5IYDE

Human core-pic in the initial transcribing state (no iis)
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
210
structure length
210
Chain Sequence
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule tags Transcription, transferase/dna/rna
source organism Homo sapiens
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 57
structure length 210
sequence length 210
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 5iydE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 5iydE02
3K7AE 4A3ME 4BY1E 4AYBH 5M5YE 3HOZE 3HOUE 5M5XE 2R92E 5C3EE 4Y7NE 1TWCE 4A3GE 2JA7E 1SFOE 3H0GE 4C3HE 3FKIE 2E2IE 2JA8E 4A3LE 5IP9E 3S1RE 3S17E 5C44E 3HOYE 3M4OE 1WCME 4A3BE 4A3IE 4X6AE 3PO2E 2E2JE 1R9TE 4BY7E 4C3JE 2R7ZE 2WB1H 3GTKE 2VUME 1DZFA 3HOWE 1I3QE 3S2DE 4A3FE 3PO3E 3I4NE 3RZOE 4Y52E 5M3ME 3HOXE 1TWGE 4A3DE 4C2ME 1TWFE 2NVQE 3S2HE 2Y0SH 5IP7E 2PMZH 5C4JE 5M5WE 3CQZE 1K83E 4A93E 2B63E 3I4ME 5M3FE 2WAQH 3GTLE 2NVTE 3S16E 3HOVE 1I50E 4A3JE 3GTQE 3S1QE 3GTOE 4A3CE 2NVXE 3S14E 4C3IE 3GTGE 2JA6E 3H3VF 5FLME 4A3EE 5FJ8E 4BBSE 1TWAE 5IYCE 3S1NE 3RZDE 2E2HE 1EIKA 2R93E 5IYDE 2JA5E 3S1ME 1I6HE 2NVYE 3M3YE 3GTJE 5IYBE 4BXXE 5C4XE 1Y1VE 1Y1WE 3S15E 1TWHE 4BBRE 2YU9E 3GTPE 3HKZH 4QIWH 4A3KE 3GTME
chains in the Genus database with same CATH superfamily
1TWHF 4BBRF 2YU9F 3K7AE 4A3ME 4BY1E 4AYBH 5M5YE 4MEYE 4AYBK 3HOZE 3GTPF 3HOUE 5M5XE 2R92E 4KN7E 5C3EE 4Y7NE 4A3KF 3GTMF 1TWCE 5FJ8F 4Q5SE 4A3GE 2JA7E 1SFOE 5IYCF 3H0GE 4XLNE 4C3HE 3DXJE 3K7AF 4BY1F 5M5YF 4YFKE 4LJZE 2A69E 4A3MF 3HOUF 5M5XF 2R92F 3HOZF 3FKIE 2E2IE 4LK1E 4Y7NF 1TWCF 2JA8E 4A3LE 4A3GF 1SFOF 5IP9E 3S1RE 1HQME 3H0GF 4C3HF 3S17E 5D4CE 5C44E 3HOYE 3FKIF 2E2IF 3M4OE 1WCME 4A3BE 4A3IE 4X6AE 3PO2E 2E2JE 4LLGE 2JA8F 4A3LF 1R9TE 5IP9F 3S1RF 2KRXA 4BY7E 4C3JE 3S17F 4Q4ZE 5C44F 4G7ZE 3HOYF 2R7ZE 3M4OF 1WCMF 4A3BF 4A3IF 2WB1H 4X6AF 4KN4E 3GTKE 2E2JF 2A68E 3PO2F 2VUME 1R9TF 1YNNK 4YG2E 1DZFA 3HOWE 4BY7F 5E18E 1I3QE 3S2DE 4A3FE 3PO3E 2R7ZF 4ZH4E 3I4NE 3RZOE 4Y52E 4GZYE 5M3ME 5C3EF 3GTKF 5E17E 3HOXE 1TWGE 4A3DE 2VUMF 4C2ME 4OIPE 3HOWF 1TWFE 2JA7F 1I3QF 3S2DF 2NVQE 4A3FF 3S2HE 2Y0SH 4Y52F 3I4NF 3RZOF 5IP7E 5M3MF 3GTGF 3HOXF 1IW7E 4YFNE 1TWGF 4A3DF 2PMZH 4C2MF 5C4JE 1TWFF 2A6EE 5M5WE 5D4DE 2NVQF 3S2HF 3CQZE 1K83E 4OINE 2BE5E 4XLPE 4A93E 3EQLE 2B63E 3I4ME 5M3FE 2WAQH 3GTLE 2NVTE 3WODE 3S16E 5M5WF 2A6HE 3CQZF 4XSZE 3HOVE 1I50E 4A3JE 4C3JF 4MEXE 2PPBE 3GTQE 4KMUE 4G7HE 4A93F 3S1QE 4YFXE 2B63F 3GTOE 4A3CE 5M3FF 2NVXE 3I4MF 3S14E 4XSXE 4OIOE 2NVTF 3GTLF 4C3IE 3GTGE 5BYHE 3HOVF 1I50F 4JK1E 4A3JF 1YNJK 2JA6E 3H3VF 5FLME 4OIRE 3GTQF 4A3EE 1ZYRE 3PO3F 2CW0E 2WB1I 5FJ8E 4BBSE 3S1QF 1TWAE 3GTOF 3H3VG 4A3CF 2NVXF 3S14F 5IYCE 2O5IE 3S1NE 4C3IF 5IPLE 2PMZK 3RZDE 2E2HE 2JA6F 2R93E 5FLMF 1EIKA 4A3EF 4BBSF 5IYDE 1TWAF 2JA5E 4LK0E 3S1ME 5IP7F 3S1NF 5C4JF 3RZDF 2WAQK 1I6HE 1QKLA 2NVYE 2E2HF 3M3YE 2R93F 3GTJE 5IYBE 1K83F 2Y0SI 4BXXF 5IYDF 5TMCE 2JA5F 4OIQE 3S1MF 4G7OE 4BXXE 5C4XE 1Y1VE 1Y1WE 4MQ9E 5D4EE 3S15E 1TWHE 2O5JE 5TMFE 4BBRE 2YU9E 1I6HF 2NVYF 3GTPE 3M3YF 3S16F 3GTJF 3HKZH 5IYBF 3HKZK 1I6VE 4QIWH 4A3KE 3GTME 4QIWK 1SMYE 5C4XF 1Y1VF 1Y1WF 3S15F
chains in the Genus database with same CATH topology
3K7AE 4A3ME 4BY1E 4AYBH 5M5YE 3HOZE 3HOUE 5M5XE 2R92E 5C3EE 4Y7NE 1TWCE 4A3GE 2JA7E 1SFOE 3H0GE 4C3HE 3FKIE 2E2IE 2JA8E 4A3LE 5IP9E 3S1RE 3S17E 5C44E 3HOYE 3M4OE 1WCME 4A3BE 4A3IE 4X6AE 3PO2E 2E2JE 1R9TE 4BY7E 4C3JE 2R7ZE 2WB1H 3GTKE 2VUME 1DZFA 3HOWE 1I3QE 3S2DE 4A3FE 3PO3E 3I4NE 3RZOE 4Y52E 5M3ME 3HOXE 1TWGE 4A3DE 4C2ME 1TWFE 2NVQE 3S2HE 2Y0SH 5IP7E 2PMZH 5C4JE 5M5WE 3CQZE 1K83E 4A93E 2B63E 3I4ME 5M3FE 2WAQH 3GTLE 2NVTE 3S16E 3HOVE 1I50E 4A3JE 3GTQE 3S1QE 3GTOE 4A3CE 2NVXE 3S14E 4C3IE 3GTGE 2JA6E 3H3VF 5FLME 4A3EE 5FJ8E 4BBSE 1TWAE 5IYCE 3S1NE 3RZDE 2E2HE 1EIKA 2R93E 5IYDE 2JA5E 3S1ME 1I6HE 2NVYE 3M3YE 3GTJE 5IYBE 4BXXE 5C4XE 1Y1VE 1Y1WE 3S15E 1TWHE 4BBRE 2YU9E 3GTPE 3HKZH 4QIWH 4A3KE 3GTME
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K7A E;  4A3M E;  4BY1 E;  4AYB H;  5M5Y E;  3HOZ E;  3HOU E;  5M5X E;  2R92 E;  5C3E E;  4Y7N E;  1TWC E;  4A3G E;  2JA7 E;  1SFO E;  3H0G E;  4C3H E;  3FKI E;  2E2I E;  2JA8 E;  4A3L E;  5IP9 E;  3S1R E;  3S17 E;  5C44 E;  3HOY E;  3M4O E;  1WCM E;  4A3B E;  4A3I E;  4X6A E;  3PO2 E;  2E2J E;  1R9T E;  4BY7 E;  4C3J E;  2R7Z E;  2WB1 H;  3GTK E;  2VUM E;  1DZF A;  3HOW E;  1I3Q E;  3S2D E;  4A3F E;  3PO3 E;  3I4N E;  3RZO E;  4Y52 E;  5M3M E;  3HOX E;  1TWG E;  4A3D E;  4C2M E;  1TWF E;  2NVQ E;  3S2H E;  2Y0S H;  5IP7 E;  2PMZ H;  5C4J E;  5M5W E;  3CQZ E;  1K83 E;  4A93 E;  2B63 E;  3I4M E;  5M3F E;  2WAQ H;  3GTL E;  2NVT E;  3S16 E;  3HOV E;  1I50 E;  4A3J E;  3GTQ E;  3S1Q E;  3GTO E;  4A3C E;  2NVX E;  3S14 E;  4C3I E;  3GTG E;  2JA6 E;  3H3V F;  5FLM E;  4A3E E;  5FJ8 E;  4BBS E;  1TWA E;  5IYC E;  3S1N E;  3RZD E;  2E2H E;  1EIK A;  2R93 E;  5IYD E;  2JA5 E;  3S1M E;  1I6H E;  2NVY E;  3M3Y E;  3GTJ E;  5IYB E;  4BXX E;  5C4X E;  1Y1V E;  1Y1W E;  3S15 E;  1TWH E;  4BBR E;  2YU9 E;  3GTP E;  3HKZ H;  4QIW H;  4A3K E;  3GTM E; 
#chains in the Genus database with same CATH topology
 1TWH F;  4BBR F;  2YU9 F;  3K7A E;  4A3M E;  4BY1 E;  4AYB H;  5M5Y E;  4MEY E;  4AYB K;  3HOZ E;  3GTP F;  3HOU E;  5M5X E;  2R92 E;  4KN7 E;  5C3E E;  4Y7N E;  4A3K F;  3GTM F;  1TWC E;  5FJ8 F;  4Q5S E;  4A3G E;  2JA7 E;  1SFO E;  5IYC F;  3H0G E;  4XLN E;  4C3H E;  3DXJ E;  3K7A F;  4BY1 F;  5M5Y F;  4YFK E;  4LJZ E;  2A69 E;  4A3M F;  3HOU F;  5M5X F;  2R92 F;  3HOZ F;  3FKI E;  2E2I E;  4LK1 E;  4Y7N F;  1TWC F;  2JA8 E;  4A3L E;  4A3G F;  1SFO F;  5IP9 E;  3S1R E;  1HQM E;  3H0G F;  4C3H F;  3S17 E;  5D4C E;  5C44 E;  3HOY E;  3FKI F;  2E2I F;  3M4O E;  1WCM E;  4A3B E;  4A3I E;  4X6A E;  3PO2 E;  2E2J E;  4LLG E;  2JA8 F;  4A3L F;  1R9T E;  5IP9 F;  3S1R F;  2KRX A;  4BY7 E;  4C3J E;  3S17 F;  4Q4Z E;  5C44 F;  4G7Z E;  3HOY F;  2R7Z E;  3M4O F;  1WCM F;  4A3B F;  4A3I F;  2WB1 H;  4X6A F;  4KN4 E;  3GTK E;  2E2J F;  2A68 E;  3PO2 F;  2VUM E;  1R9T F;  1YNN K;  4YG2 E;  1DZF A;  3HOW E;  4BY7 F;  5E18 E;  1I3Q E;  3S2D E;  4A3F E;  3PO3 E;  2R7Z F;  4ZH4 E;  3I4N E;  3RZO E;  4Y52 E;  4GZY E;  5M3M E;  5C3E F;  3GTK F;  5E17 E;  3HOX E;  1TWG E;  4A3D E;  2VUM F;  4C2M E;  4OIP E;  3HOW F;  1TWF E;  2JA7 F;  1I3Q F;  3S2D F;  2NVQ E;  4A3F F;  3S2H E;  2Y0S H;  4Y52 F;  3I4N F;  3RZO F;  5IP7 E;  5M3M F;  3GTG F;  3HOX F;  1IW7 E;  4YFN E;  1TWG F;  4A3D F;  2PMZ H;  4C2M F;  5C4J E;  1TWF F;  2A6E E;  5M5W E;  5D4D E;  2NVQ F;  3S2H F;  3CQZ E;  1K83 E;  4OIN E;  2BE5 E;  4XLP E;  4A93 E;  3EQL E;  2B63 E;  3I4M E;  5M3F E;  2WAQ H;  3GTL E;  2NVT E;  3WOD E;  3S16 E;  5M5W F;  2A6H E;  3CQZ F;  4XSZ E;  3HOV E;  1I50 E;  4A3J E;  4C3J F;  4MEX E;  2PPB E;  3GTQ E;  4KMU E;  4G7H E;  4A93 F;  3S1Q E;  4YFX E;  2B63 F;  3GTO E;  4A3C E;  5M3F F;  2NVX E;  3I4M F;  3S14 E;  4XSX E;  4OIO E;  2NVT F;  3GTL F;  4C3I E;  3GTG E;  5BYH E;  3HOV F;  1I50 F;  4JK1 E;  4A3J F;  1YNJ K;  2JA6 E;  3H3V F;  5FLM E;  4OIR E;  3GTQ F;  4A3E E;  1ZYR E;  3PO3 F;  2CW0 E;  2WB1 I;  5FJ8 E;  4BBS E;  3S1Q F;  1TWA E;  3GTO F;  3H3V G;  4A3C F;  2NVX F;  3S14 F;  5IYC E;  2O5I E;  3S1N E;  4C3I F;  5IPL E;  2PMZ K;  3RZD E;  2E2H E;  2JA6 F;  2R93 E;  5FLM F;  1EIK A;  4A3E F;  4BBS F;  5IYD E;  1TWA F;  2JA5 E;  4LK0 E;  3S1M E;  5IP7 F;  3S1N F;  5C4J F;  3RZD F;  2WAQ K;  1I6H E;  1QKL A;  2NVY E;  2E2H F;  3M3Y E;  2R93 F;  3GTJ E;  5IYB E;  1K83 F;  2Y0S I;  4BXX F;  5IYD F;  5TMC E;  2JA5 F;  4OIQ E;  3S1M F;  4G7O E;  4BXX E;  5C4X E;  1Y1V E;  1Y1W E;  4MQ9 E;  5D4E E;  3S15 E;  1TWH E;  2O5J E;  5TMF E;  4BBR E;  2YU9 E;  1I6H F;  2NVY F;  3GTP E;  3M3Y F;  3S16 F;  3GTJ F;  3HKZ H;  5IYB F;  3HKZ K;  1I6V E;  4QIW H;  4A3K E;  3GTM E;  4QIW K;  1SMY E;  5C4X F;  1Y1V F;  1Y1W F;  3S15 F; 
#chains in the Genus database with same CATH homology
 3K7A E;  4A3M E;  4BY1 E;  4AYB H;  5M5Y E;  3HOZ E;  3HOU E;  5M5X E;  2R92 E;  5C3E E;  4Y7N E;  1TWC E;  4A3G E;  2JA7 E;  1SFO E;  3H0G E;  4C3H E;  3FKI E;  2E2I E;  2JA8 E;  4A3L E;  5IP9 E;  3S1R E;  3S17 E;  5C44 E;  3HOY E;  3M4O E;  1WCM E;  4A3B E;  4A3I E;  4X6A E;  3PO2 E;  2E2J E;  1R9T E;  4BY7 E;  4C3J E;  2R7Z E;  2WB1 H;  3GTK E;  2VUM E;  1DZF A;  3HOW E;  1I3Q E;  3S2D E;  4A3F E;  3PO3 E;  3I4N E;  3RZO E;  4Y52 E;  5M3M E;  3HOX E;  1TWG E;  4A3D E;  4C2M E;  1TWF E;  2NVQ E;  3S2H E;  2Y0S H;  5IP7 E;  2PMZ H;  5C4J E;  5M5W E;  3CQZ E;  1K83 E;  4A93 E;  2B63 E;  3I4M E;  5M3F E;  2WAQ H;  3GTL E;  2NVT E;  3S16 E;  3HOV E;  1I50 E;  4A3J E;  3GTQ E;  3S1Q E;  3GTO E;  4A3C E;  2NVX E;  3S14 E;  4C3I E;  3GTG E;  2JA6 E;  3H3V F;  5FLM E;  4A3E E;  5FJ8 E;  4BBS E;  1TWA E;  5IYC E;  3S1N E;  3RZD E;  2E2H E;  1EIK A;  2R93 E;  5IYD E;  2JA5 E;  3S1M E;  1I6H E;  2NVY E;  3M3Y E;  3GTJ E;  5IYB E;  4BXX E;  5C4X E;  1Y1V E;  1Y1W E;  3S15 E;  1TWH E;  4BBR E;  2YU9 E;  3GTP E;  3HKZ H;  4QIW H;  4A3K E;  3GTM E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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