5TMCE

Re-refinement of thermus thermopiles dna-directed rna polymerase structure
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title On the validation of crystallographic symmetry and the quality of structures.
pubmed doi rcsb
molecule tags Transferase
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 18
structure length 95
sequence length 95
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2016-10-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 5tmcE00
4JK1E 1QKLA 3CQZF 3GTJF 4OINE 4C2MF 4YFKE 2A69E 1TWAF 2NVQF 2R7ZF 3S2DF 5TMCE 4G7HE 1K83F 3GTOF 4A3GF 2Y0SI 4A3EF 4BY1F 5C4XF 4A3IF 1Y1VF 4LK0E 3RZDF 4LK1E 4A3CF 2CW0E 4A3JF 2JA5F 4GZYE 1R9TF 4C3JF 4A3MF 5M5XF 3H3VG 5E17E 5C44F 2R93F 4YG2E 3DXJE 5IYDF 5FJ8F 2YU9F 3PO3F 1SMYE 5IYCF 1TWFF 2O5IE 5M3MF 3HKZK 2VUMF 3RZOF 3GTKF 4C3IF 3EQLE 4A3FF 1HQME 4KN4E 4G7ZE 1YNNK 3S1RF 3S14F 5FLMF 3GTGF 4XSXE 3FKIF 2WB1I 1Y1WF 2JA6F 4XLNE 3S1MF 2E2JF 1I6HF 5D4EE 3S1QF 2PMZK 5M5YF 4KN7E 3S17F 1ZYRE 4XSZE 4MEXE 3HOYF 4LLGE 4Y7NF 3S16F 4MQ9E 3S2HF 3GTPF 2O5JE 4A3DF 2NVYF 1IW7E 1SFOF 3WODE 5M5WF 3HOVF 1YNJK 4AYBK 3GTLF 2B63F 5E18E 1I6VE 4OIQE 4ZH4E 5IPLE 2A68E 3I4NF 5IP7F 1TWGF 4LJZE 2A6EE 4A3LF 4A3BF 4MEYE 4C3HF 4BBSF 4A93F 5D4CE 1WCMF 4BY7F 3HOXF 4BXXF 2PPBE 1I50F 1TWHF 4OIPE 2E2IF 3I4MF 3H0GF 5BYHE 4KMUE 4Q4ZE 4X6AF 4BBRF 2JA7F 4XLPE 2JA8F 5C4JF 4OIRE 5C3EF 3GTMF 1TWCF 4YFNE 5TMFE 3S15F 3HOZF 3K7AF 2R92F 4G7OE 3M4OF 4YFXE 5D4DE 2NVTF 4Y52F 5IP9F 4OIOE 3S1NF 2WAQK 3HOUF 5M3FF 2E2HF 2A6HE 5IYBF 2NVXF 3PO2F 3M3YF 4Q5SE 3HOWF 2BE5E 4A3KF 3GTQF 1I3QF
chains in the Genus database with same CATH superfamily
4JK1E 1QKLA 3CQZF 4BBRE 4C2ME 3GTJF 4OINE 2JA7E 2NVQE 2R7ZE 3S2DE 4C2MF 4YFKE 2A69E 1TWAF 1K83E 2NVQF 2R7ZF 3S2DF 5TMCE 4G7HE 1K83F 3GTOF 4A3GE 3S15E 3HOZE 4A3EE 3K7AE 5C4XE 4A3GF 4AYBH 4A3IE 2Y0SI 4A3EF 4BY1F 2WB1H 1Y1VE 5C4XF 2NVTE 4A3IF 3RZDE 4A3CE 3HKZH 5IP9E 1Y1VF 4LK0E 3RZDF 4LK1E 4A3CF 2CW0E 1R9TE 4C3JE 4A3ME 4A3JF 5M5XE 2JA5F 4GZYE 1R9TF 4C3JF 4A3MF 5M5XF 3H3VG 5C44E 2R93E 5E17E 2PMZH 5C44F 2R93F 4YG2E 5IYDE 5FJ8E 1TWAE 2YU9E 3PO3E 3DXJE 5IYDF 5FJ8F 5IYCE 2YU9F 2VUME 1SMYE 5M3ME 3GTOE 5IYCF 1TWFF 3GTKE 3PO3F 2O5IE 5M3MF 3HKZK 2VUMF 3RZOF 3GTKF 4A3FE 4C3IF 3S1RE 4BY1E 3S14E 5FLME 1DZFA 2KRXA 3EQLE 4A3FF 3GTGE 1HQME 4KN4E 4G7ZE 1YNNK 3S1RF 3S14F 5FLMF 3GTGF 2JA6E 4XSXE 3FKIF 1EIKA 3S1ME 1I6HE 4A3JE 2WB1I 1Y1WF 5M5YE 2JA6F 2JA5E 4XLNE 3HOYE 3S1MF 3S1QE 4Y7NE 2E2JF 5D4EE 1I6HF 2PMZK 4KN7E 5M5YF 3S16E 1ZYRE 4XSZE 4MEXE 3S17F 4LLGE 4Y7NF 3S16F 3HOYF 3S2HE 3GTPE 4A3DE 4MQ9E 1SFOE 3S2HF 3GTPF 2O5JE 4A3DF 2NVYF 4QIWH 1IW7E 1SFOF 5M5WE 3WODE 5M5WF 3GTLE 3HOVF 2B63E 1TWFE 3GTJE 1YNJK 4AYBK 3GTLF 2B63F 3RZOE 5E18E 3I4NE 1I6VE 4C3IE 5IP7E 4OIQE 1TWGE 4ZH4E 5IPLE 2A68E 3I4NF 5IP7F 4A3LE 1TWGF 4A3BE 4LJZE 2A6EE 4C3HE 4A3LF 3S1QF 4A93E 3FKIE 4A3BF 4MEYE 1WCME 4C3HF 4BBSF 1Y1WE 3HOXE 4A93F 4BXXE 1I50E 1WCMF 1TWHE 5D4CE 2E2JE 4BY7F 3HOXF 3S17E 3I4ME 3H0GE 2WAQH 2PPBE 1I50F 4BXXF 1TWHF 4OIPE 2E2IF 3I4MF 4QIWK 3H0GF 5BYHE 4X6AE 4KMUE 2NVYE 4Q4ZE 4X6AF 2JA8E 5C4JE 4BBRF 3GTME 5C3EE 2JA7F 4XLPE 1TWCE 2JA8F 2Y0SH 5C4JF 3HOVE 4OIRE 5C3EF 3GTMF 1TWCF 4YFNE 5TMFE 2R92E 3S15F 3HOZF 3K7AF 3M4OE 2R92F 4G7OE 4Y52E 3M4OF 4YFXE 3S1NE 5D4DE 2NVTF 4Y52F 5M3FE 3HOUE 5IP9F 2E2HE 4OIOE 5IYBE 2NVXE 3S1NF 4BBSE 2WAQK 3HOUF 5M3FF 2E2HF 3M3YE 2A6HE 5IYBF 2NVXF 3PO2E 3HOWE 4BY7E 3PO2F 3M3YF 4A3KE 4Q5SE 2E2IE 3HOWF 3GTQE 2BE5E 3H3VF 4A3KF 1I3QE 3GTQF 3CQZE 1I3QF
chains in the Genus database with same CATH topology
4JK1E 1QKLA 3CQZF 3GTJF 4OINE 4C2MF 4YFKE 2A69E 1TWAF 2NVQF 2R7ZF 3S2DF 5TMCE 4G7HE 1K83F 3GTOF 4A3GF 2Y0SI 4A3EF 4BY1F 5C4XF 4A3IF 1Y1VF 4LK0E 3RZDF 4LK1E 4A3CF 2CW0E 4A3JF 2JA5F 4GZYE 1R9TF 4C3JF 4A3MF 5M5XF 3H3VG 5E17E 5C44F 2R93F 4YG2E 3DXJE 5IYDF 5FJ8F 2YU9F 3PO3F 1SMYE 5IYCF 1TWFF 2O5IE 5M3MF 3HKZK 2VUMF 3RZOF 3GTKF 4C3IF 3EQLE 2KRXA 4A3FF 1HQME 4KN4E 4G7ZE 1YNNK 3S1RF 3S14F 5FLMF 3GTGF 4XSXE 3FKIF 2WB1I 1Y1WF 2JA6F 4XLNE 3S1MF 2E2JF 1I6HF 5D4EE 3S1QF 2PMZK 4KN7E 5M5YF 3S17F 1ZYRE 4XSZE 4MEXE 3HOYF 4LLGE 4Y7NF 3S16F 4MQ9E 3S2HF 3GTPF 2O5JE 4A3DF 2NVYF 1IW7E 1SFOF 3WODE 5M5WF 3HOVF 1YNJK 4AYBK 3GTLF 2B63F 5E18E 1I6VE 4OIQE 4ZH4E 5IPLE 2A68E 3I4NF 5IP7F 1TWGF 4LJZE 2A6EE 4A3LF 4A3BF 4MEYE 4C3HF 4BBSF 4A93F 5D4CE 1WCMF 4BY7F 3HOXF 4BXXF 2PPBE 1I50F 1TWHF 4OIPE 2E2IF 3I4MF 4QIWK 3H0GF 5BYHE 4KMUE 4Q4ZE 4X6AF 4BBRF 2JA7F 4XLPE 2JA8F 5C4JF 4OIRE 5C3EF 3GTMF 1TWCF 4YFNE 5TMFE 3S15F 3HOZF 3K7AF 2R92F 4G7OE 3M4OF 4YFXE 5D4DE 2NVTF 4Y52F 5IP9F 4OIOE 3S1NF 2WAQK 3HOUF 5M3FF 2E2HF 2A6HE 5IYBF 2NVXF 3PO2F 3M3YF 4Q5SE 3HOWF 2BE5E 4A3KF 3GTQF 1I3QF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JK1 E;  1QKL A;  3CQZ F;  3GTJ F;  4OIN E;  4C2M F;  4YFK E;  2A69 E;  1TWA F;  2NVQ F;  2R7Z F;  3S2D F;  5TMC E;  4G7H E;  1K83 F;  3GTO F;  4A3G F;  2Y0S I;  4A3E F;  4BY1 F;  5C4X F;  4A3I F;  1Y1V F;  4LK0 E;  3RZD F;  4LK1 E;  4A3C F;  2CW0 E;  4A3J F;  2JA5 F;  4GZY E;  1R9T F;  4C3J F;  4A3M F;  5M5X F;  3H3V G;  5E17 E;  5C44 F;  2R93 F;  4YG2 E;  3DXJ E;  5IYD F;  5FJ8 F;  2YU9 F;  3PO3 F;  1SMY E;  5IYC F;  1TWF F;  2O5I E;  5M3M F;  3HKZ K;  2VUM F;  3RZO F;  3GTK F;  4C3I F;  3EQL E;  4A3F F;  1HQM E;  4KN4 E;  4G7Z E;  1YNN K;  3S1R F;  3S14 F;  5FLM F;  3GTG F;  4XSX E;  3FKI F;  2WB1 I;  1Y1W F;  2JA6 F;  4XLN E;  3S1M F;  2E2J F;  1I6H F;  5D4E E;  3S1Q F;  2PMZ K;  5M5Y F;  4KN7 E;  3S17 F;  1ZYR E;  4XSZ E;  4MEX E;  3HOY F;  4LLG E;  4Y7N F;  3S16 F;  4MQ9 E;  3S2H F;  3GTP F;  2O5J E;  4A3D F;  2NVY F;  1IW7 E;  1SFO F;  3WOD E;  5M5W F;  3HOV F;  1YNJ K;  4AYB K;  3GTL F;  2B63 F;  5E18 E;  1I6V E;  4OIQ E;  4ZH4 E;  5IPL E;  2A68 E;  3I4N F;  5IP7 F;  1TWG F;  4LJZ E;  2A6E E;  4A3L F;  4A3B F;  4MEY E;  4C3H F;  4BBS F;  4A93 F;  5D4C E;  1WCM F;  4BY7 F;  3HOX F;  4BXX F;  2PPB E;  1I50 F;  1TWH F;  4OIP E;  2E2I F;  3I4M F;  3H0G F;  5BYH E;  4KMU E;  4Q4Z E;  4X6A F;  4BBR F;  2JA7 F;  4XLP E;  2JA8 F;  5C4J F;  4OIR E;  5C3E F;  3GTM F;  1TWC F;  4YFN E;  5TMF E;  3S15 F;  3HOZ F;  3K7A F;  2R92 F;  4G7O E;  3M4O F;  4YFX E;  5D4D E;  2NVT F;  4Y52 F;  5IP9 F;  4OIO E;  3S1N F;  2WAQ K;  3HOU F;  5M3F F;  2E2H F;  2A6H E;  5IYB F;  2NVX F;  3PO2 F;  3M3Y F;  4Q5S E;  3HOW F;  2BE5 E;  4A3K F;  3GTQ F;  1I3Q F; 
#chains in the Genus database with same CATH topology
 4JK1 E;  1QKL A;  3CQZ F;  4BBR E;  4C2M E;  3GTJ F;  4OIN E;  2JA7 E;  2NVQ E;  2R7Z E;  3S2D E;  4C2M F;  4YFK E;  2A69 E;  1TWA F;  1K83 E;  2NVQ F;  2R7Z F;  3S2D F;  5TMC E;  4G7H E;  1K83 F;  3GTO F;  4A3G E;  3S15 E;  3HOZ E;  4A3E E;  3K7A E;  5C4X E;  4A3G F;  4AYB H;  4A3I E;  2Y0S I;  4A3E F;  4BY1 F;  2WB1 H;  1Y1V E;  5C4X F;  2NVT E;  4A3I F;  3RZD E;  4A3C E;  3HKZ H;  5IP9 E;  1Y1V F;  4LK0 E;  3RZD F;  4LK1 E;  4A3C F;  2CW0 E;  1R9T E;  4C3J E;  4A3M E;  4A3J F;  5M5X E;  2JA5 F;  4GZY E;  1R9T F;  4C3J F;  4A3M F;  5M5X F;  3H3V G;  5C44 E;  2R93 E;  5E17 E;  2PMZ H;  5C44 F;  2R93 F;  4YG2 E;  5IYD E;  5FJ8 E;  1TWA E;  2YU9 E;  3PO3 E;  3DXJ E;  5IYD F;  5FJ8 F;  5IYC E;  2YU9 F;  2VUM E;  1SMY E;  5M3M E;  3GTO E;  5IYC F;  1TWF F;  3GTK E;  3PO3 F;  2O5I E;  5M3M F;  3HKZ K;  2VUM F;  3RZO F;  3GTK F;  4A3F E;  4C3I F;  3S1R E;  4BY1 E;  3S14 E;  5FLM E;  1DZF A;  2KRX A;  3EQL E;  4A3F F;  3GTG E;  1HQM E;  4KN4 E;  4G7Z E;  1YNN K;  3S1R F;  3S14 F;  5FLM F;  3GTG F;  2JA6 E;  4XSX E;  3FKI F;  1EIK A;  3S1M E;  1I6H E;  4A3J E;  2WB1 I;  1Y1W F;  5M5Y E;  2JA6 F;  2JA5 E;  4XLN E;  3HOY E;  3S1M F;  3S1Q E;  4Y7N E;  2E2J F;  5D4E E;  1I6H F;  2PMZ K;  4KN7 E;  5M5Y F;  3S16 E;  1ZYR E;  4XSZ E;  4MEX E;  3S17 F;  4LLG E;  4Y7N F;  3S16 F;  3HOY F;  3S2H E;  3GTP E;  4A3D E;  4MQ9 E;  1SFO E;  3S2H F;  3GTP F;  2O5J E;  4A3D F;  2NVY F;  4QIW H;  1IW7 E;  1SFO F;  5M5W E;  3WOD E;  5M5W F;  3GTL E;  3HOV F;  2B63 E;  1TWF E;  3GTJ E;  1YNJ K;  4AYB K;  3GTL F;  2B63 F;  3RZO E;  5E18 E;  3I4N E;  1I6V E;  4C3I E;  5IP7 E;  4OIQ E;  1TWG E;  4ZH4 E;  5IPL E;  2A68 E;  3I4N F;  5IP7 F;  4A3L E;  1TWG F;  4A3B E;  4LJZ E;  2A6E E;  4C3H E;  4A3L F;  3S1Q F;  4A93 E;  3FKI E;  4A3B F;  4MEY E;  1WCM E;  4C3H F;  4BBS F;  1Y1W E;  3HOX E;  4A93 F;  4BXX E;  1I50 E;  1WCM F;  1TWH E;  5D4C E;  2E2J E;  4BY7 F;  3HOX F;  3S17 E;  3I4M E;  3H0G E;  2WAQ H;  2PPB E;  1I50 F;  4BXX F;  1TWH F;  4OIP E;  2E2I F;  3I4M F;  4QIW K;  3H0G F;  5BYH E;  4X6A E;  4KMU E;  2NVY E;  4Q4Z E;  4X6A F;  2JA8 E;  5C4J E;  4BBR F;  3GTM E;  5C3E E;  2JA7 F;  4XLP E;  1TWC E;  2JA8 F;  2Y0S H;  5C4J F;  3HOV E;  4OIR E;  5C3E F;  3GTM F;  1TWC F;  4YFN E;  5TMF E;  2R92 E;  3S15 F;  3HOZ F;  3K7A F;  3M4O E;  2R92 F;  4G7O E;  4Y52 E;  3M4O F;  4YFX E;  3S1N E;  5D4D E;  2NVT F;  4Y52 F;  5M3F E;  3HOU E;  5IP9 F;  2E2H E;  4OIO E;  5IYB E;  2NVX E;  3S1N F;  4BBS E;  2WAQ K;  3HOU F;  5M3F F;  2E2H F;  3M3Y E;  2A6H E;  5IYB F;  2NVX F;  3PO2 E;  3HOW E;  4BY7 E;  3PO2 F;  3M3Y F;  4A3K E;  4Q5S E;  2E2I E;  3HOW F;  3GTQ E;  2BE5 E;  3H3V F;  4A3K F;  1I3Q E;  3GTQ F;  3CQZ E;  1I3Q F; 
#chains in the Genus database with same CATH homology
 4JK1 E;  1QKL A;  3CQZ F;  3GTJ F;  4OIN E;  4C2M F;  4YFK E;  2A69 E;  1TWA F;  2NVQ F;  2R7Z F;  3S2D F;  5TMC E;  4G7H E;  1K83 F;  3GTO F;  4A3G F;  2Y0S I;  4A3E F;  4BY1 F;  5C4X F;  4A3I F;  1Y1V F;  4LK0 E;  3RZD F;  4LK1 E;  4A3C F;  2CW0 E;  4A3J F;  2JA5 F;  4GZY E;  1R9T F;  4C3J F;  4A3M F;  5M5X F;  3H3V G;  5E17 E;  5C44 F;  2R93 F;  4YG2 E;  3DXJ E;  5IYD F;  5FJ8 F;  2YU9 F;  3PO3 F;  1SMY E;  5IYC F;  1TWF F;  2O5I E;  5M3M F;  3HKZ K;  2VUM F;  3RZO F;  3GTK F;  4C3I F;  3EQL E;  2KRX A;  4A3F F;  1HQM E;  4KN4 E;  4G7Z E;  1YNN K;  3S1R F;  3S14 F;  5FLM F;  3GTG F;  4XSX E;  3FKI F;  2WB1 I;  1Y1W F;  2JA6 F;  4XLN E;  3S1M F;  2E2J F;  1I6H F;  5D4E E;  3S1Q F;  2PMZ K;  4KN7 E;  5M5Y F;  3S17 F;  1ZYR E;  4XSZ E;  4MEX E;  3HOY F;  4LLG E;  4Y7N F;  3S16 F;  4MQ9 E;  3S2H F;  3GTP F;  2O5J E;  4A3D F;  2NVY F;  1IW7 E;  1SFO F;  3WOD E;  5M5W F;  3HOV F;  1YNJ K;  4AYB K;  3GTL F;  2B63 F;  5E18 E;  1I6V E;  4OIQ E;  4ZH4 E;  5IPL E;  2A68 E;  3I4N F;  5IP7 F;  1TWG F;  4LJZ E;  2A6E E;  4A3L F;  4A3B F;  4MEY E;  4C3H F;  4BBS F;  4A93 F;  5D4C E;  1WCM F;  4BY7 F;  3HOX F;  4BXX F;  2PPB E;  1I50 F;  1TWH F;  4OIP E;  2E2I F;  3I4M F;  4QIW K;  3H0G F;  5BYH E;  4KMU E;  4Q4Z E;  4X6A F;  4BBR F;  2JA7 F;  4XLP E;  2JA8 F;  5C4J F;  4OIR E;  5C3E F;  3GTM F;  1TWC F;  4YFN E;  5TMF E;  3S15 F;  3HOZ F;  3K7A F;  2R92 F;  4G7O E;  3M4O F;  4YFX E;  5D4D E;  2NVT F;  4Y52 F;  5IP9 F;  4OIO E;  3S1N F;  2WAQ K;  3HOU F;  5M3F F;  2E2H F;  2A6H E;  5IYB F;  2NVX F;  3PO2 F;  3M3Y F;  4Q5S E;  3HOW F;  2BE5 E;  4A3K F;  3GTQ F;  1I3Q F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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