMF E;  3GTJ E;  4A3K E;  3GTL F;  4Y52 E;  3GTQ F;  3S14 F;  1K83 F;  3H3V G;  3S15 E;  5IYD F;  1R9T E;  5FLM E;  2JA6 F;  2R7Z F;  3S2H E;  4X6A F;  3GTO E;  5M5W E;  3HOU E;  5C3E E;  2WB1 I;  3HOZ E;  3S1Q E;  4BY1 E;  4A3I F;  3I4M E;  5C44 F;  3GTP E;  3GTK E;  4A3F F; 
#chains in the Genus database with same CATH homology
 5M3M E;  3S1M E;  3K7A E;  3GTL E;  3GTQ E;  3S14 E;  1K83 E;  5IYD E;  2JA6 E;  2R7Z E;  4X6A E;  2JA7 E;  4A3I E;  5C44 E;  5IP9 E;  1Y1W E;  3HOW E;  3M3Y E;  4A3L E;  5C4J E;  4A3G E;  2E2H E;  2NVY E;  3S2D E;  3HOY E;  4BY7 E;  2B63 E;  2JA8 E;  1TWC E;  2E2I E;  5FJ8 E;  5IYC E;  5M3F E;  3PO3 E;  4C3J E;  2Y0S H;  1WCM E;  3S1N E;  3H3V F;  1I6H E;  2WAQ H;  2NVT E;  5M5Y E;  4BBR E;  1I3Q E;  2NVQ E;  2R92 E;  3HKZ H;  3RZO E;  2R93 E;  5M5X E;  3RZD E;  3CQZ E;  2NVX E;  1SFO E;  3HOV E;  4BBS E;  4C3I E;  2E2J E;  3FKI E;  4A3C E;  1DZF A;  3M4O E;  4AYB H;  3PO2 E;  3S16 E;  4A3D E;  4QIW H;  2VUM E;  3I4N E;  1I50 E;  1TWG E;  2YU9 E;  4A3E E;  4C2M E;  3S17 E;  2JA5 E;  3H0G E;  1EIK A;  4BXX E;  4A3B E;  3GTG E;  4A93 E;  5IYB E;  5C4X E;  3S1R E;  3GTM E;  4C3H E;  1TWA E;  1Y1V E;  5IP7 E;  4Y7N E;  1TWH E;  1TWF E;  4A3M E;  3HOX E;  4A3F E;  2WB1 H;  2PMZ H;  4A3J E;  3GTJ E;  4A3K E;  4Y52 E;  3S15 E;  1R9T E;  5FLM E;  3S2H E;  3GTO E;  5M5W E;  3HOU E;  5C3E E;  3HOZ E;  3S1Q E;  4BY1 E;  3I4M E;  3GTP E;  3GTK E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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