5JB4A

A simplified bpti variant containing 21 alanines out 58 of residues
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
58
structure length
58
Chain Sequence
RPAFCLEPPYAGPGAAAIIRYFYNAAAGAAQAFVYGGVRAKRNNFASAADALAACAAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Bos taurus
molecule keywords Pancreatic trypsin inhibitor
total genus 9
structure length 58
sequence length 58
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2016-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 5jb4A00
2FTMB 4ISNB 1BPTA 3UIRC 3U1JE 4U32X 2FTLI 3AUEA 3LDIA 3TGII 4BQDA 3WNYA 1FY8I 4Y11I 2LFLA 3BTKI 1FANA 4ISLB 1LD5A 1KTHA 3BYBA 5C67C 1KUNA 3BTQI 4U30W 1JV9A 1FAKI 2FI3I 3BTHI 2IJOI 3UOUB 1B0CA 5JB7A 1TFXC 1YLDB 1NAGA 8PTIA 1TAPA 4Y0YI 2TGPI 1JV8A 2R9PE 4WXVC 3AUDA 1MTND 1JC6A 1QLQA 4WWYC 5JB6A 4Y0ZI 3OFWA 3AUGA 3AUBA 4PTIA 3TGKI 1T8NB 1BUNB 1AAPA 1CBWD 1TOCR 1F5RI 1T7CB 3GYMI 5JB5A 3CI7A 1P2II 1K6UA 4ISOB 3LDJA 2J6DA 2KNTA 2UUXA 3M7QB 1Y62A 3LDMA 2DDJA 5JB4A 1DTXA 2FI5I 3BTWI 6PTIA 1PITA 2PTCI 1ZJDB 1P2JI 1BTHP 1KIGI 1AALA 4BNRI 1DEMA 1IRHA 1YLCB 2W8XA 3TPII 4NTXB 3L3TE 1EJMB 3BTEI 1CO7I 3L33E 1P2KI 2ODYE 3BTMI 1BZXI 1P2MB 3AUIA 3D65I 5PTIA 4BD9B 1BF0A 1DTKA 3FP7J 1D0DB 3FP8I 1EAWB 1P2NB 2JOTA 2DDIA 1BHCA 1KNTA 1UUAA 1F7ZI 3AUHA 7PTIA 2HEXA 2UUYB 3AUCA 1BRCI 1BPIA 1G6XA 2CA7A 1OA55 1ADZA 1CA0D 1YKTB 2FI4I 1TPAI 2ZVXA 4Y10I 1BTIA 1T8OB 2KCRA 4DG4C 4TPII 3P92E 3BTDI 1P2OB 1TCPA 3T62D 1TAWB 2TPII 4DTGK 3BTGI 4NTYB 1T8MB 1SHPA 1LD6A 3OTJI 1BIKA 3FP6I 1UUBA 1P2QB 2M01A 3P95E 1YC0I 1ZR0B 1D0DA 3BTFI 2M99A 1OA65 1BZ5A 1DENA 1T8LB 3TGJI 2ZJXA 4NTWB 2LFKA 2KAII 1BRBI 3BTTI 2RA3C 9PTIA
chains in the Genus database with same CATH superfamily
2FTMB 4ISNB 1BPTA 3UIRC 3U1JE 4U32X 2FTLI 3AUEA 3LDIA 3TGII 4BQDA 3WNYA 1FY8I 4Y11I 2LFLA 3BTKI 1FANA 4ISLB 1LD5A 1KTHA 3BYBA 5C67C 1KUNA 3BTQI 4U30W 1JV9A 1FAKI 2FI3I 3BTHI 2IJOI 3UOUB 1B0CA 5JB7A 1TFXC 1YLDB 1NAGA 8PTIA 1TAPA 4Y0YI 2TGPI 1JV8A 2R9PE 4WXVC 3AUDA 1MTND 1JC6A 1QLQA 4WWYC 5JB6A 4Y0ZI 3OFWA 3AUGA 3AUBA 4PTIA 3TGKI 1T8NB 1BUNB 1AAPA 1CBWD 1TOCR 1F5RI 1T7CB 3GYMI 5JB5A 3CI7A 1P2II 1K6UA 4ISOB 3LDJA 2J6DA 2KNTA 2UUXA 3M7QB 1Y62A 3LDMA 2DDJA 5JB4A 1DTXA 2FI5I 3BTWI 6PTIA 1PITA 2PTCI 1ZJDB 1P2JI 1BTHP 1KIGI 1AALA 4BNRI 1DEMA 1IRHA 1YLCB 2W8XA 3TPII 4NTXB 3L3TE 1EJMB 3BTEI 1CO7I 3L33E 1P2KI 2ODYE 3BTMI 1BZXI 1P2MB 3AUIA 3D65I 5PTIA 4BD9B 1BF0A 1DTKA 3FP7J 1D0DB 3FP8I 1EAWB 1P2NB 2JOTA 2DDIA 1BHCA 1KNTA 1UUAA 1F7ZI 3AUHA 7PTIA 2HEXA 2UUYB 3AUCA 1BRCI 1BPIA 1G6XA 2CA7A 1OA55 1ADZA 1CA0D 1YKTB 2FI4I 1TPAI 2ZVXA 4Y10I 1BTIA 1T8OB 2KCRA 4DG4C 4TPII 3P92E 3BTDI 1P2OB 1TCPA 3T62D 1TAWB 2TPII 4DTGK 3BTGI 4NTYB 1T8MB 1SHPA 1LD6A 3OTJI 1BIKA 3FP6I 1UUBA 1P2QB 2M01A 3P95E 1YC0I 1ZR0B 1D0DA 3BTFI 2M99A 1OA65 1BZ5A 1DENA 1T8LB 3TGJI 2ZJXA 4NTWB 2LFKA 2KAII 1BRBI 3BTTI 2RA3C 9PTIA
chains in the Genus database with same CATH topology
2FTMB 4ISNB 1BPTA 3UIRC 3U1JE 4U32X 2FTLI 3AUEA 3LDIA 3TGII 4BQDA 3WNYA 1FY8I 4Y11I 2LFLA 3BTKI 1FANA 4ISLB 1LD5A 1KTHA 3BYBA 5C67C 1KUNA 3BTQI 4U30W 1JV9A 1FAKI 2FI3I 3BTHI 2IJOI 3UOUB 1B0CA 5JB7A 1TFXC 1YLDB 1NAGA 8PTIA 1TAPA 4Y0YI 2TGPI 1JV8A 2R9PE 4WXVC 3AUDA 1MTND 1JC6A 1QLQA 4WWYC 5JB6A 4Y0ZI 3OFWA 3AUGA 3AUBA 4PTIA 3TGKI 1T8NB 1BUNB 1AAPA 1CBWD 1TOCR 1F5RI 1T7CB 3GYMI 5JB5A 3CI7A 1P2II 1K6UA 4ISOB 3LDJA 2J6DA 2KNTA 2UUXA 3M7QB 1Y62A 3LDMA 2DDJA 5JB4A 1DTXA 2FI5I 3BTWI 6PTIA 1PITA 2PTCI 1ZJDB 1P2JI 1BTHP 1KIGI 1AALA 4BNRI 1DEMA 1IRHA 1YLCB 2W8XA 3TPII 4NTXB 3L3TE 1EJMB 3BTEI 1CO7I 3L33E 1P2KI 2ODYE 3BTMI 1BZXI 1P2MB 3AUIA 3D65I 5PTIA 4BD9B 1BF0A 1DTKA 3FP7J 1D0DB 3FP8I 1EAWB 1P2NB 2JOTA 2DDIA 1BHCA 1KNTA 1UUAA 1F7ZI 3AUHA 7PTIA 2HEXA 2UUYB 3AUCA 1BRCI 1BPIA 1G6XA 2CA7A 1OA55 1ADZA 1CA0D 1YKTB 2FI4I 1TPAI 2ZVXA 4Y10I 1BTIA 1T8OB 2KCRA 4DG4C 4TPII 3P92E 3BTDI 1P2OB 1TCPA 3T62D 1TAWB 2TPII 4DTGK 3BTGI 4NTYB 1T8MB 1SHPA 1LD6A 3OTJI 1BIKA 3FP6I 1UUBA 1P2QB 2M01A 3P95E 1YC0I 1ZR0B 1D0DA 3BTFI 2M99A 1OA65 1BZ5A 1DENA 1T8LB 3TGJI 2ZJXA 4NTWB 2LFKA 2KAII 1BRBI 3BTTI 2RA3C 9PTIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FTM B;  4ISN B;  1BPT A;  3UIR C;  3U1J E;  4U32 X;  2FTL I;  3AUE A;  3LDI A;  3TGI I;  4BQD A;  3WNY A;  1FY8 I;  4Y11 I;  2LFL A;  3BTK I;  1FAN A;  4ISL B;  1LD5 A;  1KTH A;  3BYB A;  5C67 C;  1KUN A;  3BTQ I;  4U30 W;  1JV9 A;  1FAK I;  2FI3 I;  3BTH I;  2IJO I;  3UOU B;  1B0C A;  5JB7 A;  1TFX C;  1YLD B;  1NAG A;  8PTI A;  1TAP A;  4Y0Y I;  2TGP I;  1JV8 A;  2R9P E;  4WXV C;  3AUD A;  1MTN D;  1JC6 A;  1QLQ A;  4WWY C;  5JB6 A;  4Y0Z I;  3OFW A;  3AUG A;  3AUB A;  4PTI A;  3TGK I;  1T8N B;  1BUN B;  1AAP A;  1CBW D;  1TOC R;  1F5R I;  1T7C B;  3GYM I;  5JB5 A;  3CI7 A;  1P2I I;  1K6U A;  4ISO B;  3LDJ A;  2J6D A;  2KNT A;  2UUX A;  3M7Q B;  1Y62 A;  3LDM A;  2DDJ A;  5JB4 A;  1DTX A;  2FI5 I;  3BTW I;  6PTI A;  1PIT A;  2PTC I;  1ZJD B;  1P2J I;  1BTH P;  1KIG I;  1AAL A;  4BNR I;  1DEM A;  1IRH A;  1YLC B;  2W8X A;  3TPI I;  4NTX B;  3L3T E;  1EJM B;  3BTE I;  1CO7 I;  3L33 E;  1P2K I;  2ODY E;  3BTM I;  1BZX I;  1P2M B;  3AUI A;  3D65 I;  5PTI A;  4BD9 B;  1BF0 A;  1DTK A;  3FP7 J;  1D0D B;  3FP8 I;  1EAW B;  1P2N B;  2JOT A;  2DDI A;  1BHC A;  1KNT A;  1UUA A;  1F7Z I;  3AUH A;  7PTI A;  2HEX A;  2UUY B;  3AUC A;  1BRC I;  1BPI A;  1G6X A;  2CA7 A;  1OA5 5;  1ADZ A;  1CA0 D;  1YKT B;  2FI4 I;  1TPA I;  2ZVX A;  4Y10 I;  1BTI A;  1T8O B;  2KCR A;  4DG4 C;  4TPI I;  3P92 E;  3BTD I;  1P2O B;  1TCP A;  3T62 D;  1TAW B;  2TPI I;  4DTG K;  3BTG I;  4NTY B;  1T8M B;  1SHP A;  1LD6 A;  3OTJ I;  1BIK A;  3FP6 I;  1UUB A;  1P2Q B;  2M01 A;  3P95 E;  1YC0 I;  1ZR0 B;  1D0D A;  3BTF I;  2M99 A;  1OA6 5;  1BZ5 A;  1DEN A;  1T8L B;  3TGJ I;  2ZJX A;  4NTW B;  2LFK A;  2KAI I;  1BRB I;  3BTT I;  2RA3 C;  9PTI A; 
#chains in the Genus database with same CATH topology
 2FTM B;  4ISN B;  1BPT A;  3UIR C;  3U1J E;  4U32 X;  2FTL I;  3AUE A;  3LDI A;  3TGI I;  4BQD A;  3WNY A;  1FY8 I;  4Y11 I;  2LFL A;  3BTK I;  1FAN A;  4ISL B;  1LD5 A;  1KTH A;  3BYB A;  5C67 C;  1KUN A;  3BTQ I;  4U30 W;  1JV9 A;  1FAK I;  2FI3 I;  3BTH I;  2IJO I;  3UOU B;  1B0C A;  5JB7 A;  1TFX C;  1YLD B;  1NAG A;  8PTI A;  1TAP A;  4Y0Y I;  2TGP I;  1JV8 A;  2R9P E;  4WXV C;  3AUD A;  1MTN D;  1JC6 A;  1QLQ A;  4WWY C;  5JB6 A;  4Y0Z I;  3OFW A;  3AUG A;  3AUB A;  4PTI A;  3TGK I;  1T8N B;  1BUN B;  1AAP A;  1CBW D;  1TOC R;  1F5R I;  1T7C B;  3GYM I;  5JB5 A;  3CI7 A;  1P2I I;  1K6U A;  4ISO B;  3LDJ A;  2J6D A;  2KNT A;  2UUX A;  3M7Q B;  1Y62 A;  3LDM A;  2DDJ A;  5JB4 A;  1DTX A;  2FI5 I;  3BTW I;  6PTI A;  1PIT A;  2PTC I;  1ZJD B;  1P2J I;  1BTH P;  1KIG I;  1AAL A;  4BNR I;  1DEM A;  1IRH A;  1YLC B;  2W8X A;  3TPI I;  4NTX B;  3L3T E;  1EJM B;  3BTE I;  1CO7 I;  3L33 E;  1P2K I;  2ODY E;  3BTM I;  1BZX I;  1P2M B;  3AUI A;  3D65 I;  5PTI A;  4BD9 B;  1BF0 A;  1DTK A;  3FP7 J;  1D0D B;  3FP8 I;  1EAW B;  1P2N B;  2JOT A;  2DDI A;  1BHC A;  1KNT A;  1UUA A;  1F7Z I;  3AUH A;  7PTI A;  2HEX A;  2UUY B;  3AUC A;  1BRC I;  1BPI A;  1G6X A;  2CA7 A;  1OA5 5;  1ADZ A;  1CA0 D;  1YKT B;  2FI4 I;  1TPA I;  2ZVX A;  4Y10 I;  1BTI A;  1T8O B;  2KCR A;  4DG4 C;  4TPI I;  3P92 E;  3BTD I;  1P2O B;  1TCP A;  3T62 D;  1TAW B;  2TPI I;  4DTG K;  3BTG I;  4NTY B;  1T8M B;  1SHP A;  1LD6 A;  3OTJ I;  1BIK A;  3FP6 I;  1UUB A;  1P2Q B;  2M01 A;  3P95 E;  1YC0 I;  1ZR0 B;  1D0D A;  3BTF I;  2M99 A;  1OA6 5;  1BZ5 A;  1DEN A;  1T8L B;  3TGJ I;  2ZJX A;  4NTW B;  2LFK A;  2KAI I;  1BRB I;  3BTT I;  2RA3 C;  9PTI A; 
#chains in the Genus database with same CATH homology
 2FTM B;  4ISN B;  1BPT A;  3UIR C;  3U1J E;  4U32 X;  2FTL I;  3AUE A;  3LDI A;  3TGI I;  4BQD A;  3WNY A;  1FY8 I;  4Y11 I;  2LFL A;  3BTK I;  1FAN A;  4ISL B;  1LD5 A;  1KTH A;  3BYB A;  5C67 C;  1KUN A;  3BTQ I;  4U30 W;  1JV9 A;  1FAK I;  2FI3 I;  3BTH I;  2IJO I;  3UOU B;  1B0C A;  5JB7 A;  1TFX C;  1YLD B;  1NAG A;  8PTI A;  1TAP A;  4Y0Y I;  2TGP I;  1JV8 A;  2R9P E;  4WXV C;  3AUD A;  1MTN D;  1JC6 A;  1QLQ A;  4WWY C;  5JB6 A;  4Y0Z I;  3OFW A;  3AUG A;  3AUB A;  4PTI A;  3TGK I;  1T8N B;  1BUN B;  1AAP A;  1CBW D;  1TOC R;  1F5R I;  1T7C B;  3GYM I;  5JB5 A;  3CI7 A;  1P2I I;  1K6U A;  4ISO B;  3LDJ A;  2J6D A;  2KNT A;  2UUX A;  3M7Q B;  1Y62 A;  3LDM A;  2DDJ A;  5JB4 A;  1DTX A;  2FI5 I;  3BTW I;  6PTI A;  1PIT A;  2PTC I;  1ZJD B;  1P2J I;  1BTH P;  1KIG I;  1AAL A;  4BNR I;  1DEM A;  1IRH A;  1YLC B;  2W8X A;  3TPI I;  4NTX B;  3L3T E;  1EJM B;  3BTE I;  1CO7 I;  3L33 E;  1P2K I;  2ODY E;  3BTM I;  1BZX I;  1P2M B;  3AUI A;  3D65 I;  5PTI A;  4BD9 B;  1BF0 A;  1DTK A;  3FP7 J;  1D0D B;  3FP8 I;  1EAW B;  1P2N B;  2JOT A;  2DDI A;  1BHC A;  1KNT A;  1UUA A;  1F7Z I;  3AUH A;  7PTI A;  2HEX A;  2UUY B;  3AUC A;  1BRC I;  1BPI A;  1G6X A;  2CA7 A;  1OA5 5;  1ADZ A;  1CA0 D;  1YKT B;  2FI4 I;  1TPA I;  2ZVX A;  4Y10 I;  1BTI A;  1T8O B;  2KCR A;  4DG4 C;  4TPI I;  3P92 E;  3BTD I;  1P2O B;  1TCP A;  3T62 D;  1TAW B;  2TPI I;  4DTG K;  3BTG I;  4NTY B;  1T8M B;  1SHP A;  1LD6 A;  3OTJ I;  1BIK A;  3FP6 I;  1UUB A;  1P2Q B;  2M01 A;  3P95 E;  1YC0 I;  1ZR0 B;  1D0D A;  3BTF I;  2M99 A;  1OA6 5;  1BZ5 A;  1DEN A;  1T8L B;  3TGJ I;  2ZJX A;  4NTW B;  2LFK A;  2KAI I;  1BRB I;  3BTT I;  2RA3 C;  9PTI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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