2GGCA

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 87
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2ggcA00
2Q93A 1YW9A 4A6VA 4S01A 4RGZ1 2GZ5A 1Y1NA 5JFRA 5D6EA 2BN7A 1BOAA 1CHMA 2V6CA 4IECA 5FCHA 4IF7A 4U6EA 4IU6A 2G6PA 4S00A 3FMQA 2GG7A 2BHCA 3IU8A 1YW8A 5CDLA 1YW7A 3FMRA 1JAWA 4RZYA 4FLKA 3MX6A 4FO7A 1B6AA 2Q96A 3CB6A 4EGEA 5CE6A 2BWSA 3Q6DA 4U1BA 4U69A 2BH3A 3PKEA 5CDVA 1XNZA 4ZWOA 2BWVA 2GU7A 1O0XA 2NQ6A 2BHAA 2GTXA 5JHUA 3IU9A 3IG4A 3RVAA 2BHDA 3PKBA 4U6ZA 1KQ9A 1C27A 1R5GA 1R5HA 2GU5A 4IKTA 3TAVA 4U75A 4S2RP 1PV9A 2GG5A 2EA2A 1BN5A 1XGOA 2GGCA 2GG2A 2GU4A 4FKCA 1N51A 1WL6A 4U76A 2GG0A 4ZWPA 5CDEA 2BWWA 3BIPA 1C23A 2GGBA 2NQ7A 2Q92A 5D6FA 1R58A 2BB7A 5E5BA 2IW2A 4FLIA 4U70A 3TB5A 5CIKA 1C22A 2BWYA 1XGNA 1XGSA 4OOKA 4B28A 1QXWA 1WLRA 2Q8KA 2V3YA 2V3XA 2P98A 1WBQA 4S2TP 1M35A 2GG9A 4ZWUA 1W2MA 3S6BA 2MATA 1XGMA 3PKCA 2B3KA 4PNCA 2HOWA 2Q95A 4HXXA 3L7GA 4JUQA 2BHBA 1A16A 5FCFA 4FUKA 3RORA 4U71A 2EVCA 1C24A 1WL9A 4IDYA 1QXYA 3IU7A 3L24A 3CB5A 2DFIA 1KP0A 4IPAA 2P9AA 4U73A 1WN1A 5CNXA 4PV4A 3BITA 5CLSA 2GU6A 2GG8A 4IKSA 2BWXA 1WY2A 2B3LA 2V3ZA 1W7VA 2EVOA 1YVMA 4FLJA 3PKAA 4RZZA 3PKDA 2BWUA 1QZYA 4ZNGA 4QR8A 4A6WA 1KQ0A 3FM3A 1B59A 1C21A 2ZSGA 2GA2A 2GG3A 2OKNA 4IKUA 2ADUA 2EVMA 1WKMA 4MATA 5JI6A 2Q94A 4FLLA 4U6CA 4U6JA 2P99A 4U6WA 3BIQA 4KM3A 4R60A 3MATA 4FO8A 3D27A 1QXZA 1YJ3A 1MATA 2B3HA 4IKRA 2BWTA 4Z7MA 2OAZA 3MR1A 3CTZA 2EA4A
chains in the Genus database with same CATH superfamily
2Q93A 1YW9A 4A6VA 4S01A 4RGZ1 2GZ5A 1Y1NA 5JFRA 5D6EA 2BN7A 1BOAA 1CHMA 2V6CA 4IECA 5FCHA 4IF7A 4U6EA 4IU6A 2G6PA 4S00A 3FMQA 2GG7A 2BHCA 3IU8A 1YW8A 5CDLA 1YW7A 3FMRA 1JAWA 4RZYA 4FLKA 3MX6A 4FO7A 1B6AA 2Q96A 3CB6A 4EGEA 5CE6A 2BWSA 3Q6DA 4U1BA 4U69A 2BH3A 3PKEA 5CDVA 1XNZA 4ZWOA 2BWVA 2GU7A 1O0XA 2NQ6A 2BHAA 2GTXA 5JHUA 3IU9A 3IG4A 3RVAA 2BHDA 3PKBA 4U6ZA 1KQ9A 1C27A 1R5GA 1R5HA 2GU5A 4IKTA 3TAVA 4U75A 4S2RP 1PV9A 2GG5A 2EA2A 1BN5A 1XGOA 2GGCA 2GG2A 2GU4A 4FKCA 1N51A 1WL6A 4U76A 2GG0A 4ZWPA 5CDEA 2BWWA 3BIPA 1C23A 2GGBA 2NQ7A 2Q92A 5D6FA 1R58A 2BB7A 5E5BA 2IW2A 4FLIA 4U70A 3TB5A 5CIKA 1C22A 2BWYA 1XGNA 1XGSA 4OOKA 4B28A 1QXWA 1WLRA 2Q8KA 2V3YA 2V3XA 2P98A 1WBQA 4S2TP 1M35A 2GG9A 4ZWUA 1W2MA 3S6BA 2MATA 1XGMA 3PKCA 2B3KA 4PNCA 2HOWA 2Q95A 4HXXA 3L7GA 4JUQA 2BHBA 1A16A 5FCFA 4FUKA 3RORA 4U71A 2EVCA 1C24A 1WL9A 4IDYA 1QXYA 3IU7A 3L24A 3CB5A 2DFIA 1KP0A 4IPAA 2P9AA 4U73A 1WN1A 5CNXA 4PV4A 3BITA 5CLSA 2GU6A 2GG8A 4IKSA 2BWXA 1WY2A 2B3LA 2V3ZA 1W7VA 2EVOA 1YVMA 4FLJA 3PKAA 4RZZA 3PKDA 2BWUA 1QZYA 4ZNGA 4QR8A 4A6WA 1KQ0A 3FM3A 1B59A 1C21A 2ZSGA 2GA2A 2GG3A 2OKNA 4IKUA 2ADUA 2EVMA 1WKMA 4MATA 5JI6A 2Q94A 4FLLA 4U6CA 4U6JA 2P99A 4U6WA 3BIQA 4KM3A 4R60A 3MATA 4FO8A 3D27A 1QXZA 1YJ3A 1MATA 2B3HA 4IKRA 2BWTA 4Z7MA 2OAZA 3MR1A 3CTZA 2EA4A
chains in the Genus database with same CATH topology
2Q93A 1YW9A 4A6VA 4S01A 4RGZ1 2GZ5A 1Y1NA 5JFRA 5D6EA 2BN7A 1BOAA 1CHMA 2V6CA 4IECA 5FCHA 4IF7A 4U6EA 4IU6A 2G6PA 4S00A 3FMQA 2GG7A 2BHCA 3IU8A 1YW8A 5CDLA 1YW7A 3FMRA 1JAWA 4RZYA 4FLKA 3MX6A 4FO7A 1B6AA 2Q96A 3CB6A 4EGEA 5CE6A 2BWSA 3Q6DA 4U1BA 4U69A 2BH3A 3PKEA 5CDVA 1XNZA 4ZWOA 2BWVA 2GU7A 1O0XA 2NQ6A 2BHAA 2GTXA 5JHUA 3IU9A 3IG4A 3RVAA 2BHDA 3PKBA 4U6ZA 1KQ9A 1C27A 1R5GA 1R5HA 2GU5A 4IKTA 3TAVA 4U75A 4S2RP 1PV9A 2GG5A 2EA2A 1BN5A 1XGOA 2GGCA 2GG2A 2GU4A 4FKCA 1N51A 1WL6A 4U76A 2GG0A 4ZWPA 5CDEA 2BWWA 3BIPA 1C23A 2GGBA 2NQ7A 2Q92A 5D6FA 1R58A 2BB7A 5E5BA 2IW2A 4FLIA 4U70A 3TB5A 5CIKA 1C22A 2BWYA 1XGNA 1XGSA 4OOKA 4B28A 1QXWA 1WLRA 2Q8KA 2V3YA 2V3XA 2P98A 1WBQA 4S2TP 1M35A 2GG9A 4ZWUA 1W2MA 3S6BA 2MATA 1XGMA 3PKCA 2B3KA 4PNCA 2HOWA 2Q95A 4HXXA 3L7GA 4JUQA 2BHBA 1A16A 5FCFA 4FUKA 3RORA 4U71A 2EVCA 1C24A 1WL9A 4IDYA 1QXYA 3IU7A 3L24A 3CB5A 2DFIA 1KP0A 4IPAA 2P9AA 4U73A 1WN1A 5CNXA 4PV4A 3BITA 5CLSA 2GU6A 2GG8A 4IKSA 2BWXA 1WY2A 2B3LA 2V3ZA 1W7VA 2EVOA 1YVMA 4FLJA 3PKAA 4RZZA 3PKDA 2BWUA 1QZYA 4ZNGA 4QR8A 4A6WA 1KQ0A 3FM3A 1B59A 1C21A 2ZSGA 2GA2A 2GG3A 2OKNA 4IKUA 2ADUA 2EVMA 1WKMA 4MATA 5JI6A 2Q94A 4FLLA 4U6CA 4U6JA 2P99A 4U6WA 3BIQA 4KM3A 4R60A 3MATA 4FO8A 3D27A 1QXZA 1YJ3A 1MATA 2B3HA 4IKRA 2BWTA 4Z7MA 2OAZA 3MR1A 3CTZA 2EA4A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2Q93 A;  1YW9 A;  4A6V A;  4S01 A;  4RGZ 1;  2GZ5 A;  1Y1N A;  5JFR A;  5D6E A;  2BN7 A;  1BOA A;  1CHM A;  2V6C A;  4IEC A;  5FCH A;  4IF7 A;  4U6E A;  4IU6 A;  2G6P A;  4S00 A;  3FMQ A;  2GG7 A;  2BHC A;  3IU8 A;  1YW8 A;  5CDL A;  1YW7 A;  3FMR A;  1JAW A;  4RZY A;  4FLK A;  3MX6 A;  4FO7 A;  1B6A A;  2Q96 A;  3CB6 A;  4EGE A;  5CE6 A;  2BWS A;  3Q6D A;  4U1B A;  4U69 A;  2BH3 A;  3PKE A;  5CDV A;  1XNZ A;  4ZWO A;  2BWV A;  2GU7 A;  1O0X A;  2NQ6 A;  2BHA A;  2GTX A;  5JHU A;  3IU9 A;  3IG4 A;  3RVA A;  2BHD A;  3PKB A;  4U6Z A;  1KQ9 A;  1C27 A;  1R5G A;  1R5H A;  2GU5 A;  4IKT A;  3TAV A;  4U75 A;  4S2R P;  1PV9 A;  2GG5 A;  2EA2 A;  1BN5 A;  1XGO A;  2GGC A;  2GG2 A;  2GU4 A;  4FKC A;  1N51 A;  1WL6 A;  4U76 A;  2GG0 A;  4ZWP A;  5CDE A;  2BWW A;  3BIP A;  1C23 A;  2GGB A;  2NQ7 A;  2Q92 A;  5D6F A;  1R58 A;  2BB7 A;  5E5B A;  2IW2 A;  4FLI A;  4U70 A;  3TB5 A;  5CIK A;  1C22 A;  2BWY A;  1XGN A;  1XGS A;  4OOK A;  4B28 A;  1QXW A;  1WLR A;  2Q8K A;  2V3Y A;  2V3X A;  2P98 A;  1WBQ A;  4S2T P;  1M35 A;  2GG9 A;  4ZWU A;  1W2M A;  3S6B A;  2MAT A;  1XGM A;  3PKC A;  2B3K A;  4PNC A;  2HOW A;  2Q95 A;  4HXX A;  3L7G A;  4JUQ A;  2BHB A;  1A16 A;  5FCF A;  4FUK A;  3ROR A;  4U71 A;  2EVC A;  1C24 A;  1WL9 A;  4IDY A;  1QXY A;  3IU7 A;  3L24 A;  3CB5 A;  2DFI A;  1KP0 A;  4IPA A;  2P9A A;  4U73 A;  1WN1 A;  5CNX A;  4PV4 A;  3BIT A;  5CLS A;  2GU6 A;  2GG8 A;  4IKS A;  2BWX A;  1WY2 A;  2B3L A;  2V3Z A;  1W7V A;  2EVO A;  1YVM A;  4FLJ A;  3PKA A;  4RZZ A;  3PKD A;  2BWU A;  1QZY A;  4ZNG A;  4QR8 A;  4A6W A;  1KQ0 A;  3FM3 A;  1B59 A;  1C21 A;  2ZSG A;  2GA2 A;  2GG3 A;  2OKN A;  4IKU A;  2ADU A;  2EVM A;  1WKM A;  4MAT A;  5JI6 A;  2Q94 A;  4FLL A;  4U6C A;  4U6J A;  2P99 A;  4U6W A;  3BIQ A;  4KM3 A;  4R60 A;  3MAT A;  4FO8 A;  3D27 A;  1QXZ A;  1YJ3 A;  1MAT A;  2B3H A;  4IKR A;  2BWT A;  4Z7M A;  2OAZ A;  3MR1 A;  3CTZ A;  2EA4 A; 
#chains in the Genus database with same CATH topology
 2Q93 A;  1YW9 A;  4A6V A;  4S01 A;  4RGZ 1;  2GZ5 A;  1Y1N A;  5JFR A;  5D6E A;  2BN7 A;  1BOA A;  1CHM A;  2V6C A;  4IEC A;  5FCH A;  4IF7 A;  4U6E A;  4IU6 A;  2G6P A;  4S00 A;  3FMQ A;  2GG7 A;  2BHC A;  3IU8 A;  1YW8 A;  5CDL A;  1YW7 A;  3FMR A;  1JAW A;  4RZY A;  4FLK A;  3MX6 A;  4FO7 A;  1B6A A;  2Q96 A;  3CB6 A;  4EGE A;  5CE6 A;  2BWS A;  3Q6D A;  4U1B A;  4U69 A;  2BH3 A;  3PKE A;  5CDV A;  1XNZ A;  4ZWO A;  2BWV A;  2GU7 A;  1O0X A;  2NQ6 A;  2BHA A;  2GTX A;  5JHU A;  3IU9 A;  3IG4 A;  3RVA A;  2BHD A;  3PKB A;  4U6Z A;  1KQ9 A;  1C27 A;  1R5G A;  1R5H A;  2GU5 A;  4IKT A;  3TAV A;  4U75 A;  4S2R P;  1PV9 A;  2GG5 A;  2EA2 A;  1BN5 A;  1XGO A;  2GGC A;  2GG2 A;  2GU4 A;  4FKC A;  1N51 A;  1WL6 A;  4U76 A;  2GG0 A;  4ZWP A;  5CDE A;  2BWW A;  3BIP A;  1C23 A;  2GGB A;  2NQ7 A;  2Q92 A;  5D6F A;  1R58 A;  2BB7 A;  5E5B A;  2IW2 A;  4FLI A;  4U70 A;  3TB5 A;  5CIK A;  1C22 A;  2BWY A;  1XGN A;  1XGS A;  4OOK A;  4B28 A;  1QXW A;  1WLR A;  2Q8K A;  2V3Y A;  2V3X A;  2P98 A;  1WBQ A;  4S2T P;  1M35 A;  2GG9 A;  4ZWU A;  1W2M A;  3S6B A;  2MAT A;  1XGM A;  3PKC A;  2B3K A;  4PNC A;  2HOW A;  2Q95 A;  4HXX A;  3L7G A;  4JUQ A;  2BHB A;  1A16 A;  5FCF A;  4FUK A;  3ROR A;  4U71 A;  2EVC A;  1C24 A;  1WL9 A;  4IDY A;  1QXY A;  3IU7 A;  3L24 A;  3CB5 A;  2DFI A;  1KP0 A;  4IPA A;  2P9A A;  4U73 A;  1WN1 A;  5CNX A;  4PV4 A;  3BIT A;  5CLS A;  2GU6 A;  2GG8 A;  4IKS A;  2BWX A;  1WY2 A;  2B3L A;  2V3Z A;  1W7V A;  2EVO A;  1YVM A;  4FLJ A;  3PKA A;  4RZZ A;  3PKD A;  2BWU A;  1QZY A;  4ZNG A;  4QR8 A;  4A6W A;  1KQ0 A;  3FM3 A;  1B59 A;  1C21 A;  2ZSG A;  2GA2 A;  2GG3 A;  2OKN A;  4IKU A;  2ADU A;  2EVM A;  1WKM A;  4MAT A;  5JI6 A;  2Q94 A;  4FLL A;  4U6C A;  4U6J A;  2P99 A;  4U6W A;  3BIQ A;  4KM3 A;  4R60 A;  3MAT A;  4FO8 A;  3D27 A;  1QXZ A;  1YJ3 A;  1MAT A;  2B3H A;  4IKR A;  2BWT A;  4Z7M A;  2OAZ A;  3MR1 A;  3CTZ A;  2EA4 A; 
#chains in the Genus database with same CATH homology
 2Q93 A;  1YW9 A;  4A6V A;  4S01 A;  4RGZ 1;  2GZ5 A;  1Y1N A;  5JFR A;  5D6E A;  2BN7 A;  1BOA A;  1CHM A;  2V6C A;  4IEC A;  5FCH A;  4IF7 A;  4U6E A;  4IU6 A;  2G6P A;  4S00 A;  3FMQ A;  2GG7 A;  2BHC A;  3IU8 A;  1YW8 A;  5CDL A;  1YW7 A;  3FMR A;  1JAW A;  4RZY A;  4FLK A;  3MX6 A;  4FO7 A;  1B6A A;  2Q96 A;  3CB6 A;  4EGE A;  5CE6 A;  2BWS A;  3Q6D A;  4U1B A;  4U69 A;  2BH3 A;  3PKE A;  5CDV A;  1XNZ A;  4ZWO A;  2BWV A;  2GU7 A;  1O0X A;  2NQ6 A;  2BHA A;  2GTX A;  5JHU A;  3IU9 A;  3IG4 A;  3RVA A;  2BHD A;  3PKB A;  4U6Z A;  1KQ9 A;  1C27 A;  1R5G A;  1R5H A;  2GU5 A;  4IKT A;  3TAV A;  4U75 A;  4S2R P;  1PV9 A;  2GG5 A;  2EA2 A;  1BN5 A;  1XGO A;  2GGC A;  2GG2 A;  2GU4 A;  4FKC A;  1N51 A;  1WL6 A;  4U76 A;  2GG0 A;  4ZWP A;  5CDE A;  2BWW A;  3BIP A;  1C23 A;  2GGB A;  2NQ7 A;  2Q92 A;  5D6F A;  1R58 A;  2BB7 A;  5E5B A;  2IW2 A;  4FLI A;  4U70 A;  3TB5 A;  5CIK A;  1C22 A;  2BWY A;  1XGN A;  1XGS A;  4OOK A;  4B28 A;  1QXW A;  1WLR A;  2Q8K A;  2V3Y A;  2V3X A;  2P98 A;  1WBQ A;  4S2T P;  1M35 A;  2GG9 A;  4ZWU A;  1W2M A;  3S6B A;  2MAT A;  1XGM A;  3PKC A;  2B3K A;  4PNC A;  2HOW A;  2Q95 A;  4HXX A;  3L7G A;  4JUQ A;  2BHB A;  1A16 A;  5FCF A;  4FUK A;  3ROR A;  4U71 A;  2EVC A;  1C24 A;  1WL9 A;  4IDY A;  1QXY A;  3IU7 A;  3L24 A;  3CB5 A;  2DFI A;  1KP0 A;  4IPA A;  2P9A A;  4U73 A;  1WN1 A;  5CNX A;  4PV4 A;  3BIT A;  5CLS A;  2GU6 A;  2GG8 A;  4IKS A;  2BWX A;  1WY2 A;  2B3L A;  2V3Z A;  1W7V A;  2EVO A;  1YVM A;  4FLJ A;  3PKA A;  4RZZ A;  3PKD A;  2BWU A;  1QZY A;  4ZNG A;  4QR8 A;  4A6W A;  1KQ0 A;  3FM3 A;  1B59 A;  1C21 A;  2ZSG A;  2GA2 A;  2GG3 A;  2OKN A;  4IKU A;  2ADU A;  2EVM A;  1WKM A;  4MAT A;  5JI6 A;  2Q94 A;  4FLL A;  4U6C A;  4U6J A;  2P99 A;  4U6W A;  3BIQ A;  4KM3 A;  4R60 A;  3MAT A;  4FO8 A;  3D27 A;  1QXZ A;  1YJ3 A;  1MAT A;  2B3H A;  4IKR A;  2BWT A;  4Z7M A;  2OAZ A;  3MR1 A;  3CTZ A;  2EA4 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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