4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
4U69A 2GG0A 1R5HA 4IKTA 3L7GA 4FLIA 5CNXA 2MATA 4FUKA 4U6CA 4B28A 5FCFA 2GG9A 3PKCA 4PNCA 3MX6A 2GA2A 2GG3A 2EA4A 2EVOA 1Y1NA 2V3ZA 1BN5A 2GTXA 3PKDA 2B3HA 4IF7A 4PV4A 2Q96A 1W2MA 3PKEA 4IDYA 1WKMA 2OAZA 1C22A 1M35A 4U6JA 4ZNGA 2ADUA 1C24A 4FO7A 4S2TP 2GGBA 1B6AA 1KQ0A 2IW2A 1C21A 2Q95A 4S01A 3FM3A 4S2RP 4U75A 3MATA 3PKBA 4FLLA 1WN1A 3Q6DA 2GZ5A 2Q94A 2B3LA 4EGEA 2GG2A 4IU6A 1WLRA 2BB7A 1PV9A 1YW8A 4U1BA 1XGMA 2BHAA 2P99A 2V3YA 1B59A 3IU7A 3S6BA 5D6EA 4A6VA 2P98A 5CE6A 4IPAA 2GU5A 2BH3A 1N51A 4FLJA 3RVAA 2G6PA 5D6FA 4HXXA 2BWTA 2OKNA 4FO8A 4IECA 4A6WA 4U6EA 2GG7A 2Q92A 1R5GA 1QZYA 2P9AA 1QXZA 1BOAA 1XGSA 2EVMA 5JHUA 1XGOA 4RZYA 4RZZA 3L24A 5E5BA 1KQ9A 1CHMA 4U71A 4RGZ1 2GGCA 2GG5A 1YW7A 5CIKA 1W7VA 2BWVA 2GU7A 4MATA 4IKRA 1YJ3A 2GU6A 3MR1A 1WY2A 2V3XA 4U6ZA 2BHDA 4U70A 5CDEA 2EVCA 2NQ7A 4U73A 4U76A 2V6CA 2BHCA 1XNZA 3FMRA 4U6WA 3TB5A 1JAWA 4IKUA 5CDVA 2BN7A 2BWYA 2Q8KA 5FCHA 2ZSGA 2B3KA 1WBQA 1C23A 1KP0A 3IU9A 3BIPA 3D27A 5CDLA 5JFRA 1XGNA 4Z7MA 1O0XA 5CLSA 1YW9A 3FMQA 1QXWA 3TAVA 1YVMA 4FLKA 3PKAA 4QR8A 2BWXA 2GG8A 2HOWA 3RORA 3CB6A 4FKCA 1WL9A 3CTZA 2BWSA 4KM3A 4S00A 4IKSA 4ZWOA 2BWUA 4ZWUA 3BIQA 1WL6A 4R60A 3CB5A 2BHBA 2DFIA 4JUQA 1C27A 3IU8A 2BWWA 5JI6A 2GU4A 2Q93A 3IG4A 2NQ6A 1QXYA 2EA2A 4ZWPA 3BITA 1R58A 4OOKA 1MATA 1A16A
chains in the Genus database with same CATH superfamily
4U69A 2GG0A 1R5HA 4IKTA 3L7GA 4FLIA 5CNXA 2MATA 4FUKA 4U6CA 4B28A 5FCFA 2GG9A 3PKCA 4PNCA 3MX6A 2GA2A 2GG3A 2EA4A 2EVOA 1Y1NA 2V3ZA 1BN5A 2GTXA 3PKDA 2B3HA 4IF7A 4PV4A 2Q96A 1W2MA 3PKEA 4IDYA 1WKMA 2OAZA 1C22A 1M35A 4U6JA 4ZNGA 2ADUA 1C24A 4FO7A 4S2TP 2GGBA 1B6AA 1KQ0A 2IW2A 1C21A 2Q95A 4S01A 3FM3A 4S2RP 4U75A 3MATA 3PKBA 4FLLA 1WN1A 3Q6DA 2GZ5A 2Q94A 2B3LA 4EGEA 2GG2A 4IU6A 1WLRA 2BB7A 1PV9A 1YW8A 4U1BA 1XGMA 2BHAA 2P99A 2V3YA 1B59A 3IU7A 3S6BA 5D6EA 4A6VA 2P98A 5CE6A 4IPAA 2GU5A 2BH3A 1N51A 4FLJA 3RVAA 2G6PA 5D6FA 4HXXA 2BWTA 2OKNA 4FO8A 4IECA 4A6WA 4U6EA 2GG7A 2Q92A 1R5GA 1QZYA 2P9AA 1QXZA 1BOAA 1XGSA 2EVMA 5JHUA 1XGOA 4RZYA 4RZZA 3L24A 5E5BA 1KQ9A 1CHMA 4U71A 4RGZ1 2GGCA 2GG5A 1YW7A 5CIKA 1W7VA 2BWVA 2GU7A 4MATA 4IKRA 1YJ3A 2GU6A 3MR1A 1WY2A 2V3XA 4U6ZA 2BHDA 4U70A 5CDEA 2EVCA 2NQ7A 4U73A 4U76A 2V6CA 2BHCA 1XNZA 3FMRA 4U6WA 3TB5A 1JAWA 4IKUA 5CDVA 2BN7A 2BWYA 2Q8KA 5FCHA 2ZSGA 2B3KA 1WBQA 1C23A 1KP0A 3IU9A 3BIPA 3D27A 5CDLA 5JFRA 1XGNA 4Z7MA 1O0XA 5CLSA 1YW9A 3FMQA 1QXWA 3TAVA 1YVMA 4FLKA 3PKAA 4QR8A 2BWXA 2GG8A 2HOWA 3RORA 3CB6A 4FKCA 1WL9A 3CTZA 2BWSA 4KM3A 4S00A 4IKSA 4ZWOA 2BWUA 4ZWUA 3BIQA 1WL6A 4R60A 3CB5A 2BHBA 2DFIA 4JUQA 1C27A 3IU8A 2BWWA 5JI6A 2GU4A 2Q93A 3IG4A 2NQ6A 1QXYA 2EA2A 4ZWPA 3BITA 1R58A 4OOKA 1MATA 1A16A
chains in the Genus database with same CATH topology
4U69A 2GG0A 1R5HA 4IKTA 3L7GA 4FLIA 5CNXA 2MATA 4FUKA 4U6CA 4B28A 5FCFA 2GG9A 3PKCA 4PNCA 3MX6A 2GA2A 2GG3A 2EA4A 2EVOA 1Y1NA 2V3ZA 1BN5A 2GTXA 3PKDA 2B3HA 4IF7A 4PV4A 2Q96A 1W2MA 3PKEA 4IDYA 1WKMA 2OAZA 1C22A 1M35A 4U6JA 4ZNGA 2ADUA 1C24A 4FO7A 4S2TP 2GGBA 1B6AA 1KQ0A 2IW2A 1C21A 2Q95A 4S01A 3FM3A 4S2RP 4U75A 3MATA 3PKBA 4FLLA 1WN1A 3Q6DA 2GZ5A 2Q94A 2B3LA 4EGEA 2GG2A 4IU6A 1WLRA 2BB7A 1PV9A 1YW8A 4U1BA 1XGMA 2BHAA 2P99A 2V3YA 1B59A 3IU7A 3S6BA 5D6EA 4A6VA 2P98A 5CE6A 4IPAA 2GU5A 2BH3A 1N51A 4FLJA 3RVAA 2G6PA 5D6FA 4HXXA 2BWTA 2OKNA 4FO8A 4IECA 4A6WA 4U6EA 2GG7A 2Q92A 1R5GA 1QZYA 2P9AA 1QXZA 1BOAA 1XGSA 2EVMA 5JHUA 1XGOA 4RZYA 4RZZA 3L24A 5E5BA 1KQ9A 1CHMA 4U71A 4RGZ1 2GGCA 2GG5A 1YW7A 5CIKA 1W7VA 2BWVA 2GU7A 4MATA 4IKRA 1YJ3A 2GU6A 3MR1A 1WY2A 2V3XA 4U6ZA 2BHDA 4U70A 5CDEA 2EVCA 2NQ7A 4U73A 4U76A 2V6CA 2BHCA 1XNZA 3FMRA 4U6WA 3TB5A 1JAWA 4IKUA 5CDVA 2BN7A 2BWYA 2Q8KA 5FCHA 2ZSGA 2B3KA 1WBQA 1C23A 1KP0A 3IU9A 3BIPA 3D27A 5CDLA 5JFRA 1XGNA 4Z7MA 1O0XA 5CLSA 1YW9A 3FMQA 1QXWA 3TAVA 1YVMA 4FLKA 3PKAA 4QR8A 2BWXA 2GG8A 2HOWA 3RORA 3CB6A 4FKCA 1WL9A 3CTZA 2BWSA 4KM3A 4S00A 4IKSA 4ZWOA 2BWUA 4ZWUA 3BIQA 1WL6A 4R60A 3CB5A 2BHBA 2DFIA 4JUQA 1C27A 3IU8A 2BWWA 5JI6A 2GU4A 2Q93A 3IG4A 2NQ6A 1QXYA 2EA2A 4ZWPA 3BITA 1R58A 4OOKA 1MATA 1A16A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4U69 A;  2GG0 A;  1R5H A;  4IKT A;  3L7G A;  4FLI A;  5CNX A;  2MAT A;  4FUK A;  4U6C A;  4B28 A;  5FCF A;  2GG9 A;  3PKC A;  4PNC A;  3MX6 A;  2GA2 A;  2GG3 A;  2EA4 A;  2EVO A;  1Y1N A;  2V3Z A;  1BN5 A;  2GTX A;  3PKD A;  2B3H A;  4IF7 A;  4PV4 A;  2Q96 A;  1W2M A;  3PKE A;  4IDY A;  1WKM A;  2OAZ A;  1C22 A;  1M35 A;  4U6J A;  4ZNG A;  2ADU A;  1C24 A;  4FO7 A;  4S2T P;  2GGB A;  1B6A A;  1KQ0 A;  2IW2 A;  1C21 A;  2Q95 A;  4S01 A;  3FM3 A;  4S2R P;  4U75 A;  3MAT A;  3PKB A;  4FLL A;  1WN1 A;  3Q6D A;  2GZ5 A;  2Q94 A;  2B3L A;  4EGE A;  2GG2 A;  4IU6 A;  1WLR A;  2BB7 A;  1PV9 A;  1YW8 A;  4U1B A;  1XGM A;  2BHA A;  2P99 A;  2V3Y A;  1B59 A;  3IU7 A;  3S6B A;  5D6E A;  4A6V A;  2P98 A;  5CE6 A;  4IPA A;  2GU5 A;  2BH3 A;  1N51 A;  4FLJ A;  3RVA A;  2G6P A;  5D6F A;  4HXX A;  2BWT A;  2OKN A;  4FO8 A;  4IEC A;  4A6W A;  4U6E A;  2GG7 A;  2Q92 A;  1R5G A;  1QZY A;  2P9A A;  1QXZ A;  1BOA A;  1XGS A;  2EVM A;  5JHU A;  1XGO A;  4RZY A;  4RZZ A;  3L24 A;  5E5B A;  1KQ9 A;  1CHM A;  4U71 A;  4RGZ 1;  2GGC A;  2GG5 A;  1YW7 A;  5CIK A;  1W7V A;  2BWV A;  2GU7 A;  4MAT A;  4IKR A;  1YJ3 A;  2GU6 A;  3MR1 A;  1WY2 A;  2V3X A;  4U6Z A;  2BHD A;  4U70 A;  5CDE A;  2EVC A;  2NQ7 A;  4U73 A;  4U76 A;  2V6C A;  2BHC A;  1XNZ A;  3FMR A;  4U6W A;  3TB5 A;  1JAW A;  4IKU A;  5CDV A;  2BN7 A;  2BWY A;  2Q8K A;  5FCH A;  2ZSG A;  2B3K A;  1WBQ A;  1C23 A;  1KP0 A;  3IU9 A;  3BIP A;  3D27 A;  5CDL A;  5JFR A;  1XGN A;  4Z7M A;  1O0X A;  5CLS A;  1YW9 A;  3FMQ A;  1QXW A;  3TAV A;  1YVM A;  4FLK A;  3PKA A;  4QR8 A;  2BWX A;  2GG8 A;  2HOW A;  3ROR A;  3CB6 A;  4FKC A;  1WL9 A;  3CTZ A;  2BWS A;  4KM3 A;  4S00 A;  4IKS A;  4ZWO A;  2BWU A;  4ZWU A;  3BIQ A;  1WL6 A;  4R60 A;  3CB5 A;  2BHB A;  2DFI A;  4JUQ A;  1C27 A;  3IU8 A;  2BWW A;  5JI6 A;  2GU4 A;  2Q93 A;  3IG4 A;  2NQ6 A;  1QXY A;  2EA2 A;  4ZWP A;  3BIT A;  1R58 A;  4OOK A;  1MAT A;  1A16 A; 
#chains in the Genus database with same CATH topology
 4U69 A;  2GG0 A;  1R5H A;  4IKT A;  3L7G A;  4FLI A;  5CNX A;  2MAT A;  4FUK A;  4U6C A;  4B28 A;  5FCF A;  2GG9 A;  3PKC A;  4PNC A;  3MX6 A;  2GA2 A;  2GG3 A;  2EA4 A;  2EVO A;  1Y1N A;  2V3Z A;  1BN5 A;  2GTX A;  3PKD A;  2B3H A;  4IF7 A;  4PV4 A;  2Q96 A;  1W2M A;  3PKE A;  4IDY A;  1WKM A;  2OAZ A;  1C22 A;  1M35 A;  4U6J A;  4ZNG A;  2ADU A;  1C24 A;  4FO7 A;  4S2T P;  2GGB A;  1B6A A;  1KQ0 A;  2IW2 A;  1C21 A;  2Q95 A;  4S01 A;  3FM3 A;  4S2R P;  4U75 A;  3MAT A;  3PKB A;  4FLL A;  1WN1 A;  3Q6D A;  2GZ5 A;  2Q94 A;  2B3L A;  4EGE A;  2GG2 A;  4IU6 A;  1WLR A;  2BB7 A;  1PV9 A;  1YW8 A;  4U1B A;  1XGM A;  2BHA A;  2P99 A;  2V3Y A;  1B59 A;  3IU7 A;  3S6B A;  5D6E A;  4A6V A;  2P98 A;  5CE6 A;  4IPA A;  2GU5 A;  2BH3 A;  1N51 A;  4FLJ A;  3RVA A;  2G6P A;  5D6F A;  4HXX A;  2BWT A;  2OKN A;  4FO8 A;  4IEC A;  4A6W A;  4U6E A;  2GG7 A;  2Q92 A;  1R5G A;  1QZY A;  2P9A A;  1QXZ A;  1BOA A;  1XGS A;  2EVM A;  5JHU A;  1XGO A;  4RZY A;  4RZZ A;  3L24 A;  5E5B A;  1KQ9 A;  1CHM A;  4U71 A;  4RGZ 1;  2GGC A;  2GG5 A;  1YW7 A;  5CIK A;  1W7V A;  2BWV A;  2GU7 A;  4MAT A;  4IKR A;  1YJ3 A;  2GU6 A;  3MR1 A;  1WY2 A;  2V3X A;  4U6Z A;  2BHD A;  4U70 A;  5CDE A;  2EVC A;  2NQ7 A;  4U73 A;  4U76 A;  2V6C A;  2BHC A;  1XNZ A;  3FMR A;  4U6W A;  3TB5 A;  1JAW A;  4IKU A;  5CDV A;  2BN7 A;  2BWY A;  2Q8K A;  5FCH A;  2ZSG A;  2B3K A;  1WBQ A;  1C23 A;  1KP0 A;  3IU9 A;  3BIP A;  3D27 A;  5CDL A;  5JFR A;  1XGN A;  4Z7M A;  1O0X A;  5CLS A;  1YW9 A;  3FMQ A;  1QXW A;  3TAV A;  1YVM A;  4FLK A;  3PKA A;  4QR8 A;  2BWX A;  2GG8 A;  2HOW A;  3ROR A;  3CB6 A;  4FKC A;  1WL9 A;  3CTZ A;  2BWS A;  4KM3 A;  4S00 A;  4IKS A;  4ZWO A;  2BWU A;  4ZWU A;  3BIQ A;  1WL6 A;  4R60 A;  3CB5 A;  2BHB A;  2DFI A;  4JUQ A;  1C27 A;  3IU8 A;  2BWW A;  5JI6 A;  2GU4 A;  2Q93 A;  3IG4 A;  2NQ6 A;  1QXY A;  2EA2 A;  4ZWP A;  3BIT A;  1R58 A;  4OOK A;  1MAT A;  1A16 A; 
#chains in the Genus database with same CATH homology
 4U69 A;  2GG0 A;  1R5H A;  4IKT A;  3L7G A;  4FLI A;  5CNX A;  2MAT A;  4FUK A;  4U6C A;  4B28 A;  5FCF A;  2GG9 A;  3PKC A;  4PNC A;  3MX6 A;  2GA2 A;  2GG3 A;  2EA4 A;  2EVO A;  1Y1N A;  2V3Z A;  1BN5 A;  2GTX A;  3PKD A;  2B3H A;  4IF7 A;  4PV4 A;  2Q96 A;  1W2M A;  3PKE A;  4IDY A;  1WKM A;  2OAZ A;  1C22 A;  1M35 A;  4U6J A;  4ZNG A;  2ADU A;  1C24 A;  4FO7 A;  4S2T P;  2GGB A;  1B6A A;  1KQ0 A;  2IW2 A;  1C21 A;  2Q95 A;  4S01 A;  3FM3 A;  4S2R P;  4U75 A;  3MAT A;  3PKB A;  4FLL A;  1WN1 A;  3Q6D A;  2GZ5 A;  2Q94 A;  2B3L A;  4EGE A;  2GG2 A;  4IU6 A;  1WLR A;  2BB7 A;  1PV9 A;  1YW8 A;  4U1B A;  1XGM A;  2BHA A;  2P99 A;  2V3Y A;  1B59 A;  3IU7 A;  3S6B A;  5D6E A;  4A6V A;  2P98 A;  5CE6 A;  4IPA A;  2GU5 A;  2BH3 A;  1N51 A;  4FLJ A;  3RVA A;  2G6P A;  5D6F A;  4HXX A;  2BWT A;  2OKN A;  4FO8 A;  4IEC A;  4A6W A;  4U6E A;  2GG7 A;  2Q92 A;  1R5G A;  1QZY A;  2P9A A;  1QXZ A;  1BOA A;  1XGS A;  2EVM A;  5JHU A;  1XGO A;  4RZY A;  4RZZ A;  3L24 A;  5E5B A;  1KQ9 A;  1CHM A;  4U71 A;  4RGZ 1;  2GGC A;  2GG5 A;  1YW7 A;  5CIK A;  1W7V A;  2BWV A;  2GU7 A;  4MAT A;  4IKR A;  1YJ3 A;  2GU6 A;  3MR1 A;  1WY2 A;  2V3X A;  4U6Z A;  2BHD A;  4U70 A;  5CDE A;  2EVC A;  2NQ7 A;  4U73 A;  4U76 A;  2V6C A;  2BHC A;  1XNZ A;  3FMR A;  4U6W A;  3TB5 A;  1JAW A;  4IKU A;  5CDV A;  2BN7 A;  2BWY A;  2Q8K A;  5FCH A;  2ZSG A;  2B3K A;  1WBQ A;  1C23 A;  1KP0 A;  3IU9 A;  3BIP A;  3D27 A;  5CDL A;  5JFR A;  1XGN A;  4Z7M A;  1O0X A;  5CLS A;  1YW9 A;  3FMQ A;  1QXW A;  3TAV A;  1YVM A;  4FLK A;  3PKA A;  4QR8 A;  2BWX A;  2GG8 A;  2HOW A;  3ROR A;  3CB6 A;  4FKC A;  1WL9 A;  3CTZ A;  2BWS A;  4KM3 A;  4S00 A;  4IKS A;  4ZWO A;  2BWU A;  4ZWU A;  3BIQ A;  1WL6 A;  4R60 A;  3CB5 A;  2BHB A;  2DFI A;  4JUQ A;  1C27 A;  3IU8 A;  2BWW A;  5JI6 A;  2GU4 A;  2Q93 A;  3IG4 A;  2NQ6 A;  1QXY A;  2EA2 A;  4ZWP A;  3BIT A;  1R58 A;  4OOK A;  1MAT A;  1A16 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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