2GG2A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 84
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg2A00
2BHCA 4A6WA 2B3KA 4EGEA 3CB6A 3S6BA 1KQ9A 2GG7A 5FCFA 3TB5A 1M35A 1QXWA 2MATA 2B3LA 4FLKA 1YVMA 2ADUA 4RZZA 2G6PA 4MATA 5CLSA 3IU7A 4U6JA 1WL6A 1B6AA 3CB5A 2EVMA 1WL9A 1XGMA 2Q93A 1XGOA 4OOKA 4FLJA 4Z7MA 2V6CA 1A16A 2Q95A 1C22A 1WLRA 2B3HA 2V3ZA 3IG4A 4IDYA 4KM3A 1WBQA 5D6FA 1KP0A 4FO8A 4IPAA 1W2MA 2GG9A 1C27A 1CHMA 2BWWA 4U76A 1C24A 3PKAA 4ZWPA 5JHUA 4U70A 3TAVA 2Q94A 3Q6DA 3PKBA 5CDLA 3PKEA 1Y1NA 4IKTA 3IU9A 2V3YA 4FO7A 4U73A 2GGBA 4B28A 2V3XA 1O0XA 3PKCA 5CDEA 2EVCA 2BWVA 1C21A 2GU7A 4S2TP 2EA2A 4FLIA 4U6CA 1XGSA 2ZSGA 3D27A 4R60A 1QXZA 2NQ7A 5CE6A 4U1BA 3MATA 4U6ZA 1WKMA 1YJ3A 2GG8A 3L7GA 2BWTA 1BN5A 1XNZA 2P98A 3RORA 2EVOA 5D6EA 2IW2A 1YW9A 1B59A 1YW8A 2Q96A 4IKSA 4U6WA 1R5HA 5JFRA 1KQ0A 1W7VA 2BWYA 4IF7A 2BHAA 4U71A 5JI6A 4IKRA 4S00A 1QZYA 4RZYA 2BHBA 1JAWA 2GU5A 1N51A 3FM3A 4ZWUA 1R5GA 4RGZ1 2Q8KA 3BITA 2BWSA 2GG5A 2OKNA 3FMQA 2GG0A 4PV4A 2GU6A 1WY2A 2GU4A 5E5BA 4FUKA 2GTXA 2OAZA 3FMRA 2BHDA 4IECA 1R58A 4FKCA 2GGCA 2HOWA 3BIQA 3CTZA 4ZWOA 3RVAA 2GA2A 5CNXA 4U69A 2BWXA 1PV9A 2Q92A 1YW7A 2BN7A 4HXXA 4PNCA 2GG2A 1QXYA 1C23A 2P9AA 5CDVA 1BOAA 1MATA 4IU6A 2BB7A 2GG3A 4S01A 4QR8A 4JUQA 2BWUA 2P99A 3MX6A 4A6VA 1WN1A 2BH3A 5FCHA 3PKDA 4S2RP 4U6EA 4U75A 2NQ6A 3IU8A 3BIPA 4FLLA 2GZ5A 3MR1A 1XGNA 2EA4A 4IKUA 3L24A 2DFIA 4ZNGA 5CIKA
chains in the Genus database with same CATH superfamily
2BHCA 4A6WA 2B3KA 4EGEA 3CB6A 3S6BA 1KQ9A 2GG7A 5FCFA 3TB5A 1M35A 1QXWA 2MATA 2B3LA 4FLKA 1YVMA 2ADUA 4RZZA 2G6PA 4MATA 5CLSA 3IU7A 4U6JA 1WL6A 1B6AA 3CB5A 2EVMA 1WL9A 1XGMA 2Q93A 1XGOA 4OOKA 4FLJA 4Z7MA 2V6CA 1A16A 2Q95A 1C22A 1WLRA 2B3HA 2V3ZA 3IG4A 4IDYA 4KM3A 1WBQA 5D6FA 1KP0A 4FO8A 4IPAA 1W2MA 2GG9A 1C27A 1CHMA 2BWWA 4U76A 1C24A 3PKAA 4ZWPA 5JHUA 4U70A 3TAVA 2Q94A 3Q6DA 3PKBA 5CDLA 3PKEA 1Y1NA 4IKTA 3IU9A 2V3YA 4FO7A 4U73A 2GGBA 4B28A 2V3XA 1O0XA 3PKCA 5CDEA 2EVCA 2BWVA 1C21A 2GU7A 4S2TP 2EA2A 4FLIA 4U6CA 1XGSA 2ZSGA 3D27A 4R60A 1QXZA 2NQ7A 5CE6A 4U1BA 3MATA 4U6ZA 1WKMA 1YJ3A 2GG8A 3L7GA 2BWTA 1BN5A 1XNZA 2P98A 3RORA 2EVOA 5D6EA 2IW2A 1YW9A 1B59A 1YW8A 2Q96A 4IKSA 4U6WA 1R5HA 5JFRA 1KQ0A 1W7VA 2BWYA 4IF7A 2BHAA 4U71A 5JI6A 4IKRA 4S00A 1QZYA 4RZYA 2BHBA 1JAWA 2GU5A 1N51A 3FM3A 4ZWUA 1R5GA 4RGZ1 2Q8KA 3BITA 2BWSA 2GG5A 2OKNA 3FMQA 2GG0A 4PV4A 2GU6A 1WY2A 2GU4A 5E5BA 4FUKA 2GTXA 2OAZA 3FMRA 2BHDA 4IECA 1R58A 4FKCA 2GGCA 2HOWA 3BIQA 3CTZA 4ZWOA 3RVAA 2GA2A 5CNXA 4U69A 2BWXA 1PV9A 2Q92A 1YW7A 2BN7A 4HXXA 4PNCA 2GG2A 1QXYA 1C23A 2P9AA 5CDVA 1BOAA 1MATA 4IU6A 2BB7A 2GG3A 4S01A 4QR8A 4JUQA 2BWUA 2P99A 3MX6A 4A6VA 1WN1A 2BH3A 5FCHA 3PKDA 4S2RP 4U6EA 4U75A 2NQ6A 3IU8A 3BIPA 4FLLA 2GZ5A 3MR1A 1XGNA 2EA4A 4IKUA 3L24A 2DFIA 4ZNGA 5CIKA
chains in the Genus database with same CATH topology
2BHCA 4A6WA 2B3KA 4EGEA 3CB6A 3S6BA 1KQ9A 2GG7A 5FCFA 3TB5A 1M35A 1QXWA 2MATA 2B3LA 4FLKA 1YVMA 2ADUA 4RZZA 2G6PA 4MATA 5CLSA 3IU7A 4U6JA 1WL6A 1B6AA 3CB5A 2EVMA 1WL9A 1XGMA 2Q93A 1XGOA 4OOKA 4FLJA 4Z7MA 2V6CA 1A16A 2Q95A 1C22A 1WLRA 2B3HA 2V3ZA 3IG4A 4IDYA 4KM3A 1WBQA 5D6FA 1KP0A 4FO8A 4IPAA 1W2MA 2GG9A 1C27A 1CHMA 2BWWA 4U76A 1C24A 3PKAA 4ZWPA 5JHUA 4U70A 3TAVA 2Q94A 3Q6DA 3PKBA 5CDLA 3PKEA 1Y1NA 4IKTA 3IU9A 2V3YA 4FO7A 4U73A 2GGBA 4B28A 2V3XA 1O0XA 3PKCA 5CDEA 2EVCA 2BWVA 1C21A 2GU7A 4S2TP 2EA2A 4FLIA 4U6CA 1XGSA 2ZSGA 3D27A 4R60A 1QXZA 2NQ7A 5CE6A 4U1BA 3MATA 4U6ZA 1WKMA 1YJ3A 2GG8A 3L7GA 2BWTA 1BN5A 1XNZA 2P98A 3RORA 2EVOA 5D6EA 2IW2A 1YW9A 1B59A 1YW8A 2Q96A 4IKSA 4U6WA 1R5HA 5JFRA 1KQ0A 1W7VA 2BWYA 4IF7A 2BHAA 4U71A 5JI6A 4IKRA 4S00A 1QZYA 4RZYA 2BHBA 1JAWA 2GU5A 1N51A 3FM3A 4ZWUA 1R5GA 4RGZ1 2Q8KA 3BITA 2BWSA 2GG5A 2OKNA 3FMQA 2GG0A 4PV4A 2GU6A 1WY2A 2GU4A 5E5BA 4FUKA 2GTXA 2OAZA 3FMRA 2BHDA 4IECA 1R58A 4FKCA 2GGCA 2HOWA 3BIQA 3CTZA 4ZWOA 3RVAA 2GA2A 5CNXA 4U69A 2BWXA 1PV9A 2Q92A 1YW7A 2BN7A 4HXXA 4PNCA 2GG2A 1QXYA 1C23A 2P9AA 5CDVA 1BOAA 1MATA 4IU6A 2BB7A 2GG3A 4S01A 4QR8A 4JUQA 2BWUA 2P99A 3MX6A 4A6VA 1WN1A 2BH3A 5FCHA 3PKDA 4S2RP 4U6EA 4U75A 2NQ6A 3IU8A 3BIPA 4FLLA 2GZ5A 3MR1A 1XGNA 2EA4A 4IKUA 3L24A 2DFIA 4ZNGA 5CIKA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BHC A;  4A6W A;  2B3K A;  4EGE A;  3CB6 A;  3S6B A;  1KQ9 A;  2GG7 A;  5FCF A;  3TB5 A;  1M35 A;  1QXW A;  2MAT A;  2B3L A;  4FLK A;  1YVM A;  2ADU A;  4RZZ A;  2G6P A;  4MAT A;  5CLS A;  3IU7 A;  4U6J A;  1WL6 A;  1B6A A;  3CB5 A;  2EVM A;  1WL9 A;  1XGM A;  2Q93 A;  1XGO A;  4OOK A;  4FLJ A;  4Z7M A;  2V6C A;  1A16 A;  2Q95 A;  1C22 A;  1WLR A;  2B3H A;  2V3Z A;  3IG4 A;  4IDY A;  4KM3 A;  1WBQ A;  5D6F A;  1KP0 A;  4FO8 A;  4IPA A;  1W2M A;  2GG9 A;  1C27 A;  1CHM A;  2BWW A;  4U76 A;  1C24 A;  3PKA A;  4ZWP A;  5JHU A;  4U70 A;  3TAV A;  2Q94 A;  3Q6D A;  3PKB A;  5CDL A;  3PKE A;  1Y1N A;  4IKT A;  3IU9 A;  2V3Y A;  4FO7 A;  4U73 A;  2GGB A;  4B28 A;  2V3X A;  1O0X A;  3PKC A;  5CDE A;  2EVC A;  2BWV A;  1C21 A;  2GU7 A;  4S2T P;  2EA2 A;  4FLI A;  4U6C A;  1XGS A;  2ZSG A;  3D27 A;  4R60 A;  1QXZ A;  2NQ7 A;  5CE6 A;  4U1B A;  3MAT A;  4U6Z A;  1WKM A;  1YJ3 A;  2GG8 A;  3L7G A;  2BWT A;  1BN5 A;  1XNZ A;  2P98 A;  3ROR A;  2EVO A;  5D6E A;  2IW2 A;  1YW9 A;  1B59 A;  1YW8 A;  2Q96 A;  4IKS A;  4U6W A;  1R5H A;  5JFR A;  1KQ0 A;  1W7V A;  2BWY A;  4IF7 A;  2BHA A;  4U71 A;  5JI6 A;  4IKR A;  4S00 A;  1QZY A;  4RZY A;  2BHB A;  1JAW A;  2GU5 A;  1N51 A;  3FM3 A;  4ZWU A;  1R5G A;  4RGZ 1;  2Q8K A;  3BIT A;  2BWS A;  2GG5 A;  2OKN A;  3FMQ A;  2GG0 A;  4PV4 A;  2GU6 A;  1WY2 A;  2GU4 A;  5E5B A;  4FUK A;  2GTX A;  2OAZ A;  3FMR A;  2BHD A;  4IEC A;  1R58 A;  4FKC A;  2GGC A;  2HOW A;  3BIQ A;  3CTZ A;  4ZWO A;  3RVA A;  2GA2 A;  5CNX A;  4U69 A;  2BWX A;  1PV9 A;  2Q92 A;  1YW7 A;  2BN7 A;  4HXX A;  4PNC A;  2GG2 A;  1QXY A;  1C23 A;  2P9A A;  5CDV A;  1BOA A;  1MAT A;  4IU6 A;  2BB7 A;  2GG3 A;  4S01 A;  4QR8 A;  4JUQ A;  2BWU A;  2P99 A;  3MX6 A;  4A6V A;  1WN1 A;  2BH3 A;  5FCH A;  3PKD A;  4S2R P;  4U6E A;  4U75 A;  2NQ6 A;  3IU8 A;  3BIP A;  4FLL A;  2GZ5 A;  3MR1 A;  1XGN A;  2EA4 A;  4IKU A;  3L24 A;  2DFI A;  4ZNG A;  5CIK A; 
#chains in the Genus database with same CATH topology
 2BHC A;  4A6W A;  2B3K A;  4EGE A;  3CB6 A;  3S6B A;  1KQ9 A;  2GG7 A;  5FCF A;  3TB5 A;  1M35 A;  1QXW A;  2MAT A;  2B3L A;  4FLK A;  1YVM A;  2ADU A;  4RZZ A;  2G6P A;  4MAT A;  5CLS A;  3IU7 A;  4U6J A;  1WL6 A;  1B6A A;  3CB5 A;  2EVM A;  1WL9 A;  1XGM A;  2Q93 A;  1XGO A;  4OOK A;  4FLJ A;  4Z7M A;  2V6C A;  1A16 A;  2Q95 A;  1C22 A;  1WLR A;  2B3H A;  2V3Z A;  3IG4 A;  4IDY A;  4KM3 A;  1WBQ A;  5D6F A;  1KP0 A;  4FO8 A;  4IPA A;  1W2M A;  2GG9 A;  1C27 A;  1CHM A;  2BWW A;  4U76 A;  1C24 A;  3PKA A;  4ZWP A;  5JHU A;  4U70 A;  3TAV A;  2Q94 A;  3Q6D A;  3PKB A;  5CDL A;  3PKE A;  1Y1N A;  4IKT A;  3IU9 A;  2V3Y A;  4FO7 A;  4U73 A;  2GGB A;  4B28 A;  2V3X A;  1O0X A;  3PKC A;  5CDE A;  2EVC A;  2BWV A;  1C21 A;  2GU7 A;  4S2T P;  2EA2 A;  4FLI A;  4U6C A;  1XGS A;  2ZSG A;  3D27 A;  4R60 A;  1QXZ A;  2NQ7 A;  5CE6 A;  4U1B A;  3MAT A;  4U6Z A;  1WKM A;  1YJ3 A;  2GG8 A;  3L7G A;  2BWT A;  1BN5 A;  1XNZ A;  2P98 A;  3ROR A;  2EVO A;  5D6E A;  2IW2 A;  1YW9 A;  1B59 A;  1YW8 A;  2Q96 A;  4IKS A;  4U6W A;  1R5H A;  5JFR A;  1KQ0 A;  1W7V A;  2BWY A;  4IF7 A;  2BHA A;  4U71 A;  5JI6 A;  4IKR A;  4S00 A;  1QZY A;  4RZY A;  2BHB A;  1JAW A;  2GU5 A;  1N51 A;  3FM3 A;  4ZWU A;  1R5G A;  4RGZ 1;  2Q8K A;  3BIT A;  2BWS A;  2GG5 A;  2OKN A;  3FMQ A;  2GG0 A;  4PV4 A;  2GU6 A;  1WY2 A;  2GU4 A;  5E5B A;  4FUK A;  2GTX A;  2OAZ A;  3FMR A;  2BHD A;  4IEC A;  1R58 A;  4FKC A;  2GGC A;  2HOW A;  3BIQ A;  3CTZ A;  4ZWO A;  3RVA A;  2GA2 A;  5CNX A;  4U69 A;  2BWX A;  1PV9 A;  2Q92 A;  1YW7 A;  2BN7 A;  4HXX A;  4PNC A;  2GG2 A;  1QXY A;  1C23 A;  2P9A A;  5CDV A;  1BOA A;  1MAT A;  4IU6 A;  2BB7 A;  2GG3 A;  4S01 A;  4QR8 A;  4JUQ A;  2BWU A;  2P99 A;  3MX6 A;  4A6V A;  1WN1 A;  2BH3 A;  5FCH A;  3PKD A;  4S2R P;  4U6E A;  4U75 A;  2NQ6 A;  3IU8 A;  3BIP A;  4FLL A;  2GZ5 A;  3MR1 A;  1XGN A;  2EA4 A;  4IKU A;  3L24 A;  2DFI A;  4ZNG A;  5CIK A; 
#chains in the Genus database with same CATH homology
 2BHC A;  4A6W A;  2B3K A;  4EGE A;  3CB6 A;  3S6B A;  1KQ9 A;  2GG7 A;  5FCF A;  3TB5 A;  1M35 A;  1QXW A;  2MAT A;  2B3L A;  4FLK A;  1YVM A;  2ADU A;  4RZZ A;  2G6P A;  4MAT A;  5CLS A;  3IU7 A;  4U6J A;  1WL6 A;  1B6A A;  3CB5 A;  2EVM A;  1WL9 A;  1XGM A;  2Q93 A;  1XGO A;  4OOK A;  4FLJ A;  4Z7M A;  2V6C A;  1A16 A;  2Q95 A;  1C22 A;  1WLR A;  2B3H A;  2V3Z A;  3IG4 A;  4IDY A;  4KM3 A;  1WBQ A;  5D6F A;  1KP0 A;  4FO8 A;  4IPA A;  1W2M A;  2GG9 A;  1C27 A;  1CHM A;  2BWW A;  4U76 A;  1C24 A;  3PKA A;  4ZWP A;  5JHU A;  4U70 A;  3TAV A;  2Q94 A;  3Q6D A;  3PKB A;  5CDL A;  3PKE A;  1Y1N A;  4IKT A;  3IU9 A;  2V3Y A;  4FO7 A;  4U73 A;  2GGB A;  4B28 A;  2V3X A;  1O0X A;  3PKC A;  5CDE A;  2EVC A;  2BWV A;  1C21 A;  2GU7 A;  4S2T P;  2EA2 A;  4FLI A;  4U6C A;  1XGS A;  2ZSG A;  3D27 A;  4R60 A;  1QXZ A;  2NQ7 A;  5CE6 A;  4U1B A;  3MAT A;  4U6Z A;  1WKM A;  1YJ3 A;  2GG8 A;  3L7G A;  2BWT A;  1BN5 A;  1XNZ A;  2P98 A;  3ROR A;  2EVO A;  5D6E A;  2IW2 A;  1YW9 A;  1B59 A;  1YW8 A;  2Q96 A;  4IKS A;  4U6W A;  1R5H A;  5JFR A;  1KQ0 A;  1W7V A;  2BWY A;  4IF7 A;  2BHA A;  4U71 A;  5JI6 A;  4IKR A;  4S00 A;  1QZY A;  4RZY A;  2BHB A;  1JAW A;  2GU5 A;  1N51 A;  3FM3 A;  4ZWU A;  1R5G A;  4RGZ 1;  2Q8K A;  3BIT A;  2BWS A;  2GG5 A;  2OKN A;  3FMQ A;  2GG0 A;  4PV4 A;  2GU6 A;  1WY2 A;  2GU4 A;  5E5B A;  4FUK A;  2GTX A;  2OAZ A;  3FMR A;  2BHD A;  4IEC A;  1R58 A;  4FKC A;  2GGC A;  2HOW A;  3BIQ A;  3CTZ A;  4ZWO A;  3RVA A;  2GA2 A;  5CNX A;  4U69 A;  2BWX A;  1PV9 A;  2Q92 A;  1YW7 A;  2BN7 A;  4HXX A;  4PNC A;  2GG2 A;  1QXY A;  1C23 A;  2P9A A;  5CDV A;  1BOA A;  1MAT A;  4IU6 A;  2BB7 A;  2GG3 A;  4S01 A;  4QR8 A;  4JUQ A;  2BWU A;  2P99 A;  3MX6 A;  4A6V A;  1WN1 A;  2BH3 A;  5FCH A;  3PKD A;  4S2R P;  4U6E A;  4U75 A;  2NQ6 A;  3IU8 A;  3BIP A;  4FLL A;  2GZ5 A;  3MR1 A;  1XGN A;  2EA4 A;  4IKU A;  3L24 A;  2DFI A;  4ZNG A;  5CIK A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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