1XNZA

Crystal structure of mn(ii) form of e. coli. methionine aminopeptidase in complex with 5-(2-chlorophenyl)furan-2-carboxylic acid
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Metalloform-Selective Inhibitors of Escherichia coli Methionine Aminopeptidase and X-ray Structure of a Mn(II)-Form Enzyme Complexed with an Inhibitor.
pubmed doi rcsb
source organism Escherichia coli
total genus 90
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2004-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1xnzA00
1C24A 1WN1A 4PV4A 4U69A 2BWVA 2GGBA 5CIKA 2ADUA 1XNZA 5CDEA 2Q96A 1R5GA 4OOKA 4KM3A 1MATA 3PKEA 2B3KA 5CE6A 4S2RP 1WBQA 3PKCA 4U6WA 2GG5A 1C21A 1N51A 1YW9A 3FMQA 1Y1NA 2EVOA 1BOAA 3MATA 5D6EA 1A16A 1WLRA 2BN7A 2V3XA 1JAWA 1CHMA 2B3LA 4EGEA 1O0XA 4IPAA 3TAVA 3IG4A 4IF7A 1YJ3A 2EVCA 1C22A 4MATA 2ZSGA 4U73A 5JI6A 2BWTA 2P99A 4S00A 1KP0A 4HXXA 3L24A 5CDLA 2BHAA 1BN5A 4FLKA 3CB5A 4FUKA 4IDYA 2GG8A 2Q93A 2GTXA 2GG3A 4U6JA 2Q92A 2BHCA 1B6AA 4FO8A 3IU7A 2GZ5A 2BHBA 1R5HA 1C23A 2NQ7A 2GG0A 2OKNA 1KQ0A 3MX6A 4U76A 4ZWUA 4U6EA 4R60A 5D6FA 5CDVA 2BWWA 4U6CA 1R58A 2IW2A 1WKMA 4ZWPA 1WY2A 2V3YA 4IECA 3TB5A 4RZZA 4Z7MA 4FLJA 2EA4A 4S2TP 1XGOA 2B3HA 2NQ6A 1QXYA 2BB7A 3FMRA 2GG2A 2Q95A 2P9AA 4U75A 3S6BA 2BWUA 1QZYA 1PV9A 4IKTA 4A6WA 4IKRA 2BWSA 1XGNA 1YW7A 4FKCA 4U70A 2BWYA 2G6PA 2GA2A 1YW8A 3D27A 4ZNGA 3PKAA 2Q8KA 2BH3A 5E5BA 4A6VA 2V6CA 3PKDA 4IKSA 5CNXA 3MR1A 4U71A 5JFRA 1YVMA 4RGZ1 2HOWA 1WL6A 1WL9A 2GU4A 4PNCA 3FM3A 4RZYA 2OAZA 3L7GA 2GU5A 2V3ZA 5JHUA 3RVAA 2DFIA 1W7VA 4QR8A 5CLSA 2GU7A 2P98A 4U6ZA 1QXZA 2Q94A 3CB6A 3BITA 1QXWA 5FCFA 3RORA 5FCHA 4FO7A 2GG9A 2BHDA 2EVMA 4FLIA 4B28A 4IU6A 4FLLA 1XGMA 3IU8A 3IU9A 3BIPA 4ZWOA 3BIQA 1W2MA 3Q6DA 4JUQA 1M35A 4U1BA 3CTZA 2MATA 1C27A 2GGCA 2GG7A 4IKUA 2EA2A 3PKBA 2BWXA 4S01A 2GU6A 1KQ9A 1XGSA 1B59A
chains in the Genus database with same CATH superfamily
1C24A 1WN1A 4PV4A 4U69A 2BWVA 2GGBA 5CIKA 2ADUA 1XNZA 5CDEA 2Q96A 1R5GA 4OOKA 4KM3A 1MATA 3PKEA 2B3KA 5CE6A 4S2RP 1WBQA 3PKCA 4U6WA 2GG5A 1C21A 1N51A 1YW9A 3FMQA 1Y1NA 2EVOA 1BOAA 3MATA 5D6EA 1A16A 1WLRA 2BN7A 2V3XA 1JAWA 1CHMA 2B3LA 4EGEA 1O0XA 4IPAA 3TAVA 3IG4A 4IF7A 1YJ3A 2EVCA 1C22A 4MATA 2ZSGA 4U73A 5JI6A 2BWTA 2P99A 4S00A 1KP0A 4HXXA 3L24A 5CDLA 2BHAA 1BN5A 4FLKA 3CB5A 4FUKA 4IDYA 2GG8A 2Q93A 2GTXA 2GG3A 4U6JA 2Q92A 2BHCA 1B6AA 4FO8A 3IU7A 2GZ5A 2BHBA 1R5HA 1C23A 2NQ7A 2GG0A 2OKNA 1KQ0A 3MX6A 4U76A 4ZWUA 4U6EA 4R60A 5D6FA 5CDVA 2BWWA 4U6CA 1R58A 2IW2A 1WKMA 4ZWPA 1WY2A 2V3YA 4IECA 3TB5A 4RZZA 4Z7MA 4FLJA 2EA4A 4S2TP 1XGOA 2B3HA 2NQ6A 1QXYA 2BB7A 3FMRA 2GG2A 2Q95A 2P9AA 4U75A 3S6BA 2BWUA 1QZYA 1PV9A 4IKTA 4A6WA 4IKRA 2BWSA 1XGNA 1YW7A 4FKCA 4U70A 2BWYA 2G6PA 2GA2A 1YW8A 3D27A 4ZNGA 3PKAA 2Q8KA 2BH3A 5E5BA 4A6VA 2V6CA 3PKDA 4IKSA 5CNXA 3MR1A 4U71A 5JFRA 1YVMA 4RGZ1 2HOWA 1WL6A 1WL9A 2GU4A 4PNCA 3FM3A 4RZYA 2OAZA 3L7GA 2GU5A 2V3ZA 5JHUA 3RVAA 2DFIA 1W7VA 4QR8A 5CLSA 2GU7A 2P98A 4U6ZA 1QXZA 2Q94A 3CB6A 3BITA 1QXWA 5FCFA 3RORA 5FCHA 4FO7A 2GG9A 2BHDA 2EVMA 4FLIA 4B28A 4IU6A 4FLLA 1XGMA 3IU8A 3IU9A 3BIPA 4ZWOA 3BIQA 1W2MA 3Q6DA 4JUQA 1M35A 4U1BA 3CTZA 2MATA 1C27A 2GGCA 2GG7A 4IKUA 2EA2A 3PKBA 2BWXA 4S01A 2GU6A 1KQ9A 1XGSA 1B59A
chains in the Genus database with same CATH topology
1C24A 1WN1A 4PV4A 4U69A 2BWVA 2GGBA 5CIKA 2ADUA 1XNZA 5CDEA 2Q96A 1R5GA 4OOKA 4KM3A 1MATA 3PKEA 2B3KA 5CE6A 4S2RP 1WBQA 3PKCA 4U6WA 2GG5A 1C21A 1N51A 1YW9A 3FMQA 1Y1NA 2EVOA 1BOAA 3MATA 5D6EA 1A16A 1WLRA 2BN7A 2V3XA 1JAWA 1CHMA 2B3LA 4EGEA 1O0XA 4IPAA 3TAVA 3IG4A 4IF7A 1YJ3A 2EVCA 1C22A 4MATA 2ZSGA 4U73A 5JI6A 2BWTA 2P99A 4S00A 1KP0A 4HXXA 3L24A 5CDLA 2BHAA 1BN5A 4FLKA 3CB5A 4FUKA 4IDYA 2GG8A 2Q93A 2GTXA 2GG3A 4U6JA 2Q92A 2BHCA 1B6AA 4FO8A 3IU7A 2GZ5A 2BHBA 1R5HA 1C23A 2NQ7A 2GG0A 2OKNA 1KQ0A 3MX6A 4U76A 4ZWUA 4U6EA 4R60A 5D6FA 5CDVA 2BWWA 4U6CA 1R58A 2IW2A 1WKMA 4ZWPA 1WY2A 2V3YA 4IECA 3TB5A 4RZZA 4Z7MA 4FLJA 2EA4A 4S2TP 1XGOA 2B3HA 2NQ6A 1QXYA 2BB7A 3FMRA 2GG2A 2Q95A 2P9AA 4U75A 3S6BA 2BWUA 1QZYA 1PV9A 4IKTA 4A6WA 4IKRA 2BWSA 1XGNA 1YW7A 4FKCA 4U70A 2BWYA 2G6PA 2GA2A 1YW8A 3D27A 4ZNGA 3PKAA 2Q8KA 2BH3A 5E5BA 4A6VA 2V6CA 3PKDA 4IKSA 5CNXA 3MR1A 4U71A 5JFRA 1YVMA 4RGZ1 2HOWA 1WL6A 1WL9A 2GU4A 4PNCA 3FM3A 4RZYA 2OAZA 3L7GA 2GU5A 2V3ZA 5JHUA 3RVAA 2DFIA 1W7VA 4QR8A 5CLSA 2GU7A 2P98A 4U6ZA 1QXZA 2Q94A 3CB6A 3BITA 1QXWA 5FCFA 3RORA 5FCHA 4FO7A 2GG9A 2BHDA 2EVMA 4FLIA 4B28A 4IU6A 4FLLA 1XGMA 3IU8A 3IU9A 3BIPA 4ZWOA 3BIQA 1W2MA 3Q6DA 4JUQA 1M35A 4U1BA 3CTZA 2MATA 1C27A 2GGCA 2GG7A 4IKUA 2EA2A 3PKBA 2BWXA 4S01A 2GU6A 1KQ9A 1XGSA 1B59A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1C24 A;  1WN1 A;  4PV4 A;  4U69 A;  2BWV A;  2GGB A;  5CIK A;  2ADU A;  1XNZ A;  5CDE A;  2Q96 A;  1R5G A;  4OOK A;  4KM3 A;  1MAT A;  3PKE A;  2B3K A;  5CE6 A;  4S2R P;  1WBQ A;  3PKC A;  4U6W A;  2GG5 A;  1C21 A;  1N51 A;  1YW9 A;  3FMQ A;  1Y1N A;  2EVO A;  1BOA A;  3MAT A;  5D6E A;  1A16 A;  1WLR A;  2BN7 A;  2V3X A;  1JAW A;  1CHM A;  2B3L A;  4EGE A;  1O0X A;  4IPA A;  3TAV A;  3IG4 A;  4IF7 A;  1YJ3 A;  2EVC A;  1C22 A;  4MAT A;  2ZSG A;  4U73 A;  5JI6 A;  2BWT A;  2P99 A;  4S00 A;  1KP0 A;  4HXX A;  3L24 A;  5CDL A;  2BHA A;  1BN5 A;  4FLK A;  3CB5 A;  4FUK A;  4IDY A;  2GG8 A;  2Q93 A;  2GTX A;  2GG3 A;  4U6J A;  2Q92 A;  2BHC A;  1B6A A;  4FO8 A;  3IU7 A;  2GZ5 A;  2BHB A;  1R5H A;  1C23 A;  2NQ7 A;  2GG0 A;  2OKN A;  1KQ0 A;  3MX6 A;  4U76 A;  4ZWU A;  4U6E A;  4R60 A;  5D6F A;  5CDV A;  2BWW A;  4U6C A;  1R58 A;  2IW2 A;  1WKM A;  4ZWP A;  1WY2 A;  2V3Y A;  4IEC A;  3TB5 A;  4RZZ A;  4Z7M A;  4FLJ A;  2EA4 A;  4S2T P;  1XGO A;  2B3H A;  2NQ6 A;  1QXY A;  2BB7 A;  3FMR A;  2GG2 A;  2Q95 A;  2P9A A;  4U75 A;  3S6B A;  2BWU A;  1QZY A;  1PV9 A;  4IKT A;  4A6W A;  4IKR A;  2BWS A;  1XGN A;  1YW7 A;  4FKC A;  4U70 A;  2BWY A;  2G6P A;  2GA2 A;  1YW8 A;  3D27 A;  4ZNG A;  3PKA A;  2Q8K A;  2BH3 A;  5E5B A;  4A6V A;  2V6C A;  3PKD A;  4IKS A;  5CNX A;  3MR1 A;  4U71 A;  5JFR A;  1YVM A;  4RGZ 1;  2HOW A;  1WL6 A;  1WL9 A;  2GU4 A;  4PNC A;  3FM3 A;  4RZY A;  2OAZ A;  3L7G A;  2GU5 A;  2V3Z A;  5JHU A;  3RVA A;  2DFI A;  1W7V A;  4QR8 A;  5CLS A;  2GU7 A;  2P98 A;  4U6Z A;  1QXZ A;  2Q94 A;  3CB6 A;  3BIT A;  1QXW A;  5FCF A;  3ROR A;  5FCH A;  4FO7 A;  2GG9 A;  2BHD A;  2EVM A;  4FLI A;  4B28 A;  4IU6 A;  4FLL A;  1XGM A;  3IU8 A;  3IU9 A;  3BIP A;  4ZWO A;  3BIQ A;  1W2M A;  3Q6D A;  4JUQ A;  1M35 A;  4U1B A;  3CTZ A;  2MAT A;  1C27 A;  2GGC A;  2GG7 A;  4IKU A;  2EA2 A;  3PKB A;  2BWX A;  4S01 A;  2GU6 A;  1KQ9 A;  1XGS A;  1B59 A; 
#chains in the Genus database with same CATH topology
 1C24 A;  1WN1 A;  4PV4 A;  4U69 A;  2BWV A;  2GGB A;  5CIK A;  2ADU A;  1XNZ A;  5CDE A;  2Q96 A;  1R5G A;  4OOK A;  4KM3 A;  1MAT A;  3PKE A;  2B3K A;  5CE6 A;  4S2R P;  1WBQ A;  3PKC A;  4U6W A;  2GG5 A;  1C21 A;  1N51 A;  1YW9 A;  3FMQ A;  1Y1N A;  2EVO A;  1BOA A;  3MAT A;  5D6E A;  1A16 A;  1WLR A;  2BN7 A;  2V3X A;  1JAW A;  1CHM A;  2B3L A;  4EGE A;  1O0X A;  4IPA A;  3TAV A;  3IG4 A;  4IF7 A;  1YJ3 A;  2EVC A;  1C22 A;  4MAT A;  2ZSG A;  4U73 A;  5JI6 A;  2BWT A;  2P99 A;  4S00 A;  1KP0 A;  4HXX A;  3L24 A;  5CDL A;  2BHA A;  1BN5 A;  4FLK A;  3CB5 A;  4FUK A;  4IDY A;  2GG8 A;  2Q93 A;  2GTX A;  2GG3 A;  4U6J A;  2Q92 A;  2BHC A;  1B6A A;  4FO8 A;  3IU7 A;  2GZ5 A;  2BHB A;  1R5H A;  1C23 A;  2NQ7 A;  2GG0 A;  2OKN A;  1KQ0 A;  3MX6 A;  4U76 A;  4ZWU A;  4U6E A;  4R60 A;  5D6F A;  5CDV A;  2BWW A;  4U6C A;  1R58 A;  2IW2 A;  1WKM A;  4ZWP A;  1WY2 A;  2V3Y A;  4IEC A;  3TB5 A;  4RZZ A;  4Z7M A;  4FLJ A;  2EA4 A;  4S2T P;  1XGO A;  2B3H A;  2NQ6 A;  1QXY A;  2BB7 A;  3FMR A;  2GG2 A;  2Q95 A;  2P9A A;  4U75 A;  3S6B A;  2BWU A;  1QZY A;  1PV9 A;  4IKT A;  4A6W A;  4IKR A;  2BWS A;  1XGN A;  1YW7 A;  4FKC A;  4U70 A;  2BWY A;  2G6P A;  2GA2 A;  1YW8 A;  3D27 A;  4ZNG A;  3PKA A;  2Q8K A;  2BH3 A;  5E5B A;  4A6V A;  2V6C A;  3PKD A;  4IKS A;  5CNX A;  3MR1 A;  4U71 A;  5JFR A;  1YVM A;  4RGZ 1;  2HOW A;  1WL6 A;  1WL9 A;  2GU4 A;  4PNC A;  3FM3 A;  4RZY A;  2OAZ A;  3L7G A;  2GU5 A;  2V3Z A;  5JHU A;  3RVA A;  2DFI A;  1W7V A;  4QR8 A;  5CLS A;  2GU7 A;  2P98 A;  4U6Z A;  1QXZ A;  2Q94 A;  3CB6 A;  3BIT A;  1QXW A;  5FCF A;  3ROR A;  5FCH A;  4FO7 A;  2GG9 A;  2BHD A;  2EVM A;  4FLI A;  4B28 A;  4IU6 A;  4FLL A;  1XGM A;  3IU8 A;  3IU9 A;  3BIP A;  4ZWO A;  3BIQ A;  1W2M A;  3Q6D A;  4JUQ A;  1M35 A;  4U1B A;  3CTZ A;  2MAT A;  1C27 A;  2GGC A;  2GG7 A;  4IKU A;  2EA2 A;  3PKB A;  2BWX A;  4S01 A;  2GU6 A;  1KQ9 A;  1XGS A;  1B59 A; 
#chains in the Genus database with same CATH homology
 1C24 A;  1WN1 A;  4PV4 A;  4U69 A;  2BWV A;  2GGB A;  5CIK A;  2ADU A;  1XNZ A;  5CDE A;  2Q96 A;  1R5G A;  4OOK A;  4KM3 A;  1MAT A;  3PKE A;  2B3K A;  5CE6 A;  4S2R P;  1WBQ A;  3PKC A;  4U6W A;  2GG5 A;  1C21 A;  1N51 A;  1YW9 A;  3FMQ A;  1Y1N A;  2EVO A;  1BOA A;  3MAT A;  5D6E A;  1A16 A;  1WLR A;  2BN7 A;  2V3X A;  1JAW A;  1CHM A;  2B3L A;  4EGE A;  1O0X A;  4IPA A;  3TAV A;  3IG4 A;  4IF7 A;  1YJ3 A;  2EVC A;  1C22 A;  4MAT A;  2ZSG A;  4U73 A;  5JI6 A;  2BWT A;  2P99 A;  4S00 A;  1KP0 A;  4HXX A;  3L24 A;  5CDL A;  2BHA A;  1BN5 A;  4FLK A;  3CB5 A;  4FUK A;  4IDY A;  2GG8 A;  2Q93 A;  2GTX A;  2GG3 A;  4U6J A;  2Q92 A;  2BHC A;  1B6A A;  4FO8 A;  3IU7 A;  2GZ5 A;  2BHB A;  1R5H A;  1C23 A;  2NQ7 A;  2GG0 A;  2OKN A;  1KQ0 A;  3MX6 A;  4U76 A;  4ZWU A;  4U6E A;  4R60 A;  5D6F A;  5CDV A;  2BWW A;  4U6C A;  1R58 A;  2IW2 A;  1WKM A;  4ZWP A;  1WY2 A;  2V3Y A;  4IEC A;  3TB5 A;  4RZZ A;  4Z7M A;  4FLJ A;  2EA4 A;  4S2T P;  1XGO A;  2B3H A;  2NQ6 A;  1QXY A;  2BB7 A;  3FMR A;  2GG2 A;  2Q95 A;  2P9A A;  4U75 A;  3S6B A;  2BWU A;  1QZY A;  1PV9 A;  4IKT A;  4A6W A;  4IKR A;  2BWS A;  1XGN A;  1YW7 A;  4FKC A;  4U70 A;  2BWY A;  2G6P A;  2GA2 A;  1YW8 A;  3D27 A;  4ZNG A;  3PKA A;  2Q8K A;  2BH3 A;  5E5B A;  4A6V A;  2V6C A;  3PKD A;  4IKS A;  5CNX A;  3MR1 A;  4U71 A;  5JFR A;  1YVM A;  4RGZ 1;  2HOW A;  1WL6 A;  1WL9 A;  2GU4 A;  4PNC A;  3FM3 A;  4RZY A;  2OAZ A;  3L7G A;  2GU5 A;  2V3Z A;  5JHU A;  3RVA A;  2DFI A;  1W7V A;  4QR8 A;  5CLS A;  2GU7 A;  2P98 A;  4U6Z A;  1QXZ A;  2Q94 A;  3CB6 A;  3BIT A;  1QXW A;  5FCF A;  3ROR A;  5FCH A;  4FO7 A;  2GG9 A;  2BHD A;  2EVM A;  4FLI A;  4B28 A;  4IU6 A;  4FLL A;  1XGM A;  3IU8 A;  3IU9 A;  3BIP A;  4ZWO A;  3BIQ A;  1W2M A;  3Q6D A;  4JUQ A;  1M35 A;  4U1B A;  3CTZ A;  2MAT A;  1C27 A;  2GGC A;  2GG7 A;  4IKU A;  2EA2 A;  3PKB A;  2BWX A;  4S01 A;  2GU6 A;  1KQ9 A;  1XGS A;  1B59 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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