2GG5A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 81
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg5A00
3MR1A 4IKTA 4U6EA 4OOKA 4PNCA 2Q93A 4S00A 5JHUA 2V3ZA 4RZZA 3PKAA 2OAZA 1YW7A 2GG2A 1WL6A 1QXWA 3PKBA 2P9AA 2GZ5A 5CDVA 2V6CA 4FLIA 5JFRA 3L7GA 3S6BA 2GA2A 2OKNA 5CLSA 4FLLA 1R5GA 1WKMA 4A6VA 2NQ6A 1YW9A 4IPAA 2BB7A 4ZWPA 3FMRA 2Q8KA 3RVAA 2B3LA 3BIPA 2BWWA 1BOAA 2GU6A 1QXZA 4A6WA 1KQ0A 2Q92A 2V3XA 5D6EA 4MATA 4ZNGA 2BH3A 2EA2A 5CNXA 2EVMA 1A16A 1XNZA 4U6CA 5JI6A 5CE6A 2G6PA 2BWTA 2GGCA 2Q94A 1R5HA 2BHCA 4RGZ1 1C23A 1M35A 2IW2A 2EVOA 3TB5A 4IECA 2DFIA 1W7VA 3BITA 2BWUA 2V3YA 5D6FA 2BHAA 2P99A 2BHDA 4R60A 4PV4A 4EGEA 3IU8A 1N51A 2GU7A 5CDLA 1C27A 1WN1A 1C24A 3PKEA 4JUQA 1WBQA 1C21A 1XGNA 2ADUA 1QXYA 3PKCA 4ZWOA 4QR8A 3Q6DA 4ZWUA 1XGMA 3CTZA 1WLRA 4U70A 2EVCA 1B6AA 3PKDA 4U76A 1W2MA 2GG9A 1YW8A 2GGBA 1XGSA 1R58A 4IDYA 4KM3A 3IG4A 4FKCA 5CDEA 2HOWA 4U6JA 2GU4A 1B59A 2GG5A 2GTXA 2GU5A 5CIKA 2BWYA 4Z7MA 1PV9A 1YJ3A 3D27A 2GG8A 4FO8A 1XGOA 2Q95A 4FLKA 4S2RP 3TAVA 3MATA 4U73A 3MX6A 2EA4A 2P98A 4U1BA 1BN5A 1KQ9A 4U69A 3RORA 3CB6A 4FLJA 5FCFA 3FMQA 4U75A 2GG7A 1KP0A 1O0XA 2BN7A 3IU7A 4U6ZA 4S01A 4S2TP 4U71A 2Q96A 4IKUA 4IKRA 2BWXA 5FCHA 4IF7A 2B3HA 2B3KA 3BIQA 5E5BA 1CHMA 2MATA 3L24A 2BHBA 2GG0A 4IKSA 4IU6A 4FO7A 4HXXA 1WL9A 1WY2A 2ZSGA 1YVMA 1C22A 1QZYA 3IU9A 4B28A 2BWSA 1JAWA 4RZYA 3FM3A 4U6WA 3CB5A 2NQ7A 1MATA 1Y1NA 2BWVA 2GG3A 4FUKA
chains in the Genus database with same CATH superfamily
3MR1A 4IKTA 4U6EA 4OOKA 4PNCA 2Q93A 4S00A 5JHUA 2V3ZA 4RZZA 3PKAA 2OAZA 1YW7A 2GG2A 1WL6A 1QXWA 3PKBA 2P9AA 2GZ5A 5CDVA 2V6CA 4FLIA 5JFRA 3L7GA 3S6BA 2GA2A 2OKNA 5CLSA 4FLLA 1R5GA 1WKMA 4A6VA 2NQ6A 1YW9A 4IPAA 2BB7A 4ZWPA 3FMRA 2Q8KA 3RVAA 2B3LA 3BIPA 2BWWA 1BOAA 2GU6A 1QXZA 4A6WA 1KQ0A 2Q92A 2V3XA 5D6EA 4MATA 4ZNGA 2BH3A 2EA2A 5CNXA 2EVMA 1A16A 1XNZA 4U6CA 5JI6A 5CE6A 2G6PA 2BWTA 2GGCA 2Q94A 1R5HA 2BHCA 4RGZ1 1C23A 1M35A 2IW2A 2EVOA 3TB5A 4IECA 2DFIA 1W7VA 3BITA 2BWUA 2V3YA 5D6FA 2BHAA 2P99A 2BHDA 4R60A 4PV4A 4EGEA 3IU8A 1N51A 2GU7A 5CDLA 1C27A 1WN1A 1C24A 3PKEA 4JUQA 1WBQA 1C21A 1XGNA 2ADUA 1QXYA 3PKCA 4ZWOA 4QR8A 3Q6DA 4ZWUA 1XGMA 3CTZA 1WLRA 4U70A 2EVCA 1B6AA 3PKDA 4U76A 1W2MA 2GG9A 1YW8A 2GGBA 1XGSA 1R58A 4IDYA 4KM3A 3IG4A 4FKCA 5CDEA 2HOWA 4U6JA 2GU4A 1B59A 2GG5A 2GTXA 2GU5A 5CIKA 2BWYA 4Z7MA 1PV9A 1YJ3A 3D27A 2GG8A 4FO8A 1XGOA 2Q95A 4FLKA 4S2RP 3TAVA 3MATA 4U73A 3MX6A 2EA4A 2P98A 4U1BA 1BN5A 1KQ9A 4U69A 3RORA 3CB6A 4FLJA 5FCFA 3FMQA 4U75A 2GG7A 1KP0A 1O0XA 2BN7A 3IU7A 4U6ZA 4S01A 4S2TP 4U71A 2Q96A 4IKUA 4IKRA 2BWXA 5FCHA 4IF7A 2B3HA 2B3KA 3BIQA 5E5BA 1CHMA 2MATA 3L24A 2BHBA 2GG0A 4IKSA 4IU6A 4FO7A 4HXXA 1WL9A 1WY2A 2ZSGA 1YVMA 1C22A 1QZYA 3IU9A 4B28A 2BWSA 1JAWA 4RZYA 3FM3A 4U6WA 3CB5A 2NQ7A 1MATA 1Y1NA 2BWVA 2GG3A 4FUKA
chains in the Genus database with same CATH topology
3MR1A 4IKTA 4U6EA 4OOKA 4PNCA 2Q93A 4S00A 5JHUA 2V3ZA 4RZZA 3PKAA 2OAZA 1YW7A 2GG2A 1WL6A 1QXWA 3PKBA 2P9AA 2GZ5A 5CDVA 2V6CA 4FLIA 5JFRA 3L7GA 3S6BA 2GA2A 2OKNA 5CLSA 4FLLA 1R5GA 1WKMA 4A6VA 2NQ6A 1YW9A 4IPAA 2BB7A 4ZWPA 3FMRA 2Q8KA 3RVAA 2B3LA 3BIPA 2BWWA 1BOAA 2GU6A 1QXZA 4A6WA 1KQ0A 2Q92A 2V3XA 5D6EA 4MATA 4ZNGA 2BH3A 2EA2A 5CNXA 2EVMA 1A16A 1XNZA 4U6CA 5JI6A 5CE6A 2G6PA 2BWTA 2GGCA 2Q94A 1R5HA 2BHCA 4RGZ1 1C23A 1M35A 2IW2A 2EVOA 3TB5A 4IECA 2DFIA 1W7VA 3BITA 2BWUA 2V3YA 5D6FA 2BHAA 2P99A 2BHDA 4R60A 4PV4A 4EGEA 3IU8A 1N51A 2GU7A 5CDLA 1C27A 1WN1A 1C24A 3PKEA 4JUQA 1WBQA 1C21A 1XGNA 2ADUA 1QXYA 3PKCA 4ZWOA 4QR8A 3Q6DA 4ZWUA 1XGMA 3CTZA 1WLRA 4U70A 2EVCA 1B6AA 3PKDA 4U76A 1W2MA 2GG9A 1YW8A 2GGBA 1XGSA 1R58A 4IDYA 4KM3A 3IG4A 4FKCA 5CDEA 2HOWA 4U6JA 2GU4A 1B59A 2GG5A 2GTXA 2GU5A 5CIKA 2BWYA 4Z7MA 1PV9A 1YJ3A 3D27A 2GG8A 4FO8A 1XGOA 2Q95A 4FLKA 4S2RP 3TAVA 3MATA 4U73A 3MX6A 2EA4A 2P98A 4U1BA 1BN5A 1KQ9A 4U69A 3RORA 3CB6A 4FLJA 5FCFA 3FMQA 4U75A 2GG7A 1KP0A 1O0XA 2BN7A 3IU7A 4U6ZA 4S01A 4S2TP 4U71A 2Q96A 4IKUA 4IKRA 2BWXA 5FCHA 4IF7A 2B3HA 2B3KA 3BIQA 5E5BA 1CHMA 2MATA 3L24A 2BHBA 2GG0A 4IKSA 4IU6A 4FO7A 4HXXA 1WL9A 1WY2A 2ZSGA 1YVMA 1C22A 1QZYA 3IU9A 4B28A 2BWSA 1JAWA 4RZYA 3FM3A 4U6WA 3CB5A 2NQ7A 1MATA 1Y1NA 2BWVA 2GG3A 4FUKA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3MR1 A;  4IKT A;  4U6E A;  4OOK A;  4PNC A;  2Q93 A;  4S00 A;  5JHU A;  2V3Z A;  4RZZ A;  3PKA A;  2OAZ A;  1YW7 A;  2GG2 A;  1WL6 A;  1QXW A;  3PKB A;  2P9A A;  2GZ5 A;  5CDV A;  2V6C A;  4FLI A;  5JFR A;  3L7G A;  3S6B A;  2GA2 A;  2OKN A;  5CLS A;  4FLL A;  1R5G A;  1WKM A;  4A6V A;  2NQ6 A;  1YW9 A;  4IPA A;  2BB7 A;  4ZWP A;  3FMR A;  2Q8K A;  3RVA A;  2B3L A;  3BIP A;  2BWW A;  1BOA A;  2GU6 A;  1QXZ A;  4A6W A;  1KQ0 A;  2Q92 A;  2V3X A;  5D6E A;  4MAT A;  4ZNG A;  2BH3 A;  2EA2 A;  5CNX A;  2EVM A;  1A16 A;  1XNZ A;  4U6C A;  5JI6 A;  5CE6 A;  2G6P A;  2BWT A;  2GGC A;  2Q94 A;  1R5H A;  2BHC A;  4RGZ 1;  1C23 A;  1M35 A;  2IW2 A;  2EVO A;  3TB5 A;  4IEC A;  2DFI A;  1W7V A;  3BIT A;  2BWU A;  2V3Y A;  5D6F A;  2BHA A;  2P99 A;  2BHD A;  4R60 A;  4PV4 A;  4EGE A;  3IU8 A;  1N51 A;  2GU7 A;  5CDL A;  1C27 A;  1WN1 A;  1C24 A;  3PKE A;  4JUQ A;  1WBQ A;  1C21 A;  1XGN A;  2ADU A;  1QXY A;  3PKC A;  4ZWO A;  4QR8 A;  3Q6D A;  4ZWU A;  1XGM A;  3CTZ A;  1WLR A;  4U70 A;  2EVC A;  1B6A A;  3PKD A;  4U76 A;  1W2M A;  2GG9 A;  1YW8 A;  2GGB A;  1XGS A;  1R58 A;  4IDY A;  4KM3 A;  3IG4 A;  4FKC A;  5CDE A;  2HOW A;  4U6J A;  2GU4 A;  1B59 A;  2GG5 A;  2GTX A;  2GU5 A;  5CIK A;  2BWY A;  4Z7M A;  1PV9 A;  1YJ3 A;  3D27 A;  2GG8 A;  4FO8 A;  1XGO A;  2Q95 A;  4FLK A;  4S2R P;  3TAV A;  3MAT A;  4U73 A;  3MX6 A;  2EA4 A;  2P98 A;  4U1B A;  1BN5 A;  1KQ9 A;  4U69 A;  3ROR A;  3CB6 A;  4FLJ A;  5FCF A;  3FMQ A;  4U75 A;  2GG7 A;  1KP0 A;  1O0X A;  2BN7 A;  3IU7 A;  4U6Z A;  4S01 A;  4S2T P;  4U71 A;  2Q96 A;  4IKU A;  4IKR A;  2BWX A;  5FCH A;  4IF7 A;  2B3H A;  2B3K A;  3BIQ A;  5E5B A;  1CHM A;  2MAT A;  3L24 A;  2BHB A;  2GG0 A;  4IKS A;  4IU6 A;  4FO7 A;  4HXX A;  1WL9 A;  1WY2 A;  2ZSG A;  1YVM A;  1C22 A;  1QZY A;  3IU9 A;  4B28 A;  2BWS A;  1JAW A;  4RZY A;  3FM3 A;  4U6W A;  3CB5 A;  2NQ7 A;  1MAT A;  1Y1N A;  2BWV A;  2GG3 A;  4FUK A; 
#chains in the Genus database with same CATH topology
 3MR1 A;  4IKT A;  4U6E A;  4OOK A;  4PNC A;  2Q93 A;  4S00 A;  5JHU A;  2V3Z A;  4RZZ A;  3PKA A;  2OAZ A;  1YW7 A;  2GG2 A;  1WL6 A;  1QXW A;  3PKB A;  2P9A A;  2GZ5 A;  5CDV A;  2V6C A;  4FLI A;  5JFR A;  3L7G A;  3S6B A;  2GA2 A;  2OKN A;  5CLS A;  4FLL A;  1R5G A;  1WKM A;  4A6V A;  2NQ6 A;  1YW9 A;  4IPA A;  2BB7 A;  4ZWP A;  3FMR A;  2Q8K A;  3RVA A;  2B3L A;  3BIP A;  2BWW A;  1BOA A;  2GU6 A;  1QXZ A;  4A6W A;  1KQ0 A;  2Q92 A;  2V3X A;  5D6E A;  4MAT A;  4ZNG A;  2BH3 A;  2EA2 A;  5CNX A;  2EVM A;  1A16 A;  1XNZ A;  4U6C A;  5JI6 A;  5CE6 A;  2G6P A;  2BWT A;  2GGC A;  2Q94 A;  1R5H A;  2BHC A;  4RGZ 1;  1C23 A;  1M35 A;  2IW2 A;  2EVO A;  3TB5 A;  4IEC A;  2DFI A;  1W7V A;  3BIT A;  2BWU A;  2V3Y A;  5D6F A;  2BHA A;  2P99 A;  2BHD A;  4R60 A;  4PV4 A;  4EGE A;  3IU8 A;  1N51 A;  2GU7 A;  5CDL A;  1C27 A;  1WN1 A;  1C24 A;  3PKE A;  4JUQ A;  1WBQ A;  1C21 A;  1XGN A;  2ADU A;  1QXY A;  3PKC A;  4ZWO A;  4QR8 A;  3Q6D A;  4ZWU A;  1XGM A;  3CTZ A;  1WLR A;  4U70 A;  2EVC A;  1B6A A;  3PKD A;  4U76 A;  1W2M A;  2GG9 A;  1YW8 A;  2GGB A;  1XGS A;  1R58 A;  4IDY A;  4KM3 A;  3IG4 A;  4FKC A;  5CDE A;  2HOW A;  4U6J A;  2GU4 A;  1B59 A;  2GG5 A;  2GTX A;  2GU5 A;  5CIK A;  2BWY A;  4Z7M A;  1PV9 A;  1YJ3 A;  3D27 A;  2GG8 A;  4FO8 A;  1XGO A;  2Q95 A;  4FLK A;  4S2R P;  3TAV A;  3MAT A;  4U73 A;  3MX6 A;  2EA4 A;  2P98 A;  4U1B A;  1BN5 A;  1KQ9 A;  4U69 A;  3ROR A;  3CB6 A;  4FLJ A;  5FCF A;  3FMQ A;  4U75 A;  2GG7 A;  1KP0 A;  1O0X A;  2BN7 A;  3IU7 A;  4U6Z A;  4S01 A;  4S2T P;  4U71 A;  2Q96 A;  4IKU A;  4IKR A;  2BWX A;  5FCH A;  4IF7 A;  2B3H A;  2B3K A;  3BIQ A;  5E5B A;  1CHM A;  2MAT A;  3L24 A;  2BHB A;  2GG0 A;  4IKS A;  4IU6 A;  4FO7 A;  4HXX A;  1WL9 A;  1WY2 A;  2ZSG A;  1YVM A;  1C22 A;  1QZY A;  3IU9 A;  4B28 A;  2BWS A;  1JAW A;  4RZY A;  3FM3 A;  4U6W A;  3CB5 A;  2NQ7 A;  1MAT A;  1Y1N A;  2BWV A;  2GG3 A;  4FUK A; 
#chains in the Genus database with same CATH homology
 3MR1 A;  4IKT A;  4U6E A;  4OOK A;  4PNC A;  2Q93 A;  4S00 A;  5JHU A;  2V3Z A;  4RZZ A;  3PKA A;  2OAZ A;  1YW7 A;  2GG2 A;  1WL6 A;  1QXW A;  3PKB A;  2P9A A;  2GZ5 A;  5CDV A;  2V6C A;  4FLI A;  5JFR A;  3L7G A;  3S6B A;  2GA2 A;  2OKN A;  5CLS A;  4FLL A;  1R5G A;  1WKM A;  4A6V A;  2NQ6 A;  1YW9 A;  4IPA A;  2BB7 A;  4ZWP A;  3FMR A;  2Q8K A;  3RVA A;  2B3L A;  3BIP A;  2BWW A;  1BOA A;  2GU6 A;  1QXZ A;  4A6W A;  1KQ0 A;  2Q92 A;  2V3X A;  5D6E A;  4MAT A;  4ZNG A;  2BH3 A;  2EA2 A;  5CNX A;  2EVM A;  1A16 A;  1XNZ A;  4U6C A;  5JI6 A;  5CE6 A;  2G6P A;  2BWT A;  2GGC A;  2Q94 A;  1R5H A;  2BHC A;  4RGZ 1;  1C23 A;  1M35 A;  2IW2 A;  2EVO A;  3TB5 A;  4IEC A;  2DFI A;  1W7V A;  3BIT A;  2BWU A;  2V3Y A;  5D6F A;  2BHA A;  2P99 A;  2BHD A;  4R60 A;  4PV4 A;  4EGE A;  3IU8 A;  1N51 A;  2GU7 A;  5CDL A;  1C27 A;  1WN1 A;  1C24 A;  3PKE A;  4JUQ A;  1WBQ A;  1C21 A;  1XGN A;  2ADU A;  1QXY A;  3PKC A;  4ZWO A;  4QR8 A;  3Q6D A;  4ZWU A;  1XGM A;  3CTZ A;  1WLR A;  4U70 A;  2EVC A;  1B6A A;  3PKD A;  4U76 A;  1W2M A;  2GG9 A;  1YW8 A;  2GGB A;  1XGS A;  1R58 A;  4IDY A;  4KM3 A;  3IG4 A;  4FKC A;  5CDE A;  2HOW A;  4U6J A;  2GU4 A;  1B59 A;  2GG5 A;  2GTX A;  2GU5 A;  5CIK A;  2BWY A;  4Z7M A;  1PV9 A;  1YJ3 A;  3D27 A;  2GG8 A;  4FO8 A;  1XGO A;  2Q95 A;  4FLK A;  4S2R P;  3TAV A;  3MAT A;  4U73 A;  3MX6 A;  2EA4 A;  2P98 A;  4U1B A;  1BN5 A;  1KQ9 A;  4U69 A;  3ROR A;  3CB6 A;  4FLJ A;  5FCF A;  3FMQ A;  4U75 A;  2GG7 A;  1KP0 A;  1O0X A;  2BN7 A;  3IU7 A;  4U6Z A;  4S01 A;  4S2T P;  4U71 A;  2Q96 A;  4IKU A;  4IKR A;  2BWX A;  5FCH A;  4IF7 A;  2B3H A;  2B3K A;  3BIQ A;  5E5B A;  1CHM A;  2MAT A;  3L24 A;  2BHB A;  2GG0 A;  4IKS A;  4IU6 A;  4FO7 A;  4HXX A;  1WL9 A;  1WY2 A;  2ZSG A;  1YVM A;  1C22 A;  1QZY A;  3IU9 A;  4B28 A;  2BWS A;  1JAW A;  4RZY A;  3FM3 A;  4U6W A;  3CB5 A;  2NQ7 A;  1MAT A;  1Y1N A;  2BWV A;  2GG3 A;  4FUK A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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