5JB5A

A simplified bpti variant containing 22 alanines out of 58 residues
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
57
structure length
57
Chain Sequence
RPAFCLEPPYAGPGAAAIIRYFYNAAAGAAQAFVYGGVAAKRNNFASAADALAACAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Bos taurus
molecule keywords Pancreatic trypsin inhibitor
total genus 9
structure length 57
sequence length 57
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2016-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 5jb5A00
2HEXA 1SHPA 3P95E 1ZR0B 4NTWB 1T8NB 2TGPI 4PTIA 1T8OB 1P2II 1KUNA 3AUHA 1LD6A 3TGKI 4U30W 4BNRI 1YKTB 3BTHI 6PTIA 2KNTA 2LFLA 2ZVXA 3OTJI 2J6DA 3LDIA 1T8MB 3TGJI 1IRHA 1TOCR 3BTKI 1P2OB 3LDMA 1TAPA 1AALA 2IJOI 2KAII 3BTMI 7PTIA 3LDJA 1PITA 3TPII 9PTIA 4NTXB 3AUIA 1BPIA 1FY8I 2UUYB 1KNTA 1P2KI 1OA55 1CA0D 5PTIA 3M7QB 3TGII 3BYBA 4Y0ZI 3UIRC 1YLCB 1Y62A 1T8LB 1G6XA 2CA7A 2R9PE 2UUXA 1ADZA 1TAWB 1F5RI 1P2NB 2LFKA 4WXVC 1FAKI 1NAGA 4Y11I 1BF0A 3AUDA 4ISLB 3AUCA 1P2JI 2ZJXA 1BUNB 1EAWB 2W8XA 2DDIA 4WWYC 5JB6A 1CO7I 1DTKA 2DDJA 4BQDA 2FTMB 1JV8A 1DEMA 3OFWA 2ODYE 3L3TE 1BTHP 1TCPA 2FTLI 3BTWI 2M99A 3GYMI 1B0CA 1LD5A 1TFXC 1P2QB 5C67C 3FP6I 2KCRA 1OA65 5JB4A 1D0DA 1TPAI 1P2MB 4TPII 3BTFI 8PTIA 4Y10I 4BD9B 1DENA 5JB7A 4Y0YI 1FANA 1BHCA 1KTHA 4U32X 1F7ZI 3AUEA 1YLDB 4ISNB 1JC6A 1ZJDB 1UUBA 3AUGA 3BTTI 1BIKA 1UUAA 3BTEI 4DTGK 5JB5A 1CBWD 4NTYB 1BTIA 3CI7A 3P92E 1BZXI 1BPTA 3D65I 1KIGI 3U1JE 1EJMB 4ISOB 2JOTA 1AAPA 3WNYA 2RA3C 3BTDI 1QLQA 2TPII 4DG4C 1BZ5A 3UOUB 2FI5I 2PTCI 2FI3I 3BTQI 2M01A 1T7CB 1D0DB 1BRBI 2FI4I 3FP7J 3FP8I 1YC0I 1DTXA 1JV9A 1K6UA 3T62D 3BTGI 1MTND 3AUBA 3L33E 1BRCI
chains in the Genus database with same CATH superfamily
2HEXA 1SHPA 3P95E 1ZR0B 4NTWB 1T8NB 2TGPI 4PTIA 1T8OB 1P2II 1KUNA 3AUHA 1LD6A 3TGKI 4U30W 4BNRI 1YKTB 3BTHI 6PTIA 2KNTA 2LFLA 2ZVXA 3OTJI 2J6DA 3LDIA 1T8MB 3TGJI 1IRHA 1TOCR 3BTKI 1P2OB 3LDMA 1TAPA 1AALA 2IJOI 2KAII 3BTMI 7PTIA 3LDJA 1PITA 3TPII 9PTIA 4NTXB 3AUIA 1BPIA 1FY8I 2UUYB 1KNTA 1P2KI 1OA55 1CA0D 5PTIA 3M7QB 3TGII 3BYBA 4Y0ZI 3UIRC 1YLCB 1Y62A 1T8LB 1G6XA 2CA7A 2R9PE 2UUXA 1ADZA 1TAWB 1F5RI 1P2NB 2LFKA 4WXVC 1FAKI 1NAGA 4Y11I 1BF0A 3AUDA 4ISLB 3AUCA 1P2JI 2ZJXA 1BUNB 1EAWB 2W8XA 2DDIA 4WWYC 5JB6A 1CO7I 1DTKA 2DDJA 4BQDA 2FTMB 1JV8A 1DEMA 3OFWA 2ODYE 3L3TE 1BTHP 1TCPA 2FTLI 3BTWI 2M99A 3GYMI 1B0CA 1LD5A 1TFXC 1P2QB 5C67C 3FP6I 2KCRA 1OA65 5JB4A 1D0DA 1TPAI 1P2MB 4TPII 3BTFI 8PTIA 4Y10I 4BD9B 1DENA 5JB7A 4Y0YI 1FANA 1BHCA 1KTHA 4U32X 1F7ZI 3AUEA 1YLDB 4ISNB 1JC6A 1ZJDB 1UUBA 3AUGA 3BTTI 1BIKA 1UUAA 3BTEI 4DTGK 5JB5A 1CBWD 4NTYB 1BTIA 3CI7A 3P92E 1BZXI 1BPTA 3D65I 1KIGI 3U1JE 1EJMB 4ISOB 2JOTA 1AAPA 3WNYA 2RA3C 3BTDI 1QLQA 2TPII 4DG4C 1BZ5A 3UOUB 2FI5I 2PTCI 2FI3I 3BTQI 2M01A 1T7CB 1D0DB 1BRBI 2FI4I 3FP7J 3FP8I 1YC0I 1DTXA 1JV9A 1K6UA 3T62D 3BTGI 1MTND 3AUBA 3L33E 1BRCI
chains in the Genus database with same CATH topology
2HEXA 1SHPA 3P95E 1ZR0B 4NTWB 1T8NB 2TGPI 4PTIA 1T8OB 1P2II 1KUNA 3AUHA 1LD6A 3TGKI 4U30W 4BNRI 1YKTB 3BTHI 6PTIA 2KNTA 2LFLA 2ZVXA 3OTJI 2J6DA 3LDIA 1T8MB 3TGJI 1IRHA 1TOCR 3BTKI 1P2OB 3LDMA 1TAPA 1AALA 2IJOI 2KAII 3BTMI 7PTIA 3LDJA 1PITA 3TPII 9PTIA 4NTXB 3AUIA 1BPIA 1FY8I 2UUYB 1KNTA 1P2KI 1OA55 1CA0D 5PTIA 3M7QB 3TGII 3BYBA 4Y0ZI 3UIRC 1YLCB 1Y62A 1T8LB 1G6XA 2CA7A 2R9PE 2UUXA 1ADZA 1TAWB 1F5RI 1P2NB 2LFKA 4WXVC 1FAKI 1NAGA 4Y11I 1BF0A 3AUDA 4ISLB 3AUCA 1P2JI 2ZJXA 1BUNB 1EAWB 2W8XA 2DDIA 4WWYC 5JB6A 1CO7I 1DTKA 2DDJA 4BQDA 2FTMB 1JV8A 1DEMA 3OFWA 2ODYE 3L3TE 1BTHP 1TCPA 2FTLI 3BTWI 2M99A 3GYMI 1B0CA 1LD5A 1TFXC 1P2QB 5C67C 3FP6I 2KCRA 1OA65 5JB4A 1D0DA 1TPAI 1P2MB 4TPII 3BTFI 8PTIA 4Y10I 4BD9B 1DENA 5JB7A 4Y0YI 1FANA 1BHCA 1KTHA 4U32X 1F7ZI 3AUEA 1YLDB 4ISNB 1JC6A 1ZJDB 1UUBA 3AUGA 3BTTI 1BIKA 1UUAA 3BTEI 4DTGK 5JB5A 1CBWD 4NTYB 1BTIA 3CI7A 3P92E 1BZXI 1BPTA 3D65I 1KIGI 3U1JE 1EJMB 4ISOB 2JOTA 1AAPA 3WNYA 2RA3C 3BTDI 1QLQA 2TPII 4DG4C 1BZ5A 3UOUB 2FI5I 2PTCI 2FI3I 3BTQI 2M01A 1T7CB 1D0DB 1BRBI 2FI4I 3FP7J 3FP8I 1YC0I 1DTXA 1JV9A 1K6UA 3T62D 3BTGI 1MTND 3AUBA 3L33E 1BRCI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HEX A;  1SHP A;  3P95 E;  1ZR0 B;  4NTW B;  1T8N B;  2TGP I;  4PTI A;  1T8O B;  1P2I I;  1KUN A;  3AUH A;  1LD6 A;  3TGK I;  4U30 W;  4BNR I;  1YKT B;  3BTH I;  6PTI A;  2KNT A;  2LFL A;  2ZVX A;  3OTJ I;  2J6D A;  3LDI A;  1T8M B;  3TGJ I;  1IRH A;  1TOC R;  3BTK I;  1P2O B;  3LDM A;  1TAP A;  1AAL A;  2IJO I;  2KAI I;  3BTM I;  7PTI A;  3LDJ A;  1PIT A;  3TPI I;  9PTI A;  4NTX B;  3AUI A;  1BPI A;  1FY8 I;  2UUY B;  1KNT A;  1P2K I;  1OA5 5;  1CA0 D;  5PTI A;  3M7Q B;  3TGI I;  3BYB A;  4Y0Z I;  3UIR C;  1YLC B;  1Y62 A;  1T8L B;  1G6X A;  2CA7 A;  2R9P E;  2UUX A;  1ADZ A;  1TAW B;  1F5R I;  1P2N B;  2LFK A;  4WXV C;  1FAK I;  1NAG A;  4Y11 I;  1BF0 A;  3AUD A;  4ISL B;  3AUC A;  1P2J I;  2ZJX A;  1BUN B;  1EAW B;  2W8X A;  2DDI A;  4WWY C;  5JB6 A;  1CO7 I;  1DTK A;  2DDJ A;  4BQD A;  2FTM B;  1JV8 A;  1DEM A;  3OFW A;  2ODY E;  3L3T E;  1BTH P;  1TCP A;  2FTL I;  3BTW I;  2M99 A;  3GYM I;  1B0C A;  1LD5 A;  1TFX C;  1P2Q B;  5C67 C;  3FP6 I;  2KCR A;  1OA6 5;  5JB4 A;  1D0D A;  1TPA I;  1P2M B;  4TPI I;  3BTF I;  8PTI A;  4Y10 I;  4BD9 B;  1DEN A;  5JB7 A;  4Y0Y I;  1FAN A;  1BHC A;  1KTH A;  4U32 X;  1F7Z I;  3AUE A;  1YLD B;  4ISN B;  1JC6 A;  1ZJD B;  1UUB A;  3AUG A;  3BTT I;  1BIK A;  1UUA A;  3BTE I;  4DTG K;  5JB5 A;  1CBW D;  4NTY B;  1BTI A;  3CI7 A;  3P92 E;  1BZX I;  1BPT A;  3D65 I;  1KIG I;  3U1J E;  1EJM B;  4ISO B;  2JOT A;  1AAP A;  3WNY A;  2RA3 C;  3BTD I;  1QLQ A;  2TPI I;  4DG4 C;  1BZ5 A;  3UOU B;  2FI5 I;  2PTC I;  2FI3 I;  3BTQ I;  2M01 A;  1T7C B;  1D0D B;  1BRB I;  2FI4 I;  3FP7 J;  3FP8 I;  1YC0 I;  1DTX A;  1JV9 A;  1K6U A;  3T62 D;  3BTG I;  1MTN D;  3AUB A;  3L33 E;  1BRC I; 
#chains in the Genus database with same CATH topology
 2HEX A;  1SHP A;  3P95 E;  1ZR0 B;  4NTW B;  1T8N B;  2TGP I;  4PTI A;  1T8O B;  1P2I I;  1KUN A;  3AUH A;  1LD6 A;  3TGK I;  4U30 W;  4BNR I;  1YKT B;  3BTH I;  6PTI A;  2KNT A;  2LFL A;  2ZVX A;  3OTJ I;  2J6D A;  3LDI A;  1T8M B;  3TGJ I;  1IRH A;  1TOC R;  3BTK I;  1P2O B;  3LDM A;  1TAP A;  1AAL A;  2IJO I;  2KAI I;  3BTM I;  7PTI A;  3LDJ A;  1PIT A;  3TPI I;  9PTI A;  4NTX B;  3AUI A;  1BPI A;  1FY8 I;  2UUY B;  1KNT A;  1P2K I;  1OA5 5;  1CA0 D;  5PTI A;  3M7Q B;  3TGI I;  3BYB A;  4Y0Z I;  3UIR C;  1YLC B;  1Y62 A;  1T8L B;  1G6X A;  2CA7 A;  2R9P E;  2UUX A;  1ADZ A;  1TAW B;  1F5R I;  1P2N B;  2LFK A;  4WXV C;  1FAK I;  1NAG A;  4Y11 I;  1BF0 A;  3AUD A;  4ISL B;  3AUC A;  1P2J I;  2ZJX A;  1BUN B;  1EAW B;  2W8X A;  2DDI A;  4WWY C;  5JB6 A;  1CO7 I;  1DTK A;  2DDJ A;  4BQD A;  2FTM B;  1JV8 A;  1DEM A;  3OFW A;  2ODY E;  3L3T E;  1BTH P;  1TCP A;  2FTL I;  3BTW I;  2M99 A;  3GYM I;  1B0C A;  1LD5 A;  1TFX C;  1P2Q B;  5C67 C;  3FP6 I;  2KCR A;  1OA6 5;  5JB4 A;  1D0D A;  1TPA I;  1P2M B;  4TPI I;  3BTF I;  8PTI A;  4Y10 I;  4BD9 B;  1DEN A;  5JB7 A;  4Y0Y I;  1FAN A;  1BHC A;  1KTH A;  4U32 X;  1F7Z I;  3AUE A;  1YLD B;  4ISN B;  1JC6 A;  1ZJD B;  1UUB A;  3AUG A;  3BTT I;  1BIK A;  1UUA A;  3BTE I;  4DTG K;  5JB5 A;  1CBW D;  4NTY B;  1BTI A;  3CI7 A;  3P92 E;  1BZX I;  1BPT A;  3D65 I;  1KIG I;  3U1J E;  1EJM B;  4ISO B;  2JOT A;  1AAP A;  3WNY A;  2RA3 C;  3BTD I;  1QLQ A;  2TPI I;  4DG4 C;  1BZ5 A;  3UOU B;  2FI5 I;  2PTC I;  2FI3 I;  3BTQ I;  2M01 A;  1T7C B;  1D0D B;  1BRB I;  2FI4 I;  3FP7 J;  3FP8 I;  1YC0 I;  1DTX A;  1JV9 A;  1K6U A;  3T62 D;  3BTG I;  1MTN D;  3AUB A;  3L33 E;  1BRC I; 
#chains in the Genus database with same CATH homology
 2HEX A;  1SHP A;  3P95 E;  1ZR0 B;  4NTW B;  1T8N B;  2TGP I;  4PTI A;  1T8O B;  1P2I I;  1KUN A;  3AUH A;  1LD6 A;  3TGK I;  4U30 W;  4BNR I;  1YKT B;  3BTH I;  6PTI A;  2KNT A;  2LFL A;  2ZVX A;  3OTJ I;  2J6D A;  3LDI A;  1T8M B;  3TGJ I;  1IRH A;  1TOC R;  3BTK I;  1P2O B;  3LDM A;  1TAP A;  1AAL A;  2IJO I;  2KAI I;  3BTM I;  7PTI A;  3LDJ A;  1PIT A;  3TPI I;  9PTI A;  4NTX B;  3AUI A;  1BPI A;  1FY8 I;  2UUY B;  1KNT A;  1P2K I;  1OA5 5;  1CA0 D;  5PTI A;  3M7Q B;  3TGI I;  3BYB A;  4Y0Z I;  3UIR C;  1YLC B;  1Y62 A;  1T8L B;  1G6X A;  2CA7 A;  2R9P E;  2UUX A;  1ADZ A;  1TAW B;  1F5R I;  1P2N B;  2LFK A;  4WXV C;  1FAK I;  1NAG A;  4Y11 I;  1BF0 A;  3AUD A;  4ISL B;  3AUC A;  1P2J I;  2ZJX A;  1BUN B;  1EAW B;  2W8X A;  2DDI A;  4WWY C;  5JB6 A;  1CO7 I;  1DTK A;  2DDJ A;  4BQD A;  2FTM B;  1JV8 A;  1DEM A;  3OFW A;  2ODY E;  3L3T E;  1BTH P;  1TCP A;  2FTL I;  3BTW I;  2M99 A;  3GYM I;  1B0C A;  1LD5 A;  1TFX C;  1P2Q B;  5C67 C;  3FP6 I;  2KCR A;  1OA6 5;  5JB4 A;  1D0D A;  1TPA I;  1P2M B;  4TPI I;  3BTF I;  8PTI A;  4Y10 I;  4BD9 B;  1DEN A;  5JB7 A;  4Y0Y I;  1FAN A;  1BHC A;  1KTH A;  4U32 X;  1F7Z I;  3AUE A;  1YLD B;  4ISN B;  1JC6 A;  1ZJD B;  1UUB A;  3AUG A;  3BTT I;  1BIK A;  1UUA A;  3BTE I;  4DTG K;  5JB5 A;  1CBW D;  4NTY B;  1BTI A;  3CI7 A;  3P92 E;  1BZX I;  1BPT A;  3D65 I;  1KIG I;  3U1J E;  1EJM B;  4ISO B;  2JOT A;  1AAP A;  3WNY A;  2RA3 C;  3BTD I;  1QLQ A;  2TPI I;  4DG4 C;  1BZ5 A;  3UOU B;  2FI5 I;  2PTC I;  2FI3 I;  3BTQ I;  2M01 A;  1T7C B;  1D0D B;  1BRB I;  2FI4 I;  3FP7 J;  3FP8 I;  1YC0 I;  1DTX A;  1JV9 A;  1K6U A;  3T62 D;  3BTG I;  1MTN D;  3AUB A;  3L33 E;  1BRC I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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