2GG7A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 85
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg7A00
1N51A 2B3KA 4IKRA 1XGSA 1WBQA 2GU7A 1B6AA 1WLRA 1YW8A 1C21A 2BN7A 2B3LA 4Z7MA 4PV4A 4FUKA 1YW7A 1BOAA 1XGOA 1YVMA 4FLIA 2BWXA 2GGCA 1W7VA 2Q92A 3S6BA 1QXYA 2P98A 5CNXA 4U73A 1KQ9A 4S00A 3L24A 1CHMA 5CE6A 4S2RP 3TB5A 3PKAA 1QXZA 5CDVA 1A16A 2GGBA 3MX6A 2GTXA 2EA2A 1W2MA 3IG4A 4U6WA 1XNZA 1XGMA 2Q95A 4U76A 5FCFA 1C22A 1C23A 4IKSA 4FO7A 4U75A 2NQ7A 2P99A 4OOKA 5JHUA 1YJ3A 1WY2A 4JUQA 2GU6A 1C27A 2DFIA 2NQ6A 3L7GA 2BWWA 1KP0A 3D27A 2Q93A 3FMQA 3FMRA 1O0XA 3RORA 2V3ZA 2ZSGA 3IU9A 2GU4A 5JFRA 1C24A 1R5HA 2IW2A 1WN1A 4FLJA 4U6JA 1M35A 4U71A 1R5GA 2P9AA 3BIQA 4KM3A 4RZZA 4IECA 3PKDA 2OAZA 4IKUA 3PKEA 2GG8A 3CB5A 5CDLA 3BIPA 2GU5A 1YW9A 1B59A 2GG0A 4EGEA 3RVAA 2BHCA 4A6VA 5E5BA 4U6EA 1WL9A 3MR1A 4RZYA 4U70A 4U6CA 2BB7A 2EVMA 3IU7A 4ZWUA 2GG2A 2OKNA 2MATA 4IKTA 3CTZA 4U1BA 5D6EA 4FKCA 2GG5A 3Q6DA 4R60A 1XGNA 4S01A 3FM3A 1Y1NA 2BH3A 1KQ0A 1QZYA 2GZ5A 2Q94A 2GG3A 5CDEA 5D6FA 2BWUA 4U6ZA 2BWSA 2Q8KA 2B3HA 2EVCA 5CIKA 2BHAA 4IU6A 1WKMA 4S2TP 2EVOA 4FLKA 2BHDA 3PKBA 4IPAA 4ZWOA 4B28A 2V3YA 1R58A 2ADUA 4RGZ1 4A6WA 5CLSA 2V3XA 3PKCA 4HXXA 2GG7A 1BN5A 3TAVA 3CB6A 2BWYA 4U69A 1JAWA 2EA4A 4MATA 5JI6A 2HOWA 2BHBA 2BWVA 4FLLA 2V6CA 2G6PA 1QXWA 4IF7A 4ZNGA 5FCHA 4FO8A 4IDYA 2BWTA 3BITA 2GA2A 3MATA 3IU8A 1WL6A 2GG9A 2Q96A 4PNCA 4QR8A 1PV9A 1MATA 4ZWPA
chains in the Genus database with same CATH superfamily
1N51A 2B3KA 4IKRA 1XGSA 1WBQA 2GU7A 1B6AA 1WLRA 1YW8A 1C21A 2BN7A 2B3LA 4Z7MA 4PV4A 4FUKA 1YW7A 1BOAA 1XGOA 1YVMA 4FLIA 2BWXA 2GGCA 1W7VA 2Q92A 3S6BA 1QXYA 2P98A 5CNXA 4U73A 1KQ9A 4S00A 3L24A 1CHMA 5CE6A 4S2RP 3TB5A 3PKAA 1QXZA 5CDVA 1A16A 2GGBA 3MX6A 2GTXA 2EA2A 1W2MA 3IG4A 4U6WA 1XNZA 1XGMA 2Q95A 4U76A 5FCFA 1C22A 1C23A 4IKSA 4FO7A 4U75A 2NQ7A 2P99A 4OOKA 5JHUA 1YJ3A 1WY2A 4JUQA 2GU6A 1C27A 2DFIA 2NQ6A 3L7GA 2BWWA 1KP0A 3D27A 2Q93A 3FMQA 3FMRA 1O0XA 3RORA 2V3ZA 2ZSGA 3IU9A 2GU4A 5JFRA 1C24A 1R5HA 2IW2A 1WN1A 4FLJA 4U6JA 1M35A 4U71A 1R5GA 2P9AA 3BIQA 4KM3A 4RZZA 4IECA 3PKDA 2OAZA 4IKUA 3PKEA 2GG8A 3CB5A 5CDLA 3BIPA 2GU5A 1YW9A 1B59A 2GG0A 4EGEA 3RVAA 2BHCA 4A6VA 5E5BA 4U6EA 1WL9A 3MR1A 4RZYA 4U70A 4U6CA 2BB7A 2EVMA 3IU7A 4ZWUA 2GG2A 2OKNA 2MATA 4IKTA 3CTZA 4U1BA 5D6EA 4FKCA 2GG5A 3Q6DA 4R60A 1XGNA 4S01A 3FM3A 1Y1NA 2BH3A 1KQ0A 1QZYA 2GZ5A 2Q94A 2GG3A 5CDEA 5D6FA 2BWUA 4U6ZA 2BWSA 2Q8KA 2B3HA 2EVCA 5CIKA 2BHAA 4IU6A 1WKMA 4S2TP 2EVOA 4FLKA 2BHDA 3PKBA 4IPAA 4ZWOA 4B28A 2V3YA 1R58A 2ADUA 4RGZ1 4A6WA 5CLSA 2V3XA 3PKCA 4HXXA 2GG7A 1BN5A 3TAVA 3CB6A 2BWYA 4U69A 1JAWA 2EA4A 4MATA 5JI6A 2HOWA 2BHBA 2BWVA 4FLLA 2V6CA 2G6PA 1QXWA 4IF7A 4ZNGA 5FCHA 4FO8A 4IDYA 2BWTA 3BITA 2GA2A 3MATA 3IU8A 1WL6A 2GG9A 2Q96A 4PNCA 4QR8A 1PV9A 1MATA 4ZWPA
chains in the Genus database with same CATH topology
1N51A 2B3KA 4IKRA 1XGSA 1WBQA 2GU7A 1B6AA 1WLRA 1YW8A 1C21A 2BN7A 2B3LA 4Z7MA 4PV4A 4FUKA 1YW7A 1BOAA 1XGOA 1YVMA 4FLIA 2BWXA 2GGCA 1W7VA 2Q92A 3S6BA 1QXYA 2P98A 5CNXA 4U73A 1KQ9A 4S00A 3L24A 1CHMA 5CE6A 4S2RP 3TB5A 3PKAA 1QXZA 5CDVA 1A16A 2GGBA 3MX6A 2GTXA 2EA2A 1W2MA 3IG4A 4U6WA 1XNZA 1XGMA 2Q95A 4U76A 5FCFA 1C22A 1C23A 4IKSA 4FO7A 4U75A 2NQ7A 2P99A 4OOKA 5JHUA 1YJ3A 1WY2A 4JUQA 2GU6A 1C27A 2DFIA 2NQ6A 3L7GA 2BWWA 1KP0A 3D27A 2Q93A 3FMQA 3FMRA 1O0XA 3RORA 2V3ZA 2ZSGA 3IU9A 2GU4A 5JFRA 1C24A 1R5HA 2IW2A 1WN1A 4FLJA 4U6JA 1M35A 4U71A 1R5GA 2P9AA 3BIQA 4KM3A 4RZZA 4IECA 3PKDA 2OAZA 4IKUA 3PKEA 2GG8A 3CB5A 5CDLA 3BIPA 2GU5A 1YW9A 1B59A 2GG0A 4EGEA 3RVAA 2BHCA 4A6VA 5E5BA 4U6EA 1WL9A 3MR1A 4RZYA 4U70A 4U6CA 2BB7A 2EVMA 3IU7A 4ZWUA 2GG2A 2OKNA 2MATA 4IKTA 3CTZA 4U1BA 5D6EA 4FKCA 2GG5A 3Q6DA 4R60A 1XGNA 4S01A 3FM3A 1Y1NA 2BH3A 1KQ0A 1QZYA 2GZ5A 2Q94A 2GG3A 5CDEA 5D6FA 2BWUA 4U6ZA 2BWSA 2Q8KA 2B3HA 2EVCA 5CIKA 2BHAA 4IU6A 1WKMA 4S2TP 2EVOA 4FLKA 2BHDA 3PKBA 4IPAA 4ZWOA 4B28A 2V3YA 1R58A 2ADUA 4RGZ1 4A6WA 5CLSA 2V3XA 3PKCA 4HXXA 2GG7A 1BN5A 3TAVA 3CB6A 2BWYA 4U69A 1JAWA 2EA4A 4MATA 5JI6A 2HOWA 2BHBA 2BWVA 4FLLA 2V6CA 2G6PA 1QXWA 4IF7A 4ZNGA 5FCHA 4FO8A 4IDYA 2BWTA 3BITA 2GA2A 3MATA 3IU8A 1WL6A 2GG9A 2Q96A 4PNCA 4QR8A 1PV9A 1MATA 4ZWPA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1N51 A;  2B3K A;  4IKR A;  1XGS A;  1WBQ A;  2GU7 A;  1B6A A;  1WLR A;  1YW8 A;  1C21 A;  2BN7 A;  2B3L A;  4Z7M A;  4PV4 A;  4FUK A;  1YW7 A;  1BOA A;  1XGO A;  1YVM A;  4FLI A;  2BWX A;  2GGC A;  1W7V A;  2Q92 A;  3S6B A;  1QXY A;  2P98 A;  5CNX A;  4U73 A;  1KQ9 A;  4S00 A;  3L24 A;  1CHM A;  5CE6 A;  4S2R P;  3TB5 A;  3PKA A;  1QXZ A;  5CDV A;  1A16 A;  2GGB A;  3MX6 A;  2GTX A;  2EA2 A;  1W2M A;  3IG4 A;  4U6W A;  1XNZ A;  1XGM A;  2Q95 A;  4U76 A;  5FCF A;  1C22 A;  1C23 A;  4IKS A;  4FO7 A;  4U75 A;  2NQ7 A;  2P99 A;  4OOK A;  5JHU A;  1YJ3 A;  1WY2 A;  4JUQ A;  2GU6 A;  1C27 A;  2DFI A;  2NQ6 A;  3L7G A;  2BWW A;  1KP0 A;  3D27 A;  2Q93 A;  3FMQ A;  3FMR A;  1O0X A;  3ROR A;  2V3Z A;  2ZSG A;  3IU9 A;  2GU4 A;  5JFR A;  1C24 A;  1R5H A;  2IW2 A;  1WN1 A;  4FLJ A;  4U6J A;  1M35 A;  4U71 A;  1R5G A;  2P9A A;  3BIQ A;  4KM3 A;  4RZZ A;  4IEC A;  3PKD A;  2OAZ A;  4IKU A;  3PKE A;  2GG8 A;  3CB5 A;  5CDL A;  3BIP A;  2GU5 A;  1YW9 A;  1B59 A;  2GG0 A;  4EGE A;  3RVA A;  2BHC A;  4A6V A;  5E5B A;  4U6E A;  1WL9 A;  3MR1 A;  4RZY A;  4U70 A;  4U6C A;  2BB7 A;  2EVM A;  3IU7 A;  4ZWU A;  2GG2 A;  2OKN A;  2MAT A;  4IKT A;  3CTZ A;  4U1B A;  5D6E A;  4FKC A;  2GG5 A;  3Q6D A;  4R60 A;  1XGN A;  4S01 A;  3FM3 A;  1Y1N A;  2BH3 A;  1KQ0 A;  1QZY A;  2GZ5 A;  2Q94 A;  2GG3 A;  5CDE A;  5D6F A;  2BWU A;  4U6Z A;  2BWS A;  2Q8K A;  2B3H A;  2EVC A;  5CIK A;  2BHA A;  4IU6 A;  1WKM A;  4S2T P;  2EVO A;  4FLK A;  2BHD A;  3PKB A;  4IPA A;  4ZWO A;  4B28 A;  2V3Y A;  1R58 A;  2ADU A;  4RGZ 1;  4A6W A;  5CLS A;  2V3X A;  3PKC A;  4HXX A;  2GG7 A;  1BN5 A;  3TAV A;  3CB6 A;  2BWY A;  4U69 A;  1JAW A;  2EA4 A;  4MAT A;  5JI6 A;  2HOW A;  2BHB A;  2BWV A;  4FLL A;  2V6C A;  2G6P A;  1QXW A;  4IF7 A;  4ZNG A;  5FCH A;  4FO8 A;  4IDY A;  2BWT A;  3BIT A;  2GA2 A;  3MAT A;  3IU8 A;  1WL6 A;  2GG9 A;  2Q96 A;  4PNC A;  4QR8 A;  1PV9 A;  1MAT A;  4ZWP A; 
#chains in the Genus database with same CATH topology
 1N51 A;  2B3K A;  4IKR A;  1XGS A;  1WBQ A;  2GU7 A;  1B6A A;  1WLR A;  1YW8 A;  1C21 A;  2BN7 A;  2B3L A;  4Z7M A;  4PV4 A;  4FUK A;  1YW7 A;  1BOA A;  1XGO A;  1YVM A;  4FLI A;  2BWX A;  2GGC A;  1W7V A;  2Q92 A;  3S6B A;  1QXY A;  2P98 A;  5CNX A;  4U73 A;  1KQ9 A;  4S00 A;  3L24 A;  1CHM A;  5CE6 A;  4S2R P;  3TB5 A;  3PKA A;  1QXZ A;  5CDV A;  1A16 A;  2GGB A;  3MX6 A;  2GTX A;  2EA2 A;  1W2M A;  3IG4 A;  4U6W A;  1XNZ A;  1XGM A;  2Q95 A;  4U76 A;  5FCF A;  1C22 A;  1C23 A;  4IKS A;  4FO7 A;  4U75 A;  2NQ7 A;  2P99 A;  4OOK A;  5JHU A;  1YJ3 A;  1WY2 A;  4JUQ A;  2GU6 A;  1C27 A;  2DFI A;  2NQ6 A;  3L7G A;  2BWW A;  1KP0 A;  3D27 A;  2Q93 A;  3FMQ A;  3FMR A;  1O0X A;  3ROR A;  2V3Z A;  2ZSG A;  3IU9 A;  2GU4 A;  5JFR A;  1C24 A;  1R5H A;  2IW2 A;  1WN1 A;  4FLJ A;  4U6J A;  1M35 A;  4U71 A;  1R5G A;  2P9A A;  3BIQ A;  4KM3 A;  4RZZ A;  4IEC A;  3PKD A;  2OAZ A;  4IKU A;  3PKE A;  2GG8 A;  3CB5 A;  5CDL A;  3BIP A;  2GU5 A;  1YW9 A;  1B59 A;  2GG0 A;  4EGE A;  3RVA A;  2BHC A;  4A6V A;  5E5B A;  4U6E A;  1WL9 A;  3MR1 A;  4RZY A;  4U70 A;  4U6C A;  2BB7 A;  2EVM A;  3IU7 A;  4ZWU A;  2GG2 A;  2OKN A;  2MAT A;  4IKT A;  3CTZ A;  4U1B A;  5D6E A;  4FKC A;  2GG5 A;  3Q6D A;  4R60 A;  1XGN A;  4S01 A;  3FM3 A;  1Y1N A;  2BH3 A;  1KQ0 A;  1QZY A;  2GZ5 A;  2Q94 A;  2GG3 A;  5CDE A;  5D6F A;  2BWU A;  4U6Z A;  2BWS A;  2Q8K A;  2B3H A;  2EVC A;  5CIK A;  2BHA A;  4IU6 A;  1WKM A;  4S2T P;  2EVO A;  4FLK A;  2BHD A;  3PKB A;  4IPA A;  4ZWO A;  4B28 A;  2V3Y A;  1R58 A;  2ADU A;  4RGZ 1;  4A6W A;  5CLS A;  2V3X A;  3PKC A;  4HXX A;  2GG7 A;  1BN5 A;  3TAV A;  3CB6 A;  2BWY A;  4U69 A;  1JAW A;  2EA4 A;  4MAT A;  5JI6 A;  2HOW A;  2BHB A;  2BWV A;  4FLL A;  2V6C A;  2G6P A;  1QXW A;  4IF7 A;  4ZNG A;  5FCH A;  4FO8 A;  4IDY A;  2BWT A;  3BIT A;  2GA2 A;  3MAT A;  3IU8 A;  1WL6 A;  2GG9 A;  2Q96 A;  4PNC A;  4QR8 A;  1PV9 A;  1MAT A;  4ZWP A; 
#chains in the Genus database with same CATH homology
 1N51 A;  2B3K A;  4IKR A;  1XGS A;  1WBQ A;  2GU7 A;  1B6A A;  1WLR A;  1YW8 A;  1C21 A;  2BN7 A;  2B3L A;  4Z7M A;  4PV4 A;  4FUK A;  1YW7 A;  1BOA A;  1XGO A;  1YVM A;  4FLI A;  2BWX A;  2GGC A;  1W7V A;  2Q92 A;  3S6B A;  1QXY A;  2P98 A;  5CNX A;  4U73 A;  1KQ9 A;  4S00 A;  3L24 A;  1CHM A;  5CE6 A;  4S2R P;  3TB5 A;  3PKA A;  1QXZ A;  5CDV A;  1A16 A;  2GGB A;  3MX6 A;  2GTX A;  2EA2 A;  1W2M A;  3IG4 A;  4U6W A;  1XNZ A;  1XGM A;  2Q95 A;  4U76 A;  5FCF A;  1C22 A;  1C23 A;  4IKS A;  4FO7 A;  4U75 A;  2NQ7 A;  2P99 A;  4OOK A;  5JHU A;  1YJ3 A;  1WY2 A;  4JUQ A;  2GU6 A;  1C27 A;  2DFI A;  2NQ6 A;  3L7G A;  2BWW A;  1KP0 A;  3D27 A;  2Q93 A;  3FMQ A;  3FMR A;  1O0X A;  3ROR A;  2V3Z A;  2ZSG A;  3IU9 A;  2GU4 A;  5JFR A;  1C24 A;  1R5H A;  2IW2 A;  1WN1 A;  4FLJ A;  4U6J A;  1M35 A;  4U71 A;  1R5G A;  2P9A A;  3BIQ A;  4KM3 A;  4RZZ A;  4IEC A;  3PKD A;  2OAZ A;  4IKU A;  3PKE A;  2GG8 A;  3CB5 A;  5CDL A;  3BIP A;  2GU5 A;  1YW9 A;  1B59 A;  2GG0 A;  4EGE A;  3RVA A;  2BHC A;  4A6V A;  5E5B A;  4U6E A;  1WL9 A;  3MR1 A;  4RZY A;  4U70 A;  4U6C A;  2BB7 A;  2EVM A;  3IU7 A;  4ZWU A;  2GG2 A;  2OKN A;  2MAT A;  4IKT A;  3CTZ A;  4U1B A;  5D6E A;  4FKC A;  2GG5 A;  3Q6D A;  4R60 A;  1XGN A;  4S01 A;  3FM3 A;  1Y1N A;  2BH3 A;  1KQ0 A;  1QZY A;  2GZ5 A;  2Q94 A;  2GG3 A;  5CDE A;  5D6F A;  2BWU A;  4U6Z A;  2BWS A;  2Q8K A;  2B3H A;  2EVC A;  5CIK A;  2BHA A;  4IU6 A;  1WKM A;  4S2T P;  2EVO A;  4FLK A;  2BHD A;  3PKB A;  4IPA A;  4ZWO A;  4B28 A;  2V3Y A;  1R58 A;  2ADU A;  4RGZ 1;  4A6W A;  5CLS A;  2V3X A;  3PKC A;  4HXX A;  2GG7 A;  1BN5 A;  3TAV A;  3CB6 A;  2BWY A;  4U69 A;  1JAW A;  2EA4 A;  4MAT A;  5JI6 A;  2HOW A;  2BHB A;  2BWV A;  4FLL A;  2V6C A;  2G6P A;  1QXW A;  4IF7 A;  4ZNG A;  5FCH A;  4FO8 A;  4IDY A;  2BWT A;  3BIT A;  2GA2 A;  3MAT A;  3IU8 A;  1WL6 A;  2GG9 A;  2Q96 A;  4PNC A;  4QR8 A;  1PV9 A;  1MAT A;  4ZWP A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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