2P98A

E. coli methionine aminopeptidase monometalated with inhibitor ye7
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
source organism Escherichia coli
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p98A00
2BWXA 5CNXA 2GU6A 2GGBA 1YJ3A 2B3HA 5CDVA 4FLKA 3S6BA 2P9AA 4S00A 5CLSA 4B28A 2BHBA 1WKMA 3IU8A 1WN1A 1WL6A 4U73A 3IU9A 4OOKA 4U6JA 1QXZA 3BITA 4IDYA 1KQ9A 4RGZ1 1C23A 4RZYA 4IECA 2GTXA 2GU7A 5D6FA 2BWTA 2GG7A 1BOAA 3RORA 4PV4A 4PNCA 1C22A 3IU7A 2BHCA 4IKSA 5CE6A 1YW7A 2BN7A 4S01A 2GZ5A 2Q94A 4U76A 4S2TP 4EGEA 5JHUA 4IKTA 5CDLA 2V3XA 1W7VA 1YVMA 3BIPA 3MR1A 2Q95A 4QR8A 4U6EA 1XGMA 2GG9A 1YW8A 1WY2A 3RVAA 3BIQA 5E5BA 2Q92A 2BHDA 4FLLA 3MX6A 1KQ0A 1XNZA 2GGCA 2V3YA 1BN5A 3PKCA 4ZWUA 1XGNA 1CHMA 2IW2A 1W2MA 3PKAA 1KP0A 3L7GA 4U71A 1QZYA 2B3LA 2BWVA 2DFIA 4KM3A 4A6VA 2NQ7A 2ADUA 3Q6DA 3CB5A 5CIKA 2EA2A 5CDEA 5JFRA 1R5GA 2GG8A 1YW9A 2GU4A 2BWYA 1WBQA 2GU5A 2Q93A 4FKCA 1WL9A 4S2RP 4U6CA 4U70A 4FO7A 1MATA 2G6PA 2B3KA 4ZWPA 1JAWA 1PV9A 2OAZA 2BB7A 3L24A 1C24A 4FUKA 4ZNGA 4IU6A 1R58A 2MATA 4FO8A 4ZWOA 3PKDA 2V6CA 4U69A 1Y1NA 3CTZA 5FCFA 2EVOA 2GG0A 2ZSGA 1R5HA 1XGOA 4HXXA 2Q96A 4IKUA 2GA2A 3TB5A 4IPAA 5D6EA 1M35A 2GG3A 1C27A 2BWWA 2P98A 1O0XA 5JI6A 3FMQA 3IG4A 2NQ6A 1XGSA 2V3ZA 4FLJA 4U75A 4A6WA 4IF7A 1WLRA 4R60A 4JUQA 1C21A 3CB6A 4U6WA 2EA4A 2BWSA 2BH3A 2BHAA 2GG5A 4FLIA 1B6AA 2GG2A 4IKRA 1A16A 4U6ZA 1N51A 4RZZA 3PKEA 3TAVA 3PKBA 2P99A 2BWUA 2EVMA 1QXWA 5FCHA 4Z7MA 2EVCA 3FMRA 3D27A 4MATA 3MATA 2OKNA 2HOWA 2Q8KA 3FM3A 1QXYA 4U1BA 1B59A
chains in the Genus database with same CATH superfamily
2BWXA 5CNXA 2GU6A 2GGBA 1YJ3A 2B3HA 5CDVA 4FLKA 3S6BA 2P9AA 4S00A 5CLSA 4B28A 2BHBA 1WKMA 3IU8A 1WN1A 1WL6A 4U73A 3IU9A 4OOKA 4U6JA 1QXZA 3BITA 4IDYA 1KQ9A 4RGZ1 1C23A 4RZYA 4IECA 2GTXA 2GU7A 5D6FA 2BWTA 2GG7A 1BOAA 3RORA 4PV4A 4PNCA 1C22A 3IU7A 2BHCA 4IKSA 5CE6A 1YW7A 2BN7A 4S01A 2GZ5A 2Q94A 4U76A 4S2TP 4EGEA 5JHUA 4IKTA 5CDLA 2V3XA 1W7VA 1YVMA 3BIPA 3MR1A 2Q95A 4QR8A 4U6EA 1XGMA 2GG9A 1YW8A 1WY2A 3RVAA 3BIQA 5E5BA 2Q92A 2BHDA 4FLLA 3MX6A 1KQ0A 1XNZA 2GGCA 2V3YA 1BN5A 3PKCA 4ZWUA 1XGNA 1CHMA 2IW2A 1W2MA 3PKAA 1KP0A 3L7GA 4U71A 1QZYA 2B3LA 2BWVA 2DFIA 4KM3A 4A6VA 2NQ7A 2ADUA 3Q6DA 3CB5A 5CIKA 2EA2A 5CDEA 5JFRA 1R5GA 2GG8A 1YW9A 2GU4A 2BWYA 1WBQA 2GU5A 2Q93A 4FKCA 1WL9A 4S2RP 4U6CA 4U70A 4FO7A 1MATA 2G6PA 2B3KA 4ZWPA 1JAWA 1PV9A 2OAZA 2BB7A 3L24A 1C24A 4FUKA 4ZNGA 4IU6A 1R58A 2MATA 4FO8A 4ZWOA 3PKDA 2V6CA 4U69A 1Y1NA 3CTZA 5FCFA 2EVOA 2GG0A 2ZSGA 1R5HA 1XGOA 4HXXA 2Q96A 4IKUA 2GA2A 3TB5A 4IPAA 5D6EA 1M35A 2GG3A 1C27A 2BWWA 2P98A 1O0XA 5JI6A 3FMQA 3IG4A 2NQ6A 1XGSA 2V3ZA 4FLJA 4U75A 4A6WA 4IF7A 1WLRA 4R60A 4JUQA 1C21A 3CB6A 4U6WA 2EA4A 2BWSA 2BH3A 2BHAA 2GG5A 4FLIA 1B6AA 2GG2A 4IKRA 1A16A 4U6ZA 1N51A 4RZZA 3PKEA 3TAVA 3PKBA 2P99A 2BWUA 2EVMA 1QXWA 5FCHA 4Z7MA 2EVCA 3FMRA 3D27A 4MATA 3MATA 2OKNA 2HOWA 2Q8KA 3FM3A 1QXYA 4U1BA 1B59A
chains in the Genus database with same CATH topology
2BWXA 5CNXA 2GU6A 2GGBA 1YJ3A 2B3HA 5CDVA 4FLKA 3S6BA 2P9AA 4S00A 5CLSA 4B28A 2BHBA 1WKMA 3IU8A 1WN1A 1WL6A 4U73A 3IU9A 4OOKA 4U6JA 1QXZA 3BITA 4IDYA 1KQ9A 4RGZ1 1C23A 4RZYA 4IECA 2GTXA 2GU7A 5D6FA 2BWTA 2GG7A 1BOAA 3RORA 4PV4A 4PNCA 1C22A 3IU7A 2BHCA 4IKSA 5CE6A 1YW7A 2BN7A 4S01A 2GZ5A 2Q94A 4U76A 4S2TP 4EGEA 5JHUA 4IKTA 5CDLA 2V3XA 1W7VA 1YVMA 3BIPA 3MR1A 2Q95A 4QR8A 4U6EA 1XGMA 2GG9A 1YW8A 1WY2A 3RVAA 3BIQA 5E5BA 2Q92A 2BHDA 4FLLA 3MX6A 1KQ0A 1XNZA 2GGCA 2V3YA 1BN5A 3PKCA 4ZWUA 1XGNA 1CHMA 2IW2A 1W2MA 3PKAA 1KP0A 3L7GA 4U71A 1QZYA 2B3LA 2BWVA 2DFIA 4KM3A 4A6VA 2NQ7A 2ADUA 3Q6DA 3CB5A 5CIKA 2EA2A 5CDEA 5JFRA 1R5GA 2GG8A 1YW9A 2GU4A 2BWYA 1WBQA 2GU5A 2Q93A 4FKCA 1WL9A 4S2RP 4U6CA 4U70A 4FO7A 1MATA 2G6PA 2B3KA 4ZWPA 1JAWA 1PV9A 2OAZA 2BB7A 3L24A 1C24A 4FUKA 4ZNGA 4IU6A 1R58A 2MATA 4FO8A 4ZWOA 3PKDA 2V6CA 4U69A 1Y1NA 3CTZA 5FCFA 2EVOA 2GG0A 2ZSGA 1R5HA 1XGOA 4HXXA 2Q96A 4IKUA 2GA2A 3TB5A 4IPAA 5D6EA 1M35A 2GG3A 1C27A 2BWWA 2P98A 1O0XA 5JI6A 3FMQA 3IG4A 2NQ6A 1XGSA 2V3ZA 4FLJA 4U75A 4A6WA 4IF7A 1WLRA 4R60A 4JUQA 1C21A 3CB6A 4U6WA 2EA4A 2BWSA 2BH3A 2BHAA 2GG5A 4FLIA 1B6AA 2GG2A 4IKRA 1A16A 4U6ZA 1N51A 4RZZA 3PKEA 3TAVA 3PKBA 2P99A 2BWUA 2EVMA 1QXWA 5FCHA 4Z7MA 2EVCA 3FMRA 3D27A 4MATA 3MATA 2OKNA 2HOWA 2Q8KA 3FM3A 1QXYA 4U1BA 1B59A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BWX A;  5CNX A;  2GU6 A;  2GGB A;  1YJ3 A;  2B3H A;  5CDV A;  4FLK A;  3S6B A;  2P9A A;  4S00 A;  5CLS A;  4B28 A;  2BHB A;  1WKM A;  3IU8 A;  1WN1 A;  1WL6 A;  4U73 A;  3IU9 A;  4OOK A;  4U6J A;  1QXZ A;  3BIT A;  4IDY A;  1KQ9 A;  4RGZ 1;  1C23 A;  4RZY A;  4IEC A;  2GTX A;  2GU7 A;  5D6F A;  2BWT A;  2GG7 A;  1BOA A;  3ROR A;  4PV4 A;  4PNC A;  1C22 A;  3IU7 A;  2BHC A;  4IKS A;  5CE6 A;  1YW7 A;  2BN7 A;  4S01 A;  2GZ5 A;  2Q94 A;  4U76 A;  4S2T P;  4EGE A;  5JHU A;  4IKT A;  5CDL A;  2V3X A;  1W7V A;  1YVM A;  3BIP A;  3MR1 A;  2Q95 A;  4QR8 A;  4U6E A;  1XGM A;  2GG9 A;  1YW8 A;  1WY2 A;  3RVA A;  3BIQ A;  5E5B A;  2Q92 A;  2BHD A;  4FLL A;  3MX6 A;  1KQ0 A;  1XNZ A;  2GGC A;  2V3Y A;  1BN5 A;  3PKC A;  4ZWU A;  1XGN A;  1CHM A;  2IW2 A;  1W2M A;  3PKA A;  1KP0 A;  3L7G A;  4U71 A;  1QZY A;  2B3L A;  2BWV A;  2DFI A;  4KM3 A;  4A6V A;  2NQ7 A;  2ADU A;  3Q6D A;  3CB5 A;  5CIK A;  2EA2 A;  5CDE A;  5JFR A;  1R5G A;  2GG8 A;  1YW9 A;  2GU4 A;  2BWY A;  1WBQ A;  2GU5 A;  2Q93 A;  4FKC A;  1WL9 A;  4S2R P;  4U6C A;  4U70 A;  4FO7 A;  1MAT A;  2G6P A;  2B3K A;  4ZWP A;  1JAW A;  1PV9 A;  2OAZ A;  2BB7 A;  3L24 A;  1C24 A;  4FUK A;  4ZNG A;  4IU6 A;  1R58 A;  2MAT A;  4FO8 A;  4ZWO A;  3PKD A;  2V6C A;  4U69 A;  1Y1N A;  3CTZ A;  5FCF A;  2EVO A;  2GG0 A;  2ZSG A;  1R5H A;  1XGO A;  4HXX A;  2Q96 A;  4IKU A;  2GA2 A;  3TB5 A;  4IPA A;  5D6E A;  1M35 A;  2GG3 A;  1C27 A;  2BWW A;  2P98 A;  1O0X A;  5JI6 A;  3FMQ A;  3IG4 A;  2NQ6 A;  1XGS A;  2V3Z A;  4FLJ A;  4U75 A;  4A6W A;  4IF7 A;  1WLR A;  4R60 A;  4JUQ A;  1C21 A;  3CB6 A;  4U6W A;  2EA4 A;  2BWS A;  2BH3 A;  2BHA A;  2GG5 A;  4FLI A;  1B6A A;  2GG2 A;  4IKR A;  1A16 A;  4U6Z A;  1N51 A;  4RZZ A;  3PKE A;  3TAV A;  3PKB A;  2P99 A;  2BWU A;  2EVM A;  1QXW A;  5FCH A;  4Z7M A;  2EVC A;  3FMR A;  3D27 A;  4MAT A;  3MAT A;  2OKN A;  2HOW A;  2Q8K A;  3FM3 A;  1QXY A;  4U1B A;  1B59 A; 
#chains in the Genus database with same CATH topology
 2BWX A;  5CNX A;  2GU6 A;  2GGB A;  1YJ3 A;  2B3H A;  5CDV A;  4FLK A;  3S6B A;  2P9A A;  4S00 A;  5CLS A;  4B28 A;  2BHB A;  1WKM A;  3IU8 A;  1WN1 A;  1WL6 A;  4U73 A;  3IU9 A;  4OOK A;  4U6J A;  1QXZ A;  3BIT A;  4IDY A;  1KQ9 A;  4RGZ 1;  1C23 A;  4RZY A;  4IEC A;  2GTX A;  2GU7 A;  5D6F A;  2BWT A;  2GG7 A;  1BOA A;  3ROR A;  4PV4 A;  4PNC A;  1C22 A;  3IU7 A;  2BHC A;  4IKS A;  5CE6 A;  1YW7 A;  2BN7 A;  4S01 A;  2GZ5 A;  2Q94 A;  4U76 A;  4S2T P;  4EGE A;  5JHU A;  4IKT A;  5CDL A;  2V3X A;  1W7V A;  1YVM A;  3BIP A;  3MR1 A;  2Q95 A;  4QR8 A;  4U6E A;  1XGM A;  2GG9 A;  1YW8 A;  1WY2 A;  3RVA A;  3BIQ A;  5E5B A;  2Q92 A;  2BHD A;  4FLL A;  3MX6 A;  1KQ0 A;  1XNZ A;  2GGC A;  2V3Y A;  1BN5 A;  3PKC A;  4ZWU A;  1XGN A;  1CHM A;  2IW2 A;  1W2M A;  3PKA A;  1KP0 A;  3L7G A;  4U71 A;  1QZY A;  2B3L A;  2BWV A;  2DFI A;  4KM3 A;  4A6V A;  2NQ7 A;  2ADU A;  3Q6D A;  3CB5 A;  5CIK A;  2EA2 A;  5CDE A;  5JFR A;  1R5G A;  2GG8 A;  1YW9 A;  2GU4 A;  2BWY A;  1WBQ A;  2GU5 A;  2Q93 A;  4FKC A;  1WL9 A;  4S2R P;  4U6C A;  4U70 A;  4FO7 A;  1MAT A;  2G6P A;  2B3K A;  4ZWP A;  1JAW A;  1PV9 A;  2OAZ A;  2BB7 A;  3L24 A;  1C24 A;  4FUK A;  4ZNG A;  4IU6 A;  1R58 A;  2MAT A;  4FO8 A;  4ZWO A;  3PKD A;  2V6C A;  4U69 A;  1Y1N A;  3CTZ A;  5FCF A;  2EVO A;  2GG0 A;  2ZSG A;  1R5H A;  1XGO A;  4HXX A;  2Q96 A;  4IKU A;  2GA2 A;  3TB5 A;  4IPA A;  5D6E A;  1M35 A;  2GG3 A;  1C27 A;  2BWW A;  2P98 A;  1O0X A;  5JI6 A;  3FMQ A;  3IG4 A;  2NQ6 A;  1XGS A;  2V3Z A;  4FLJ A;  4U75 A;  4A6W A;  4IF7 A;  1WLR A;  4R60 A;  4JUQ A;  1C21 A;  3CB6 A;  4U6W A;  2EA4 A;  2BWS A;  2BH3 A;  2BHA A;  2GG5 A;  4FLI A;  1B6A A;  2GG2 A;  4IKR A;  1A16 A;  4U6Z A;  1N51 A;  4RZZ A;  3PKE A;  3TAV A;  3PKB A;  2P99 A;  2BWU A;  2EVM A;  1QXW A;  5FCH A;  4Z7M A;  2EVC A;  3FMR A;  3D27 A;  4MAT A;  3MAT A;  2OKN A;  2HOW A;  2Q8K A;  3FM3 A;  1QXY A;  4U1B A;  1B59 A; 
#chains in the Genus database with same CATH homology
 2BWX A;  5CNX A;  2GU6 A;  2GGB A;  1YJ3 A;  2B3H A;  5CDV A;  4FLK A;  3S6B A;  2P9A A;  4S00 A;  5CLS A;  4B28 A;  2BHB A;  1WKM A;  3IU8 A;  1WN1 A;  1WL6 A;  4U73 A;  3IU9 A;  4OOK A;  4U6J A;  1QXZ A;  3BIT A;  4IDY A;  1KQ9 A;  4RGZ 1;  1C23 A;  4RZY A;  4IEC A;  2GTX A;  2GU7 A;  5D6F A;  2BWT A;  2GG7 A;  1BOA A;  3ROR A;  4PV4 A;  4PNC A;  1C22 A;  3IU7 A;  2BHC A;  4IKS A;  5CE6 A;  1YW7 A;  2BN7 A;  4S01 A;  2GZ5 A;  2Q94 A;  4U76 A;  4S2T P;  4EGE A;  5JHU A;  4IKT A;  5CDL A;  2V3X A;  1W7V A;  1YVM A;  3BIP A;  3MR1 A;  2Q95 A;  4QR8 A;  4U6E A;  1XGM A;  2GG9 A;  1YW8 A;  1WY2 A;  3RVA A;  3BIQ A;  5E5B A;  2Q92 A;  2BHD A;  4FLL A;  3MX6 A;  1KQ0 A;  1XNZ A;  2GGC A;  2V3Y A;  1BN5 A;  3PKC A;  4ZWU A;  1XGN A;  1CHM A;  2IW2 A;  1W2M A;  3PKA A;  1KP0 A;  3L7G A;  4U71 A;  1QZY A;  2B3L A;  2BWV A;  2DFI A;  4KM3 A;  4A6V A;  2NQ7 A;  2ADU A;  3Q6D A;  3CB5 A;  5CIK A;  2EA2 A;  5CDE A;  5JFR A;  1R5G A;  2GG8 A;  1YW9 A;  2GU4 A;  2BWY A;  1WBQ A;  2GU5 A;  2Q93 A;  4FKC A;  1WL9 A;  4S2R P;  4U6C A;  4U70 A;  4FO7 A;  1MAT A;  2G6P A;  2B3K A;  4ZWP A;  1JAW A;  1PV9 A;  2OAZ A;  2BB7 A;  3L24 A;  1C24 A;  4FUK A;  4ZNG A;  4IU6 A;  1R58 A;  2MAT A;  4FO8 A;  4ZWO A;  3PKD A;  2V6C A;  4U69 A;  1Y1N A;  3CTZ A;  5FCF A;  2EVO A;  2GG0 A;  2ZSG A;  1R5H A;  1XGO A;  4HXX A;  2Q96 A;  4IKU A;  2GA2 A;  3TB5 A;  4IPA A;  5D6E A;  1M35 A;  2GG3 A;  1C27 A;  2BWW A;  2P98 A;  1O0X A;  5JI6 A;  3FMQ A;  3IG4 A;  2NQ6 A;  1XGS A;  2V3Z A;  4FLJ A;  4U75 A;  4A6W A;  4IF7 A;  1WLR A;  4R60 A;  4JUQ A;  1C21 A;  3CB6 A;  4U6W A;  2EA4 A;  2BWS A;  2BH3 A;  2BHA A;  2GG5 A;  4FLI A;  1B6A A;  2GG2 A;  4IKR A;  1A16 A;  4U6Z A;  1N51 A;  4RZZ A;  3PKE A;  3TAV A;  3PKB A;  2P99 A;  2BWU A;  2EVM A;  1QXW A;  5FCH A;  4Z7M A;  2EVC A;  3FMR A;  3D27 A;  4MAT A;  3MAT A;  2OKN A;  2HOW A;  2Q8K A;  3FM3 A;  1QXY A;  4U1B A;  1B59 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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