5FPFC

Crystal structure of human tankyrase 2 in complex with ta-91
Total Genus 0
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
0
sequence length
46
structure length
46
Chain Sequence
AHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Design, Synthesis and Evaluation of Novel Dual- Binding Inhibitors of the Tankyrases and Wnt Signalling.
rcsb
molecule keywords TANKYRASE-2
molecule tags Transferase
source organism Homo sapiens
structure length 46
sequence length 46
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-11-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 5fpfC00
4UI6C 5C5RC 4L34C 4UI7C 5FPFC 4L31C 4HLMC 4L0IC 4L0BC 4L10C 4HMHC 4UVPB 4HLHC 5ADTB 4UI4C 5ADSB 5C5QC 5ADRB 4L0VC 4HKNC 4HKIC 4HKKB 4L2FC 4KZLC 4UI8C 4L32C 4HLKC 4L09C 4UI5C 4KZUC 4L0TC 5ADQB 4HLFC 4UI3C 4HLGC 4L33C 4L2KC 5C5PC 4L2GC 4HL5C 4L0SC 4KZQC
chains in the Genus database with same CATH superfamily
4UI6C 5C5RC 4L34C 4UI7C 5FPFC 4L31C 4HLMC 3OEIE 4L0IC 4L0BC 4L10C 4HMHC 4UVPB 4HLHC 3HRYA 2ZIXB 5ADTB 2A6QA 4UI4C 3OEIA 4ZLXA 5ADSB 4ZM0A 5C5QC 4ZM2A 5ADRB 4L0VC 3D55A 4HKNC 2ODKA 3CTOA 4HKIC 4HKKB 4L2FC 3K6QA 3HJ6A 4KZLC 4UI8C 4L32C 4HLKC 4L09C 3K33B 4KZUC 4L0TC 4UI5C 4HLFC 5ADQB 4UI3C 3KH2E 4HLGC 4L33C 3G5OA 4L2KC 5C5PC 4L2GC 3HS2A 4HL5C 4L0SC 4KZQC
chains in the Genus database with same CATH topology
4UI6C 5C5RC 4L34C 4UI7C 5FPFC 4L31C 4HLMC 4L0IC 4L0BC 4L10C 4HMHC 4UVPB 4HLHC 2ZIXB 5ADTB 4UI4C 5ADSB 5C5QC 5ADRB 4L0VC 4HKNC 4HKIC 4HKKB 4L2FC 3HJ6A 4KZLC 4UI8C 4L32C 4HLKC 4L09C 4UI5C 4KZUC 4L0TC 5ADQB 4HLFC 4UI3C 4HLGC 4L33C 4L2KC 5C5PC 4L2GC 4HL5C 4L0SC 4KZQC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UI6 C;  5C5R C;  4L34 C;  4UI7 C;  5FPF C;  4L31 C;  4HLM C;  4L0I C;  4L0B C;  4L10 C;  4HMH C;  4UVP B;  4HLH C;  5ADT B;  4UI4 C;  5ADS B;  5C5Q C;  5ADR B;  4L0V C;  4HKN C;  4HKI C;  4HKK B;  4L2F C;  4KZL C;  4UI8 C;  4L32 C;  4HLK C;  4L09 C;  4UI5 C;  4KZU C;  4L0T C;  5ADQ B;  4HLF C;  4UI3 C;  4HLG C;  4L33 C;  4L2K C;  5C5P C;  4L2G C;  4HL5 C;  4L0S C;  4KZQ C; 
#chains in the Genus database with same CATH topology
 4UI6 C;  5C5R C;  4L34 C;  4UI7 C;  5FPF C;  4L31 C;  4HLM C;  3OEI E;  4L0I C;  4L0B C;  4L10 C;  4HMH C;  4UVP B;  4HLH C;  3HRY A;  2ZIX B;  5ADT B;  2A6Q A;  4UI4 C;  3OEI A;  4ZLX A;  5ADS B;  4ZM0 A;  5C5Q C;  4ZM2 A;  5ADR B;  4L0V C;  3D55 A;  4HKN C;  2ODK A;  3CTO A;  4HKI C;  4HKK B;  4L2F C;  3K6Q A;  3HJ6 A;  4KZL C;  4UI8 C;  4L32 C;  4HLK C;  4L09 C;  3K33 B;  4KZU C;  4L0T C;  4UI5 C;  4HLF C;  5ADQ B;  4UI3 C;  3KH2 E;  4HLG C;  4L33 C;  3G5O A;  4L2K C;  5C5P C;  4L2G C;  3HS2 A;  4HL5 C;  4L0S C;  4KZQ C; 
#chains in the Genus database with same CATH homology
 4UI6 C;  5C5R C;  4L34 C;  4UI7 C;  5FPF C;  4L31 C;  4HLM C;  4L0I C;  4L0B C;  4L10 C;  4HMH C;  4UVP B;  4HLH C;  2ZIX B;  5ADT B;  4UI4 C;  5ADS B;  5C5Q C;  5ADR B;  4L0V C;  4HKN C;  4HKI C;  4HKK B;  4L2F C;  3HJ6 A;  4KZL C;  4UI8 C;  4L32 C;  4HLK C;  4L09 C;  4UI5 C;  4KZU C;  4L0T C;  5ADQ B;  4HLF C;  4UI3 C;  4HLG C;  4L33 C;  4L2K C;  5C5P C;  4L2G C;  4HL5 C;  4L0S C;  4KZQ C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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