5IYCE

Human core-pic in the initial transcribing state
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
210
structure length
210
Chain Sequence
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule tags Transcription, transferase/dna
source organism Homo sapiens
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 56
structure length 210
sequence length 210
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 5iycE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 5iycE02
4A3ME 3RZOE 4BY1E 4BBRE 5C4JE 4A3GE 5M5WE 4A3EE 3S16E 1Y1VE 3S2DE 4A93E 2NVYE 5M5YE 3PO3E 4C3IE 2R92E 4X6AE 4A3DE 2JA5E 3I4NE 5IYBE 2NVTE 1I50E 2R93E 3RZDE 1DZFA 4BXXE 3GTOE 4C2ME 3GTQE 4A3CE 5C4XE 5IYDE 3S1ME 3GTKE 4A3JE 3GTJE 4AYBH 2JA7E 3HOYE 3M4OE 2Y0SH 3GTPE 2E2HE 3S14E 4Y7NE 3HOZE 2B63E 3S15E 3GTLE 3S2HE 4A3BE 5FJ8E 1TWHE 1TWCE 1I3QE 2JA8E 5FLME 3H0GE 1TWGE 4BBSE 3H3VF 4A3KE 3M3YE 3S1NE 3HOWE 4C3JE 2JA6E 5C3EE 5IYCE 3HOVE 2WAQH 3S17E 1Y1WE 1EIKA 3CQZE 3HOXE 1SFOE 1TWAE 4BY7E 4A3FE 2VUME 3S1RE 5IP7E 3PO2E 2YU9E 3FKIE 4Y52E 2PMZH 5C44E 3S1QE 4QIWH 5M5XE 1TWFE 2WB1H 2E2IE 3HOUE 5IP9E 5M3ME 2E2JE 2NVQE 3GTME 1I6HE 4C3HE 1WCME 3GTGE 3I4ME 1R9TE 3K7AE 5M3FE 2R7ZE 4A3IE 4A3LE 2NVXE 3HKZH 1K83E
chains in the Genus database with same CATH superfamily
3RZDF 4BXXF 4A3ME 3RZOE 2A68E 4OINE 4BY1E 4BBRE 4C2MF 3GTOF 4GZYE 5E17E 3GTQF 4A3CF 5C4JE 4A3GE 1ZYRE 5M5WE 5IYDF 4A3EE 3S16E 3S1MF 1Y1VE 3S2DE 3HKZK 4OIRE 5C4JF 4A93E 4KMUE 2NVYE 4A3JF 4OIPE 5D4CE 3GTJF 3S2DF 5M5YE 3PO3E 4C3IE 2WB1I 2JA7F 2O5IE 3M4OF 3HOYF 4OIQE 3GTPF 2R92E 4X6AE 2E2HF 3S14F 4A3DE 2JA5E 4KN7E 4Y7NF 3HOZF 3I4NE 4G7ZE 4X6AF 5IYBE 2BE5E 2NVTE 1I50E 2R93E 3RZDE 1DZFA 3S2HF 3S15F 4BXXE 4A3BF 4A3DF 3I4NF 3GTOE 4C2ME 2JA8F 1I3QF 1TWCF 3GTQE 4A3CE 1SMYE 5C4XE 4YFNE 2R93F 3H0GF 5IYDE 3S1ME 1YNNK 5C4XF 1TWGF 3GTKE 4A3JE 4MEYE 3GTJE 3M3YF 3S1NF 4AYBH 3HOWF 4C3JF 2JA7E 3HOYE 3M4OE 2JA6F 2Y0SH 3GTKF 3GTPE 1IW7E 5C3EF 5IYCF 2E2HE 4XLNE 4YFKE 3H3VG 3S14E 3HOVF 3S17F 4Y7NE 5BYHE 3HOZE 2CW0E 1Y1WF 3CQZF 4ZH4E 2B63E 3HOXF 1SFOF 1TWAF 3S15E 4A3FF 2VUMF 3GTLE 3S2HE 4A3BE 5D4DE 3S1RF 2PPBE 4AYBK 5IP7F 3PO2F 5FJ8E 1TWHE 1TWCE 1I3QE 2JA8E 2YU9F 5FLME 3FKIF 2B63F 4LLGE 3H0GE 3GTLF 4YG2E 5E18E 5FJ8F 1TWHF 5C44F 4LK0E 1TWFF 5M5XF 5FLMF 3S1QF 1TWGE 4BBSE 4LJZE 2E2IF 3WODE 3H3VF 4A3KE 1HQME 4YFXE 5D4EE 3M3YE 3S1NE 2KRXA 5IP9F 4Q4ZE 3HOWE 4C3JE 3HOUF 2E2JF 4LK1E 2JA6E 4BBSF 4QIWK 5IPLE 5C3EE 5IYCE 3HOVE 2WAQH 3S17E 3EQLE 4A3KF 1Y1WE 2NVQF 1EIKA 3CQZE 1I6HF 3HOXE 1SFOE 2A6EE 1TWAE 4BY7E 4A3FE 2VUME 3GTGF 3S1RE 4OIOE 3I4MF 5IP7E 3PO2E 2YU9E 2O5JE 1QKLA 3FKIE 4BY7F 1I6VE 5M3FF 4Y52E 5TMFE 2WAQK 2PMZH 5C44E 3S1QE 4QIWH 4A3IF 5M5XE 1TWFE 2WB1H 4A3LF 2NVXF 2E2IE 4Y52F 2Y0SI 4MQ9E 3HOUE 5IP9E 4XSZE 1K83F 2A6HE 5M3ME 2E2JE 4Q5SE 4A3MF 3RZOF 4BY1F 1YNJK 4BBRF 5IYBF 3DXJE 4A3GF 5M3MF 2PMZK 2NVQE 5M5WF 3GTME 1I6HE 4A3EF 4MEXE 1Y1VF 3S16F 4C3HE 4JK1E 4XLPE 4KN4E 4A93F 1WCME 3GTGE 2NVYF 3I4ME 3GTMF 1R9TE 4C3HF 3K7AE 5M3FE 5M5YF 4G7HE 4C3IF 3PO3F 2R7ZE 1WCMF 4G7OE 2R92F 2A69E 1R9TF 5TMCE 4A3IE 4A3LE 3K7AF 4XSXE 2NVXE 3HKZH 2JA5F 2R7ZF 1K83E 2NVTF 1I50F
chains in the Genus database with same CATH topology
4A3ME 3RZOE 4BY1E 4BBRE 5C4JE 4A3GE 5M5WE 4A3EE 3S16E 1Y1VE 3S2DE 4A93E 2NVYE 5M5YE 3PO3E 4C3IE 2R92E 4X6AE 4A3DE 2JA5E 3I4NE 5IYBE 2NVTE 1I50E 2R93E 3RZDE 1DZFA 4BXXE 3GTOE 4C2ME 3GTQE 4A3CE 5C4XE 5IYDE 3S1ME 3GTKE 4A3JE 3GTJE 4AYBH 2JA7E 3HOYE 3M4OE 2Y0SH 3GTPE 2E2HE 3S14E 4Y7NE 3HOZE 2B63E 3S15E 3GTLE 3S2HE 4A3BE 5FJ8E 1TWHE 1TWCE 1I3QE 2JA8E 5FLME 3H0GE 1TWGE 4BBSE 3H3VF 4A3KE 3M3YE 3S1NE 3HOWE 4C3JE 2JA6E 5C3EE 5IYCE 3HOVE 2WAQH 3S17E 1Y1WE 1EIKA 3CQZE 3HOXE 1SFOE 1TWAE 4BY7E 4A3FE 2VUME 3S1RE 5IP7E 3PO2E 2YU9E 3FKIE 4Y52E 2PMZH 5C44E 3S1QE 4QIWH 5M5XE 1TWFE 2WB1H 2E2IE 3HOUE 5IP9E 5M3ME 2E2JE 2NVQE 3GTME 1I6HE 4C3HE 1WCME 3GTGE 3I4ME 1R9TE 3K7AE 5M3FE 2R7ZE 4A3IE 4A3LE 2NVXE 3HKZH 1K83E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3M E;  3RZO E;  4BY1 E;  4BBR E;  5C4J E;  4A3G E;  5M5W E;  4A3E E;  3S16 E;  1Y1V E;  3S2D E;  4A93 E;  2NVY E;  5M5Y E;  3PO3 E;  4C3I E;  2R92 E;  4X6A E;  4A3D E;  2JA5 E;  3I4N E;  5IYB E;  2NVT E;  1I50 E;  2R93 E;  3RZD E;  1DZF A;  4BXX E;  3GTO E;  4C2M E;  3GTQ E;  4A3C E;  5C4X E;  5IYD E;  3S1M E;  3GTK E;  4A3J E;  3GTJ E;  4AYB H;  2JA7 E;  3HOY E;  3M4O E;  2Y0S H;  3GTP E;  2E2H E;  3S14 E;  4Y7N E;  3HOZ E;  2B63 E;  3S15 E;  3GTL E;  3S2H E;  4A3B E;  5FJ8 E;  1TWH E;  1TWC E;  1I3Q E;  2JA8 E;  5FLM E;  3H0G E;  1TWG E;  4BBS E;  3H3V F;  4A3K E;  3M3Y E;  3S1N E;  3HOW E;  4C3J E;  2JA6 E;  5C3E E;  5IYC E;  3HOV E;  2WAQ H;  3S17 E;  1Y1W E;  1EIK A;  3CQZ E;  3HOX E;  1SFO E;  1TWA E;  4BY7 E;  4A3F E;  2VUM E;  3S1R E;  5IP7 E;  3PO2 E;  2YU9 E;  3FKI E;  4Y52 E;  2PMZ H;  5C44 E;  3S1Q E;  4QIW H;  5M5X E;  1TWF E;  2WB1 H;  2E2I E;  3HOU E;  5IP9 E;  5M3M E;  2E2J E;  2NVQ E;  3GTM E;  1I6H E;  4C3H E;  1WCM E;  3GTG E;  3I4M E;  1R9T E;  3K7A E;  5M3F E;  2R7Z E;  4A3I E;  4A3L E;  2NVX E;  3HKZ H;  1K83 E; 
#chains in the Genus database with same CATH topology
 3RZD F;  4BXX F;  4A3M E;  3RZO E;  2A68 E;  4OIN E;  4BY1 E;  4BBR E;  4C2M F;  3GTO F;  4GZY E;  5E17 E;  3GTQ F;  4A3C F;  5C4J E;  4A3G E;  1ZYR E;  5M5W E;  5IYD F;  4A3E E;  3S16 E;  3S1M F;  1Y1V E;  3S2D E;  3HKZ K;  4OIR E;  5C4J F;  4A93 E;  4KMU E;  2NVY E;  4A3J F;  4OIP E;  5D4C E;  3GTJ F;  3S2D F;  5M5Y E;  3PO3 E;  4C3I E;  2WB1 I;  2JA7 F;  2O5I E;  3M4O F;  3HOY F;  4OIQ E;  3GTP F;  2R92 E;  4X6A E;  2E2H F;  3S14 F;  4A3D E;  2JA5 E;  4KN7 E;  4Y7N F;  3HOZ F;  3I4N E;  4G7Z E;  4X6A F;  5IYB E;  2BE5 E;  2NVT E;  1I50 E;  2R93 E;  3RZD E;  1DZF A;  3S2H F;  3S15 F;  4BXX E;  4A3B F;  4A3D F;  3I4N F;  3GTO E;  4C2M E;  2JA8 F;  1I3Q F;  1TWC F;  3GTQ E;  4A3C E;  1SMY E;  5C4X E;  4YFN E;  2R93 F;  3H0G F;  5IYD E;  3S1M E;  1YNN K;  5C4X F;  1TWG F;  3GTK E;  4A3J E;  4MEY E;  3GTJ E;  3M3Y F;  3S1N F;  4AYB H;  3HOW F;  4C3J F;  2JA7 E;  3HOY E;  3M4O E;  2JA6 F;  2Y0S H;  3GTK F;  3GTP E;  1IW7 E;  5C3E F;  5IYC F;  2E2H E;  4XLN E;  4YFK E;  3H3V G;  3S14 E;  3HOV F;  3S17 F;  4Y7N E;  5BYH E;  3HOZ E;  2CW0 E;  1Y1W F;  3CQZ F;  4ZH4 E;  2B63 E;  3HOX F;  1SFO F;  1TWA F;  3S15 E;  4A3F F;  2VUM F;  3GTL E;  3S2H E;  4A3B E;  5D4D E;  3S1R F;  2PPB E;  4AYB K;  5IP7 F;  3PO2 F;  5FJ8 E;  1TWH E;  1TWC E;  1I3Q E;  2JA8 E;  2YU9 F;  5FLM E;  3FKI F;  2B63 F;  4LLG E;  3H0G E;  3GTL F;  4YG2 E;  5E18 E;  5FJ8 F;  1TWH F;  5C44 F;  4LK0 E;  1TWF F;  5M5X F;  5FLM F;  3S1Q F;  1TWG E;  4BBS E;  4LJZ E;  2E2I F;  3WOD E;  3H3V F;  4A3K E;  1HQM E;  4YFX E;  5D4E E;  3M3Y E;  3S1N E;  2KRX A;  5IP9 F;  4Q4Z E;  3HOW E;  4C3J E;  3HOU F;  2E2J F;  4LK1 E;  2JA6 E;  4BBS F;  4QIW K;  5IPL E;  5C3E E;  5IYC E;  3HOV E;  2WAQ H;  3S17 E;  3EQL E;  4A3K F;  1Y1W E;  2NVQ F;  1EIK A;  3CQZ E;  1I6H F;  3HOX E;  1SFO E;  2A6E E;  1TWA E;  4BY7 E;  4A3F E;  2VUM E;  3GTG F;  3S1R E;  4OIO E;  3I4M F;  5IP7 E;  3PO2 E;  2YU9 E;  2O5J E;  1QKL A;  3FKI E;  4BY7 F;  1I6V E;  5M3F F;  4Y52 E;  5TMF E;  2WAQ K;  2PMZ H;  5C44 E;  3S1Q E;  4QIW H;  4A3I F;  5M5X E;  1TWF E;  2WB1 H;  4A3L F;  2NVX F;  2E2I E;  4Y52 F;  2Y0S I;  4MQ9 E;  3HOU E;  5IP9 E;  4XSZ E;  1K83 F;  2A6H E;  5M3M E;  2E2J E;  4Q5S E;  4A3M F;  3RZO F;  4BY1 F;  1YNJ K;  4BBR F;  5IYB F;  3DXJ E;  4A3G F;  5M3M F;  2PMZ K;  2NVQ E;  5M5W F;  3GTM E;  1I6H E;  4A3E F;  4MEX E;  1Y1V F;  3S16 F;  4C3H E;  4JK1 E;  4XLP E;  4KN4 E;  4A93 F;  1WCM E;  3GTG E;  2NVY F;  3I4M E;  3GTM F;  1R9T E;  4C3H F;  3K7A E;  5M3F E;  5M5Y F;  4G7H E;  4C3I F;  3PO3 F;  2R7Z E;  1WCM F;  4G7O E;  2R92 F;  2A69 E;  1R9T F;  5TMC E;  4A3I E;  4A3L E;  3K7A F;  4XSX E;  2NVX E;  3HKZ H;  2JA5 F;  2R7Z F;  1K83 E;  2NVT F;  1I50 F; 
#chains in the Genus database with same CATH homology
 4A3M E;  3RZO E;  4BY1 E;  4BBR E;  5C4J E;  4A3G E;  5M5W E;  4A3E E;  3S16 E;  1Y1V E;  3S2D E;  4A93 E;  2NVY E;  5M5Y E;  3PO3 E;  4C3I E;  2R92 E;  4X6A E;  4A3D E;  2JA5 E;  3I4N E;  5IYB E;  2NVT E;  1I50 E;  2R93 E;  3RZD E;  1DZF A;  4BXX E;  3GTO E;  4C2M E;  3GTQ E;  4A3C E;  5C4X E;  5IYD E;  3S1M E;  3GTK E;  4A3J E;  3GTJ E;  4AYB H;  2JA7 E;  3HOY E;  3M4O E;  2Y0S H;  3GTP E;  2E2H E;  3S14 E;  4Y7N E;  3HOZ E;  2B63 E;  3S15 E;  3GTL E;  3S2H E;  4A3B E;  5FJ8 E;  1TWH E;  1TWC E;  1I3Q E;  2JA8 E;  5FLM E;  3H0G E;  1TWG E;  4BBS E;  3H3V F;  4A3K E;  3M3Y E;  3S1N E;  3HOW E;  4C3J E;  2JA6 E;  5C3E E;  5IYC E;  3HOV E;  2WAQ H;  3S17 E;  1Y1W E;  1EIK A;  3CQZ E;  3HOX E;  1SFO E;  1TWA E;  4BY7 E;  4A3F E;  2VUM E;  3S1R E;  5IP7 E;  3PO2 E;  2YU9 E;  3FKI E;  4Y52 E;  2PMZ H;  5C44 E;  3S1Q E;  4QIW H;  5M5X E;  1TWF E;  2WB1 H;  2E2I E;  3HOU E;  5IP9 E;  5M3M E;  2E2J E;  2NVQ E;  3GTM E;  1I6H E;  4C3H E;  1WCM E;  3GTG E;  3I4M E;  1R9T E;  3K7A E;  5M3F E;  2R7Z E;  4A3I E;  4A3L E;  2NVX E;  3HKZ H;  1K83 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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