5JB7A

A simplified bpti variant containing 24 alanines out of 58 residues
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
56
structure length
56
Chain Sequence
RPAFCLEAPYAGPGAAAIIRYFYNAAAGAAQAFVYGGVAAKRNNFASAAAALAACA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Bos taurus
molecule keywords Pancreatic trypsin inhibitor
total genus 9
structure length 56
sequence length 56
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2016-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 5jb7A00
3AUCA 4U30W 1KNTA 1SHPA 3TGKI 3TGII 3FP7J 2FI3I 3GYMI 1FANA 2LFKA 1BUNB 1QLQA 2ODYE 1UUBA 2M99A 1NAGA 2RA3C 3UOUB 3P92E 3BTEI 4ISNB 1ZR0B 3AUBA 1BRBI 1ZJDB 1EJMB 3BTFI 3BTMI 4ISOB 1T8NB 4BD9B 9PTIA 4U32X 1PITA 1TOCR 5JB6A 2DDIA 5JB4A 1DTXA 3OFWA 3M7QB 3BYBA 3L3TE 1JV9A 2HEXA 2TPII 1BZXI 5JB5A 4WXVC 4BNRI 3BTGI 2UUXA 1P2MB 1CO7I 2PTCI 2TGPI 1YC0I 1AALA 6PTIA 2FI4I 1KTHA 1TFXC 2J6DA 3P95E 1CA0D 1G6XA 1TAPA 1KUNA 1T8LB 1FAKI 4NTWB 1D0DB 3BTTI 1BIKA 1UUAA 1BTIA 1DTKA 1YLDB 1LD6A 3AUEA 1T8MB 4WWYC 1P2KI 3BTHI 2KCRA 7PTIA 1K6UA 3OTJI 3AUGA 4PTIA 4Y0YI 1TPAI 1BPTA 2M01A 4NTXB 1BPIA 2ZVXA 2UUYB 1P2JI 3AUDA 1F5RI 1Y62A 3LDJA 4DTGK 1BTHP 3T62D 2DDJA 3TGJI 1YLCB 2JOTA 8PTIA 1IRHA 1JC6A 4BQDA 1JV8A 5JB7A 5PTIA 1BRCI 1T8OB 1OA55 4ISLB 1BHCA 3BTWI 3D65I 4Y0ZI 2W8XA 1AAPA 1P2II 4NTYB 1TCPA 3CI7A 2FTLI 1CBWD 3BTKI 1MTND 3BTQI 4Y11I 1EAWB 1BF0A 2KNTA 3L33E 4Y10I 3UIRC 4DG4C 3BTDI 1P2NB 2LFLA 1F7ZI 1LD5A 2KAII 3TPII 1KIGI 3FP6I 1DEMA 3WNYA 2IJOI 1YKTB 1OA65 1P2OB 1ADZA 4TPII 1T7CB 2FTMB 5C67C 2ZJXA 2R9PE 1FY8I 1DENA 1B0CA 3FP8I 1P2QB 3AUHA 2FI5I 1BZ5A 1D0DA 2CA7A 3AUIA 1TAWB 3LDMA 3LDIA 3U1JE
chains in the Genus database with same CATH superfamily
3AUCA 4U30W 1KNTA 1SHPA 3TGKI 3TGII 3FP7J 2FI3I 3GYMI 1FANA 2LFKA 1BUNB 1QLQA 2ODYE 1UUBA 2M99A 1NAGA 2RA3C 3UOUB 3P92E 3BTEI 4ISNB 1ZR0B 3AUBA 1BRBI 1ZJDB 1EJMB 3BTFI 3BTMI 4ISOB 1T8NB 4BD9B 9PTIA 4U32X 1PITA 1TOCR 5JB6A 2DDIA 5JB4A 1DTXA 3OFWA 3M7QB 3BYBA 3L3TE 1JV9A 2HEXA 2TPII 1BZXI 5JB5A 4WXVC 4BNRI 3BTGI 2UUXA 1P2MB 1CO7I 2PTCI 2TGPI 1YC0I 1AALA 6PTIA 2FI4I 1KTHA 1TFXC 2J6DA 3P95E 1CA0D 1G6XA 1TAPA 1KUNA 1T8LB 1FAKI 4NTWB 1D0DB 3BTTI 1BIKA 1UUAA 1BTIA 1DTKA 1YLDB 1LD6A 3AUEA 1T8MB 4WWYC 1P2KI 3BTHI 2KCRA 7PTIA 1K6UA 3OTJI 3AUGA 4PTIA 4Y0YI 1TPAI 1BPTA 2M01A 4NTXB 1BPIA 2ZVXA 2UUYB 1P2JI 3AUDA 1F5RI 1Y62A 3LDJA 4DTGK 1BTHP 3T62D 2DDJA 3TGJI 1YLCB 2JOTA 8PTIA 1IRHA 1JC6A 4BQDA 1JV8A 5JB7A 5PTIA 1BRCI 1T8OB 1OA55 4ISLB 1BHCA 3BTWI 3D65I 4Y0ZI 2W8XA 1AAPA 1P2II 4NTYB 1TCPA 3CI7A 2FTLI 1CBWD 3BTKI 1MTND 3BTQI 4Y11I 1EAWB 1BF0A 2KNTA 3L33E 4Y10I 3UIRC 4DG4C 3BTDI 1P2NB 2LFLA 1F7ZI 1LD5A 2KAII 3TPII 1KIGI 3FP6I 1DEMA 3WNYA 2IJOI 1YKTB 1OA65 1P2OB 1ADZA 4TPII 1T7CB 2FTMB 5C67C 2ZJXA 2R9PE 1FY8I 1DENA 1B0CA 3FP8I 1P2QB 3AUHA 2FI5I 1BZ5A 1D0DA 2CA7A 3AUIA 1TAWB 3LDMA 3LDIA 3U1JE
chains in the Genus database with same CATH topology
3AUCA 4U30W 1KNTA 1SHPA 3TGKI 3TGII 3FP7J 2FI3I 3GYMI 1FANA 2LFKA 1BUNB 1QLQA 2ODYE 1UUBA 2M99A 1NAGA 2RA3C 3UOUB 3P92E 3BTEI 4ISNB 1ZR0B 3AUBA 1BRBI 1ZJDB 1EJMB 3BTFI 3BTMI 4ISOB 1T8NB 4BD9B 9PTIA 4U32X 1PITA 1TOCR 5JB6A 2DDIA 5JB4A 1DTXA 3OFWA 3M7QB 3BYBA 3L3TE 1JV9A 2HEXA 2TPII 1BZXI 5JB5A 4WXVC 4BNRI 3BTGI 2UUXA 1P2MB 1CO7I 2PTCI 2TGPI 1YC0I 1AALA 6PTIA 2FI4I 1KTHA 1TFXC 2J6DA 3P95E 1CA0D 1G6XA 1TAPA 1KUNA 1T8LB 1FAKI 4NTWB 1D0DB 3BTTI 1BIKA 1UUAA 1BTIA 1DTKA 1YLDB 1LD6A 3AUEA 1T8MB 4WWYC 1P2KI 3BTHI 2KCRA 7PTIA 1K6UA 3OTJI 3AUGA 4PTIA 4Y0YI 1TPAI 1BPTA 2M01A 4NTXB 1BPIA 2ZVXA 2UUYB 1P2JI 3AUDA 1F5RI 1Y62A 3LDJA 4DTGK 1BTHP 3T62D 2DDJA 3TGJI 1YLCB 2JOTA 8PTIA 1IRHA 1JC6A 4BQDA 1JV8A 5JB7A 5PTIA 1BRCI 1T8OB 1OA55 4ISLB 1BHCA 3BTWI 3D65I 4Y0ZI 2W8XA 1AAPA 1P2II 4NTYB 1TCPA 3CI7A 2FTLI 1CBWD 3BTKI 1MTND 3BTQI 4Y11I 1EAWB 1BF0A 2KNTA 3L33E 4Y10I 3UIRC 4DG4C 3BTDI 1P2NB 2LFLA 1F7ZI 1LD5A 2KAII 3TPII 1KIGI 3FP6I 1DEMA 3WNYA 2IJOI 1YKTB 1OA65 1P2OB 1ADZA 4TPII 1T7CB 2FTMB 5C67C 2ZJXA 2R9PE 1FY8I 1DENA 1B0CA 3FP8I 1P2QB 3AUHA 2FI5I 1BZ5A 1D0DA 2CA7A 3AUIA 1TAWB 3LDMA 3LDIA 3U1JE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AUC A;  4U30 W;  1KNT A;  1SHP A;  3TGK I;  3TGI I;  3FP7 J;  2FI3 I;  3GYM I;  1FAN A;  2LFK A;  1BUN B;  1QLQ A;  2ODY E;  1UUB A;  2M99 A;  1NAG A;  2RA3 C;  3UOU B;  3P92 E;  3BTE I;  4ISN B;  1ZR0 B;  3AUB A;  1BRB I;  1ZJD B;  1EJM B;  3BTF I;  3BTM I;  4ISO B;  1T8N B;  4BD9 B;  9PTI A;  4U32 X;  1PIT A;  1TOC R;  5JB6 A;  2DDI A;  5JB4 A;  1DTX A;  3OFW A;  3M7Q B;  3BYB A;  3L3T E;  1JV9 A;  2HEX A;  2TPI I;  1BZX I;  5JB5 A;  4WXV C;  4BNR I;  3BTG I;  2UUX A;  1P2M B;  1CO7 I;  2PTC I;  2TGP I;  1YC0 I;  1AAL A;  6PTI A;  2FI4 I;  1KTH A;  1TFX C;  2J6D A;  3P95 E;  1CA0 D;  1G6X A;  1TAP A;  1KUN A;  1T8L B;  1FAK I;  4NTW B;  1D0D B;  3BTT I;  1BIK A;  1UUA A;  1BTI A;  1DTK A;  1YLD B;  1LD6 A;  3AUE A;  1T8M B;  4WWY C;  1P2K I;  3BTH I;  2KCR A;  7PTI A;  1K6U A;  3OTJ I;  3AUG A;  4PTI A;  4Y0Y I;  1TPA I;  1BPT A;  2M01 A;  4NTX B;  1BPI A;  2ZVX A;  2UUY B;  1P2J I;  3AUD A;  1F5R I;  1Y62 A;  3LDJ A;  4DTG K;  1BTH P;  3T62 D;  2DDJ A;  3TGJ I;  1YLC B;  2JOT A;  8PTI A;  1IRH A;  1JC6 A;  4BQD A;  1JV8 A;  5JB7 A;  5PTI A;  1BRC I;  1T8O B;  1OA5 5;  4ISL B;  1BHC A;  3BTW I;  3D65 I;  4Y0Z I;  2W8X A;  1AAP A;  1P2I I;  4NTY B;  1TCP A;  3CI7 A;  2FTL I;  1CBW D;  3BTK I;  1MTN D;  3BTQ I;  4Y11 I;  1EAW B;  1BF0 A;  2KNT A;  3L33 E;  4Y10 I;  3UIR C;  4DG4 C;  3BTD I;  1P2N B;  2LFL A;  1F7Z I;  1LD5 A;  2KAI I;  3TPI I;  1KIG I;  3FP6 I;  1DEM A;  3WNY A;  2IJO I;  1YKT B;  1OA6 5;  1P2O B;  1ADZ A;  4TPI I;  1T7C B;  2FTM B;  5C67 C;  2ZJX A;  2R9P E;  1FY8 I;  1DEN A;  1B0C A;  3FP8 I;  1P2Q B;  3AUH A;  2FI5 I;  1BZ5 A;  1D0D A;  2CA7 A;  3AUI A;  1TAW B;  3LDM A;  3LDI A;  3U1J E; 
#chains in the Genus database with same CATH topology
 3AUC A;  4U30 W;  1KNT A;  1SHP A;  3TGK I;  3TGI I;  3FP7 J;  2FI3 I;  3GYM I;  1FAN A;  2LFK A;  1BUN B;  1QLQ A;  2ODY E;  1UUB A;  2M99 A;  1NAG A;  2RA3 C;  3UOU B;  3P92 E;  3BTE I;  4ISN B;  1ZR0 B;  3AUB A;  1BRB I;  1ZJD B;  1EJM B;  3BTF I;  3BTM I;  4ISO B;  1T8N B;  4BD9 B;  9PTI A;  4U32 X;  1PIT A;  1TOC R;  5JB6 A;  2DDI A;  5JB4 A;  1DTX A;  3OFW A;  3M7Q B;  3BYB A;  3L3T E;  1JV9 A;  2HEX A;  2TPI I;  1BZX I;  5JB5 A;  4WXV C;  4BNR I;  3BTG I;  2UUX A;  1P2M B;  1CO7 I;  2PTC I;  2TGP I;  1YC0 I;  1AAL A;  6PTI A;  2FI4 I;  1KTH A;  1TFX C;  2J6D A;  3P95 E;  1CA0 D;  1G6X A;  1TAP A;  1KUN A;  1T8L B;  1FAK I;  4NTW B;  1D0D B;  3BTT I;  1BIK A;  1UUA A;  1BTI A;  1DTK A;  1YLD B;  1LD6 A;  3AUE A;  1T8M B;  4WWY C;  1P2K I;  3BTH I;  2KCR A;  7PTI A;  1K6U A;  3OTJ I;  3AUG A;  4PTI A;  4Y0Y I;  1TPA I;  1BPT A;  2M01 A;  4NTX B;  1BPI A;  2ZVX A;  2UUY B;  1P2J I;  3AUD A;  1F5R I;  1Y62 A;  3LDJ A;  4DTG K;  1BTH P;  3T62 D;  2DDJ A;  3TGJ I;  1YLC B;  2JOT A;  8PTI A;  1IRH A;  1JC6 A;  4BQD A;  1JV8 A;  5JB7 A;  5PTI A;  1BRC I;  1T8O B;  1OA5 5;  4ISL B;  1BHC A;  3BTW I;  3D65 I;  4Y0Z I;  2W8X A;  1AAP A;  1P2I I;  4NTY B;  1TCP A;  3CI7 A;  2FTL I;  1CBW D;  3BTK I;  1MTN D;  3BTQ I;  4Y11 I;  1EAW B;  1BF0 A;  2KNT A;  3L33 E;  4Y10 I;  3UIR C;  4DG4 C;  3BTD I;  1P2N B;  2LFL A;  1F7Z I;  1LD5 A;  2KAI I;  3TPI I;  1KIG I;  3FP6 I;  1DEM A;  3WNY A;  2IJO I;  1YKT B;  1OA6 5;  1P2O B;  1ADZ A;  4TPI I;  1T7C B;  2FTM B;  5C67 C;  2ZJX A;  2R9P E;  1FY8 I;  1DEN A;  1B0C A;  3FP8 I;  1P2Q B;  3AUH A;  2FI5 I;  1BZ5 A;  1D0D A;  2CA7 A;  3AUI A;  1TAW B;  3LDM A;  3LDI A;  3U1J E; 
#chains in the Genus database with same CATH homology
 3AUC A;  4U30 W;  1KNT A;  1SHP A;  3TGK I;  3TGI I;  3FP7 J;  2FI3 I;  3GYM I;  1FAN A;  2LFK A;  1BUN B;  1QLQ A;  2ODY E;  1UUB A;  2M99 A;  1NAG A;  2RA3 C;  3UOU B;  3P92 E;  3BTE I;  4ISN B;  1ZR0 B;  3AUB A;  1BRB I;  1ZJD B;  1EJM B;  3BTF I;  3BTM I;  4ISO B;  1T8N B;  4BD9 B;  9PTI A;  4U32 X;  1PIT A;  1TOC R;  5JB6 A;  2DDI A;  5JB4 A;  1DTX A;  3OFW A;  3M7Q B;  3BYB A;  3L3T E;  1JV9 A;  2HEX A;  2TPI I;  1BZX I;  5JB5 A;  4WXV C;  4BNR I;  3BTG I;  2UUX A;  1P2M B;  1CO7 I;  2PTC I;  2TGP I;  1YC0 I;  1AAL A;  6PTI A;  2FI4 I;  1KTH A;  1TFX C;  2J6D A;  3P95 E;  1CA0 D;  1G6X A;  1TAP A;  1KUN A;  1T8L B;  1FAK I;  4NTW B;  1D0D B;  3BTT I;  1BIK A;  1UUA A;  1BTI A;  1DTK A;  1YLD B;  1LD6 A;  3AUE A;  1T8M B;  4WWY C;  1P2K I;  3BTH I;  2KCR A;  7PTI A;  1K6U A;  3OTJ I;  3AUG A;  4PTI A;  4Y0Y I;  1TPA I;  1BPT A;  2M01 A;  4NTX B;  1BPI A;  2ZVX A;  2UUY B;  1P2J I;  3AUD A;  1F5R I;  1Y62 A;  3LDJ A;  4DTG K;  1BTH P;  3T62 D;  2DDJ A;  3TGJ I;  1YLC B;  2JOT A;  8PTI A;  1IRH A;  1JC6 A;  4BQD A;  1JV8 A;  5JB7 A;  5PTI A;  1BRC I;  1T8O B;  1OA5 5;  4ISL B;  1BHC A;  3BTW I;  3D65 I;  4Y0Z I;  2W8X A;  1AAP A;  1P2I I;  4NTY B;  1TCP A;  3CI7 A;  2FTL I;  1CBW D;  3BTK I;  1MTN D;  3BTQ I;  4Y11 I;  1EAW B;  1BF0 A;  2KNT A;  3L33 E;  4Y10 I;  3UIR C;  4DG4 C;  3BTD I;  1P2N B;  2LFL A;  1F7Z I;  1LD5 A;  2KAI I;  3TPI I;  1KIG I;  3FP6 I;  1DEM A;  3WNY A;  2IJO I;  1YKT B;  1OA6 5;  1P2O B;  1ADZ A;  4TPI I;  1T7C B;  2FTM B;  5C67 C;  2ZJX A;  2R9P E;  1FY8 I;  1DEN A;  1B0C A;  3FP8 I;  1P2Q B;  3AUH A;  2FI5 I;  1BZ5 A;  1D0D A;  2CA7 A;  3AUI A;  1TAW B;  3LDM A;  3LDI A;  3U1J E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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